{"id":"https://openalex.org/W4416635605","doi":"https://doi.org/10.1183/13993003.congress-2025.pa480","title":"Reduction of Inhaled Corticosteroids After Biologic Therapy Initiation in Severe Asthma: Prevalence and Impact in the German Severe Asthma Registry","display_name":"Reduction of Inhaled Corticosteroids After Biologic Therapy Initiation in Severe Asthma: Prevalence and Impact in the German Severe Asthma Registry","publication_year":2025,"publication_date":"2025-09-27","ids":{"openalex":"https://openalex.org/W4416635605","doi":"https://doi.org/10.1183/13993003.congress-2025.pa480"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2025.pa480","doi":"https://doi.org/10.1183/13993003.congress-2025.pa480","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.pa480","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy and immunology","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026486168","display_name":"Slagjana Stoshikj","orcid":"https://orcid.org/0009-0000-4418-0734","observed_orcids":["https://orcid.org/0009-0000-4418-0734"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Slagjana Stoshikj","raw_affiliation_strings":["1Clinic of Internal Medicine II, Department of Pulmonology; Comprehensive Center for Chest Diseases (CCCD), Medical University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Clinic of Internal Medicine II, Department of Pulmonology; Comprehensive Center for Chest Diseases (CCCD), Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024246795","display_name":"Andreas Renner","orcid":"https://orcid.org/0000-0002-1414-5433","observed_orcids":["https://orcid.org/0000-0002-1414-5433"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Andreas Renner","raw_affiliation_strings":["1Clinic of Internal Medicine II, Department of Pulmonology; Comprehensive Center for Chest Diseases (CCCD), Medical University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Clinic of Internal Medicine II, Department of Pulmonology; Comprehensive Center for Chest Diseases (CCCD), Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011284365","display_name":"Christoph Krall","orcid":"https://orcid.org/0000-0002-0721-1797","observed_orcids":["https://orcid.org/0000-0002-0721-1797"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Christoph Krall","raw_affiliation_strings":["2Center for Medical Data Science, Medical University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Center for Medical Data Science, Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062802488","display_name":"Christina Bal","orcid":"https://orcid.org/0000-0003-3591-9490","observed_orcids":["https://orcid.org/0000-0003-3591-9490"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Christina Bal","raw_affiliation_strings":["1Clinic of Internal Medicine II, Department of Pulmonology; Comprehensive Center for Chest Diseases (CCCD), Medical University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Clinic of Internal Medicine II, Department of Pulmonology; Comprehensive Center for Chest Diseases (CCCD), Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039583899","display_name":"Katrin Milger","orcid":"https://orcid.org/0000-0003-2914-8773","observed_orcids":["https://orcid.org/0000-0003-2914-8773"]},"institutions":[{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Katrin Milger","raw_affiliation_strings":["3Department of Internal Medicine, Division of Pulmonology, Medical University of Graz, Graz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Internal Medicine, Division of Pulmonology, Medical University of Graz, Graz, Austria","institution_ids":["https://openalex.org/I202276237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103171614","display_name":"Christian Klaus Jochen Schulz","orcid":"https://orcid.org/0000-0002-4861-4517","observed_orcids":["https://orcid.org/0000-0002-4861-4517"]},"institutions":[{"id":"https://openalex.org/I3129555431","display_name":"University Hospital Regensburg","ror":"https://ror.org/01226dv09","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3129555431"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Schulz","raw_affiliation_strings":["4Respiratory Department, University Hospital Regensburg, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Respiratory Department, University Hospital Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I3129555431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014907296","display_name":"Margret