{"id":"https://openalex.org/W4416635148","doi":"https://doi.org/10.1183/13993003.congress-2025.pa5238","title":"Nasal microbiome diversity and composition are associated with respiratory health in adolescents","display_name":"Nasal microbiome diversity and composition are associated with respiratory health in adolescents","publication_year":2025,"publication_date":"2025-09-27","ids":{"openalex":"https://openalex.org/W4416635148","doi":"https://doi.org/10.1183/13993003.congress-2025.pa5238"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2025.pa5238","doi":"https://doi.org/10.1183/13993003.congress-2025.pa5238","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.pa5238","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular pathology and functional genomics","raw_type":"proceedings-article"},"parent_works":[],"lineage":["https://openalex.org/W4416635148"],"child_works_count":0,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024377581","display_name":"Javier P\u00e9rez-Garc\u00eda","orcid":"https://orcid.org/0000-0001-7813-4381","observed_orcids":["https://orcid.org/0000-0001-7813-4381"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Javier Perez-Garcia","raw_affiliation_strings":["1Department of Epidemiology and Population Health, Stanford University, Palo Alto, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Epidemiology and Population Health, Stanford University, Palo Alto, United States","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081499416","display_name":"Anne K. Bozack","orcid":"https://orcid.org/0000-0003-0046-5767","observed_orcids":["https://orcid.org/0000-0003-0046-5767"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne Bozack","raw_affiliation_strings":["1Department of Epidemiology and Population Health, Stanford University, Palo Alto, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Epidemiology and Population Health, Stanford University, Palo Alto, United States","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030667666","display_name":"Sheryl L. Rifas\u2010Shiman","orcid":"https://orcid.org/0000-0003-0033-920X","observed_orcids":["https://orcid.org/0000-0003-0033-920X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210111543","display_name":"Harvard Pilgrim Health Care","ror":"https://ror.org/01zxdeg39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210111543"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sheryl L. Rifas-Shiman","raw_affiliation_strings":["2Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School, and Harvard Pilgrim Health Care Institute, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School, and Harvard Pilgrim Health Care Institute, Boston, United States","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210111543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045303930","display_name":"Brent A. Coull","orcid":"https://orcid.org/0000-0002-1808-4156","observed_orcids":["https://orcid.org/0000-0002-1808-4156"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brent Coull","raw_affiliation_strings":["3Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, United States","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090617255","display_name":"Heike Luttmann\u2010Gibson","orcid":"https://orcid.org/0000-0002-1265-9190","observed_orcids":["https://orcid.org/0000-0002-1265-9190"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heike Luttmann-Gibson","raw_affiliation_strings":["4Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, United States","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046557560","display_name":"Joel David Schwartz","orcid":"https://orcid.org/0000-0001-6168-378X","observed_orcids":["https://orcid.org/0000-0001-6168-378X","https://orcid.org/0000-0001-5232-9957"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel Schwartz","raw_affiliation_strings":["4Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, United States","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054864150","display_name":"Marie\u2010France Hivert","orcid":"https://orcid.org/0000-0001-7752-2585","observed_orcids":["https://orcid.org/0000-0001-7752-2585"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210111543","display_name":"Harvard Pilgrim Health Care","ror":"https://ror.org/01zxdeg39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210111543"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marie-France Hivert","raw_affiliation_strings":["2Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School, and Harvard Pilgrim Health Care Institute, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School, and Harvard Pilgrim Health Care Institute, Boston, United