{"id":"https://openalex.org/W4416635239","doi":"https://doi.org/10.1183/13993003.congress-2025.pa1611","title":"Investigating imaging markers in cystic fibrosis preschoolers using manual and automated algorithms","display_name":"Investigating imaging markers in cystic fibrosis preschoolers using manual and automated algorithms","publication_year":2025,"publication_date":"2025-09-27","ids":{"openalex":"https://openalex.org/W4416635239","doi":"https://doi.org/10.1183/13993003.congress-2025.pa1611"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2025.pa1611","doi":"https://doi.org/10.1183/13993003.congress-2025.pa1611","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.pa1611","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Paediatric cystic fibrosis","raw_type":"proceedings-article"},"parent_works":[],"lineage":["https://openalex.org/W4416635239"],"child_works_count":0,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080826393","display_name":"Pranali Raut","orcid":"https://orcid.org/0000-0002-4167-8200","observed_orcids":["https://orcid.org/0000-0002-4167-8200"]},"institutions":[{"id":"https://openalex.org/I4210142620","display_name":"Erasmus MC - Sophia Children\u2019s Hospital","ror":"https://ror.org/047afsm11","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4210142620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Pranali Raut","raw_affiliation_strings":["1Department of Pediatrics, division of Respiratory Medicine and Allergology, Radiology and Nuclear Medicine, Erasmus MC -Sophia Children\u2019s Hospital, Rotterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Pediatrics, division of Respiratory Medicine and Allergology, Radiology and Nuclear Medicine, Erasmus MC -Sophia Children\u2019s Hospital, Rotterdam, Netherlands","institution_ids":["https://openalex.org/I4210142620"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093119949","display_name":"Merlijn Bonte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142620","display_name":"Erasmus MC - Sophia Children\u2019s Hospital","ror":"https://ror.org/047afsm11","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4210142620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Merlijn Bonte","raw_affiliation_strings":["2Department of Pediatrics, division of Respiratory Medicine and Allergology, Erasmus MC -Sophia Children\u2019s Hospital, Rotterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Pediatrics, division of Respiratory Medicine and Allergology, Erasmus MC -Sophia Children\u2019s Hospital, Rotterdam, Netherlands","institution_ids":["https://openalex.org/I4210142620"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080259901","display_name":"B. Mana\u00ef","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142620","display_name":"Erasmus MC - Sophia Children\u2019s Hospital","ror":"https://ror.org/047afsm11","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4210142620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Badies Manai","raw_affiliation_strings":["2Department of Pediatrics, division of Respiratory Medicine and Allergology, Erasmus MC -Sophia Children\u2019s Hospital, Rotterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Pediatrics, division of Respiratory Medicine and Allergology, Erasmus MC -Sophia Children\u2019s Hospital, Rotterdam, Netherlands","institution_ids":["https://openalex.org/I4210142620"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5095944514","display_name":"Punitkumar Makani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210142620","display_name":"Erasmus MC - Sophia Children\u2019s Hospital","ror":"https://ror.org/047afsm11","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4210142620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Punit Makani","raw_affiliation_strings":["2Department of Pediatrics, division of Respiratory Medicine and Allergology, Erasmus MC -Sophia Children\u2019s Hospital, Rotterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Pediatrics, division of Respiratory Medicine and Allergology, Erasmus MC -Sophia Children\u2019s Hospital, Rotterdam, Netherlands","institution_ids":["https://openalex.org/I4210142620"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033354610","display_name":"Pierluigi Ciet","orcid":"https://orcid.org/0000-0003-4017-8957","observed_orcids":["https://orcid.org/0000-0003-4017-8957"]},"institutions":[{"id":"https://openalex.org/I4210142620","display_name":"Erasmus MC - Sophia Children\u2019s Hospital","ror":"https://ror.org/047afsm11","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4210142620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Pier