Jandl","orcid":"https://orcid.org/0000-0001-5964-0211","observed_orcids":["https://orcid.org/0000-0001-5964-0211"]},"institutions":[{"id":"https://openalex.org/I4210161923","display_name":"Hamburg Institute for Therapy Research","ror":"https://ror.org/05yjkn316","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210161923"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Margret Jandl","raw_affiliation_strings":["5Hamburger Institut f\u00fcr Therapieforschung, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Hamburger Institut f\u00fcr Therapieforschung, Hamburg, Germany","institution_ids":["https://openalex.org/I4210161923"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109379394","display_name":"Rainer Ehmann","orcid":"https://orcid.org/0009-0004-6464-6385","observed_orcids":["https://orcid.org/0009-0004-6464-6385"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rainer Ehmann","raw_affiliation_strings":["6Outpatient Pneumology with Allergy Center (BAG), Stuttgart, Stuttgart, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Outpatient Pneumology with Allergy Center (BAG), Stuttgart, Stuttgart, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064965821","display_name":"Olaf Schmidt","orcid":"https://orcid.org/0000-0003-0098-7960","observed_orcids":["https://orcid.org/0000-0003-0098-7960"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Olaf Schmidt","raw_affiliation_strings":["7Pneumologische Gemeinschaftspraxis und Studienzentrum, KPPK, Koblenz, Koblenz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7Pneumologische Gemeinschaftspraxis und Studienzentrum, KPPK, Koblenz, Koblenz, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039635841","display_name":"Roland Buhl","orcid":"https://orcid.org/0009-0001-5695-5899","observed_orcids":["https://orcid.org/0009-0001-5695-5899"]},"institutions":[{"id":"https://openalex.org/I4210094062","display_name":"University Medical Center of the Johannes Gutenberg University Mainz","ror":"https://ror.org/00q1fsf04","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094062"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Roland Buhl","raw_affiliation_strings":["8Pulmonary Department, Mainz University Hospital, Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8Pulmonary Department, Mainz University Hospital, Mainz, Germany","institution_ids":["https://openalex.org/I4210094062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064084880","display_name":"Eckard H. Hamelmann","orcid":"https://orcid.org/0000-0002-2996-8248","observed_orcids":["https://orcid.org/0000-0002-2996-8248"]},"institutions":[{"id":"https://openalex.org/I20121455","display_name":"Bielefeld University","ror":"https://ror.org/02hpadn98","country_code":"DE","type":"education","lineage":["https://openalex.org/I20121455"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Eckard Hamelmann","raw_affiliation_strings":["9Department of Pediatrics, Children's Center Bethel, University Hospital OWL, University Bielefeld, Bielefeld, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"9Department of Pediatrics, Children's Center Bethel, University Hospital OWL, University Bielefeld, Bielefeld, Germany","institution_ids":["https://openalex.org/I20121455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040230220","display_name":"Christian Taube","orcid":"https://orcid.org/0000-0002-3546-1398","observed_orcids":["https://orcid.org/0000-0002-3546-1398"]},"institutions":[{"id":"https://openalex.org/I4210089079","display_name":"Ruhrlandklinik","ror":"https://ror.org/006c8a128","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210089079"]},{"id":"https://openalex.org/I4210119759","display_name":"Essen University Hospital","ror":"https://ror.org/02na8dn90","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210119759"]},{"id":"https://openalex.org/I4405270573","display_name":"Stiftung Universit\u00e4tsmedizin Essen","ror":"https://ror.org/00ykp8811","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4405270573"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Taube","raw_affiliation_strings":["10Department of Pulmonary Medicine, University Hospital Essen - Ruhrlandklinik, Essen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"10Department of Pulmonary Medicine, University Hospital Essen - Ruhrlandklinik, Essen, Germany","institution_ids":["https://openalex.org/I4210089079","https://openalex.org/I4210119759","https://openalex.org/I4405270573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085408217","display_name":"Dirk