States","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210111543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077350027","display_name":"Emily Oken","orcid":"https://orcid.org/0000-0003-2513-3339","observed_orcids":["https://orcid.org/0000-0003-2513-3339"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210111543","display_name":"Harvard Pilgrim Health Care","ror":"https://ror.org/01zxdeg39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210111543"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Oken","raw_affiliation_strings":["2Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School, and Harvard Pilgrim Health Care Institute, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School, and Harvard Pilgrim Health Care Institute, Boston, United States","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210111543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012005963","display_name":"Diane R. Gold","orcid":"https://orcid.org/0000-0001-8789-418X","observed_orcids":["https://orcid.org/0000-0001-8789-418X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diane R. Gold","raw_affiliation_strings":["4Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, United States","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074833807","display_name":"Andr\u00e9s C\u00e1rdenas","orcid":"https://orcid.org/0000-0003-2284-3298","observed_orcids":["https://orcid.org/0000-0003-2284-3298","https://orcid.org/0000-0003-1927-6042"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andres Cardenas","raw_affiliation_strings":["1Department of Epidemiology and Population Health, Stanford University, Palo Alto, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Epidemiology and Population Health, Stanford University, Palo Alto, United States","institution_ids":["https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"PA5238","last_page":"PA5238"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.8564000129699707,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.8564000129699707,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.05350000038743019,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10984","display_name":"Sinusitis and nasal conditions","score":0.018200000748038292,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nasal-microbiota","display_name":"nasal microbiota","score":1.0},{"id":"https://openalex.org/keywords/respiratory-health","display_name":"respiratory health","score":0.8289999961853027},{"id":"https://openalex.org/keywords/adolescents","display_name":"adolescents","score":0.9810000061988831},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.9850000143051147},{"id":"https://openalex.org/keywords/allergic-rhinitis","display_name":"allergic rhinitis","score":0.9589999914169312},{"id":"https://openalex.org/keywords/aeroallergen-sensitization","display_name":"aeroallergen sensitization","score":0.9259999990463257},{"id":"https://openalex.org/keywords/wheezing","display_name":"wheezing","score":0.953000009059906},{"id":"https://openalex.org/keywords/total-serum-ige","display_name":"total IgE","score":0.8349999785423279},{"id":"https://openalex.org/keywords/exhaled-nitric-oxide","display_name":"exhaled nitric oxide","score":0.7599999904632568},{"id":"https://openalex.org/keywords/lung-function","display_name":"lung function","score":1.0},{"id":"https://openalex.org/keywords/bacterial-diversity","display_name":"bacterial diversity","score":0.6980000138282776},{"id":"https://openalex.org/keywords/cutibacterium","display_name":"Propionibacterium","score":0.9340000152587891},{"id":"https://openalex.org/keywords/staphylococcus","display_name":"Staphylococcus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/corynebacterium","display_name":"Corynebacterium","score":0.8600000143051147},{"id":"https://openalex.org/keywords/kingella","display_name":"Kingella","score":0.8320000171661377},{"id":"https://openalex.org/keywords/leptotrichia","display_name":"Leptotrichia","score":0.8700000047683716},{"id":"https://openalex.org/keywords/granulicatella","display_name":"Granulicatella","score":0.9760000109672546},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.8379999995231628}],"concepts":[{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.8202000260353088},{"id":"https://openalex.org/C2778391694","wikidata":"https://www.wikidata.org/wiki/Q4688176","display_name":"Aeroallergen","level":4,"score":0.7605999708175659},{"id":"https://openalex.org/C2777917907","wikidata":"https://www.wikidata.org/wiki/Q272436","display_name":"Hay fever","level":3,"score":0.6500999927520752},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.5343000292778015},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49059998989105225},{"id":"https://openalex.org/C3018587741","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung function","level":3,"score":0.4790000021457672},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.47360000014305115},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.4674000144004822},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.42010000348091125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41100001335144043},{"id":"https://openalex.org/C2776012195","wikidata":"https://www.wikidata.org/wiki/Q754447","display_name":"Respiratory tract infections","level":3,"score":0.36489999294281006},{"id":"https://openalex.org/C2993206177","wikidata":"https://www.wikidata.org/wiki/Q2844457","display_name":"Amplicon sequencing","level":4,"score":0.3124000132083893},{"id":"https://openalex.org/C2777697326","wikidata":"https://www.wikidata.org/wiki/Q757678","display_name":"Atopy","level":3,"score":0.2800999879837036},{"id":"https://openalex.org/C2779278377","wikidata":"https://www.wikidata.org/wiki/Q1351647","display_name":"Rhinovirus","level":3,"score":0.260699987411499},{"id":"https://openalex.org/C2781316041","wikidata":"https://www.wikidata.org/wiki/Q1230584","display_name":"Diversity (politics)","level":2,"score":0.2583000063896179},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.2549999952316284}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/13993003.congress-2025.pa5238","doi":"https://doi.org/10.1183/13993003.congress-2025.pa5238","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.pa5238","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular pathology and functional genomics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7133045622","https://openalex.org/W4410268915","https://openalex.org/W7161576502","https://openalex.org/W2341115513","https://openalex.org/W3093041539","https://openalex.org/W4392786450","https://openalex.org/W4323565515","https://openalex.org/W7127041026","https://openalex.org/W2953371836","https://openalex.org/W4318478209"],"abstract_inverted_index":{"Background:":[0],"The":[1],"nasal":[2,19,34,46,150,212],"microbiome":[3,20,35,47,151,213],"is":[4],"associated":[5,36,142,175],"with":[6,21,37,81,113,143,148,176],"asthma":[7,127],"in":[8,32,40,54,205],"children.":[9],"However,":[10],"no":[11],"study":[12],"has":[13],"examined":[14],"the":[15,18,33,45,50,65,206,211],"association":[16],"of":[17,73,210,218],"multiple":[22,111],"respiratory":[23,38,82,219],"health":[24,39],"traits.":[25],"Aim:":[26],"We":[27,43,69,108],"aimed":[28],"to":[29,160],"identify":[30],"differences":[31],"adolescents.":[41],"Methods:":[42],"analyzed":[44],"by":[48,153,163],"sequencing":[49,106],"16S":[51],"rRNA":[52],"gene":[53],"416":[55],"adolescents":[56],"(mean":[57],"age":[58],"13":[59],"years":[60],"and":[61,78,92,105,116,132,196,200,208],"52%":[62],"female)":[63],"from":[64,136],"Project":[66],"Viva":[67],"cohort.":[68],"tested":[70],"for":[71,99,110,121,192],"associations":[72,189],"alpha":[74],"diversity,":[75],"microbial":[76],"clusters,":[77],"bacterial":[79,172],"genera":[80,173],"outcomes":[83],"(asthma,":[84],"hay":[85,129,144,178],"fever,":[86,179],"wheeze,":[87],"IgE,":[88,182],"aeroallergen":[89,133,157],"sensitization,":[90],"FeNO,":[91,180],"lung":[93,184,194],"function)":[94],"using":[95],"regression":[96],"models":[97],"adjusted":[98,109],"age,":[100],"sex,":[101],"race-ethnicity,":[102],"BMI,":[103],"season,":[104],"run.":[107],"comparisons":[112],"an":[114],"FDR<5%":[115],"conducted":[117],"sensitivity":[118],"analyses":[119],"adjusting":[120],"socioeconomic":[122],"factors.":[123],"Results:":[124],"Adolescents":[125,147],"reported":[126],"(13%),":[128],"fever":[130,145],"(20.6%),":[131],"sensitization":[134,158],"(58.8%":[135],"274).":[137],"Bacterial":[138],"diversity":[139,207],"was":[140],"positively":[141],"(FDR<0.05).":[146,186],"a":[149],"dominated":[152,162],"Propionibacterium":[154],"showed":[155],"reduced":[156,193],"compared":[159],"those":[161],"Staphylococcus":[164],"(OR:":[165],"0.2,":[166],"95%":[167],"CI:":[168],"0.1-0.6,":[169],"FDR<0.05).":[170],"12":[171],"were":[174,190],"wheezing,":[177],"total":[181],"and/or":[183],"function":[185,195],"Most":[187],"significant":[188],"detected":[191],"Leptotrichia,":[197],"Kingella,":[198],"Granulicatella,":[199],"Corynebacterium":[201],"abundances":[202],"Conclusions:":[203],"Variations":[204],"composition":[209],"may":[214],"be":[215],"potential":[216],"biomarkers":[217],"health.":[220],"Funding:":[221],"R01ES031259,":[222],"P42ES004705,":[223],"R01HD034568,":[224],"R24ES030894,":[225],"P30ES000002":[226],"(NIH)":[227]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2025-11-25T00:00:00"}