{"id":"https://openalex.org/W4416634388","doi":"https://doi.org/10.1183/13993003.congress-2025.pa1338","title":"Asthma in EGPA: insights before widespread use of biologic therapy","display_name":"Asthma in EGPA: insights before widespread use of biologic therapy","publication_year":2025,"publication_date":"2025-09-27","ids":{"openalex":"https://openalex.org/W4416634388","doi":"https://doi.org/10.1183/13993003.congress-2025.pa1338"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2025.pa1338","doi":"https://doi.org/10.1183/13993003.congress-2025.pa1338","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.pa1338","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical problems","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044458265","display_name":"Justyna Fijo\u0142ek","orcid":"https://orcid.org/0000-0002-9135-1580","observed_orcids":["https://orcid.org/0000-0002-9135-1580"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Justyna Fijo\u0142ek","raw_affiliation_strings":["1National Tuberculosis and Lung Diseases Research Institute, Warszawa, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Tuberculosis and Lung Diseases Research Institute, Warszawa, Poland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037224073","display_name":"Pawe\u0142 Bujnowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66083562","display_name":"Systems Research Institute","ror":"https://ror.org/0111cp837","country_code":"PL","type":"facility","lineage":["https://openalex.org/I66083562","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Pawe\u0142 Bujnowski","raw_affiliation_strings":["2System Research Institute Polish Academy of Sciences, Warszawa, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2System Research Institute Polish Academy of Sciences, Warszawa, Poland","institution_ids":["https://openalex.org/I66083562","https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089834792","display_name":"GAWRYLUK Dariusz Jakub","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dariusz Gawryluk","raw_affiliation_strings":["1National Tuberculosis and Lung Diseases Research Institute, Warszawa, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Tuberculosis and Lung Diseases Research Institute, Warszawa, Poland","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039360953","display_name":"El\u017cbieta Wiatr","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elzbieta Wiatr","raw_affiliation_strings":["1National Tuberculosis and Lung Diseases Research Institute, Warszawa, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1National Tuberculosis and Lung Diseases Research Institute, Warszawa, Poland","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"PA1338","last_page":"PA1338"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.8227999806404114,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.8227999806404114,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.17020000517368317,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eosinophilic-granulomatosis-with-polyangiitis","display_name":"eosinophilic granulomatosis with polyangiitis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.949999988079071},{"id":"https://openalex.org/keywords/fixed-airflow-obstruction","display_name":"fixed airflow obstruction","score":0.9430000185966492},{"id":"https://openalex.org/keywords/corticosteroid-therapy","display_name":"corticosteroid therapy","score":0.8379999995231628},{"id":"https://openalex.org/keywords/biological-therapy","display_name":"biologic therapy","score":0.8989999890327454},{"id":"https://openalex.org/keywords/asthma-exacerbations","display_name":"asthma exacerbations","score":0.9269999861717224},{"id":"https://openalex.org/keywords/recurrence","display_name":"recurrence","score":0.7919999957084656},{"id":"https://openalex.org/keywords/eosinophilia","display_name":"eosinophilia","score":0.9350000023841858},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.8149999976158142},{"id":"https://openalex.org/keywords/fev1","display_name":"FEV1","score":0.7360000014305115},{"id":"https://openalex.org/keywords/disease-duration","display_name":"disease duration","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9259999990463257},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.8919000029563904},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.48899999260902405},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4577000141143799},{"id":"https://openalex.org/C2777129736","wikidata":"https://www.wikidata.org/wiki/Q505142","display_name":"Eosinophilia","level":2,"score":0.399399995803833},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.3756999969482422},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3686000108718872},{"id":"https://openalex.org/C2778333281","wikidata":"https://www.wikidata.org/wiki/Q4330029","display_name":"Airway