{"id":"https://openalex.org/W4416635314","doi":"https://doi.org/10.1183/13993003.congress-2025.pa1849","title":"Tissue turnover biomarkers are associated with lung function and exercise capacity in idiopathic pulmonary fibrosis","display_name":"Tissue turnover biomarkers are associated with lung function and exercise capacity in idiopathic pulmonary fibrosis","publication_year":2025,"publication_date":"2025-09-27","ids":{"openalex":"https://openalex.org/W4416635314","doi":"https://doi.org/10.1183/13993003.congress-2025.pa1849"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2025.pa1849","doi":"https://doi.org/10.1183/13993003.congress-2025.pa1849","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.pa1849","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Idiopathic interstitial pneumonias","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036921451","display_name":"Filipa Bica Sim\u00f5es","orcid":"https://orcid.org/0000-0003-2010-1282","observed_orcids":["https://orcid.org/0000-0003-2010-1282"]},"institutions":[{"id":"https://openalex.org/I4210142214","display_name":"Nordic Bioscience (Denmark)","ror":"https://ror.org/03nr54n68","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210142214"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Filipa B Sim\u00f5es","raw_affiliation_strings":["1Nordic Bioscience, Herlev, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Nordic Bioscience, Herlev, Denmark","institution_ids":["https://openalex.org/I4210142214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078364928","display_name":"Nils Hoyer","orcid":"https://orcid.org/0000-0003-4395-1837","observed_orcids":["https://orcid.org/0000-0003-4395-1837"]},"institutions":[{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802582725","display_name":"Gentofte Hospital","ror":"https://ror.org/051dzw862","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802582725"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Nils Hoyer","raw_affiliation_strings":["2Department of Respiratory Medicine, Herlev and Gentofte University Hospital, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Respiratory Medicine, Herlev and Gentofte University Hospital, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2801827564","https://openalex.org/I2802582725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031089969","display_name":"Thomas Skovhus Prior","orcid":"https://orcid.org/0000-0002-0668-8454","observed_orcids":["https://orcid.org/0000-0002-0668-8454"]},"institutions":[{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Thomas S Prior","raw_affiliation_strings":["3Centre for Rare Lung Diseases, Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Centre for Rare Lung Diseases, Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113032125","display_name":"Peder Fredriksen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142214","display_name":"Nordic Bioscience (Denmark)","ror":"https://ror.org/03nr54n68","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210142214"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Peder Fredriksen","raw_affiliation_strings":["1Nordic Bioscience, Herlev, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Nordic Bioscience, Herlev, Denmark","institution_ids":["https://openalex.org/I4210142214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063475809","display_name":"M.A. Karsdal","orcid":"https://orcid.org/0000-0001-5026-8740","observed_orcids":["https://orcid.org/0000-0001-5026-8740"]},"institutions":[{"id":"https://openalex.org/I4210142214","display_name":"Nordic Bioscience (Denmark)","ror":"https://ror.org/03nr54n68","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210142214"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Morten A Karsdal","raw_affiliation_strings":["1Nordic Bioscience, Herlev, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Nordic Bioscience, Herlev, Denmark","institution_ids":["https://openalex.org/I4210142214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054029103","display_name":"Diana Julie Leeming","orcid":"https://orcid.org/0000-0002-4256-140X","observed_orcids":["https://orcid.org/0000-0002-4256-140X"]},"institutions":[{"id":"https://openalex.org/I4210142214","display_name":"Nordic Bioscience (Denmark)","ror":"https://ror.org/03nr54n68","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210142214"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Diana J Leeming","raw_affiliation_strings":["1Nordic Bioscience, Herlev, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Nordic Bioscience, Herlev, Denmark","institution_ids":["https://openalex.org/I4210142214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015736509","display_name":"Elisabeth M. Bendstrup","orcid":"https://orcid.org/0000-0002-4238-6963","observed_orcids":["https://orcid.org/0000-0002-4238-6963"]},"institutions":[{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Elisabeth