{"id":"https://openalex.org/W4416634370","doi":"https://doi.org/10.1183/13993003.congress-2025.oa5531","title":"TNF-related apoptosis-inducing ligand (TRAIL) is a critical factor in pneumococcal nasopharyngeal decolonization in mice","display_name":"TNF-related apoptosis-inducing ligand (TRAIL) is a critical factor in pneumococcal nasopharyngeal decolonization in mice","publication_year":2025,"publication_date":"2025-09-27","ids":{"openalex":"https://openalex.org/W4416634370","doi":"https://doi.org/10.1183/13993003.congress-2025.oa5531"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2025.oa5531","doi":"https://doi.org/10.1183/13993003.congress-2025.oa5531","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.oa5531","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory infections and bronchiectasis","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076609591","display_name":"Lena Ostermann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lena Ostermann","raw_affiliation_strings":["1Division of Experimental Pneumology, Hannover Medical School, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Division of Experimental Pneumology, Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Meret Sophie Pahl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Meret Sophie Pahl","raw_affiliation_strings":["1Division of Experimental Pneumology, Hannover Medical School, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Division of Experimental Pneumology, Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092500179","display_name":"Carolin Flasche","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Carolin Flasche","raw_affiliation_strings":["1Division of Experimental Pneumology, Hannover Medical School, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Division of Experimental Pneumology, Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014836793","display_name":"Regina Maus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Regina Maus","raw_affiliation_strings":["1Division of Experimental Pneumology, Hannover Medical School, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Division of Experimental Pneumology, Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044692131","display_name":"Jennifer Stolper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jennifer Stolper","raw_affiliation_strings":["1Division of Experimental Pneumology, Hannover Medical School, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Division of Experimental Pneumology, Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076681768","display_name":"Thomas S. Griffith","orcid":"https://orcid.org/0000-0002-7205-9859","observed_orcids":["https://orcid.org/0000-0002-7205-9859"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas S. Griffith","raw_affiliation_strings":["2Department of Urology, University of Minnesota, Minneapolis, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Urology, University of Minnesota, Minneapolis, United States","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028973880","display_name":"Ulrich A. Maus","orcid":"https://orcid.org/0000-0002-6172-8746","observed_orcids":["https://orcid.org/0000-0002-6172-8746"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ulrich A. Maus","raw_affiliation_strings":["1Division of Experimental Pneumology, Hannover Medical School, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Division of Experimental Pneumology, Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"OA5531","last_page":"OA5531"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.8285999894142151,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.8285999894142151,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.026200000196695328,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.02070000022649765,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trail","display_name":"TRAIL","score":0.9869999885559082},{"id":"https://openalex.org/keywords/streptococcus-pneumoniae","display_name":"Streptococcus pneumoniae","score":0.9990000128746033},{"id":"https://openalex.org/keywords/invasive-pneumococcal-disease","display_name":"invasive pneumococcal disease","score":0.8769999742507935},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.6840000152587891},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.652999997138977},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.9430000185966492},{"id":"https://openalex.org/keywords/igg-response","display_name":"IgG antibody response","score":0.6349999904632568},{"id":"https://openalex.org/keywords/passive-immunization","display_name":"passive immunization","score":0.843999981880188},{"id":"https://openalex.org/keywords/pneumococcal-surface-protein-a","display_name":"PspA","score":0.9490000009536743},{"id":"https://openalex.org/keywords/cervical-lymph-nodes","display_name":"cervical lymph