Ciet","raw_affiliation_strings":["1Department of Pediatrics, division of Respiratory Medicine and Allergology, Radiology and Nuclear Medicine, Erasmus MC -Sophia Children\u2019s Hospital, Rotterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Pediatrics, division of Respiratory Medicine and Allergology, Radiology and Nuclear Medicine, Erasmus MC -Sophia Children\u2019s Hospital, Rotterdam, Netherlands","institution_ids":["https://openalex.org/I4210142620"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079863825","display_name":"Daan Caudri","orcid":"https://orcid.org/0000-0002-8191-8598","observed_orcids":["https://orcid.org/0000-0002-8191-8598"]},"institutions":[{"id":"https://openalex.org/I4210142620","display_name":"Erasmus MC - Sophia Children\u2019s Hospital","ror":"https://ror.org/047afsm11","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4210142620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Daan Caudri","raw_affiliation_strings":["1Department of Pediatrics, division of Respiratory Medicine and Allergology, Radiology and Nuclear Medicine, Erasmus MC -Sophia Children\u2019s Hospital, Rotterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Pediatrics, division of Respiratory Medicine and Allergology, Radiology and Nuclear Medicine, Erasmus MC -Sophia Children\u2019s Hospital, Rotterdam, Netherlands","institution_ids":["https://openalex.org/I4210142620"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026591993","display_name":"Hettie M. Janssens","orcid":"https://orcid.org/0000-0002-2210-9176","observed_orcids":["https://orcid.org/0000-0002-2210-9176"]},"institutions":[{"id":"https://openalex.org/I4210142620","display_name":"Erasmus MC - Sophia Children\u2019s Hospital","ror":"https://ror.org/047afsm11","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4210142620"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Hettie M. Janssens","raw_affiliation_strings":["2Department of Pediatrics, division of Respiratory Medicine and Allergology, Erasmus MC -Sophia Children\u2019s Hospital, Rotterdam, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Pediatrics, division of Respiratory Medicine and Allergology, Erasmus MC -Sophia Children\u2019s Hospital, Rotterdam, Netherlands","institution_ids":["https://openalex.org/I4210142620"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210142620"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"PA1611","last_page":"PA1611"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cystic-fibrosis","display_name":"cystic fibrosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/preschool-children","display_name":"preschool children","score":0.9240000247955322},{"id":"https://openalex.org/keywords/chest-ct","display_name":"chest CT","score":0.6430000066757202},{"id":"https://openalex.org/keywords/lung-imaging-biomarkers","display_name":"lung imaging biomarkers","score":0.7039999961853027},{"id":"https://openalex.org/keywords/automated-image-analysis","display_name":"automated image analysis","score":0.7160000205039978},{"id":"https://openalex.org/keywords/bronchiectasis","display_name":"bronchiectasis","score":0.9330000281333923},{"id":"https://openalex.org/keywords/airway-wall-thickening","display_name":"airway wall thickening","score":0.9150000214576721},{"id":"https://openalex.org/keywords/mucus-plugging","display_name":"mucus plugging","score":0.9950000047683716},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.8679999709129333},{"id":"https://openalex.org/keywords/lung-structural-changes","display_name":"lung structural changes","score":0.35899999737739563}],"concepts":[{"id":"https://openalex.org/C2776938444","wikidata":"https://www.wikidata.org/wiki/Q178194","display_name":"Cystic fibrosis","level":2,"score":0.7857000231742859},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7222999930381775},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.48590001463890076},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.40450000762939453},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.3779999911785126},{"id":"https://openalex.org/C2777312293","wikidata":"https://www.wikidata.org/wiki/Q3649349","display_name":"Mucus","level":2,"score":0.3750999867916107},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35839998722076416},{"id":"https://openalex.org/C2983914783","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Lung disease","level":3,"score":0.33970001339912415},{"id":"https://openalex.org/C3019060180","wikidata":"https://www.wikidata.org/wiki/Q184199","display_name":"Automated