{"id":"https://openalex.org/W4416633959","doi":"https://doi.org/10.1055/s-0042-1749290","title":"Synergismus in der Phytotherapie \u2013 Pharmakologische Interaktionen eines Kombinationsarzneimittels aus Myrrhe, Kamillenbl\u00fcten und Kaffeekohle","display_name":"Synergismus in der Phytotherapie \u2013 Pharmakologische Interaktionen eines Kombinationsarzneimittels aus Myrrhe, Kamillenbl\u00fcten und Kaffeekohle","publication_year":2022,"publication_date":"2022-06-01","ids":{"openalex":"https://openalex.org/W4416633959","doi":"https://doi.org/10.1055/s-0042-1749290"},"language":"de","primary_location":{"id":"doi:10.1055/s-0042-1749290","doi":"https://doi.org/10.1055/s-0042-1749290","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0042-1749290","pdf_url":null,"source":{"id":"https://openalex.org/S4210169550","display_name":"Zeitschrift f\u00fcr Phytotherapie","issn_l":"0722-348X","issn":["0722-348X","1438-9584"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319922","host_organization_name":"MVS Medizinverlage Stuttgart","host_organization_lineage":["https://openalex.org/P4310319922","https://openalex.org/P4310320000"],"host_organization_lineage_names":["MVS Medizinverlage Stuttgart","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zeitschrift f\u00fcr Phytotherapie","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"L Schiller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100108","display_name":"Repha (Germany)","ror":"https://ror.org/0130ebz28","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210100108"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"L Schiller","raw_affiliation_strings":["Repha GmbH Biologische Arzneimittel, Langenhagen, Deutschland","Universit\u00e4t Leipzig, Medizinische Fakult\u00e4t, Institut f\u00fcr Medizinische Physik und Biophysik, Leipzig, Deutschland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Repha GmbH Biologische Arzneimittel, Langenhagen, Deutschland","institution_ids":["https://openalex.org/I4210100108"]},{"raw_affiliation_string":"Universit\u00e4t Leipzig, Medizinische Fakult\u00e4t, Institut f\u00fcr Medizinische Physik und Biophysik, Leipzig, Deutschland","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112498184","display_name":"D Hammoud Mahdi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"D Hammoud Mahdi","raw_affiliation_strings":["IRGIB-Africa University, Cotonou, Benin","Universit\u00e4t Leipzig, Medizinische Fakult\u00e4t, Institut f\u00fcr Medizinische Physik und Biophysik, Leipzig, Deutschland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRGIB-Africa University, Cotonou, Benin","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e4t Leipzig, Medizinische Fakult\u00e4t, Institut f\u00fcr Medizinische Physik und Biophysik, Leipzig, Deutschland","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078774961","display_name":"Bartosz Lipowicz","orcid":"https://orcid.org/0009-0005-1984-0303","observed_orcids":["https://orcid.org/0009-0005-1984-0303"]},"institutions":[{"id":"https://openalex.org/I4210100108","display_name":"Repha (Germany)","ror":"https://ror.org/0130ebz28","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210100108"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"B Lipowicz","raw_affiliation_strings":["Repha GmbH Biologische Arzneimittel, Langenhagen, Deutschland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Repha GmbH Biologische Arzneimittel, Langenhagen, Deutschland","institution_ids":["https://openalex.org/I4210100108"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016558026","display_name":"C Vissiennon","orcid":"https://orcid.org/0000-0002-4563-1493","observed_orcids":["https://orcid.org/0000-0002-4563-1493"]},"institutions":[{"id":"https://openalex.org/I4210100108","display_name":"Repha (Germany)","ror":"https://ror.org/0130ebz28","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210100108"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C Vissiennon","raw_affiliation_strings":["Repha GmbH Biologische Arzneimittel, Langenhagen, Deutschland","Universit\u00e4t Leipzig, Medizinische Fakult\u00e4t, Institut f\u00fcr