{"id":"https://openalex.org/W4416634337","doi":"https://doi.org/10.1183/13993003.congress-2025.pa1064","title":"Lung cellular senescence in a mouse model of idiopathic pulmonary fibrosis induced by repetitive bleomycin installations","display_name":"Lung cellular senescence in a mouse model of idiopathic pulmonary fibrosis induced by repetitive bleomycin installations","publication_year":2025,"publication_date":"2025-09-27","ids":{"openalex":"https://openalex.org/W4416634337","doi":"https://doi.org/10.1183/13993003.congress-2025.pa1064"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2025.pa1064","doi":"https://doi.org/10.1183/13993003.congress-2025.pa1064","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.pa1064","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mechanisms of lung injury and repair","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016784172","display_name":"Stine M. Jansen","orcid":"https://orcid.org/0009-0002-0243-3742","observed_orcids":["https://orcid.org/0009-0002-0243-3742"]},"institutions":[{"id":"https://openalex.org/I4210113742","display_name":"Gubra (Denmark)","ror":"https://ror.org/0244cxh34","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210113742"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Stine M. Jansen","raw_affiliation_strings":["1Gubra ApS, H\u00f8rsholm, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Gubra ApS, H\u00f8rsholm, Denmark","institution_ids":["https://openalex.org/I4210113742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073484309","display_name":"Stefanie H. Korntner","orcid":"https://orcid.org/0000-0002-5937-9938","observed_orcids":["https://orcid.org/0000-0002-5937-9938"]},"institutions":[{"id":"https://openalex.org/I4210113742","display_name":"Gubra (Denmark)","ror":"https://ror.org/0244cxh34","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210113742"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Stefanie H. Korntner","raw_affiliation_strings":["1Gubra ApS, H\u00f8rsholm, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Gubra ApS, H\u00f8rsholm, Denmark","institution_ids":["https://openalex.org/I4210113742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004410450","display_name":"Asbj\u00f8rn Graver Petersen","orcid":"https://orcid.org/0000-0002-0498-0785","observed_orcids":["https://orcid.org/0000-0002-0498-0785"]},"institutions":[{"id":"https://openalex.org/I4210113742","display_name":"Gubra (Denmark)","ror":"https://ror.org/0244cxh34","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210113742"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Asbj\u00f8rn Graver Petersen","raw_affiliation_strings":["1Gubra ApS, H\u00f8rsholm, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Gubra ApS, H\u00f8rsholm, Denmark","institution_ids":["https://openalex.org/I4210113742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008515030","display_name":"Susanne Elisabeth Pors","orcid":"https://orcid.org/0000-0003-1546-1945","observed_orcids":["https://orcid.org/0000-0003-1546-1945","https://orcid.org/0000-0002-2089-4772"]},"institutions":[{"id":"https://openalex.org/I4210113742","display_name":"Gubra (Denmark)","ror":"https://ror.org/0244cxh34","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210113742"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Susanne E. Pors","raw_affiliation_strings":["1Gubra ApS, H\u00f8rsholm, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Gubra ApS, H\u00f8rsholm, Denmark","institution_ids":["https://openalex.org/I4210113742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028186286","display_name":"Linn Salto Mamsen","orcid":"https://orcid.org/0000-0002-8827-7519","observed_orcids":["https://orcid.org/0000-0002-8827-7519"]},"institutions":[{"id":"https://openalex.org/I4210113742","display_name":"Gubra (Denmark)","ror":"https://ror.org/0244cxh34","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210113742"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Linn Salto Mamsen","raw_affiliation_strings":["1Gubra ApS, H\u00f8rsholm, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Gubra ApS, H\u00f8rsholm, Denmark","institution_ids":["https://openalex.org/I4210113742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026581166","display_name":"Mikkel Christensen\u2010Dalsgaard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113742","display_name":"Gubra (Denmark)","ror":"https://ror.org/0244cxh34","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210113742"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Mikkel