Bendstrup","raw_affiliation_strings":["4Centre for Rare Lung Diseases, Department of Respiratory Diseases and Allergy, Aarhus University Hospital. Department of Clinical Medicine, Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Centre for Rare Lung Diseases, Department of Respiratory Diseases and Allergy, Aarhus University Hospital. Department of Clinical Medicine, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076601121","display_name":"Jannie Marie B\u00fclow Sand","orcid":"https://orcid.org/0000-0002-3239-0934","observed_orcids":["https://orcid.org/0000-0002-3239-0934"]},"institutions":[{"id":"https://openalex.org/I4210142214","display_name":"Nordic Bioscience (Denmark)","ror":"https://ror.org/03nr54n68","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210142214"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jannie M B Sand","raw_affiliation_strings":["1Nordic Bioscience, Herlev, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Nordic Bioscience, Herlev, Denmark","institution_ids":["https://openalex.org/I4210142214"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108663398","display_name":"Saher Burhan Shaker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802582725","display_name":"Gentofte Hospital","ror":"https://ror.org/051dzw862","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802582725"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Saher B Shaker","raw_affiliation_strings":["2Department of Respiratory Medicine, Herlev and Gentofte University Hospital, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Respiratory Medicine, Herlev and Gentofte University Hospital, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2801827564","https://openalex.org/I2802582725"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"PA1849","last_page":"PA1849"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/idiopathic-pulmonary-fibrosis","display_name":"idiopathic pulmonary fibrosis","score":1.0},{"id":"https://openalex.org/keywords/lung-function","display_name":"lung function","score":0.7599999904632568},{"id":"https://openalex.org/keywords/exercise-capacity","display_name":"exercise capacity","score":0.9449999928474426},{"id":"https://openalex.org/keywords/6-minute-walk-distance","display_name":"6-minute walk distance","score":0.7760000228881836},{"id":"https://openalex.org/keywords/forced-vital-capacity","display_name":"forced vital capacity","score":0.7900000214576721},{"id":"https://openalex.org/keywords/diffusing-capacity-for-carbon-monoxide","display_name":"diffusing capacity for carbon monoxide","score":0.9559999704360962},{"id":"https://openalex.org/keywords/extracellular-matrix-remodeling","display_name":"extracellular matrix remodeling","score":0.7929999828338623},{"id":"https://openalex.org/keywords/fibrogenesis","display_name":"fibrogenesis","score":0.5339999794960022},{"id":"https://openalex.org/keywords/epithelial-injury","display_name":"epithelial damage","score":0.8650000095367432},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.781000018119812},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.6679999828338623},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.7820000052452087},{"id":"https://openalex.org/keywords/patient-stratification","display_name":"patient stratification","score":0.9290000200271606}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8698999881744385},{"id":"https://openalex.org/C16020263","wikidata":"https://www.wikidata.org/wiki/Q1778553","display_name":"DLCO","level":5,"score":0.8022000193595886},{"id":"https://openalex.org/C2778341716","wikidata":"https://www.wikidata.org/wiki/Q2290446","display_name":"Idiopathic pulmonary fibrosis","level":3,"score":0.7703999876976013},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6299999952316284},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5995000004768372},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5843999981880188},{"id":"https://openalex.org/C75603125","wikidata":"https://www.wikidata.org/wiki/Q1877462","display_name":"Pulmonary function testing","level":2,"score":0.519599974155426},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.5084999799728394},{"id":"https://openalex.org/C55520419","wikidata":"https://www.wikidata.org/wiki/Q660995","display_name":"Vital capacity","level":5,"score":0.49810001254081726},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4575999975204468},{"id":"https://openalex.org/C2780333948","wikidata":"https://www.wikidata.org/wiki/Q653305","display_name":"Spirometry","level":3,"score":0.45680001378059387},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.44339999556541443},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.40149998664855957},{"id":"https://openalex.org/C2777543607","wikidata":"https://www.wikidata.org/wiki/Q1153419","display_name":"Interstitial