Medizinische Physik und Biophysik, Leipzig, Deutschland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Repha GmbH Biologische Arzneimittel, Langenhagen, Deutschland","institution_ids":["https://openalex.org/I4210100108"]},{"raw_affiliation_string":"Universit\u00e4t Leipzig, Medizinische Fakult\u00e4t, Institut f\u00fcr Medizinische Physik und Biophysik, Leipzig, Deutschland","institution_ids":["https://openalex.org/I926574661"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"43","issue":"S 01","first_page":"S47","last_page":"S47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.5845000147819519,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.5845000147819519,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.12559999525547028,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10902","display_name":"Complementary and Alternative Medicine Studies","score":0.04820000007748604,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synergistic-effect","display_name":"synergistic effect","score":0.7910000085830688},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.843999981880188},{"id":"https://openalex.org/keywords/herbal-combination","display_name":"herbal combination","score":0.5009999871253967},{"id":"https://openalex.org/keywords/myrrh","display_name":"myrrh","score":0.8510000109672546},{"id":"https://openalex.org/keywords/chamomile","display_name":"chamomile","score":0.9049999713897705},{"id":"https://openalex.org/keywords/coffee-grounds","display_name":"coffee grounds","score":0.7390000224113464},{"id":"https://openalex.org/keywords/antispasmodic-activity","display_name":"antispasmodic activity","score":0.7839999794960022},{"id":"https://openalex.org/keywords/intestinal-inflammation","display_name":"intestinal inflammation","score":0.7300000190734863},{"id":"https://openalex.org/keywords/intestinal-barrier","display_name":"intestinal barrier","score":0.6629999876022339},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7200000286102295},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.7839999794960022},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7850000262260437},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9879999756813049},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.9850000143051147},{"id":"https://openalex.org/keywords/combination-index","display_name":"combination index","score":0.7680000066757202},{"id":"https://openalex.org/keywords/gastrointestinal-diseases","display_name":"gastrointestinal diseases","score":0.6000000238418579},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.6819999814033508},{"id":"https://openalex.org/keywords/intestinal-epithelial-cells","display_name":"intestinal epithelial cells","score":0.9430000185966492},{"id":"https://openalex.org/keywords/transepithelial-electrical-resistance","display_name":"transepithelial electrical resistance","score":0.7699999809265137}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5605000257492065},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22499999403953552},{"id":"https://openalex.org/C2780791683","wikidata":"https://www.wikidata.org/wiki/Q846785","display_name":"Action (physics)","level":2,"score":0.19830000400543213},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.19200000166893005},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.1745000034570694},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.16380000114440918},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.163100004196167},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15870000422000885},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.15639999508857727},{"id":"https://openalex.org/C90673727","wikidata":"https://www.wikidata.org/wiki/Q901718","display_name":"Product (mathematics)","level":2,"score":0.15639999508857727}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0042-1749290","doi":"https://doi.org/10.1055/s-0042-1749290","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0042-1749290","pdf_url":null,"source":{"id":"https://openalex.org/S4210169550","display_name":"Zeitschrift f\u00fcr