Christensen-Dalsgaard","raw_affiliation_strings":["1Gubra ApS, H\u00f8rsholm, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Gubra ApS, H\u00f8rsholm, Denmark","institution_ids":["https://openalex.org/I4210113742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5095955480","display_name":"Yessica Wouters-Van Looy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113742","display_name":"Gubra (Denmark)","ror":"https://ror.org/0244cxh34","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210113742"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Yessica Wouters Van Looy","raw_affiliation_strings":["1Gubra ApS, H\u00f8rsholm, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Gubra ApS, H\u00f8rsholm, Denmark","institution_ids":["https://openalex.org/I4210113742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001683046","display_name":"Henrik H. Hansen","orcid":"https://orcid.org/0000-0002-3732-0281","observed_orcids":["https://orcid.org/0000-0002-3732-0281"]},"institutions":[{"id":"https://openalex.org/I4210113742","display_name":"Gubra (Denmark)","ror":"https://ror.org/0244cxh34","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210113742"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Henrik H. Hansen","raw_affiliation_strings":["1Gubra ApS, H\u00f8rsholm, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Gubra ApS, H\u00f8rsholm, Denmark","institution_ids":["https://openalex.org/I4210113742"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067265775","display_name":"Michael Feigh","orcid":"https://orcid.org/0000-0001-5274-8799","observed_orcids":["https://orcid.org/0000-0001-5274-8799"]},"institutions":[{"id":"https://openalex.org/I4210113742","display_name":"Gubra (Denmark)","ror":"https://ror.org/0244cxh34","country_code":"DK","type":"company","lineage":["https://openalex.org/I4210113742"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Michael Feigh","raw_affiliation_strings":["1Gubra ApS, H\u00f8rsholm, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Gubra ApS, H\u00f8rsholm, Denmark","institution_ids":["https://openalex.org/I4210113742"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210113742"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"PA1064","last_page":"PA1064"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.010900000110268593,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/idiopathic-pulmonary-fibrosis","display_name":"idiopathic pulmonary fibrosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9610000252723694},{"id":"https://openalex.org/keywords/bleomycin-induced-pulmonary-fibrosis","display_name":"bleomycin-induced lung fibrosis","score":0.8790000081062317},{"id":"https://openalex.org/keywords/senescence-associated-secretory-phenotype","display_name":"senescence-associated secretory phenotype","score":0.9200000166893005},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9459999799728394},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.7400000095367432},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.8450000286102295},{"id":"https://openalex.org/keywords/senotherapeutics","display_name":"senotherapeutics","score":0.8519999980926514},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.7390000224113464},{"id":"https://openalex.org/keywords/lung-transcriptome","display_name":"lung transcriptome","score":0.546999990940094},{"id":"https://openalex.org/keywords/lung-function","display_name":"lung function","score":0.3580000102519989}],"concepts":[{"id":"https://openalex.org/C2776232574","wikidata":"https://www.wikidata.org/wiki/Q415571","display_name":"Bleomycin","level":3,"score":0.9101999998092651},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.8689000010490417},{"id":"https://openalex.org/C2778341716","wikidata":"https://www.wikidata.org/wiki/Q2290446","display_name":"Idiopathic pulmonary fibrosis","level":3,"score":0.8087000250816345},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7185999751091003},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.6920999884605408},{"id":"https://openalex.org/C2781244666","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Pulmonary