{"id":"https://openalex.org/W4416634591","doi":"https://doi.org/10.1183/13993003.congress-2025.pa1494","title":"Sputum Biomarker-Based Classification of Asthma by granulocytic activation markers","display_name":"Sputum Biomarker-Based Classification of Asthma by granulocytic activation markers","publication_year":2025,"publication_date":"2025-09-27","ids":{"openalex":"https://openalex.org/W4416634591","doi":"https://doi.org/10.1183/13993003.congress-2025.pa1494"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2025.pa1494","doi":"https://doi.org/10.1183/13993003.congress-2025.pa1494","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.pa1494","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy and immunology","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Takehiro Hasegawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takehiro Hasegawa","raw_affiliation_strings":["1Sysmex R&D Centre Europe GmbH, Research and Development Division, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Sysmex R&D Centre Europe GmbH, Research and Development Division, Hamburg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035529325","display_name":"Freda Yang","orcid":"https://orcid.org/0000-0003-2858-1559","observed_orcids":["https://orcid.org/0000-0003-2858-1559"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Freda Yang","raw_affiliation_strings":["2National Heart and Lung Institute, Imperial College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2National Heart and Lung Institute, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057676234","display_name":"Nazanin Zounemat Kermani","orcid":"https://orcid.org/0000-0003-2479-3861","observed_orcids":["https://orcid.org/0000-0003-2479-3861"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nazanin Kermani","raw_affiliation_strings":["2National Heart and Lung Institute, Imperial College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2National Heart and Lung Institute, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040808729","display_name":"Feng Zhao","orcid":"https://orcid.org/0000-0002-4441-9992","observed_orcids":["https://orcid.org/0000-0002-4441-9992"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Feng Zhao","raw_affiliation_strings":["1Sysmex R&D Centre Europe GmbH, Research and Development Division, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Sysmex R&D Centre Europe GmbH, Research and Development Division, Hamburg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085994529","display_name":"Hanna B. Lunding","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hanna Lunding","raw_affiliation_strings":["1Sysmex R&D Centre Europe GmbH, Research and Development Division, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Sysmex R&D Centre Europe GmbH, Research and Development Division, Hamburg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076688651","display_name":"Katie Raby","orcid":"https://orcid.org/0000-0003-3417-1003","observed_orcids":["https://orcid.org/0000-0003-3417-1003"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Katie Raby","raw_affiliation_strings":["2National Heart and Lung Institute, Imperial College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2National Heart and Lung Institute, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035607041","display_name":"Pankaj Kumar Bhavsar","orcid":"https://orcid.org/0000-0003-3511-756X","observed_orcids":["https://orcid.org/0000-0003-3511-756X"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Pank Bhavsar","raw_affiliation_strings":["2National Heart and Lung Institute, Imperial College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2National Heart and Lung Institute, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063587197","display_name":"Ian Michael Adcock","orcid":"https://orcid.org/0000-0003-2101-8843","observed_orcids":["https://orcid.org/0000-0003-2101-8843"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ian M Adcock","raw_affiliation_strings":["2National Heart and Lung Institute, Imperial College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2National Heart and