{"id":"https://openalex.org/W4416635081","doi":"https://doi.org/10.1183/13993003.congress-2025.pa1797","title":"Refining lung cancer prognostication: impact of the 9th edition of the tumor, node and metastasis classification (TNM-9) staging updates","display_name":"Refining lung cancer prognostication: impact of the 9th edition of the tumor, node and metastasis classification (TNM-9) staging updates","publication_year":2025,"publication_date":"2025-09-27","ids":{"openalex":"https://openalex.org/W4416635081","doi":"https://doi.org/10.1183/13993003.congress-2025.pa1797"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2025.pa1797","doi":"https://doi.org/10.1183/13993003.congress-2025.pa1797","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.pa1797","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lung cancer","raw_type":"proceedings-article"},"parent_works":[],"lineage":["https://openalex.org/W4416635081"],"child_works_count":0,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029208443","display_name":"Joana Sofia Pereira De Magalh\u00e3es Ferreira","orcid":"https://orcid.org/0000-0002-9855-4540","observed_orcids":["https://orcid.org/0000-0002-9855-4540"]},"institutions":[{"id":"https://openalex.org/I3018176973","display_name":"Hospital de S\u00e3o Jo\u00e3o","ror":"https://ror.org/04qsnc772","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I3018176973"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Joana Sofia Pereira De Magalh\u00e3es Ferreira","raw_affiliation_strings":["1Pulmonology Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Pulmonology Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Porto, Portugal","institution_ids":["https://openalex.org/I3018176973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081667450","display_name":"Pedro Magalh\u00e3es Ferreira","orcid":"https://orcid.org/0000-0003-3986-2997","observed_orcids":["https://orcid.org/0000-0003-3986-2997"]},"institutions":[{"id":"https://openalex.org/I3018176973","display_name":"Hospital de S\u00e3o Jo\u00e3o","ror":"https://ror.org/04qsnc772","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I3018176973"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Pedro Magalh\u00e3es Ferreira","raw_affiliation_strings":["1Pulmonology Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Pulmonology Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Porto, Portugal","institution_ids":["https://openalex.org/I3018176973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090590315","display_name":"Rui Campos","orcid":"https://orcid.org/0000-0002-8458-2356","observed_orcids":["https://orcid.org/0000-0002-8458-2356"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Rui Campos","raw_affiliation_strings":["2Faculty of Medicine, University of Porto, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Faculty of Medicine, University of Porto, Porto, Portugal","institution_ids":["https://openalex.org/I182534213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074732633","display_name":"Carolina Valente","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018176973","display_name":"Hospital de S\u00e3o Jo\u00e3o","ror":"https://ror.org/04qsnc772","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I3018176973"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Carolina Valente","raw_affiliation_strings":["1Pulmonology Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Pulmonology Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Porto, Portugal","institution_ids":["https://openalex.org/I3018176973"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Cl\u00e1udia Freitas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I3018176973","display_name":"Hospital de S\u00e3o Jo\u00e3o","ror":"https://ror.org/04qsnc772","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I3018176973"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Cl\u00e1udia Freitas","raw_affiliation_strings":["3Pulmonology Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o; Faculty of Medicine, University of Porto, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Pulmonology Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o; Faculty of Medicine, University of Porto, Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I3018176973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045974491","display_name":"Catarina Sousa","orcid":"https://orcid.org/0000-0002-8231-1608","observed_orcids":["https://orcid.org/0000-0002-8231-1608"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I3018176973","display_name":"Hospital de S\u00e3o Jo\u00e3o","ror":"https://ror.org/04qsnc772","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I3018176973"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Catarina Sousa","raw_affiliation_strings":["3Pulmonology Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o; Faculty of Medicine, University of Porto, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Pulmonology Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o; Faculty of