{"id":"https://openalex.org/W4416634460","doi":"https://doi.org/10.1183/13993003.congress-2025.oa6439","title":"Remote-coached spirometry as a high-quality alternative to clinic-coached spirometry in an asthma clinical trial","display_name":"Remote-coached spirometry as a high-quality alternative to clinic-coached spirometry in an asthma clinical trial","publication_year":2025,"publication_date":"2025-09-27","ids":{"openalex":"https://openalex.org/W4416634460","doi":"https://doi.org/10.1183/13993003.congress-2025.oa6439"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2025.oa6439","doi":"https://doi.org/10.1183/13993003.congress-2025.oa6439","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.oa6439","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Monitoring airway disease","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072021354","display_name":"Davinder P. S. Dosanjh","orcid":"https://orcid.org/0000-0002-9169-5607","observed_orcids":["https://orcid.org/0000-0002-9169-5607"]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Davinder Paul Singh Dosanjh","raw_affiliation_strings":["1Early Clinical Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca and Birmingham Acute Care Research, Institute of Inflammation and Ageing, University of Birmingham, Cambridge, Birmingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Early Clinical Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca and Birmingham Acute Care Research, Institute of Inflammation and Ageing, University of Birmingham, Cambridge, Birmingham, United Kingdom","institution_ids":["https://openalex.org/I105036370","https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026773546","display_name":"Tina Jellesmark Jensen","orcid":"https://orcid.org/0009-0008-4696-643X","observed_orcids":["https://orcid.org/0009-0008-4696-643X"]},"institutions":[{"id":"https://openalex.org/I4210143795","display_name":"AstraZeneca (Sweden)","ror":"https://ror.org/04wwrrg31","country_code":"SE","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210143795"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Tina Jellesmark Jensen","raw_affiliation_strings":["2Early Clinical Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Early Clinical Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden","institution_ids":["https://openalex.org/I4210143795"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M Nubli Mustapa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M Nubli Mustapa","raw_affiliation_strings":["3Early Clinical Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Early Clinical Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018614544","display_name":"Adam S. LaPrad","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adam Laprad","raw_affiliation_strings":["4ZEPHYRx, New York, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4ZEPHYRx, New York, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Erin Lennox","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erin Lennox","raw_affiliation_strings":["4ZEPHYRx, New York, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4ZEPHYRx, New York, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091035225","display_name":"Sarah Schmidt Grant","orcid":"https://orcid.org/0009-0002-4792-4676","observed_orcids":["https://orcid.org/0009-0002-4792-4676"]},"institutions":[{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah S Grant","raw_affiliation_strings":["5Early Clinical Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Early Clinical Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Boston, United States","institution_ids":["https://openalex.org/I4210150756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006299446","display_name":"Maria Gabriela Belvisi","orcid":"https://orcid.org/0000-0003-1652-4370","observed_orcids":["https://orcid.org/0000-0003-1652-4370"]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Maria G Belvisi","raw_affiliation_strings":["6Early Clinical Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca and Respiratory Pharmacology, National Heart and Lung Institute, Imperial College London, Cambridge, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Early Clinical Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca and Respiratory Pharmacology, National Heart and Lung Institute, Imperial College London, Cambridge, London, United Kingdom","institution_ids":["https://openalex.org/I105036370","https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103258710","display_name":"Rod Hughes","orcid":"https://orcid.org/0009-0006-1200-5580","observed_orcids":["https://orcid.org/0009-0006-1200-5580"]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rod Hughes","raw_affiliation_strings":["7AstraZeneca, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"7AstraZeneca, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I105036370"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"OA6439","last_page":"OA6439"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.8359000086784363,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.8359000086784363,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.121799997985363,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.652999997138977},{"id":"https://openalex.org/keywords/decentralized-clinical-trials","display_name":"decentralized clinical