method","level":2,"score":0.3312999904155731},{"id":"https://openalex.org/C104709138","wikidata":"https://www.wikidata.org/wiki/Q1671540","display_name":"Intraclass correlation","level":3,"score":0.28940001130104065},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2874000072479248},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28600001335144043},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.275299996137619},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.2727999985218048},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.27149999141693115},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.26339998841285706},{"id":"https://openalex.org/C2779379686","wikidata":"https://www.wikidata.org/wiki/Q32778","display_name":"Bronchiectasis","level":3,"score":0.26269999146461487},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.25870001316070557}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/13993003.congress-2025.pa1611","doi":"https://doi.org/10.1183/13993003.congress-2025.pa1611","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.pa1611","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Paediatric cystic fibrosis","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4410975926","https://openalex.org/W2807638880","https://openalex.org/W2806821983","https://openalex.org/W3216841914","https://openalex.org/W2471358106","https://openalex.org/W2136817065","https://openalex.org/W4413400715","https://openalex.org/W2807116332","https://openalex.org/W3001882670","https://openalex.org/W4386922426"],"abstract_inverted_index":{"Introduction:":[0],"Monitoring":[1],"structural":[2],"lung":[3],"changes":[4],"in":[5,106,216],"preschoolers":[6],"with":[7,47,87,109,125],"cystic":[8],"fibrosis":[9],"(PrewCF)":[10],"is":[11],"challenging.":[12],"Chest-CT":[13],"allows":[14],"to":[15,223],"quantify":[16],"these":[17],"changes.":[18],"We":[19,38],"evaluated":[20,105],"and":[21,24,64,73,83,94,148,164,180,198,202,221,234],"compared":[22],"manual":[23,187,196],"3":[25],"automated":[26,173,200],"imaging":[27],"analysis":[28],"tools":[29],"as":[30],"potential":[31],"biomarkers":[32],"for":[33,138,143,157,161,166,194,232],"early":[34],"disease":[35,190,224],"detection.":[36],"Methods:":[37],"included":[39],"76":[40],"PrewCF":[41,108,217],"(1-5":[42],"yrs)":[43],"from":[44],"Erasmus":[45],"MC-Sophia":[46],"177":[48,115],"chest-CT":[49],"scans.":[50,112],"Manual":[51],"PRAGMA-CF":[52],"score":[53],"assessed":[54,78,97],"%Bronchiectasis":[55],"(%BE),":[56],"%Mucus":[57],"plugging":[58,90],"(%MP),":[59],"%Airway":[60],"wall":[61,204],"thickening":[62],"(%AWT),":[63],"overall":[65],"%Disease":[66],"(%DIS).":[67],"PRAGMA-AI":[68],"(LungQTM)":[69],"quantified":[70],"%BE,":[71],"%AWT":[72,144,162],"%DIS.":[74,188],"Bronchial":[75],"dimensions":[76],"were":[77,117,122],"using":[79],"the":[80,88,129,195],"Bronchus-Artery":[81],"method,":[82],"mucus":[84,181],"plug":[85],"count":[86],"Mucus":[89],"algorithm.":[91],"Correlation,":[92],"ICC":[93],"multivariable":[95,171],"regression":[96],"agreement":[98,156,220],"between":[99],"methods.":[100],"Progression":[101],"over":[102,208,226],"time":[103],"was":[104,128,192],"41":[107],">2":[110],"CT":[111],"Results:":[113],"All":[114],"CTs":[116],"manually":[118],"scored,":[119],"126":[120],"(71%)":[121],"successfully":[123],"processed":[124],"LungQ.":[126],"AWT":[127],"most":[130],"prevalent":[131],"abnormality.":[132],"PRAGMA":[133],"methods":[134,213],"showed":[135,154],"strong":[136],"correlation":[137],"%DIS":[139,158,197,201],"(0.67,":[140],"CI:0.56-0.75),":[141],"moderate":[142,160],"(0.59,":[145],"CI:":[146,151],"0.46-0.69)":[147],"%BE":[149,167],"(0.53,":[150],"0.39-0.65).":[152],"ICC\u2019s":[153],"good":[155],"(0.77),":[159],"(0.58)":[163],"weak":[165],"(0.35).":[168],"In":[169],"a":[170],"regression,":[172],"outer":[174],"bronchial":[175,203],"diameter":[176],"(Bout/A":[177],"\u03b2=2.54,":[178],"p=0.01)":[179],"plugs":[182],"(\u03b2=0.18,":[183],"p<0.001)":[184],"independently":[185],"predicted":[186],"Significant":[189],"progression":[191,225],"detected":[193],"%AWT,":[199],"thickness":[205],"(Bwt/A":[206],"ratio)":[207],"2-4":[209],"years.":[210],"Conclusion:":[211],"Both":[212],"are":[214],"feasible":[215],"showing":[218],"reasonable":[219],"sensitivity":[222],"time,":[227],"offering":[228],"quantitative":[229],"outcomes":[230],"useful":[231],"research":[233],"clinical":[235],"care.":[236]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2025-11-25T00:00:00"}