{"id":"https://openalex.org/W4416635463","doi":"https://doi.org/10.1183/13993003.congress-2025.oa5514","title":"A binary survival model, incorporating Fibulin-3, predicts survival in pleural mesothelioma","display_name":"A binary survival model, incorporating Fibulin-3, predicts survival in pleural mesothelioma","publication_year":2025,"publication_date":"2025-09-27","ids":{"openalex":"https://openalex.org/W4416635463","doi":"https://doi.org/10.1183/13993003.congress-2025.oa5514"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2025.oa5514","doi":"https://doi.org/10.1183/13993003.congress-2025.oa5514","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.oa5514","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pleural and mediastinal malignancies","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065305755","display_name":"Harrison Stubbs","orcid":"https://orcid.org/0000-0003-1786-342X","observed_orcids":["https://orcid.org/0000-0003-1786-342X"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Harrison Stubbs","raw_affiliation_strings":["1School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025456261","display_name":"Selina Tsim","orcid":"https://orcid.org/0000-0003-2462-1488","observed_orcids":["https://orcid.org/0000-0003-2462-1488"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Selina Tsim","raw_affiliation_strings":["1School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071781603","display_name":"Laura E. Crotty Alexander","orcid":"https://orcid.org/0000-0002-5091-2660","observed_orcids":["https://orcid.org/0000-0002-5091-2660"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura Alexander","raw_affiliation_strings":["2Glasgow Oncology CTU, Glasgow, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Glasgow Oncology CTU, Glasgow, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056093407","display_name":"Caroline Kelly","orcid":"https://orcid.org/0000-0002-5330-7888","observed_orcids":["https://orcid.org/0000-0002-5330-7888"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Caroline Kelly","raw_affiliation_strings":["2Glasgow Oncology CTU, Glasgow, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Glasgow Oncology CTU, Glasgow, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Matthew Tate","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158502","display_name":"Queen Elizabeth University Hospital","ror":"https://ror.org/04y0x0x35","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800201399","https://openalex.org/I4210158502"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Matthew Tate","raw_affiliation_strings":["3Glasgow Pleural Disease Unit, Queen Elizabeth University Hospital, Glasgow, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Glasgow Pleural Disease Unit, Queen Elizabeth University Hospital, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I4210158502"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057031525","display_name":"Kevin G. Blyth","orcid":"https://orcid.org/0000-0003-2972-6641","observed_orcids":["https://orcid.org/0000-0003-2972-6641"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kevin G Blyth","raw_affiliation_strings":["1School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I7882870"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"OA5514","last_page":"OA5514"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11356","display_name":"Pleural and Pulmonary Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pleural-mesothelioma","display_name":"pleural mesothelioma","score":1.0},{"id":"https://openalex.org/keywords/fibulin-3","display_name":"fibulin-3","score":0.9049999713897705},{"id":"https://openalex.org/keywords/prognostic-model","display_name":"prognostic model","score":0.7250000238418579},{"id":"https://openalex.org/keywords/one-year-survival","display_name":"one-year survival","score":0.7649999856948853},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6809999942779541},{"id":"https://openalex.org/keywords/watch-and-wait-strategy","display_name":"watch-and-wait strategy","score":0.796999990940094},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.7379999756813049},{"id":"https://openalex.org/keywords/external-validation","display_name":"external validation","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7149999737739563},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.6629999876022339},{"id":"https://openalex.org/C2777407522","wikidata":"https://www.wikidata.org/wiki/Q1077603","display_name":"Mesothelioma","level":2,"score":0.5755000114440918},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5164999961853027},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.4896000027656555},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.4830000102519989},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4771000146865845},{"id":"https://openalex.org/C164292776","wikidata":"https://www.wikidata.org/wiki/Q5271779","display_name":"Diaphragm (acoustics)","level":3,"score":0.4758000075817108},{"id":"https://openalex.org/C48372109","wikidata":"https://www.wikidata.org/wiki/Q3913","display_name":"Binary