{"id":"https://openalex.org/W4416633078","doi":"https://doi.org/10.17816/rmmar678881","title":"Current concept of gastroesophageal reflux disease: a review","display_name":"Current concept of gastroesophageal reflux disease: a review","publication_year":2025,"publication_date":"2025-11-07","ids":{"openalex":"https://openalex.org/W4416633078","doi":"https://doi.org/10.17816/rmmar678881"},"language":"en","primary_location":{"id":"doi:10.17816/rmmar678881","doi":"https://doi.org/10.17816/rmmar678881","is_oa":false,"landing_page_url":"https://doi.org/10.17816/rmmar678881","pdf_url":null,"source":{"id":"https://openalex.org/S4210234893","display_name":"Russian Military Medical Academy Reports","issn_l":"2713-2315","issn":["2713-2315","2713-2323"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-2"],"host_organization":"https://openalex.org/P4310312788","host_organization_name":"ECO-vector","host_organization_lineage":["https://openalex.org/P4310312788"],"host_organization_lineage_names":["ECO-vector"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Russian Military Medical Academy Reports","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4416633078"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093339650","display_name":"Kseniya S. Biryukova","orcid":"https://orcid.org/0000-0002-8374-5256","observed_orcids":["https://orcid.org/0000-0002-8374-5256"]},"institutions":[{"id":"https://openalex.org/I21203515","display_name":"Kazan Federal University","ror":"https://ror.org/05256ym39","country_code":"RU","type":"education","lineage":["https://openalex.org/I21203515"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Kseniya S. Biryukova","raw_affiliation_strings":["Kazan (Volga Region) Federal University"],"raw_orcid":"https://orcid.org/0000-0002-8374-5256","affiliations":[{"raw_affiliation_string":"Kazan (Volga Region) Federal University","institution_ids":["https://openalex.org/I21203515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083240584","display_name":"D.Kh. Shakirova","orcid":"https://orcid.org/0000-0002-7840-1985","observed_orcids":["https://orcid.org/0000-0002-7840-1985"]},"institutions":[{"id":"https://openalex.org/I21203515","display_name":"Kazan Federal University","ror":"https://ror.org/05256ym39","country_code":"RU","type":"education","lineage":["https://openalex.org/I21203515"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Dilyara K. Shakirova","raw_affiliation_strings":["Kazan (Volga Region) Federal University"],"raw_orcid":"https://orcid.org/0000-0002-7840-1985","affiliations":[{"raw_affiliation_string":"Kazan (Volga Region) Federal University","institution_ids":["https://openalex.org/I21203515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074992937","display_name":"Yuri V. Miroshnichenko","orcid":"https://orcid.org/0000-0002-3645-2071","observed_orcids":["https://orcid.org/0000-0002-3645-2071"]},"institutions":[{"id":"https://openalex.org/I4210103400","display_name":"Saint - Petersburg State Chemical Pharmaceutical Academy","ror":"https://ror.org/01nrsdg41","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210103400"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Yuri V. Miroshnichenko","raw_affiliation_strings":["Saint Petersburg State Chemical and Pharmaceutical University"],"raw_orcid":"https://orcid.org/0000-0002-3645-2071","affiliations":[{"raw_affiliation_string":"Saint Petersburg State Chemical and Pharmaceutical University","institution_ids":["https://openalex.org/I4210103400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046043168","display_name":"A. B. Perfilev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1304155728","display_name":"Military Medical Academy","ror":"https://ror.org/04dt6a039","country_code":"RS","type":"healthcare","lineage":["https://openalex.org/I1304155728"]},{"id":"https://openalex.org/I4210114693","display_name":"Military Medical Academy","ror":"https://ror.org/032y5zj91","country_code":"BG","type":"healthcare","lineage":["https://openalex.org/I4210114693"]},{"id":"https://openalex.org/I4210152400","display_name":"Military Medical Academy","ror":"https://ror.org/04szvwj50","country_code":"EG","type":"healthcare","lineage":["https://openalex.org/I4210152400"]}],"countries":["BG","EG","RS"],"is_corresponding":false,"raw_author_name":"Aleksandr B. Perfilyev","raw_affiliation_strings":["Military Medical Academy"],"raw_orcid":"https://orcid.org/0000-0002-9947-1296","affiliations":[{"raw_affiliation_string":"Military Medical Academy","institution_ids":["https://openalex.org/I1304155728","https://openalex.org/I4210114693","https://openalex.org/I4210152400"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071959037","display_name":"Sayar R. Abdulkhakov","orcid":"https://orcid.org/0000-0001-9542-3580","observed_orcids":["https://orcid.org/0000-0001-9542-3580"]},"institutions":[{"id":"https://openalex.org/I21203515","display_name":"Kazan