{"id":"https://openalex.org/W4416635268","doi":"https://doi.org/10.1183/13993003.congress-2025.pa5246","title":"Biomarkers and post COVID-19 respiratory sequalae among Population","display_name":"Biomarkers and post COVID-19 respiratory sequalae among Population","publication_year":2025,"publication_date":"2025-09-27","ids":{"openalex":"https://openalex.org/W4416635268","doi":"https://doi.org/10.1183/13993003.congress-2025.pa5246"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2025.pa5246","doi":"https://doi.org/10.1183/13993003.congress-2025.pa5246","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.pa5246","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular pathology and functional genomics","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Muhammad Abdullah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142204992","display_name":"University of Lahore","ror":"https://ror.org/051jrjw38","country_code":"PK","type":"education","lineage":["https://openalex.org/I142204992"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Muhammad Abdullah","raw_affiliation_strings":["1University of Lahore, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Lahore, Lahore, Pakistan","institution_ids":["https://openalex.org/I142204992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003223453","display_name":"Anam Naz","orcid":"https://orcid.org/0000-0002-6514-5417","observed_orcids":["https://orcid.org/0000-0002-6514-5417"]},"institutions":[{"id":"https://openalex.org/I142204992","display_name":"University of Lahore","ror":"https://ror.org/051jrjw38","country_code":"PK","type":"education","lineage":["https://openalex.org/I142204992"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Anam Naz","raw_affiliation_strings":["1University of Lahore, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Lahore, Lahore, Pakistan","institution_ids":["https://openalex.org/I142204992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026821447","display_name":"Javed Anver","orcid":"https://orcid.org/0000-0001-7525-1291","observed_orcids":["https://orcid.org/0000-0001-7525-1291"]},"institutions":[{"id":"https://openalex.org/I142204992","display_name":"University of Lahore","ror":"https://ror.org/051jrjw38","country_code":"PK","type":"education","lineage":["https://openalex.org/I142204992"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Javed Anver","raw_affiliation_strings":["1University of Lahore, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Lahore, Lahore, Pakistan","institution_ids":["https://openalex.org/I142204992"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ammara Hasnain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142204992","display_name":"University of Lahore","ror":"https://ror.org/051jrjw38","country_code":"PK","type":"education","lineage":["https://openalex.org/I142204992"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Ammara Hasnain","raw_affiliation_strings":["1University of Lahore, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Lahore, Lahore, Pakistan","institution_ids":["https://openalex.org/I142204992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080096551","display_name":"Ahsan Sattar Sheikh","orcid":"https://orcid.org/0000-0002-7697-2450","observed_orcids":["https://orcid.org/0000-0002-7697-2450"]},"institutions":[{"id":"https://openalex.org/I142204992","display_name":"University of Lahore","ror":"https://ror.org/051jrjw38","country_code":"PK","type":"education","lineage":["https://openalex.org/I142204992"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Ahsan Sattar Sheikh","raw_affiliation_strings":["1University of Lahore, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Lahore, Lahore, Pakistan","institution_ids":["https://openalex.org/I142204992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104267698","display_name":"Amjed Ali","orcid":"https://orcid.org/0000-0002-0866-2346","observed_orcids":["https://orcid.org/0000-0002-0866-2346"]},"institutions":[{"id":"https://openalex.org/I142204992","display_name":"University of Lahore","ror":"https://ror.org/051jrjw38","country_code":"PK","type":"education","lineage":["https://openalex.org/I142204992"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Amjed Ali","raw_affiliation_strings":["1University of Lahore, Lahore, Pakistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Lahore, Lahore, Pakistan","institution_ids":["https://openalex.org/I142204992"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063718780","display_name":"Leah R. Reznikov","orcid":"https://orcid.org/0000-0002-4074-9070","observed_orcids":["https://orcid.org/0000-0002-4074-9070"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leah Reznikov","raw_affiliation_strings":["2University of Florida, Gianesville, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Florida, Gianesville, United States","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"PA5246","last_page":"PA5246"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11368","display_name":"Long-Term Effects of COVID-19","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11368","display_name":"Long-Term Effects of COVID-19","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.02239999920129776,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/long-covid","display_name":"long COVID","score":0.7369999885559082},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.6880000233650208},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9279999732971191},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9100000262260437},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9520000219345093},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.972000002861023},{"id":"https://openalex.org/keywords/tac1","display_name":"TAC1","score":0.5189999938011169},{"id":"https://openalex.org/keywords/cytokine-storm","display_name":"cytokine