Medicine, University of Porto, Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I3018176973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110692543","display_name":"David Rial Ara\u00fajo","orcid":"https://orcid.org/0009-0009-4210-2252","observed_orcids":["https://orcid.org/0009-0009-4210-2252"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I3018176973","display_name":"Hospital de S\u00e3o Jo\u00e3o","ror":"https://ror.org/04qsnc772","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I3018176973"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"David Ara\u00fajo","raw_affiliation_strings":["3Pulmonology Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o; Faculty of Medicine, University of Porto, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Pulmonology Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o; Faculty of Medicine, University of Porto, Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I3018176973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088198643","display_name":"H\u00e9lder Novais Bastos","orcid":"https://orcid.org/0000-0002-1412-4202","observed_orcids":["https://orcid.org/0000-0002-1412-4202"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I3018176973","display_name":"Hospital de S\u00e3o Jo\u00e3o","ror":"https://ror.org/04qsnc772","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I3018176973"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"H\u00e9lder Bastos","raw_affiliation_strings":["4Pulmonology Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o; Faculty of Medicine, University of Porto; Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Pulmonology Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o; Faculty of Medicine, University of Porto; Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I3018176973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103830732","display_name":"Adriana Magalh\u00e3es","orcid":"https://orcid.org/0009-0000-3214-9000","observed_orcids":["https://orcid.org/0009-0000-3214-9000"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I3018176973","display_name":"Hospital de S\u00e3o Jo\u00e3o","ror":"https://ror.org/04qsnc772","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I3018176973"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Adriana Magalh\u00e3es","raw_affiliation_strings":["3Pulmonology Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o; Faculty of Medicine, University of Porto, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Pulmonology Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o; Faculty of Medicine, University of Porto, Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I3018176973"]}]},{"author_position":"last","author":{"id":null,"display_name":"Maria Gabriela Oliveira Fernandes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I3018176973","display_name":"Hospital de S\u00e3o Jo\u00e3o","ror":"https://ror.org/04qsnc772","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I3018176973"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Maria Gabriela Oliveira Fernandes","raw_affiliation_strings":["4Pulmonology Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o; Faculty of Medicine, University of Porto; Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Pulmonology Department, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o; Faculty of Medicine, University of Porto; Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I3018176973"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"PA1797","last_page":"PA1797"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12379","display_name":"Cancer Diagnosis and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tnm-staging","display_name":"TNM staging","score":0.7710000276565552},{"id":"https://openalex.org/keywords/prognosis-prediction","display_name":"outcome prediction","score":0.8550000190734863},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9649999737739563},{"id":"https://openalex.org/keywords/extrathoracic-metastases","display_name":"extrathoracic metastases","score":0.7639999985694885},{"id":"https://openalex.org/keywords/downstaging","display_name":"downstaging","score":0.656000018119812},{"id":"https://openalex.org/keywords/upstaging","display_name":"upstaging","score":0.8669999837875366}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9660999774932861},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.722599983215332},{"id":"https://openalex.org/C2777693549","wikidata":"https://www.wikidata.org/wiki/Q15718270","display_name":"Lung cancer staging","level":4,"score":0.6992999911308289},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.6974999904632568},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.565500020980835},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5080999732017517},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4885999858379364},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4675999879837036},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.46230000257492065},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.44850000739097595},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.42489999532699585},{"id":"https://openalex.org/C2780325254","wikidata":"https://www.wikidata.org/wiki/Q1752284","display_name":"Cancer