{"id":"https://openalex.org/W4416634479","doi":"https://doi.org/10.1183/13993003.congress-2025.oa5525","title":"Revealing adaptive mechanisms and antibiotic tolerance in Pseudomonas aeruginosa infections: The role of host-pathogen interactions in bacterial recalcitrance","display_name":"Revealing adaptive mechanisms and antibiotic tolerance in Pseudomonas aeruginosa infections: The role of host-pathogen interactions in bacterial recalcitrance","publication_year":2025,"publication_date":"2025-09-27","ids":{"openalex":"https://openalex.org/W4416634479","doi":"https://doi.org/10.1183/13993003.congress-2025.oa5525"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2025.oa5525","doi":"https://doi.org/10.1183/13993003.congress-2025.oa5525","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.oa5525","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory infections and bronchiectasis","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Pablo Laborda Mart\u00ednez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Pablo Laborda Mart\u00ednez","raw_affiliation_strings":["1Department of Clinical Microbiology 9301, Rigshospitalet, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Clinical Microbiology 9301, Rigshospitalet, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120426464","display_name":"Stefanos Lampadariou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801134892","display_name":"Novo Nordisk Foundation","ror":"https://ror.org/04txyc737","country_code":"DK","type":"facility","lineage":["https://openalex.org/I2801134892"]},{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Stefanos Lampadariou","raw_affiliation_strings":["2The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kgs. Lyngby, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kgs. Lyngby, Denmark","institution_ids":["https://openalex.org/I2801134892","https://openalex.org/I96673099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064653584","display_name":"Ruggero La Rosa","orcid":"https://orcid.org/0000-0002-6705-3989","observed_orcids":["https://orcid.org/0000-0002-6705-3989"]},"institutions":[{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Ruggero La Rosa","raw_affiliation_strings":["1Department of Clinical Microbiology 9301, Rigshospitalet, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Clinical Microbiology 9301, Rigshospitalet, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088116014","display_name":"S\u00f8ren Molin","orcid":"https://orcid.org/0000-0002-7973-2639","observed_orcids":["https://orcid.org/0000-0002-7973-2639"]},"institutions":[{"id":"https://openalex.org/I2801134892","display_name":"Novo Nordisk Foundation","ror":"https://ror.org/04txyc737","country_code":"DK","type":"facility","lineage":["https://openalex.org/I2801134892"]},{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"S\u00f8ren Molin","raw_affiliation_strings":["2The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kgs. Lyngby, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kgs. Lyngby, Denmark","institution_ids":["https://openalex.org/I2801134892","https://openalex.org/I96673099"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034888451","display_name":"Helle Krogh Johansen","orcid":"https://orcid.org/0000-0003-0268-3717","observed_orcids":["https://orcid.org/0000-0003-0268-3717"]},"institutions":[{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Helle Krogh Johansen","raw_affiliation_strings":["1Department of Clinical Microbiology 9301, Rigshospitalet, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Clinical Microbiology 9301, Rigshospitalet, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2802709434"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.31830519,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"OA5525","last_page":"OA5525"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.015799999237060547,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":1.0},{"id":"https://openalex.org/keywords/antibiotic-tolerance","display_name":"antibiotic tolerance","score":0.8989999890327454},{"id":"https://openalex.org/keywords/host-pathogen-interaction","display_name":"host-pathogen interaction","score":0.9580000042915344},{"id":"https://openalex.org/keywords/chronic-lung-infection","display_name":"chronic lung infection","score":0.6980000138282776},{"id":"https://openalex.org/keywords/bacterial-invasiveness","display_name":"bacterial invasiveness","score":0.9240000247955322},{"id":"https://openalex.org/keywords/oxidative-stress-tolerance","display_name":"oxidative stress resistance","score":0.8980000019073486},{"id":"https://openalex.org/keywords/host-immune-modulation","display_name":"host immune modulation","score":0.7020000219345093},{"id":"https://openalex.org/keywords/macrolide-susceptibility","display_name":"macrolide susceptibility","score":0.8560000061988831},{"id":"https://openalex.org/keywords/air-liquid-interface-model","display_name":"air-liquid interface model","score":0.8659999966621399},{"id":"https://openalex.org/keywords/persistent-bacterial-infection","display_name":"persistent bacterial infection","score":0.4860000014305115},{"id":"https://openalex.org/keywords/host-directed-therapy","display_name":"host-directed therapy","score":0.8949999809265137}],"concepts":[{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.8622000217437744},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6902999877929688},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.6897000074386597},{"id":"https://openalex.org/C136622501","wikidata":"https://www.wikidata.org/wiki/Q6934671","display_name":"Multidrug