{"id":"https://openalex.org/W4416632401","doi":"https://doi.org/10.1021/acs.orglett.5c04424","title":"Photoinduced Radical-Polar Crossover Cyclization for the Synthesis of \u03b1-Exo-Alkenyl \u03b3-Lactones","display_name":"Photoinduced Radical-Polar Crossover Cyclization for the Synthesis of \u03b1-Exo-Alkenyl \u03b3-Lactones","publication_year":2025,"publication_date":"2025-11-25","ids":{"openalex":"https://openalex.org/W4416632401","doi":"https://doi.org/10.1021/acs.orglett.5c04424","pmid":"https://pubmed.ncbi.nlm.nih.gov/41288464"},"language":"en","primary_location":{"id":"doi:10.1021/acs.orglett.5c04424","doi":"https://doi.org/10.1021/acs.orglett.5c04424","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.orglett.5c04424","pdf_url":null,"source":{"id":"https://openalex.org/S201989124","display_name":"Organic Letters","issn_l":"1523-7052","issn":["1523-7052","1523-7060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084895180","display_name":"Xinke Ouyang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40963666","display_name":"Central China Normal University","ror":"https://ror.org/03x1jna21","country_code":"CN","type":"education","lineage":["https://openalex.org/I40963666"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinke Ouyang","raw_affiliation_strings":["Central China Normal University","State Key Laboratory of Green Pesticide, Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry","State Key Laboratory of Green Pesticide, Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan, Hubei 430079, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central China Normal University","institution_ids":["https://openalex.org/I40963666"]},{"raw_affiliation_string":"State Key Laboratory of Green Pesticide, Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Green Pesticide, Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan, Hubei 430079, China","institution_ids":["https://openalex.org/I40963666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108082179","display_name":"Xiaoyu Liu","orcid":"https://orcid.org/0009-0001-8033-1517","observed_orcids":["https://orcid.org/0009-0001-8033-1517"]},"institutions":[{"id":"https://openalex.org/I40963666","display_name":"Central China Normal University","ror":"https://ror.org/03x1jna21","country_code":"CN","type":"education","lineage":["https://openalex.org/I40963666"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyu Liu","raw_affiliation_strings":["Central China Normal University","State Key Laboratory of Green Pesticide, Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry","State Key Laboratory of Green Pesticide, Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan, Hubei 430079, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central China Normal University","institution_ids":["https://openalex.org/I40963666"]},{"raw_affiliation_string":"State Key Laboratory of Green Pesticide, Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Green Pesticide, Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan, Hubei 430079, China","institution_ids":["https://openalex.org/I40963666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102003531","display_name":"Zhiming Zhu","orcid":"https://orcid.org/0000-0001-6978-4155","observed_orcids":["https://orcid.org/0000-0001-6978-4155"]},"institutions":[{"id":"https://openalex.org/I40963666","display_name":"Central China Normal University","ror":"https://ror.org/03x1jna21","country_code":"CN","type":"education","lineage":["https://openalex.org/I40963666"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiming Zhu","raw_affiliation_strings":["Central China Normal University","State Key Laboratory of Green Pesticide, Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry","State Key Laboratory of Green Pesticide, Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan, Hubei 430079, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central China Normal University","institution_ids":["https://openalex.org/I40963666"]},{"raw_affiliation_string":"State Key Laboratory of Green Pesticide, Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Green Pesticide, Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan, Hubei 430079, China","institution_ids":["https://openalex.org/I40963666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101701290","display_name":"Jia Yu","orcid":"https://orcid.org/0000-0001-7423-5636","observed_orcids":["https://orcid.org/0000-0001-7423-5636"]},"institutions":[{"id":"https://openalex.org/I40963666","display_name":"Central China Normal University","ror":"https://ror.org/03x1jna21","country_code":"CN","type":"education","lineage":["https://openalex.org/I40963666"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Jia","raw_affiliation_strings":["Central China Normal