staging","level":3,"score":0.4187999963760376},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.4185999929904938},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.37059998512268066},{"id":"https://openalex.org/C2780073493","wikidata":"https://www.wikidata.org/wiki/Q7523837","display_name":"Single Center","level":2,"score":0.361299991607666},{"id":"https://openalex.org/C2780091936","wikidata":"https://www.wikidata.org/wiki/Q17103890","display_name":"T-stage","level":3,"score":0.3562000095844269},{"id":"https://openalex.org/C2776907518","wikidata":"https://www.wikidata.org/wiki/Q1734165","display_name":"Performance status","level":3,"score":0.2922999858856201},{"id":"https://openalex.org/C3019926457","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Distant metastasis","level":4,"score":0.2824999988079071},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.26350000500679016},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.2565999925136566},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.2563000023365021},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.25369998812675476},{"id":"https://openalex.org/C3017532760","wikidata":"https://www.wikidata.org/wiki/Q1752284","display_name":"Tumor stage","level":3,"score":0.2515999972820282}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/13993003.congress-2025.pa1797","doi":"https://doi.org/10.1183/13993003.congress-2025.pa1797","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.pa1797","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lung cancer","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4410984117","https://openalex.org/W6967026037","https://openalex.org/W7142239238","https://openalex.org/W4404372927","https://openalex.org/W4416182488","https://openalex.org/W4391520930","https://openalex.org/W4396515377","https://openalex.org/W7130840811","https://openalex.org/W4405865218","https://openalex.org/W4416691080"],"abstract_inverted_index":{"Introduction:":[0],"The":[1],"TNM-9":[2,99,149,216],"lung":[3,68,83,115,218],"cancer":[4,69,84,219],"classification":[5,39,66],"is":[6],"set":[7],"to":[8,58,95,163,168],"replace":[9],"the":[10,24,38,64,110,128,222,245],"8th":[11],"edition":[12],"(TNM-8)":[13],"in":[14,155,244],"clinical":[15],"practice":[16],"from":[17,161,166],"2025":[18],"onward.":[19],"Novel":[20],"staging":[21],"criteria":[22],"include":[23],"splitting":[25],"of":[26,40,67,203,207],"mediastinal":[27],"nodal":[28],"category":[29,242],"N2":[30],"into":[31],"single":[32,47],"(N2a)":[33],"and":[34,37,88,98,106,120,141,165,187,190,212],"multiple-station":[35],"(N2b),":[36],"multiple":[41,52],"extrathoracic":[42],"metastatic":[43,197],"lesions":[44],"(M1c)":[45],"as":[46,132,139,146,239],"organ":[48,53],"system":[49],"(M1c1)":[50],"or":[51],"systems":[54],"(M1c2).":[55],"We":[56],"aimed":[57],"determine":[59],"how":[60],"these":[61],"changes":[62],"impact":[63],"final":[65],"patients":[70,80,112,130,159,227],"their":[71],"overall":[72],"survival":[73],"(OS).":[74],"Methods:":[75],"Retrospective":[76],"cohort":[77],"study":[78],"including":[79],"diagnosed":[81,113],"with":[82,114],"between":[85,188],"January":[86],"2018":[87],"December":[89],"2021.":[90],"Patients":[91],"were":[92,102,118,122,137,144,171],"staged":[93,238],"according":[94],"both":[96,180],"TNM-8":[97],"criteria.":[100,150],"Stagings":[101],"assessed":[103],"regarding":[104],"OS":[105,157,176,205],"compared.":[107],"Results:":[108],"Of":[109,127],"914":[111],"cancer,":[116],"34":[117],"downstaged":[119],"8":[121],"upstaged":[123],"when":[124],"applying":[125],"TNM-9.":[126],"382":[129],"classified":[131,138,145],"stage":[133,182,193],"IVB,":[134],"128":[135],"(44.1%)":[136],"M1c1":[140],"162":[142],"(55.9%)":[143],"M1c2":[147,189,226],"using":[148],"Despite":[151],"an":[152,200],"absolute":[153],"increase":[154],"median":[156],"for":[158],"re-staged":[160],"IIB":[162],"IIA":[164],"IIIA":[167],"IIB,":[169],"differences":[170],"not":[172],"statistically":[173],"significant.":[174],"Median":[175],"was":[177,199],"significantly":[178,229],"different":[179],"within":[181],"IVB":[183],"(M1c2":[184],"versus":[185],"M1c1)":[186],"all":[191],"other":[192],"IV":[194],"patients.":[195],"Multi-organ":[196],"disease":[198],"independent":[201],"predictor":[202],"worse":[204,230],"regardless":[206],"age,":[208],"sex,":[209],"performance":[210],"status":[211],"oncologic":[213],"treatment.":[214],"Conclusion:":[215],"improves":[217],"prognostication,":[220],"supporting":[221],"M1":[223],"subcategory":[224],"division.":[225],"show":[228],"OS,":[231],"suggesting":[232],"they":[233],"may":[234],"be":[235],"more":[236],"appropriately":[237],"a":[240],"separate":[241],"(IVC)":[243],"future.":[246]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2025-11-25T00:00:00"}