number","level":2,"score":0.44209998846054077},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.40220001339912415},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.36070001125335693},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.3393000066280365},{"id":"https://openalex.org/C66905080","wikidata":"https://www.wikidata.org/wiki/Q17005494","display_name":"Binary classification","level":3,"score":0.325300008058548},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3188999891281128},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.31839999556541443},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3125},{"id":"https://openalex.org/C137668524","wikidata":"https://www.wikidata.org/wiki/Q189813","display_name":"Censoring (clinical trials)","level":2,"score":0.28940001130104065},{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.2808000147342682},{"id":"https://openalex.org/C164465091","wikidata":"https://www.wikidata.org/wiki/Q7248371","display_name":"Prognostic variable","level":3,"score":0.26660001277923584},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.25920000672340393},{"id":"https://openalex.org/C152877465","wikidata":"https://www.wikidata.org/wiki/Q208042","display_name":"Regression analysis","level":2,"score":0.25850000977516174},{"id":"https://openalex.org/C2780739268","wikidata":"https://www.wikidata.org/wiki/Q2112244","display_name":"Progression-free survival","level":3,"score":0.2563000023365021},{"id":"https://openalex.org/C2776283816","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Survival rate","level":2,"score":0.2551000118255615}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/13993003.congress-2025.oa5514","doi":"https://doi.org/10.1183/13993003.congress-2025.oa5514","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.oa5514","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pleural and mediastinal malignancies","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4416101873","https://openalex.org/W2570789884","https://openalex.org/W3208541686","https://openalex.org/W2768000878","https://openalex.org/W2905872050","https://openalex.org/W2574593173","https://openalex.org/W2344292587","https://openalex.org/W2289470045","https://openalex.org/W3019026980","https://openalex.org/W2898605682"],"abstract_inverted_index":{"Introduction:":[0],"The":[1],"Brims":[2,93,140],"model":[3,42,68,132,145,195],"classifies":[4],"patients":[5,18,34,208],"with":[6,28,190],"pleural":[7],"mesothelioma":[8],"into":[9],"4":[10],"prognostic":[11],"groups.":[12],"However":[13],"at":[14],"diagnosis,":[15],"clinicians":[16],"and":[17,94],"face":[19],"a":[20,39,198],"binary":[21,41,118,200],"choice":[22],"between":[23],"immediate":[24],"treatment":[25],"or":[26],"\u2018watch-and-wait\u2019,":[27],"the":[29,50,81,99,117,129,149],"latter":[30],"being":[31],"high-risk":[32],"if":[33],"rapidly":[35],"progress.":[36],"We":[37],"devised":[38],"new":[40],"aiming":[43],"for":[44,69,210],"similar":[45],"performance":[46,138,147,173],"to":[47,92,110,115,128,139,196,213],"Brims,":[48],"using":[49],"previously":[51],"published":[52],"DIAPHRAGM":[53,82,113,131],"study":[54],"dataset":[55,83,103],"(Tsim":[56],"et":[57],"al,":[58],"JTO":[59],"2021),":[60],"including":[61],"novel":[62],"biomarker":[63],"data.":[64],"Methods:":[65],"A":[66],"3-group":[67,130,194],"1-yr":[70,153,175],"survival":[71,154,176],"was":[72,86,107],"derived":[73],"from":[74],"multivariable":[75],"Cox":[76],"regression":[77],"hazard":[78],"ratios":[79],"in":[80,98,148,158,180,206],"(n=100).":[84],"Performance":[85],"measured":[87],"by":[88,165],"C-statistic":[89],"(C),":[90],"compared":[91],"then":[95,108],"validated":[96,193],"externally":[97,192],"Scottish":[100],"national":[101],"MDT":[102],"(n=203).":[104],"Fibulin-3":[105],"(F3)":[106],"used":[109],"stratify":[111],"intermediate-risk":[112,163],"cases":[114,164],"create":[116,197],"Glasgow":[119],"Mesothelioma":[120],"Score":[121],"(GMS).":[122],"Results:":[123],"6":[124],"independent":[125],"features":[126],"contributed":[127],"(Fig":[133],"1a),":[134],"which":[135],"delivered":[136],"superior":[137],"(C=0.72":[141],"v":[142,178],"0.66).":[143],"This":[144,202],"retained":[146],"validation":[150],"cohort":[151],"(C=0.60,":[152],"38%,":[155],"56%,":[156],"75%":[157],"high/intermediate/low-risk;":[159],"Fig1b).":[160],"Stratification":[161],"of":[162],"F3":[166,189],"(\u226516":[167],"\u00b5g/mL),":[168],"creating":[169],"GMS,":[170],"significantly":[171],"improved":[172],"(C=0.73,":[174],"70%":[177],"9%":[179],"high/low":[181],"risk,":[182],"see":[183],"Fig":[184],"1c-d).":[185],"Conclusion:":[186],"GMS":[187],"combines":[188],"an":[191],"powerful":[199],"classifier.":[201],"may":[203],"be":[204],"useful":[205],"identifying":[207],"unsuitable":[209],"\u2018watch-and-wait\u2019":[211],"due":[212],"rapid":[214],"progression":[215],"risk.":[216],"erj;66/suppl_69/OA5514/F1":[217],"F1":[218,219]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2025-11-25T00:00:00"}