University","State Key Laboratory of Green Pesticide, Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry","State Key Laboratory of Green Pesticide, Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan, Hubei 430079, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central China Normal University","institution_ids":["https://openalex.org/I40963666"]},{"raw_affiliation_string":"State Key Laboratory of Green Pesticide, Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Green Pesticide, Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan, Hubei 430079, China","institution_ids":["https://openalex.org/I40963666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079144903","display_name":"Chao Shu","orcid":"https://orcid.org/0000-0002-4722-2714","observed_orcids":["https://orcid.org/0000-0002-4722-2714"]},"institutions":[{"id":"https://openalex.org/I40963666","display_name":"Central China Normal University","ror":"https://ror.org/03x1jna21","country_code":"CN","type":"education","lineage":["https://openalex.org/I40963666"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chao Shu","raw_affiliation_strings":["Central China Normal University","State Key Laboratory of Green Pesticide, Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry","State Key Laboratory of Green Pesticide, Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan, Hubei 430079, China"],"raw_orcid":"https://orcid.org/0000-0002-4722-2714","affiliations":[{"raw_affiliation_string":"Central China Normal University","institution_ids":["https://openalex.org/I40963666"]},{"raw_affiliation_string":"State Key Laboratory of Green Pesticide, Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Green Pesticide, Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan, Hubei 430079, China","institution_ids":["https://openalex.org/I40963666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5079144903"],"corresponding_institution_ids":["https://openalex.org/I40963666"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.8939,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.70292981,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"27","issue":"49","first_page":"13552","last_page":"13558"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10701","display_name":"Radical Photochemical Reactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10701","display_name":"Radical Photochemical Reactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13859","display_name":"Organic Chemistry Synthesis Methods","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12570","display_name":"Photopolymerization techniques and applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/visible-light-photocatalysis","display_name":"visible light photocatalysis","score":0.8240000009536743},{"id":"https://openalex.org/keywords/fluorescein","display_name":"fluorescein","score":0.8949999809265137},{"id":"https://openalex.org/keywords/photocyclization","display_name":"photocyclization","score":0.7549999952316284},{"id":"https://openalex.org/keywords/reaction-mechanism","display_name":"reaction mechanism","score":0.7540000081062317},{"id":"https://openalex.org/keywords/functional-group-tolerance","display_name":"functional group tolerance","score":0.8080000281333923}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8892999887466431},{"id":"https://openalex.org/C2777332933","wikidata":"https://www.wikidata.org/wiki/Q170409","display_name":"Functional group","level":3,"score":0.5972999930381775},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.559499979019165},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.5529999732971191},{"id":"https://openalex.org/C2991944050","wikidata":"https://www.wikidata.org/wiki/Q36534","display_name":"Reaction conditions","level":3,"score":0.38530001044273376},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.38179999589920044},{"id":"https://openalex.org/C122507166","wikidata":"https://www.wikidata.org/wiki/Q628906","display_name":"Crossover","level":2,"score":0.3709999918937683},{"id":"https://openalex.org/C2910948884","wikidata":"https://www.wikidata.org/wiki/Q410922","display_name":"Sodium fluorescein","level":4,"score":0.3488999903202057},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.334199994802475},{"id":"https://openalex.org/C2781311116","wikidata":"https://www.wikidata.org/wiki/Q83306","display_name":"Group (periodic table)","level":2,"score":0.28450000286102295},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.2833999991416931},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.2784000039100647},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.27399998903274536},{"id":"https://openalex.org/C2778015030","wikidata":"https://www.wikidata.org/wiki/Q410922","display_name":"Fluorescein","level":3,"score":0.25220000743865967}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.orglett.5c04424","doi":"https://doi.org/10.1021/acs.orglett.5c04424","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.orglett.5c04424","pdf_url":null,"source":{"id":"https://openalex.org/S201989124","display_name":"Organic