tolerance","level":4,"score":0.6761000156402588},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6657000184059143},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.6463000178337097},{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.5928000211715698},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5651000142097473},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.49410000443458557},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.3984000086784363},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32829999923706055},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.32260000705718994},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.31439998745918274},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.2906999886035919},{"id":"https://openalex.org/C19655278","wikidata":"https://www.wikidata.org/wiki/Q3293735","display_name":"Bacterial cell structure","level":3,"score":0.2858999967575073},{"id":"https://openalex.org/C2993183539","wikidata":"https://www.wikidata.org/wiki/Q754447","display_name":"Respiratory infection","level":3,"score":0.28279998898506165},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.2703999876976013},{"id":"https://openalex.org/C180223184","wikidata":"https://www.wikidata.org/wiki/Q4839986","display_name":"Bacterial genetics","level":4,"score":0.26989999413490295},{"id":"https://openalex.org/C2778883795","wikidata":"https://www.wikidata.org/wiki/Q804517","display_name":"Pathogenic bacteria","level":3,"score":0.2632000148296356},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.2590999901294708},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.25690001249313354},{"id":"https://openalex.org/C87590526","wikidata":"https://www.wikidata.org/wiki/Q3592884","display_name":"Experimental evolution","level":3,"score":0.25440001487731934}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1183/13993003.congress-2025.oa5525","doi":"https://doi.org/10.1183/13993003.congress-2025.oa5525","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.oa5525","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory infections and bronchiectasis","raw_type":"proceedings-article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/f5871ad1-933f-4a74-a583-b54dd5b82f82","doi":null,"is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/f5871ad1-933f-4a74-a583-b54dd5b82f82","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Martinez , P L , Lampadariou , S , La Rosa , R , Molin , S & Johansen , H K 2025 , ' Revealing adaptive mechanisms and antibiotic tolerance in Pseudomonas aeruginosa infections : The role of host-pathogen interactions in bacterial recalcitrance ' , European Respiratory Journal. Supplement , vol. 66 , no. Suppl. 69 , OA5525 . https://doi.org/10.1183/13993003.congress-2025.OA5525","raw_type":"conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Bacterial":[0],"respiratory":[1,193],"infections":[2,42,72],"continue":[3],"to":[4,55,141,206],"pose":[5],"significant":[6],"global":[7],"health":[8],"threats,":[9],"exacerbated":[10],"by":[11],"the":[12,28,34,106,164,186,200],"rise":[13],"of":[14,30,129,155,167,175,189,202],"antibiotic":[15,67,77,110,121],"resistance.":[16,78],"While":[17],"much":[18],"attention":[19],"has":[20],"focused":[21],"on":[22],"antibiotic-driven":[23],"resistance":[24,170],"in":[25,39,69,85,93,125,135,178,192],"bacterial":[26,31,103,139],"pathogens,":[27],"role":[29,177,188],"interactions":[32,191],"with":[33,118],"host":[35,147],"and":[36,66,171],"immune":[37,148],"system":[38,53],"maintaining":[40],"persistent":[41],"remains":[43],"underexplored.":[44],"By":[45],"employing":[46],"an":[47],"air-liquid":[48],"interface":[49],"cell":[50],"culture":[51],"model":[52],"designed":[54],"replicate":[56],"human":[57],"airway":[58],"conditions,":[59,162],"we":[60,81,151],"have":[61],"revealed":[62],"novel":[63],"adaptive":[64],"mechanisms":[65],"tolerance":[68],"Pseudomonas":[70],"aeruginosa":[71,96,159],"that":[73,83],"extend":[74],"beyond":[75],"conventional":[76],"For":[79],"instance,":[80],"observed":[82],"mutations":[84,124],"a":[86,173],"multidrug":[87],"efflux":[88],"pump":[89],"regulator":[90],"-commonly":[91],"acquired":[92],"clinical":[94,136],"P.":[95,130,158],"isolates":[97],"during":[98],"chronic":[99],"lung":[100,107],"infections-":[101],"enhance":[102],"invasiveness":[104],"into":[105],"tissue,":[108],"where":[109],"penetration":[111],"is":[112],"limited,":[113],"thus":[114],"providing":[115],"these":[116,196],"bacteria":[117],"protection":[119],"from":[120],"action.":[122],"Additionally,":[123],"key":[126],"metabolic":[127],"enzymes":[128],"aeruginosa,":[131],"also":[132,145],"commonly":[133],"selected":[134],"settings,":[137],"increase":[138],"resilience":[140],"oxidative":[142],"stress":[143],"while":[144],"modulating":[146],"responses.":[149],"Furthermore,":[150],"identified":[152],"unexpected":[153],"efficacy":[154],"macrolides":[156],"against":[157],"under":[160],"infection":[161],"challenging":[163],"prevailing":[165],"notion":[166],"intrinsic":[168],"macrolide":[169],"prompting":[172],"re-evaluation":[174],"their":[176],"current":[179],"continuous":[180],"prophylactic":[181],"strategies.":[182],"These":[183],"findings":[184],"emphasize":[185],"critical":[187],"host-pathogen":[190],"infections.":[194],"Understanding":[195],"dynamics":[197],"may":[198],"inform":[199],"development":[201],"host-targeted":[203],"therapeutic":[204],"strategies":[205],"better":[207],"manage":[208],"this":[209],"threat.":[210]},"counts_by_year":[],"updated_date":"2026-07-30T17:31:21.811387","created_date":"2025-11-25T00:00:00"}