Federal University","ror":"https://ror.org/05256ym39","country_code":"RU","type":"education","lineage":["https://openalex.org/I21203515"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Sayar R. Abdulkhakov","raw_affiliation_strings":["Kazan (Volga Region) Federal University"],"raw_orcid":"https://orcid.org/0000-0001-9542-3580","affiliations":[{"raw_affiliation_string":"Kazan (Volga Region) Federal University","institution_ids":["https://openalex.org/I21203515"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5093339650"],"corresponding_institution_ids":["https://openalex.org/I21203515"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"44","issue":"4","first_page":"475","last_page":"484"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gastroesophageal-reflux-disease","display_name":"gastroesophageal reflux disease","score":1.0},{"id":"https://openalex.org/keywords/barrett-s-esophagus","display_name":"Barrett's esophagus","score":0.7850000262260437},{"id":"https://openalex.org/keywords/pathophysiology","display_name":"pathophysiology","score":0.7879999876022339},{"id":"https://openalex.org/keywords/proton-pump-inhibitors","display_name":"proton pump inhibitors","score":0.8410000205039978},{"id":"https://openalex.org/keywords/potassium-competitive-acid-blocker","display_name":"potassium-competitive acid blocker","score":0.925000011920929},{"id":"https://openalex.org/keywords/non-pharmacological-treatment","display_name":"non-pharmacological treatment","score":0.7990000247955322},{"id":"https://openalex.org/keywords/lifestyle-modification","display_name":"lifestyle modification","score":0.9769999980926514},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.44699999690055847},{"id":"https://openalex.org/keywords/self-medication","display_name":"self-medication","score":0.7960000038146973},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.6050000190734863},{"id":"https://openalex.org/keywords/abdominal-obesity","display_name":"abdominal obesity","score":0.5640000104904175},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.7789999842643738},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.34200000762939453}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8671000003814697},{"id":"https://openalex.org/C43270747","wikidata":"https://www.wikidata.org/wiki/Q898610","display_name":"Reflux","level":3,"score":0.7042999863624573},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.669700026512146},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5758000016212463},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.5580000281333923},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4343000054359436},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4077000021934509},{"id":"https://openalex.org/C2781025758","wikidata":"https://www.wikidata.org/wiki/Q421704","display_name":"Proton-pump inhibitor","level":2,"score":0.35120001435279846},{"id":"https://openalex.org/C22467394","wikidata":"https://www.wikidata.org/wiki/Q849359","display_name":"Multidisciplinary approach","level":2,"score":0.3400999903678894},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3361999988555908},{"id":"https://openalex.org/C124056412","wikidata":"https://www.wikidata.org/wiki/Q3320364","display_name":"Scientific evidence","level":2,"score":0.32710000872612},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.2635999917984009},{"id":"https://openalex.org/C46578552","wikidata":"https://www.wikidata.org/wiki/Q2725393","display_name":"Global health","level":3,"score":0.2621000111103058},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.2621000111103058},{"id":"https://openalex.org/C2777929519","wikidata":"https://www.wikidata.org/wiki/Q7144988","display_name":"Patient education","level":2,"score":0.26159998774528503}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.17816/rmmar678881","doi":"https://doi.org/10.17816/rmmar678881","is_oa":false,"landing_page_url":"https://doi.org/10.17816/rmmar678881","pdf_url":null,"source":{"id":"https://openalex.org/S4210234893","display_name":"Russian Military Medical Academy Reports","issn_l":"2713-2315","issn":["2713-2315","2713-2323"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["russia-white-list-2"],"host_organization":"https://openalex.org/P4310312788","host_organization_name":"ECO-vector","host_organization_lineage":["https://openalex.org/P4310312788"],"host_organization_lineage_names":["ECO-vector"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Russian Military Medical Academy