Letters","issn_l":"1523-7052","issn":["1523-7052","1523-7060"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic Letters","raw_type":"journal-article"},{"id":"pmid:41288464","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41288464","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G465929339","display_name":null,"funder_award_id":"22301093","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7695240593","display_name":null,"funder_award_id":"2023YFD1700500","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G7802747532","display_name":null,"funder_award_id":"22571109","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321106","display_name":"Ministry of Education of the People's Republic of China","ror":"https://ror.org/01mv9t934"},{"id":"https://openalex.org/F4320326502","display_name":"Department of Science and Technology, Hubei Provincial People's Government","ror":null},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W35926420","https://openalex.org/W1969829246","https://openalex.org/W1988050879","https://openalex.org/W1998330450","https://openalex.org/W2000500039","https://openalex.org/W2019147077","https://openalex.org/W2024404982","https://openalex.org/W2055315523","https://openalex.org/W2087416709","https://openalex.org/W2098043783","https://openalex.org/W2108615500","https://openalex.org/W2134405559","https://openalex.org/W2143945519","https://openalex.org/W2150475298","https://openalex.org/W2154508893","https://openalex.org/W2258061264","https://openalex.org/W2335499233","https://openalex.org/W2751731013","https://openalex.org/W2774981005","https://openalex.org/W2807091466","https://openalex.org/W2950871693","https://openalex.org/W2951360795","https://openalex.org/W2951918965","https://openalex.org/W2952017559","https://openalex.org/W2952086502","https://openalex.org/W2952167100","https://openalex.org/W3030852292","https://openalex.org/W3092581998","https://openalex.org/W3145228655","https://openalex.org/W3158207266","https://openalex.org/W4224235999","https://openalex.org/W4236365251","https://openalex.org/W4306353227","https://openalex.org/W4312112245","https://openalex.org/W4319812183","https://openalex.org/W4323528383","https://openalex.org/W4327575139","https://openalex.org/W4389976632","https://openalex.org/W4392004197","https://openalex.org/W4392291655","https://openalex.org/W4392456743","https://openalex.org/W4392571465","https://openalex.org/W4399654986","https://openalex.org/W4400195243","https://openalex.org/W4402321375","https://openalex.org/W4402935150","https://openalex.org/W4403458153","https://openalex.org/W4405368697","https://openalex.org/W4405719561","https://openalex.org/W4406679810","https://openalex.org/W4406874744","https://openalex.org/W4406924935","https://openalex.org/W4409800699","https://openalex.org/W4410110147","https://openalex.org/W4410370948","https://openalex.org/W4410696423","https://openalex.org/W4411213722","https://openalex.org/W4412731161","https://openalex.org/W4412845854","https://openalex.org/W4412870127","https://openalex.org/W4414370603"],"related_works":[],"abstract_inverted_index":{"\u03b1-Exoalkenyl":[0],"\u03b3-lactone":[1],"skeletons":[2],"are":[3],"of":[4,35,56],"great":[5],"significance":[6],"due":[7],"to":[8],"their":[9],"synthetic":[10,22],"challenges":[11],"and":[12,21,72],"the":[13,33,54],"diverse":[14,63],"biological":[15],"properties":[16],"exhibited":[17],"by":[18],"numerous":[19],"natural":[20],"molecules.":[23],"In":[24],"this":[25],"work,":[26],"we":[27],"developed":[28],"an":[29],"alternative":[30],"method":[31],"for":[32],"synthesis":[34],"\u03b1-exoalkenyl":[36],"\u03b3-lactones":[37,64],"via":[38],"visible":[39],"light-induced":[40],"radical-polar":[41],"crossover":[42],"cyclization":[43],"(RPCC)":[44],"reaction.":[45],"These":[46],"reactions":[47],"proceed":[48],"under":[49],"mild":[50],"photochemical":[51],"conditions":[52],"in":[53],"presence":[55],"fluorescein":[57],"sodium":[58],"as":[59],"photocatalyst,":[60],"yielding":[61],"structurally":[62],"conveniently,":[65],"while":[66],"demonstrating":[67],"good":[68],"functional":[69],"group":[70],"tolerance":[71],"a":[73,78],"broad":[74],"substrate":[75],"scope.":[76],"Furthermore,":[77],"plausible":[79],"RPCC":[80],"mechanistic":[81],"pathway":[82],"is":[83],"proposed":[84],"based":[85],"on":[86],"control":[87],"experiments.":[88]},"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-08-31T07:19:18.363097","created_date":"2025-11-25T00:00:00"}