Phytotherapie","issn_l":"0722-348X","issn":["0722-348X","1438-9584"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319922","host_organization_name":"MVS Medizinverlage Stuttgart","host_organization_lineage":["https://openalex.org/P4310319922","https://openalex.org/P4310320000"],"host_organization_lineage_names":["MVS Medizinverlage Stuttgart","Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zeitschrift f\u00fcr Phytotherapie","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":2,"referenced_works":["https://openalex.org/W2103562758","https://openalex.org/W2574529525"],"related_works":["https://openalex.org/W4317241041","https://openalex.org/W2513952988","https://openalex.org/W2766352864","https://openalex.org/W2746048290","https://openalex.org/W2885926916","https://openalex.org/W2967889899","https://openalex.org/W3202629758","https://openalex.org/W2516400043","https://openalex.org/W2973559271","https://openalex.org/W2561052060"],"abstract_inverted_index":{"Einf\u00fchrung":[0],"Synergistische":[1],"Interaktionen":[2,61],"spielen":[3],"in":[4,183],"der":[5,16,62,76,82,110,127,129,154,166,169],"Phytomedizin":[6],"eine":[7],"gro\u00dfe":[8],"Rolle,":[9],"da":[10],"sie":[11],"oftmals":[12],"die":[13,31,59,89,101],"therapeutische":[14],"\u00dcberlegenheit":[15],"Pflanzenkombinationen":[17],"gegen\u00fcber":[18],"einzelnen":[19],"Inhaltsstoffen":[20],"begr\u00fcnden.":[21],"Eine":[22],"Kombination":[23],"bestehend":[24],"aus":[25,141,150],"Myrrhe,":[26],"Kamillenbl\u00fcten":[27,167],"und":[28,35,137,144,159,168],"Kaffeekohle,":[29],"f\u00fcr":[30],"bereits":[32],"antiinflammatorische,":[33],"spasmolytische":[34,164],"barrierestabilisierende":[36],"Wirkungen":[37],"gezeigt":[38],"wurden":[39,86],"[":[40,120],"1":[41],"],":[42],"wird":[43],"traditionell":[44],"zur":[45],"Behandlung":[46],"von":[47,132],"gastrointestinalen":[48],"Erkrankungen":[49],"eingesetzt.":[50],"Ziel":[51],"Die":[52,108,163],"vorliegende":[53],"Studie":[54],"soll":[55],"einen":[56],"\u00dcberblick":[57],"\u00fcber":[58],"pharmakologischen":[60,111],"pflanzlichen":[63,180],"Komponenten":[64],"geben.":[65],"Methode":[66],"Spasmolytische":[67],"Aktivit\u00e4t":[68,165],"wurde":[69],"mit":[70,185],"isometrischen":[71],"Kontraktionsmessungen":[72],"an":[73],"isolierten":[74],"D\u00fcnndarmpr\u00e4paraten":[75],"Ratte":[77],"bestimmt.":[78],"In":[79],"einem":[80,186],"Zellmodell":[81],"entz\u00fcndeten":[83],"intestinalen":[84,151],"Mukosa":[85],"Einfl\u00fcsse":[87],"auf":[88],"proinflammatorische":[90],"Zell-Zell-Signalgebung":[91,131],"(IL-6,":[92],"IL-8,":[93],"TNF,":[94],"PGE":[95,138,147],"2":[96,121,139,148],")":[97],"mittels":[98],"ELISA":[99],"sowie":[100,153],"darauffolgende":[102],"Barrierest\u00f6rung":[103],"anhand":[104,114],"transepithelialer":[105],"Widerstandsmessungen":[106],"untersucht.":[107],"Charakterisierung":[109],"Interaktion":[112],"erfolgte":[113],"des":[115],"Kombinationsindex":[116],"(CI)":[117],"nach":[118],"Chou":[119],"].":[122],"Resultat":[123],"Vor":[124],"allem":[125],"bei":[126],"Inhibierung":[128],"pro-inflammatorischen":[130],"IL-6":[133],"(CI=0.1),":[134],"TNF":[135],"(CI=0.4)":[136],"(CI=1.1)":[140],"aktivierten":[142],"Makrophagen":[143],"IL-8":[145],"(CI=0.7),":[146],"(CI=0.6)":[149],"Epithelzellen":[152],"Barrierestabilisierung":[155],"(CI=0.8)":[156],"traten":[157],"additive":[158],"synergistische":[160],"Effekte":[161,177],"auf.":[162],"Myrrhe":[170],"erg\u00e4nzte":[171],"sich":[172],"additiv":[173],"(CI=1.0).":[174],"Diskussion":[175],"Kooperative":[176],"zwischen":[178],"den":[179,188],"Bestandteilen":[181],"k\u00f6nnen":[182],"Verbindung":[184],"Multi-Target-Ansatz":[187],"Einsatz":[189],"pflanzlicher":[190],"Kombinationsarzneimitteln":[191],"bekr\u00e4ftigen.":[192],"Publication":[193],"History":[194],"Article":[195],"published":[196],"online:":[197],"13":[198],"June":[199],"2022":[200],"\u00a9":[201],"2022.":[202],"Thieme.":[203],"All":[204],"rights":[205],"reserved.":[206],"Georg":[207],"Thieme":[208],"Verlag":[209],"R\u00fcdigerstra\u00dfe":[210],"14,":[211],"70469":[212],"Stuttgart,":[213],"Germany":[214]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-11-25T00:00:00"}