Skowasch","orcid":"https://orcid.org/0000-0003-2377-5936","observed_orcids":["https://orcid.org/0000-0003-2377-5936"]},"institutions":[{"id":"https://openalex.org/I2799391451","display_name":"University Hospital Bonn","ror":"https://ror.org/01xnwqx93","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2799391451"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dirk Skowasch","raw_affiliation_strings":["11Department of Internal Medicine II - Pneumology, University Hospital Bonn, Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"11Department of Internal Medicine II - Pneumology, University Hospital Bonn, Bonn, Germany","institution_ids":["https://openalex.org/I2799391451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056192386","display_name":"Stephanie Korn","orcid":"https://orcid.org/0009-0001-2239-5029","observed_orcids":["https://orcid.org/0009-0001-2239-5029"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephanie Korn","raw_affiliation_strings":["12Thoraxklinik Heidelberg and IKF-Pneumologie, Heidelberg and Mainz, Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"12Thoraxklinik Heidelberg and IKF-Pneumologie, Heidelberg and Mainz, Mainz, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066491154","display_name":"Marco Idzko","orcid":"https://orcid.org/0000-0002-2057-2909","observed_orcids":["https://orcid.org/0000-0002-2057-2909"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Marco Idzko","raw_affiliation_strings":["1Clinic of Internal Medicine II, Department of Pulmonology; Comprehensive Center for Chest Diseases (CCCD), Medical University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Clinic of Internal Medicine II, Department of Pulmonology; Comprehensive Center for Chest Diseases (CCCD), Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"PA480","last_page":"PA480"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/severe-asthma","display_name":"severe asthma","score":0.9750000238418579},{"id":"https://openalex.org/keywords/biological-therapy","display_name":"biologic therapy","score":0.8450000286102295},{"id":"https://openalex.org/keywords/inhaled-corticosteroids","display_name":"inhaled corticosteroids","score":0.9629999995231628},{"id":"https://openalex.org/keywords/asthma-control","display_name":"asthma control","score":0.4909999966621399},{"id":"https://openalex.org/keywords/exhaled-nitric-oxide","display_name":"exhaled nitric oxide","score":0.6850000023841858},{"id":"https://openalex.org/keywords/exacerbations","display_name":"exacerbations","score":0.6669999957084656},{"id":"https://openalex.org/keywords/fev1","display_name":"FEV1","score":0.9549999833106995},{"id":"https://openalex.org/keywords/adjunctive-therapy","display_name":"adjunctive therapy","score":0.7940000295639038},{"id":"https://openalex.org/keywords/real-world-outcomes","display_name":"real-world outcomes","score":0.6019999980926514},{"id":"https://openalex.org/keywords/treatment-response-biomarkers","display_name":"treatment response biomarkers","score":0.4580000042915344},{"id":"https://openalex.org/keywords/biologic-naive-patients","display_name":"biologic-naive patients","score":0.6010000109672546},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.40700000524520874}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9519000053405762},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.7250000238418579},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.6276999711990356},{"id":"https://openalex.org/C2991922776","wikidata":"https://www.wikidata.org/wiki/Q210420","display_name":"Inhaled corticosteroids","level":3,"score":0.5544999837875366},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3930000066757202},{"id":"https://openalex.org/C111335779","wikidata":"https://www.wikidata.org/wiki/Q3454686","display_name":"Reduction (mathematics)","level":2,"score":0.37540000677108765},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.3402999937534332},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.3043000102043152},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.30390000343322754},{"id":"https://openalex.org/C154775046","wikidata":"https://www.wikidata.org/wiki/Q188","display_name":"German","level":2,"score":0.2935999929904938},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.25380000472068787},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.25369998812675476},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.25060001015663147}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1183/13993003.congress-2025.pa480","doi":"https://doi.org/10.1183/13993003.congress-2025.pa480","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.pa480","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy and immunology","raw_type":"proceedings-article"},{"id":"pmh:oai:pub.uni-bielefeld.de:3012832","doi":null,"is_oa":false,"landing_page_url":"https://pub.uni-bielefeld.de/record/3012832","pdf_url":null,"source":{"id":"https://openalex.org/S4306401624","display_name":"Publikationen an der Universit\u00e4t Bielefeld (Universit\u00e4t Bielefeld)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I20121455","host_organization_name":"Bielefeld University","host_organization_lineage":["https://openalex.org/I20121455"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:pub.uni-bielefeld.de:3013892","doi":null,"is_oa":false,"landing_page_url":"https://pub.uni-bielefeld.de/record/3013892","pdf_url":null,"source":{"id":"https://openalex.org/S4306401624","display_name":"Publikationen an der Universit\u00e4t Bielefeld (Universit\u00e4t Bielefeld)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I20121455","host_organization_name":"Bielefeld University","host_organization_lineage":["https://openalex.org/I20121455"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7214117975","https://openalex.org/W4404046414","https://openalex.org/W7214608721","https://openalex.org/W4385792195","https://openalex.org/W4413387604","https://openalex.org/W4388188360","https://openalex.org/W4405387466","https://openalex.org/W4200545177","https://openalex.org/W4410268570","https://openalex.org/W4404101092"],"abstract_inverted_index":{"Biologics":[0,229],"for":[1,73,84],"severe":[2,236],"asthma":[3,56],"can":[4],"reduce":[5],"high-dose":[6],"inhaled":[7],"corticosteroids(hd-ICS)":[8],"use":[9,167],"while":[10,238],"improving":[11,239],"control,":[12],"but":[13,153],"real-world":[14],"data":[15],"are":[16],"limited.":[17],"We":[18],"analyzed":[19],"1,137":[20],"patients":[21,114,148],"from":[22,118],"the":[23,92,161,182],"German":[24],"Severe":[25],"Asthma":[26],"Registry":[27],"who":[28],"initiated":[29],"1":[30,190],"of":[31,113],"6":[32],"biologics":[33],"as":[34],"add-on":[35],"therapy":[36],"to":[37,55,120,141,199],"at":[38,144,155,189,203,212,216],"least":[39],"medium-dose":[40],"ICS":[41,45,137,232,246],"plus":[42],"another":[43],"controller.":[44],"dose":[46,70],"changes":[47,222],"over":[48],"2":[49,192],"years":[50],"were":[51,88,99,109],"assessed":[52],"in":[53,147,160,184,223,234],"relation":[54],"control":[57],"(ACT),":[58],"FEV\u2081,exacerbations":[59],"(AEs),":[60],"and":[61,79,86,124,130,206,245],"FeNO.":[62],"Hd-ICS":[63],"use(per":[64],"GINA)":[65],"was":[66,95,139,197],"documented,":[67],"with":[68,128,149,164],"beclometasone-equivalent":[69],"(BED)":[71],"available":[72,150],"some":[74,235],"patients.":[75],"Mixed":[76],"linear,":[77],"loglinear":[78],"negative":[80],"binomial":[81],"models":[82],"adjusted":[83],"sex":[85],"age":[87,94],"used.":[89],"At":[90],"baseline,":[91],"mean":[93],"54.9\u00b113.1":[96],"years;":[97],"42.5%":[98],"male,BMI":[100],"27.9\u00b16.2,ACT":[101],"13.3\u00b15.2,FEV\u2081%":[102],"64.7\u00b121.4,and":[103],"FeNO":[104,143,174,244],"55\u00b153.9":[105],"ppb.":[106],"Overall,":[107],"62%":[108],"biologic-na\u00efve.":[110],"The":[111,241],"proportion":[112],"on":[115],"hd-ICS":[116,133,166,195],"decreased":[117],"90.9%":[119],"78.6%(1":[121],"year,":[122],"n=503)":[123],"77.1%(2":[125],"years,":[126],"n=303),":[127],"12.3%":[129],"13.8%":[131],"reducing":[132],"without":[134],"worsening":[135],"outcomes.":[136],"reduction":[138,169,176,196,233],"linked":[140,198],"higher":[142,200],"one":[145],"year":[146,213,217],"BED(P=.04,n=":[151],"132)":[152],"not":[154,171,179,220],"two":[156],"years(P=.06,n=":[157],"549).":[158],"However,":[159,194],"overall":[162],"cohort":[163],"documented":[165],"(yes/no),":[168],"did":[170,219],"significantly":[172,180],"impact":[173],"(P>.05).ICS":[175],"also":[177],"had":[178],"impacted":[181],"change":[183],"FEV\u2081":[185],"or":[186,191,227],"AEs":[187,225],"rate":[188,226],"years(P>.05).":[193],"ACT":[201],"score":[202],"both":[204],"years(P<.0001":[205],"P=.0062,":[207],"respectively).":[208],"BED":[209],"reductions(1200":[210],"mcg":[211,215],"1,1400":[214],"2)":[218],"affect":[221],"FEV\u2081,":[224],"ACT(P>.05).":[228],"may":[230],"allow":[231],"asthmatics":[237],"control.":[240],"link":[242],"between":[243],"needs":[247],"further":[248],"study.":[249]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-11-25T00:00:00"}