Reports","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W2043894681","https://openalex.org/W2067455414","https://openalex.org/W2114442699","https://openalex.org/W2154019038","https://openalex.org/W2254809407","https://openalex.org/W2603281577","https://openalex.org/W2615285755","https://openalex.org/W2940685204","https://openalex.org/W2973422900","https://openalex.org/W3006916934","https://openalex.org/W3013056721","https://openalex.org/W3013859276","https://openalex.org/W3014840414","https://openalex.org/W3046123038","https://openalex.org/W3089253789","https://openalex.org/W3118387921","https://openalex.org/W3121805780","https://openalex.org/W3127357576","https://openalex.org/W3163634325","https://openalex.org/W3188159160","https://openalex.org/W3213420655","https://openalex.org/W3216394740","https://openalex.org/W4206061235","https://openalex.org/W4210756392","https://openalex.org/W4280572593","https://openalex.org/W4285026342","https://openalex.org/W4285588448","https://openalex.org/W4302424892","https://openalex.org/W4303422228","https://openalex.org/W4310041594","https://openalex.org/W4311083701","https://openalex.org/W4324266056","https://openalex.org/W4365517845","https://openalex.org/W4378651784","https://openalex.org/W4378905856","https://openalex.org/W4385271649","https://openalex.org/W4386922138","https://openalex.org/W4387114284","https://openalex.org/W4387357933","https://openalex.org/W4398235907","https://openalex.org/W4402548011","https://openalex.org/W4405256932"],"related_works":["https://openalex.org/W7085475263","https://openalex.org/W2158690779","https://openalex.org/W7168273468","https://openalex.org/W2064990595","https://openalex.org/W4409302040","https://openalex.org/W4402548011","https://openalex.org/W7154461207","https://openalex.org/W4396728524"],"abstract_inverted_index":{"Gastroesophageal":[0],"reflux":[1,58,97,130,186,227],"disease":[2,67,98,131],"remains":[3,200],"one":[4],"of":[5,22,41,56,123,128,150,160,183,197,225,234,245,258],"the":[6,89,93,103,148,215,232,243],"most":[7],"pressing":[8],"issues":[9],"in":[10,37,66,72,77,84,88,107,181],"modern":[11],"gastroenterology":[12],"due":[13],"to":[14,74,86,192,217,249],"its":[15],"high":[16],"prevalence,":[17],"chronic":[18],"course,":[19],"and":[20,35,43,54,121,142,173,208,254],"risk":[21,114,159],"severe":[23],"complications,":[24],"including":[25],"Barrett":[26],"esophagus.":[27],"This":[28],"review":[29],"summarizes":[30],"research":[31],"published":[32],"between":[33],"2014":[34],"2024":[36],"international":[38],"(PubMed,":[39],"Web":[40],"Science)":[42],"Russian":[44,94],"(Russian":[45],"Science":[46],"Citation":[47],"Index)":[48],"scientific":[49],"databases":[50],"addressing":[51],"epidemiology,":[52],"pathophysiology,":[53],"treatment":[55,182,194,210],"gastroesophageal":[57,96,129,185,226],"disease.":[59,187],"Epidemiological":[60],"data":[61],"demonstrate":[62,179],"a":[63,246],"global":[64],"increase":[65],"burden\u2014from":[68],"442":[69],"million":[70,76],"cases":[71],"1990":[73],"784":[75],"2019\u2014with":[78],"marked":[79],"regional":[80],"variability":[81],"(from":[82],"2.5%":[83],"China":[85],"45.4%":[87],"Middle":[90],"East).":[91],"In":[92],"Federation,":[95],"prevalence":[99],"reaches":[100],"25.6%,":[101],"with":[102,158],"highest":[104],"rates":[105],"observed":[106],"individuals":[108],"older":[109],"than":[110],"50":[111],"years.":[112],"Key":[113],"factors":[115],"include":[116,165],"abdominal":[117],"obesity,":[118],"tobacco":[119],"smoking,":[120],"use":[122,155],"nonsteroidal":[124],"anti-inflammatory":[125],"drugs.":[126],"Management":[127],"includes":[132],"both":[133],"non-pharmacologic":[134,193],"approaches":[135],"(lifestyle":[136],"modification,":[137],"diet":[138],"therapy,":[139],"breathing":[140],"exercises)":[141],"pharmacotherapy.":[143],"Proton":[144],"pump":[145],"inhibitors":[146],"remain":[147],"standard":[149],"care;":[151],"however,":[152],"their":[153],"long-term":[154],"is":[156,190],"associated":[157],"adverse":[161],"effects.":[162],"Promising":[163],"areas":[164],"combination":[166],"regimens":[167],"incorporating":[168],"antacids,":[169],"alginates,":[170],"esophagoprotective":[171],"agents,":[172],"novel":[174],"potassium-competitive":[175],"acid":[176],"blockers,":[177],"which":[178],"advantages":[180],"resistant":[184],"Special":[188],"attention":[189],"given":[191],"strategies.":[195],"Optimization":[196],"pharmaceutical":[198],"counseling":[199],"an":[201],"important":[202],"challenge":[203],"aimed":[204],"at":[205],"minimizing":[206],"self-medication":[207],"improving":[209],"adherence.":[211],"The":[212],"findings":[213],"underscore":[214],"need":[216],"develop":[218],"personalized":[219],"therapeutic":[220],"strategies":[221],"considering":[222],"clinical":[223,238],"heterogeneity":[224],"disease,":[228],"as":[229,231],"well":[230],"incorporation":[233],"innovative":[235],"methods":[236],"into":[237],"practice.":[239],"Review":[240],"results":[241],"confirm":[242],"importance":[244],"multidisciplinary":[247],"approach":[248],"reduce":[250],"healthcare":[251],"system":[252],"burden":[253],"improve":[255],"patient":[256],"quality":[257],"life.":[259]},"counts_by_year":[],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2025-11-25T00:00:00"}