obstruction","level":3,"score":0.3522999882698059},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.34630000591278076},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.34150001406669617},{"id":"https://openalex.org/C2779758542","wikidata":"https://www.wikidata.org/wiki/Q2106364","display_name":"Eosinophilic","level":2,"score":0.31299999356269836},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3109000027179718},{"id":"https://openalex.org/C2910302845","wikidata":"https://www.wikidata.org/wiki/Q4330029","display_name":"Bronchial obstruction","level":3,"score":0.30869999527931213}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/13993003.congress-2025.pa1338","doi":"https://doi.org/10.1183/13993003.congress-2025.pa1338","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.pa1338","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical problems","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2998812562","https://openalex.org/W2926161233","https://openalex.org/W2947251254","https://openalex.org/W4404046364","https://openalex.org/W4404091065","https://openalex.org/W2167474282","https://openalex.org/W4388540469","https://openalex.org/W2985869024","https://openalex.org/W4410274694","https://openalex.org/W7128528088"],"abstract_inverted_index":{"Background:":[0],"Asthma":[1,50,215],"is":[2,18,237],"a":[3,69,172],"hallmark":[4],"symptom":[5],"of":[6,11,33,55,61,86,115,126,137,156,168,175,223,234],"EGPA,":[7],"impacting":[8],"patients'":[9],"quality":[10],"life.":[12],"Understanding":[13],"its":[14],"characteristics":[15],"and":[16,40,46,74,98,236,246],"progression":[17],"crucial":[19],"for":[20,254],"better":[21],"management.":[22],"Aim:":[23],"To":[24],"characterize":[25],"asthma":[26,73,92,160],"in":[27,53,84,135,142,166,203,216,232],"EGPA":[28,35,75,95,164,217],"patients.":[29],"Methods:":[30],"Retrospective":[31],"analysis":[32],"86":[34],"patients":[36,56,87,116,138,157,204,224,235],"diagnosed":[37],"between":[38,72],"1992":[39],"2020,":[41],"including":[42],"PFTs,":[43],"clinical,":[44],"radiological,":[45],"laboratory":[47],"data.":[48],"Results:":[49],"was":[51,63,201],"present":[52],"96.5%":[54],"(83/86).":[57],"The":[58],"median":[59,173],"age":[60],"onset":[62,76],"35":[64],"years":[65],"(range:":[66,178],"4\u201370),":[67],"with":[68,90,144,171,205,219,239],"strong":[70],"correlation":[71],"(R\u00b2":[77],"=":[78,102,105,108,111,130,148,212],"74.4%).":[79],"Fixed":[80,229],"airflow":[81],"obstruction":[82,127,146,207,230],"developed":[83],"38.4%":[85,155,233],"(33/86),":[88],"associated":[89,238],"younger":[91,240],"onset,":[93,241],"longer":[94,242],"duration,":[96,244],"smoking,":[97,245],"lower":[99,247],"eosinophilia":[100],"(p":[101,129,147],"0.004,":[103],"p":[104,107,110,194,211],"0.034,":[106],"0.027,":[109],"0.021).":[112],"Fifty-two":[113],"percent":[114],"(45/86)":[117],"required":[118],"prolonged":[119,226],"CS":[120,227],"use":[121],"(median:":[122,152],"10":[123],"mg/day),":[124],"regardless":[125],"status":[128],"0.218).":[131],"Biologics":[132],"were":[133],"used":[134],"11%":[136],"(9/86),":[139],"more":[140],"frequently":[141],"those":[143],"fixed":[145,206],"0.044).":[149],"During":[150],"follow-up":[151],"5":[153],"years),":[154],"(33/86)":[158],"experienced":[159],"exacerbations,":[161],"which":[162],"preceded":[163],"relapse":[165],"51.5%":[167],"cases":[169],"(17/33),":[170],"time":[174],"4.5":[176],"weeks":[177],"4.0\u201348.0":[179],"weeks).":[180],"FEV\u2081":[181],"improved":[182,255],"significantly":[183],"during":[184],"the":[185,252],"last":[186],"remission":[187],"compared":[188],"to":[189],"baseline":[190],"(79.5%":[191],"vs.":[192,209],"85.1%;":[193],"<":[195],"0.001),":[196],"but":[197,221],"no":[198],"significant":[199],"improvement":[200],"seen":[202],"(72.0%":[208],"61.0%;":[210],"0.395).":[213],"Conclusions:":[214],"improves":[218],"treatment,":[220],"52%":[222],"require":[225],"therapy.":[228],"occurs":[231],"disease":[243],"eosinophilia.":[248],"These":[249],"findings":[250],"highlight":[251],"need":[253],"long-term":[256],"management":[257],"strategies.":[258]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-11-25T00:00:00"}