fibrosis","level":3,"score":0.6589999794960022},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5534999966621399},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.527999997138977},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5212000012397766},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4948999881744385},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.47189998626708984},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.44909998774528503},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4187000095844269},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37279999256134033},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3637999892234802},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35839998722076416},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.3517000079154968},{"id":"https://openalex.org/C75603125","wikidata":"https://www.wikidata.org/wiki/Q1877462","display_name":"Pulmonary function testing","level":2,"score":0.3084000051021576},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.3021000027656555},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30090001225471497},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.3000999987125397},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.28839999437332153},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.27140000462532043},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.266400009393692},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.2549999952316284}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/13993003.congress-2025.pa1064","doi":"https://doi.org/10.1183/13993003.congress-2025.pa1064","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.pa1064","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mechanisms of lung injury and repair","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4410273096","https://openalex.org/W4404099793","https://openalex.org/W7161585497","https://openalex.org/W4414452636","https://openalex.org/W4416637750","https://openalex.org/W4412659491","https://openalex.org/W4404097243","https://openalex.org/W2893410198","https://openalex.org/W4404098384","https://openalex.org/W7163547257"],"abstract_inverted_index":{"Introduction:":[0],"Senescent":[1],"cells":[2],"play":[3],"a":[4,26,56,138,184,215],"crucial":[5],"role":[6],"in":[7,25,165,187,225],"the":[8,71,84,150,220],"development":[9],"and":[10,75,94,114,128,140,155,200],"progression":[11],"of":[12,22,29,104,143,161,207,210,223],"idiopathic":[13],"pulmonary":[14,23,162,178,198],"fibrosis":[15,110],"(IPF).":[16],"This":[17],"study":[18],"assessed":[19],"molecular":[20,159,208],"markers":[21,103,147,209],"senescence":[24,116,164,180],"mouse":[27,194],"model":[28,195],"IPF":[30,175],"induced":[31],"by":[32,183],"repetitive":[33,192],"bleomycin":[34],"(BLEO)":[35],"installations.":[36],"Methods:":[37],"Twelve-week-old":[38],"male":[39],"C57BL/6JRj":[40],"mice":[41,78,124,167],"received":[42],"bi-weekly":[43],"intratracheal":[44],"BLEO":[45,86],"(1.75":[46],"mg/kg,":[47],"50":[48,53],"\u00b5L)":[49,54],"or":[50],"saline":[51],"(CTRL,":[52],"over":[55],"six-week":[57],"period.":[58],"A":[59],"baseline":[60],"BLEO-IPF":[61,73,123,166,193],"group":[62],"(n=13)":[63],"was":[64,181],"euthanized":[65,80],"six":[66],"weeks":[67,82],"post-final":[68],"BLEO,":[69],"while":[70],"remaining":[72],"(n=17)":[74],"CTRL":[76],"(n=10)":[77],"were":[79],"eight":[81],"after":[83],"final":[85],"dose.":[87],"Terminal":[88],"assessments":[89],"included":[90],"lung":[91,95,201,211],"function":[92,199],"testing":[93],"tissue":[96],"analysis":[97],"for":[98,218],"hydroxyproline,":[99],"Ashcroft":[100],"score,":[101],"histological":[102,129],"inflammation":[105],"(CD45,":[106],"Gal-3),":[107],"fibrogenesis":[108],"(\u03b1-SMA),":[109],"(PSR,":[111],"Col1a1,":[112],"Col3),":[113],"cellular":[115,163,179],"(p21":[117],"IHC":[118],"+":[119],"transcriptome":[120],"signatures).":[121],"Results:":[122],"exhibited":[125],"functional,":[126],"biochemical,":[127],"characteristics":[130],"consistent":[131],"with":[132,170,204],"IPF.":[133,226],"Lung":[134],"RNA":[135,171],"sequencing":[136,172],"revealed":[137],"significant":[139],"sustained":[141],"upregulation":[142],"key":[144],"gene":[145],"expression":[146],"linked":[148],"to":[149],"senescence-associated":[151],"secretory":[152],"phenotype":[153],"(SASP)":[154],"DNA":[156],"damage.":[157],"The":[158,191],"signatures":[160],"closely":[168],"aligned":[169],"data":[173],"from":[174],"patients.":[176],"Additionally,":[177],"confirmed":[182],"marked":[185],"increase":[186],"p21":[188],"expression.":[189],"Conclusions:":[190],"exhibits":[196],"impaired":[197],"fibrosis,":[202],"along":[203],"broad":[205],"overexpression":[206],"senescence,":[212],"making":[213],"it":[214],"valuable":[216],"tool":[217],"evaluating":[219],"potential":[221],"efficacy":[222],"senotherapeutics":[224]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-11-25T00:00:00"}