nodes","score":0.6769999861717224}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6881999969482422},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6093999743461609},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5539000034332275},{"id":"https://openalex.org/C91523082","wikidata":"https://www.wikidata.org/wiki/Q420496","display_name":"Antiserum","level":3,"score":0.5412999987602234},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.5299000144004822},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.5153999924659729},{"id":"https://openalex.org/C2781253189","wikidata":"https://www.wikidata.org/wiki/Q221179","display_name":"Streptococcus pneumoniae","level":3,"score":0.48539999127388},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.4625999927520752},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4586000144481659},{"id":"https://openalex.org/C2776548049","wikidata":"https://www.wikidata.org/wiki/Q1142875","display_name":"Humoral immunity","level":3,"score":0.454800009727478},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.398499995470047},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.385699987411499},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.37139999866485596},{"id":"https://openalex.org/C2778458888","wikidata":"https://www.wikidata.org/wiki/Q154625","display_name":"Neisseria meningitidis","level":3,"score":0.3637000024318695},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3634999990463257},{"id":"https://openalex.org/C2776152631","wikidata":"https://www.wikidata.org/wiki/Q4366062","display_name":"Pneumococcal infections","level":4,"score":0.33230000734329224},{"id":"https://openalex.org/C89372155","wikidata":"https://www.wikidata.org/wiki/Q420107","display_name":"Opsonin","level":3,"score":0.30869999527931213},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.30079999566078186},{"id":"https://openalex.org/C2781045504","wikidata":"https://www.wikidata.org/wiki/Q128578","display_name":"Porcine circovirus","level":3,"score":0.3000999987125397},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.2946000099182129},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.2921999990940094},{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.25189998745918274},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.25099998712539673}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/13993003.congress-2025.oa5531","doi":"https://doi.org/10.1183/13993003.congress-2025.oa5531","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.oa5531","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory infections and bronchiectasis","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2790396480","https://openalex.org/W2354303659","https://openalex.org/W2573750671","https://openalex.org/W2117563914","https://openalex.org/W2133454819","https://openalex.org/W835118332","https://openalex.org/W2139420153","https://openalex.org/W1502873161","https://openalex.org/W2927161796","https://openalex.org/W7011646288"],"abstract_inverted_index":{"We":[0],"previously":[1],"found":[2],"that":[3,159,178],"TRAIL":[4,24,179],"plays":[5,25,180],"an":[6],"important":[7],"role":[8,27,183],"in":[9,18,28,52,67,86,150,184,197],"lung":[10],"antibacterial":[11],"immunity":[12],"against":[13,135],"Streptococcus":[14],"pneumoniae":[15,33,46,196],"(S.":[16],"pneumoniae)":[17],"mice.":[19,54,96,198],"However,":[20],"whether":[21],"or":[22],"not":[23],"a":[26,49,181],"nasopharyngeal":[29,68,192],"decolonization":[30,51,193],"of":[31,39,59,74,89,109,123,128,152,169,172,194],"S.":[32,45,195],"is":[34,167],"currently":[35],"unknown.":[36],"Nasopharyngeal":[37],"colonization":[38],"WT":[40,95,103,124,130,154],"and":[41,64,70,155],"Trail-/-":[42,53,76,91,111,156],"mice":[43,104,112,125,131],"with":[44,99,107,126,139],"led":[47],"to":[48,94,115,164,191],"delayed":[50],"Despite":[55],"significantly":[56],"increased":[57,146],"numbers":[58],"myeloid":[60],"dendritic":[61],"cells":[62,66],"(mDCs)":[63],"B":[65],"digests":[69],"cervical":[71],"lymph":[72],"nodes":[73],"colonized":[75,90,110,129],"mice,":[77,157],"we":[78],"observed":[79],"drastically":[80],"reduced":[81],"anti-pneumococcal":[82],"IgG":[83],"antibody":[84,148],"levels":[85,149],"the":[87,160,170,175],"serum":[88,151],"as":[92],"compared":[93],"In":[97],"line":[98],"this":[100],"finding,":[101],"na\u00efve":[102],"passively":[105],"immunized":[106],"antiserum":[108,127],"quickly":[113],"succumbed":[114],"invasive":[116],"pneumococcal":[117,140],"disease":[118],"(IPD),":[119],"whereas":[120],"passive":[121],"immunization":[122,138],"provided":[132],"full":[133],"protection":[134],"IPD.":[136],"Importantly,":[137],"surface":[141],"protein":[142,165],"A":[143],"(PspA)":[144],"similarly":[145],"PspA-specific":[147],"both":[153],"suggesting":[158],"adaptive":[161,188],"immune":[162,189],"response":[163],"antigen":[166],"independent":[168],"presence":[171],"TRAIL.":[173],"Collectively,":[174],"data":[176],"suggest":[177],"particular":[182],"innate":[185],"rather":[186],"than":[187],"responses":[190]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2025-11-25T00:00:00"}