lung disease","level":3,"score":0.3871999979019165},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.3813999891281128},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.37770000100135803},{"id":"https://openalex.org/C68443243","wikidata":"https://www.wikidata.org/wiki/Q2786686","display_name":"Quartile","level":3,"score":0.3774999976158142},{"id":"https://openalex.org/C2781244666","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Pulmonary fibrosis","level":3,"score":0.37299999594688416},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.37139999866485596},{"id":"https://openalex.org/C2777405647","wikidata":"https://www.wikidata.org/wiki/Q17147306","display_name":"Usual interstitial pneumonia","level":4,"score":0.36059999465942383},{"id":"https://openalex.org/C165637977","wikidata":"https://www.wikidata.org/wiki/Q11067835","display_name":"Diffusing capacity","level":4,"score":0.3605000078678131},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.3573000133037567},{"id":"https://openalex.org/C2779869378","wikidata":"https://www.wikidata.org/wiki/Q409747","display_name":"Elastin","level":2,"score":0.3449000120162964},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3192000091075897},{"id":"https://openalex.org/C3018587741","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung function","level":3,"score":0.3133000135421753},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.28519999980926514},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2678999900817871},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.2648000121116638}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/13993003.congress-2025.pa1849","doi":"https://doi.org/10.1183/13993003.congress-2025.pa1849","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.pa1849","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Idiopathic interstitial pneumonias","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4312994313","https://openalex.org/W6889718603","https://openalex.org/W3095790484","https://openalex.org/W4386222527","https://openalex.org/W3216892526","https://openalex.org/W4250169171","https://openalex.org/W7204472535","https://openalex.org/W6976981137","https://openalex.org/W2902697612","https://openalex.org/W4409713888"],"abstract_inverted_index":{"Background:":[0],"Idiopathic":[1],"Pulmonary":[2],"Fibrosis":[3],"(IPF)":[4],"is":[5],"a":[6,99],"progressive":[7],"disease":[8,36],"characterized":[9],"by":[10],"epithelial":[11,132],"injury":[12],"and":[13,32,69,76,91,108,117,135,162,173],"extracellular":[14],"matrix":[15],"remodeling,":[16],"with":[17,71,121,151],"varying":[18],"clinical":[19,33,183],"courses.":[20],"This":[21,155],"study":[22,58,156],"investigated":[23],"associations":[24,70,158],"between":[25,159],"blood-based":[26],"biomarkers,":[27],"reflecting":[28],"key":[29],"pathological":[30],"processes,":[31],"measures":[34],"of":[35],"severity":[37],"at":[38,47],"diagnosis.":[39],"Methods:":[40],"19":[41],"biomarkers":[42,166],"(Table":[43],"1)":[44],"were":[45,61,81,84,119,139,149,167],"measured":[46],"baseline":[48],"in":[49,55,63],"serum":[50],"from":[51],"incident":[52],"IPF":[53,163],"patients":[54,97],"the":[56],"PFBIO":[57,96],"(n=185-231).":[59],"Patients":[60],"divided":[62],"quartiles":[64],"based":[65],"on":[66],"biomarker":[67],"levels,":[68],"pulmonary":[72],"function":[73,172],"tests":[74],"(FVC/DLCO)":[75],"6-minute":[77],"walk":[78],"distance":[79],"(6MWD)":[80],"evaluated.":[82],"Data":[83],"analysed":[85],"using":[86],"ANCOVA":[87],"adjusted":[88],"for":[89,179],"age":[90],"sex.":[92],"Results:":[93],"At":[94],"baseline,":[95],"had":[98],"median":[100],"87%":[101],"FVC":[102],"[IQR:":[103],"75-100.25%],":[104],"52%":[105],"DLCO":[106],"[42-61%]":[107],"453m":[109],"6MWD":[110],"[375-510.5m].":[111],"Higher":[112],"PRO-C6,":[113],"PRO-C8,":[114],"PRO-FIB,":[115],"SPARCM":[116],"VIM":[118],"associated":[120,150],"lower":[122,143],"%FVC.":[123],"Tissue":[124],"destruction":[125],"(C3M/C6M),":[126],"fibrogenesis":[127],"(PRO-C6),":[128],"elastin":[129],"breakdown":[130],"(ELM7),":[131],"damage":[133],"(PRO-C4/C4M),":[134],"inflammation":[136],"(CRPM)":[137],"markers":[138,147],"also":[140],"related":[141,168],"to":[142,169],"%DLCO.":[144],"Additionally,":[145],"most":[146],"(11/19)":[148],"shorter":[152],"6MWD.":[153],"Conclusions:":[154],"identifies":[157],"tissue":[160],"remodelling":[161],"severity.":[164],"Various":[165],"reduced":[170],"lung":[171],"exercise":[174],"capacity,":[175],"being":[176],"potential":[177],"tools":[178],"patient":[180],"stratification":[181],"alongside":[182],"parameters.":[184],"erj;66/suppl_69/PA1849/F1":[185],"F1":[186,187]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2025-11-25T00:00:00"}