trials","score":0.8489999771118164},{"id":"https://openalex.org/keywords/home-spirometry","display_name":"home spirometry","score":0.8830000162124634},{"id":"https://openalex.org/keywords/fev1","display_name":"FEV1","score":0.7919999957084656},{"id":"https://openalex.org/keywords/forced-vital-capacity","display_name":"forced vital capacity","score":1.0},{"id":"https://openalex.org/keywords/method-agreement","display_name":"measurement agreement","score":0.7239999771118164},{"id":"https://openalex.org/keywords/spirometry-quality","display_name":"spirometry quality","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C2780333948","wikidata":"https://www.wikidata.org/wiki/Q653305","display_name":"Spirometry","level":3,"score":0.9330000281333923},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8137999773025513},{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.6877999901771545},{"id":"https://openalex.org/C104709138","wikidata":"https://www.wikidata.org/wiki/Q1671540","display_name":"Intraclass correlation","level":3,"score":0.6365000009536743},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.5716999769210815},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.5515000224113464},{"id":"https://openalex.org/C55520419","wikidata":"https://www.wikidata.org/wiki/Q660995","display_name":"Vital capacity","level":5,"score":0.4713999927043915},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.44530001282691956},{"id":"https://openalex.org/C2777012970","wikidata":"https://www.wikidata.org/wiki/Q2659932","display_name":"Respiratory Medicine","level":2,"score":0.3176000118255615},{"id":"https://openalex.org/C154020017","wikidata":"https://www.wikidata.org/wiki/Q520171","display_name":"Repeatability","level":2,"score":0.30000001192092896},{"id":"https://openalex.org/C43214815","wikidata":"https://www.wikidata.org/wiki/Q7310987","display_name":"Reliability (semiconductor)","level":3,"score":0.2948000133037567},{"id":"https://openalex.org/C27101514","wikidata":"https://www.wikidata.org/wiki/Q206120","display_name":"Lung volumes","level":3,"score":0.28220000863075256},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27160000801086426}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/13993003.congress-2025.oa6439","doi":"https://doi.org/10.1183/13993003.congress-2025.oa6439","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.oa6439","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Monitoring airway disease","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4416638698","https://openalex.org/W4404098159","https://openalex.org/W4404046107","https://openalex.org/W4382199827","https://openalex.org/W4390974720","https://openalex.org/W4299674579","https://openalex.org/W2081768819","https://openalex.org/W4407217274","https://openalex.org/W3095890395","https://openalex.org/W3095679786"],"abstract_inverted_index":{"RATIONALE:":[0],"Spirometric":[1],"assessment":[2],"is":[3,60],"a":[4,110],"key":[5],"outcome":[6],"measure":[7],"in":[8,18,48,98],"respiratory":[9,19],"studies.":[10],"To":[11],"fully":[12],"realise":[13],"the":[14,22,34,42,63,119,139,203],"opportunity":[15],"of":[16,24,33,46,202],"decentralisation":[17],"clinical":[20],"trials,":[21],"veracity":[23],"out-of-clinic":[25],"spirometry":[26,53,58,174,197],"must":[27],"be":[28,199],"validated.":[29],"METHODS:":[30],"As":[31],"part":[32],"ongoing":[35],"AJAX":[36],"trial":[37],"(":[38],"NCT06020014":[39],"),":[40],"investigating":[41],"efficacy":[43],"and":[44,55,66,72,80,102,109,116,133,137,165],"safety":[45],"londamocitinib":[47],"participants":[49],"with":[50,62,88,191],"asthma,":[51],"clinic-coached":[52],"(CS)":[54],"paired":[56,122],"remote-coached":[57],"(RCS)":[59],"performed":[61,75,113,200],"ZEPHYRx":[64],"Kiosk":[65],"Home":[67],"solutions":[68],"(ZEPHYRx,":[69],"USA).":[70],"CS":[71,115,132,164],"RCS":[73,117,134,166,186],"are":[74],"at":[76,138],"Day":[77,81],"1":[78,99],"(pre-randomisation)":[79],"29,":[82],"according":[83],"to":[84],"ERS/ATS":[85],"2019":[86],"standards,":[87],"overread":[89],"by":[90,172],"ArtiQ.QC":[91],"(ArtiQ":[92],"nv,":[93],"Belgium).":[94],"Forced":[95],"expiratory":[96],"volume":[97],"second":[100],"(FEV1)":[101],"forced":[103],"vital":[104],"capacity":[105],"(FVC)":[106],"were":[107],"recorded,":[108],"concordance":[111,190],"analysis":[112],"between":[114,131,163],"for":[118],"first":[120],"182":[121],"measurements.":[123],"RESULTS:":[124],"Intraclass":[125],"correlation":[126],"coefficients":[127],"showed":[128],"strong":[129],"agreement":[130],"measurements":[135,187],"overall":[136,143,150],"individual":[140],"visits":[141],"(FEV1:":[142,177],"0.94,":[144],"D1":[145,152],"0.95,":[146],"D28":[147],"0.94;":[148],"FVC:":[149,181],"0.85,":[151],"0.87,":[153],"D29":[154],"0.83)":[155],"(Fig.":[156],"1).":[157],"The":[158],"difference":[159],"(mean":[160],"\u00b1":[161,179,183],"SD)":[162],"values":[167],"was":[168],"not":[169],"clinically":[170],"significant":[171],"ERS":[173],"repeatability":[175],"criteria":[176],"0.00":[178],"0.19L;":[180],"0.07":[182],"0.46L).":[184],"CONCLUSIONS:":[185],"demonstrated":[188],"high":[189],"CS,":[192],"illustrating":[193],"that":[194],"accurate,":[195],"high-quality":[196],"can":[198],"outside":[201],"clinic":[204],"setting.":[205],"erj;66/suppl_69/OA6439/F1":[206],"F1":[207,208]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2025-11-25T00:00:00"}