{"id":"https://openalex.org/W4416634248","doi":"https://doi.org/10.1183/13993003.congress-2025.pa1455","title":"Development of Clinical COPD from Pre-COPD","display_name":"Development of Clinical COPD from Pre-COPD","publication_year":2025,"publication_date":"2025-09-27","ids":{"openalex":"https://openalex.org/W4416634248","doi":"https://doi.org/10.1183/13993003.congress-2025.pa1455"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2025.pa1455","doi":"https://doi.org/10.1183/13993003.congress-2025.pa1455","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.pa1455","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Monitoring airway disease","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002199943","display_name":"Shoaib Afzal","orcid":"https://orcid.org/0000-0002-1442-4694","observed_orcids":["https://orcid.org/0000-0002-1442-4694","https://orcid.org/0009-0009-5490-6098"]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Shoaib Afzal","raw_affiliation_strings":["1Department of Clinical Biochemitry, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Clinical Biochemitry, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark","institution_ids":["https://openalex.org/I2802567020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046399622","display_name":"Surya Prakash Bhatt","orcid":"https://orcid.org/0000-0002-8418-4497","observed_orcids":["https://orcid.org/0000-0002-8418-4497"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Surya P. Bhatt","raw_affiliation_strings":["2Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, United States","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009938646","display_name":"Gregory L. Kinney","orcid":"https://orcid.org/0000-0002-5218-4986","observed_orcids":["https://orcid.org/0000-0002-5218-4986"]},"institutions":[{"id":"https://openalex.org/I151808059","display_name":"Colorado School of Public Health","ror":"https://ror.org/005x9g035","country_code":"US","type":"education","lineage":["https://openalex.org/I151808059"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Greg Kinney","raw_affiliation_strings":["3Department of Epidemiology, Colorado School of Public Health, Aurora, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Epidemiology, Colorado School of Public Health, Aurora, United States","institution_ids":["https://openalex.org/I151808059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058532986","display_name":"Richard H. Casaburi","orcid":"https://orcid.org/0000-0002-8851-8589","observed_orcids":["https://orcid.org/0000-0002-8851-8589"]},"institutions":[{"id":"https://openalex.org/I177607063","display_name":"The Lundquist Institute","ror":"https://ror.org/025j2nd68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I177607063"]},{"id":"https://openalex.org/I4210165985","display_name":"Harbor\u2013UCLA Medical Center","ror":"https://ror.org/05h4zj272","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I4210165985"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Casaburi","raw_affiliation_strings":["4Respiratory Research Center, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Respiratory Research Center, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, United States","institution_ids":["https://openalex.org/I177607063","https://openalex.org/I4210165985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079728437","display_name":"B\u00f8rge Gr\u00f8nne Nordestgaard","orcid":"https://orcid.org/0000-0002-1954-7220","observed_orcids":["https://orcid.org/0000-0002-1954-7220"]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"B\u00f8rge G. Nordestgaard","raw_affiliation_strings":["1Department of Clinical Biochemitry, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Clinical Biochemitry, Copenhagen University Hospital - Herlev and Gentofte, Herlev, Denmark","institution_ids":["https://openalex.org/I2802567020"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Peter Lange","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802582725","display_name":"Gentofte Hospital","ror":"https://ror.org/051dzw862","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802582725"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Peter Lange","raw_affiliation_strings":["5Department of Respiratory Medicine and the Copenhagen General Population Study, Copenhagen University Hospital \u2013 Herlev and Gentofte, Herlev, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Department of Respiratory Medicine and the Copenhagen General Population Study, Copenhagen University Hospital \u2013 Herlev and Gentofte, Herlev, Denmark","institution_ids":["https://openalex.org/I2801827564","https://openalex.org/I2802567020","https://openalex.org/I2802582725"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076194390","display_name":"Yunus \u00c7olak","orcid":"https://orcid.org/0000-0003-2045-829X","observed_orcids":["https://orcid.org/0000-0003-2045-829X"]},"institutions":[{"id":"https://openalex.org/I2801827564","display_name":"Herlev Hospital","ror":"https://ror.org/00wys9y90","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2801827564","https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802582725","display_name":"Gentofte Hospital","ror":"https://ror.org/051dzw862","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802582725"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Yunus \u00c7olak","raw_affiliation_strings":["5Department of Respiratory Medicine and the Copenhagen General Population Study, Copenhagen University Hospital \u2013 Herlev and Gentofte, Herlev, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Department of Respiratory Medicine and the Copenhagen General Population Study, Copenhagen University Hospital \u2013 Herlev and Gentofte, Herlev, Denmark","institution_ids":["https://openalex.org/I2801827564","https://openalex.org/I2802567020","https://openalex.org/I2802582725"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"PA1455","last_page":"PA1455"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9570000171661377},{"id":"https://openalex.org/keywords/pre-copd","display_name":"pre-COPD","score":0.9879999756813049},{"id":"https://openalex.org/keywords/copd-prediction","display_name":"COPD prediction","score":0.7390000224113464},{"id":"https://openalex.org/keywords/copd-progression","display_name":"COPD progression","score":0.6790000200271606},{"id":"https://openalex.org/keywords/copd-risk-stratification","display_name":"COPD risk stratification","score":0.6420000195503235},{"id":"https://openalex.org/keywords/copd-prevention","display_name":"COPD prevention","score":0.574999988079071}],"concepts":[{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.8802000284194946},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8374000191688538},{"id":"https://openalex.org/C2780333948","wikidata":"https://www.wikidata.org/wiki/Q653305","display_name":"Spirometry","level":3,"score":0.7455000281333923},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.47380000352859497},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4528000056743622},{"id":"https://openalex.org/C2992779976","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Pulmonary disease","level":2,"score":0.42590001225471497},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4250999987125397},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.38429999351501465},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3481999933719635},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.34220001101493835},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.29750001430511475},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.2797999978065491},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.273499995470047},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.26669999957084656}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/13993003.congress-2025.pa1455","doi":"https://doi.org/10.1183/13993003.congress-2025.pa1455","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2025.pa1455","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Monitoring airway disease","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4387970568","https://openalex.org/W4304974791","https://openalex.org/W4416168755","https://openalex.org/W4389888743","https://openalex.org/W4391886252","https://openalex.org/W4210431639","https://openalex.org/W7160264522","https://openalex.org/W3096972882","https://openalex.org/W3095492646","https://openalex.org/W4416637488"],"abstract_inverted_index":{"Background:":[0],"Identifying":[1],"individuals":[2,54],"at":[3],"risk":[4,41,92,173,236],"for":[5,21,120,135,217,233],"development":[6,141,218],"of":[7,87,104,126,142,174,219],"chronic":[8],"obstructive":[9],"pulmonary":[10],"disease":[11],"(COPD)":[12],"by":[13,38,98],"using":[14,246],"a":[15,40],"pre-disease":[16],"state":[17],"\u201cpre-COPD\u201d":[18],"could":[19],"allow":[20],"early":[22],"preventive":[23],"measures":[24,248],"to":[25,33,47,102,140,253],"halt":[26],"progression":[27],"towards":[28],"COPD":[29,160,176,221,256],"development.":[30],"We":[31,52],"aimed":[32],"define":[34],"and":[35,43,74,96,114,117,149,167,189,201,205,209,229,249],"quantify":[36],"pre-COPD":[37,91,235,243],"developing":[39],"score":[42,93],"evaluating":[44],"its":[45],"ability":[46],"predict":[48,254],"clinical":[49,143,159,175,220,255],"COPD.":[50],"Methods:":[51],"identified":[53],"aged":[55],"\u226550":[56],"years":[57,137],"from":[58],"three":[59],"cohorts,":[60],"the":[61,234],"Copenhagen":[62,68],"General":[63],"Population":[64],"Study":[65,71],"(CGPS)":[66],"(N=9272),":[67],"City":[69],"Heart":[70],"(CCHS)":[72],"(N=5401),":[73],"COPDGene":[75,232],"(N=2381),":[76],"without":[77],"airflow":[78],"obstruction,":[79],"defined":[80,145],"as":[81,146],"FEV1/FVC":[82,115,147],"<0.70":[83,148],"or":[84],"<lower":[85],"limit":[86],"normal":[88],"(LLN).":[89],"A":[90],"was":[94,179],"created":[95],"validated":[97],"assigning":[99],"1":[100],"point":[101],"each":[103],"smoking":[105],"history":[106],"\u226510":[107],"pack-years,":[108],"active":[109],"smoking,":[110],"respiratory":[111],"symptoms,":[112],"asthma,":[113],"0.70-0.75,":[116],"4":[118],"points":[119],"FEV1":[121,150],"<80%":[122,151],"predicted,":[123],"indicating":[124],"presence":[125],"Preserved":[127],"Ratio":[128],"Impaired":[129],"Spirometry":[130],"(PRISm).":[131],"Individuals":[132],"were":[133,197,222],"followed":[134],"5-10":[136],"with":[138],"regards":[139],"COPD,":[144],"predicted.":[152],"Results:":[153],"During":[154],"follow-up,":[155],"537":[156],"(5.8%)":[157],"developed":[158],"in":[161,165,170,177,181,184,187,191,203,211,224,227,231],"CGPS,":[162,225],"525":[163],"(9.7%)":[164],"CCHS,":[166,204,228],"355":[168],"(15%)":[169],"COPDGene.":[171],"Absolute":[172],"CGPS":[178],"1.9%":[180],"low,":[182],"11%":[183],"intermediate,":[185],"24%":[186],"high,":[188],"46%":[190],"very":[192],"high-risk":[193],"category.":[194],"Corresponding":[195],"risks":[196],"4.4%,":[198],"8.5%,":[199],"14%,":[200,207],"28%":[202],"7.0%,":[206],"27%,":[208],"31%":[210],"COPDGene,":[212],"respectively.":[213],"Areas":[214],"under":[215],"curve":[216],"0.86":[223],"0.75":[226,230],"score.":[237],"Conclusions:":[238],"Our":[239],"findings":[240],"show":[241],"that":[242],"is":[244],"definable":[245],"simple":[247],"can":[250],"be":[251],"used":[252],"accurately.":[257]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-11-25T00:00:00"}