Lung Institute, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091504243","display_name":"Marc Chadeau\u2010Hyam","orcid":"https://orcid.org/0000-0001-8341-5436","observed_orcids":["https://orcid.org/0000-0001-8341-5436"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Marc Chadeau","raw_affiliation_strings":["3School of Public Health, Imperial College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3School of Public Health, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036414874","display_name":"Kian Fan Chung","orcid":"https://orcid.org/0000-0001-7101-1426","observed_orcids":["https://orcid.org/0000-0001-7101-1426"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kian Fan Chung","raw_affiliation_strings":["2National Heart and Lung Institute, Imperial College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2National Heart and Lung Institute, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"PA1494","last_page":"PA1494"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12208","display_name":"Occupational exposure and asthma","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/severe-asthma","display_name":"severe asthma","score":0.9160000085830688},{"id":"https://openalex.org/keywords/sputum-biomarkers","display_name":"sputum biomarkers","score":0.8479999899864197},{"id":"https://openalex.org/keywords/eosinophilic-asthma","display_name":"eosinophilic asthma","score":0.8659999966621399},{"id":"https://openalex.org/keywords/neutrophilic-asthma","display_name":"neutrophilic asthma","score":1.0},{"id":"https://openalex.org/keywords/granulocyte-activation","display_name":"granulocyte activation","score":0.7770000100135803},{"id":"https://openalex.org/keywords/induced-sputum","display_name":"induced sputum","score":0.8080000281333923},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9319999814033508},{"id":"https://openalex.org/keywords/endothelin","display_name":"endothelin","score":0.6700000166893005},{"id":"https://openalex.org/keywords/myeloperoxidase","display_name":"myeloperoxidase","score":0.9940000176429749},{"id":"https://openalex.org/keywords/asthma-phenotyping","display_name":"asthma phenotyping","score":0.5210000276565552},{"id":"https://openalex.org/keywords/asthma-exacerbations","display_name":"asthma exacerbations","score":0.722000002861023},{"id":"https://openalex.org/keywords/fev1","display_name":"FEV1","score":0.49799999594688416},{"id":"https://openalex.org/keywords/blood-eosinophils","display_name":"blood eosinophils","score":0.6940000057220459},{"id":"https://openalex.org/keywords/exhaled-nitric-oxide","display_name":"exhaled nitric oxide","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8432000279426575},{"id":"https://openalex.org/C2776301714","wikidata":"https://www.wikidata.org/wiki/Q259346","display_name":"Sputum","level":3,"score":0.8374999761581421},{"id":"https://openalex.org/C2777037409","wikidata":"https://www.wikidata.org/wiki/Q107238","display_name":"Eosinophil","level":3,"score":0.762499988079071},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.7348999977111816},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6741999983787537},{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.5565000176429749},{"id":"https://openalex.org/C88675164","wikidata":"https://www.wikidata.org/wiki/Q22677314","display_name":"Eosinophil cationic protein","level":4,"score":0.5530999898910522},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5253000259399414},{"id":"https://openalex.org/C2777983669","wikidata":"https://www.wikidata.org/wiki/Q223143","display_name":"Granulocyte","level":2,"score":0.45899999141693115},{"id":"https://openalex.org/C203565725","wikidata":"https://www.wikidata.org/wiki/Q420012","display_name":"Myeloperoxidase","level":3,"score":0.40220001339912415},{"id":"https://openalex.org/C2777129736","wikidata":"https://www.wikidata.org/wiki/Q505142","display_name":"Eosinophilia","level":2,"score":0.4007999897003174},{"id":"https://openalex.org/C2779758542","wikidata":"https://www.wikidata.org/wiki/Q2106364","display_name":"Eosinophilic","level":2,"score":0.373199999332428},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3723999857902527},{"id":"https://openalex.org/C2776317360","wikidata":"https://www.wikidata.org/wiki/Q14905648","display_name":"Neutrophil