storm","score":0.8199999928474426},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6940000057220459},{"id":"https://openalex.org/keywords/respiratory-symptoms","display_name":"respiratory symptoms","score":0.6620000004768372},{"id":"https://openalex.org/keywords/dry-cough","display_name":"dry cough","score":0.5950000286102295},{"id":"https://openalex.org/keywords/dyspnea","display_name":"dyspnea","score":0.8019999861717224},{"id":"https://openalex.org/keywords/tachypnea","display_name":"tachypnea","score":0.6600000262260437},{"id":"https://openalex.org/keywords/mrna-expression","display_name":"mRNA expression","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7533000111579895},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.651199996471405},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.598800003528595},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5509999990463257},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.5364999771118164},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5195000171661377},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5054000020027161},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.48919999599456787},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.43459999561309814},{"id":"https://openalex.org/C72859922","wikidata":"https://www.wikidata.org/wiki/Q11068","display_name":"Circulatory system","level":2,"score":0.39989998936653137},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.3921000063419342},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3774999976158142},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.36399999260902405},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.3610000014305115},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.3463999927043915},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.33959999680519104},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.30140000581741333},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.298799991607666},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.29339998960494995},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.2930999994277954},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.2768999934196472},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.26170000433921814},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2551000118255615}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/13993003.congress-2025.pa5246","doi":"https://doi.org/10.1183/13993003.congress-2025.pa5246","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.pa5246","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular pathology and functional genomics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4403985552","https://openalex.org/W4386770592","https://openalex.org/W7196966782","https://openalex.org/W4311698198","https://openalex.org/W4402038112","https://openalex.org/W4398775771","https://openalex.org/W4404705442","https://openalex.org/W4289885998","https://openalex.org/W4283270353","https://openalex.org/W4312549968"],"abstract_inverted_index":{"Background:":[0],"The":[1,75],"COVID-19":[2,53,106,129,187,197],"pandemic":[3],"affected":[4],"global":[5],"health":[6],"and":[7,143],"escalated":[8],"a":[9,29,137],"broad":[10],"range":[11],"of":[12,31,62,77,97,170],"respiratory":[13,22],"issues":[14],"in":[15,28,87,104,127,150,192,195],"survivors.":[16],"Objectives:":[17],"This":[18,37,48],"study":[19,38,49,140],"investigated":[20],"major":[21],"symptoms,":[23],"circulatory":[24],"cytokines":[25,193],"&":[26,58,72,100,108,123,172,180],"neuropeptide":[27,67],"cohort":[30],"individuals":[32],"who":[33],"recovered":[34],"from":[35],"COVID-19.":[36,94],"also":[39],"used":[40],"In":[41,152],"silico":[42,153],"analysis":[43,154],"for":[44,119,185],"signalling":[45],"pathway.":[46],"Methods:":[47],"consisted":[50],"n=50":[51],"post":[52,93,105,128,186,196],"survivors,":[54],"stratified":[55],"into":[56],"symptomatic,asymptomatic":[57],"controls.":[59],"Circulatory":[60],"levels":[61,96],"cytokines(IL-6,":[63],"IL-1\u03b2,":[64],"TNF\u03b1,":[65,121],"IL-10)&":[66],"(SP)were":[68],"assessed":[69],"by":[70],"ELISA":[71],"rt-qPCR.":[73],"Results:":[74],"sympotms":[76],"dry":[78],"coughing":[79],"(45%),":[80],"tachypnea(40%),":[81],"dyspnea(38%),":[82],"SOB(40%)&":[83],"glass":[84],"ground":[85],"opacities":[86],"lung":[88],"(18%)":[89],"were":[90,102,125,148],"prevalent":[91],"among":[92],"Protein":[95,159],"IL-6,TNF\u03b1,":[98,178],"IL-10":[99,122,179],"SP":[101,181],"elevated":[103],"symptomatic":[107,130],"asymptomatic":[109],"subjects":[110,131],"as":[111],"compared":[112,132],"to":[113,133],"control":[114],"(p<0.05).":[115,135],"A":[116],"mRNA":[117],"expression":[118],"IL-6,":[120],"TAC1":[124],"upregulated":[126,149],"controls":[134],"Furthermore,":[136],"mice":[138],"model":[139],"was":[141],"conducted":[142],"found":[144,155],"that":[145,156],"these":[146],"biomarkers":[147,184],"inflammation.":[151],"Mitogen":[157],"Activated":[158],"Kinase/Extracellular":[160],"Signal":[161],"Regulated":[162],"Kinase":[163,164],"(MEK/MAPKs)":[165],"signaling":[166],"pathway":[167,189],"caused":[168],"production":[169],"chemokines":[171],"cytokines.":[173],"erj;66/suppl_69/PA5246/F1":[174],"F1":[175,176],"Conclusion:":[177],"are":[182],"potential":[183],"sequalae.MEK/MAPKs":[188],"may":[190],"involve":[191],"storm":[194],"subjects.":[198]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-11-25T00:00:00"}