elastase","level":3,"score":0.3504999876022339},{"id":"https://openalex.org/C2781142857","wikidata":"https://www.wikidata.org/wiki/Q5420174","display_name":"Exhaled nitric oxide","level":4,"score":0.3237000107765198},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3100000023841858},{"id":"https://openalex.org/C2778292693","wikidata":"https://www.wikidata.org/wiki/Q22328664","display_name":"Calprotectin","level":4,"score":0.30570000410079956},{"id":"https://openalex.org/C74133956","wikidata":"https://www.wikidata.org/wiki/Q4669824","display_name":"Absolute neutrophil count","level":4,"score":0.29670000076293945},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.29109999537467957},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.28839999437332153},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2603999972343445}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/13993003.congress-2025.pa1494","doi":"https://doi.org/10.1183/13993003.congress-2025.pa1494","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.pa1494","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy and immunology","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7220932440","https://openalex.org/W3000585793","https://openalex.org/W2051954214","https://openalex.org/W2080420512","https://openalex.org/W2564564201","https://openalex.org/W2970626661","https://openalex.org/W1931987655","https://openalex.org/W1827408114","https://openalex.org/W1981352040","https://openalex.org/W2111115925"],"abstract_inverted_index":{"Background":[0],"Eosinophilic":[1],"and":[2,10,64,82,104,118,131,142,148,159,163,168,174,178,188],"neutrophilic":[3],"asthma":[4,55,62],"are":[5],"usually":[6],"identified":[7,121],"by":[8],"eosinophil":[9,98,161,176,189],"neutrophil":[11,109,187],"counts":[12],"in":[13,47,87],"sputum.":[14],"We":[15],"have":[16],"used":[17],"sputum":[18,49,97,108],"granulocyte":[19],"biomarkers":[20,28],"to":[21,90,126],"assess":[22],"the":[23,123,152,179,195],"inflammatory":[24],"component.":[25],"Methods":[26],"Eighteen":[27],"(IL-1\u03b2,":[29],"IL-4,":[30],"IL-6,":[31],"IL-8,":[32,80,116],"IL-17,":[33],"IL-18,":[34],"CCL3,":[35],"CCL5,":[36],"CCL17,":[37],"CCL18,":[38],"CXCL9,":[39],"TSLP,":[40],"TNF-\u03b1,":[41],"EDN,":[42,81,117],"MPO,":[43],"POSTN)":[44],"were":[45,85,120,133],"measured":[46],"induced":[48],"supernatants":[50],"of":[51,194,198],"participants":[52],"with":[53,96,107],"severe":[54,199],"(SA,":[56],"non-,":[57],"ex-,":[58],"current":[59],"smokers),":[60],"mild-to-moderate":[61],"(non-smokers),":[63],"healthy":[65],"controls":[66],"(HC,":[67],"non-smokers)":[68],"from":[69,129],"U-BIOPRED":[70],"cohort":[71],"using":[72,122],"an":[73],"automated":[74],"immune":[75],"analyser":[76],"HISCLTM.":[77],"Findings":[78],"Sputum":[79],"MPO":[83,105,119],"levels":[84,94,162,177,185],"higher":[86,172],"SA":[88,128],"compared":[89],"HC":[91],"(p<0.001).":[92],"EDN":[93],"correlated":[95,106],"%":[99,110],"(rs":[100,111],"=0.65),":[101],"whereas":[102],"IL-8":[103],"=0.37,0.43).":[112],"Cutoff":[113],"values":[114],"for":[115],"Youden":[124],"Index":[125],"distinguish":[127],"HC,":[130],"asthmatics":[132],"classified":[134],"into":[135],"EDNhigh,":[136],"IL-8high,":[137],"MPOhigh,":[138],"mixed":[139],"(IL-8/EDNhigh,":[140],"MPO/EDNhigh),":[141],"Low":[143],"subgroups":[144],"(IL-8/EDNlow,":[145],"MPO/EDNlow).":[146],"IL-8high":[147],"MPOhigh":[149],"groups":[150,170],"had":[151,171],"highest":[153],"exacerbation":[154],"frequency,":[155],"but":[156],"lower":[157],"FeNO":[158,173],"blood":[160,175],"better":[164,192],"FEV1%":[165,181],"predicted.":[166,182],"IL-8/EDNhigh":[167],"MPO/EDNhigh":[169],"lowest":[180],"Conclusion:":[183],"Biomarker":[184],"representing":[186],"activation":[190],"provides":[191],"granularity":[193],"treatable":[196],"traits":[197],"asthma.":[200],"erj;66/suppl_69/PA1494/F1":[201],"F1":[202,203]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-11-25T00:00:00"}
