{"id":"https://openalex.org/W4416631659","doi":"https://doi.org/10.3389/frtra.2025.1662187","title":"Glycocalyx kinetics and injury during liver procurement and transplantation as predictors of early graft dysfunction","display_name":"Glycocalyx kinetics and injury during liver procurement and transplantation as predictors of early graft dysfunction","publication_year":2025,"publication_date":"2025-11-25","ids":{"openalex":"https://openalex.org/W4416631659","doi":"https://doi.org/10.3389/frtra.2025.1662187","pmid":"https://pubmed.ncbi.nlm.nih.gov/41377853"},"language":"en","primary_location":{"id":"doi:10.3389/frtra.2025.1662187","doi":"https://doi.org/10.3389/frtra.2025.1662187","is_oa":true,"landing_page_url":"https://doi.org/10.3389/frtra.2025.1662187","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/transplantation/articles/10.3389/frtra.2025.1662187/pdf","source":{"id":"https://openalex.org/S4387280090","display_name":"Frontiers in Transplantation","issn_l":"2813-2440","issn":["2813-2440"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://public-pages-files-2025.frontiersin.org/journals/transplantation/articles/10.3389/frtra.2025.1662187/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027673700","display_name":"Nassiba Beghdadi","orcid":"https://orcid.org/0000-0002-5649-0702","observed_orcids":["https://orcid.org/0000-0002-5649-0702"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210164847","display_name":"H\u00f4pital Paul-Brousse","ror":"https://ror.org/05n7yzd13","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210164847","https://openalex.org/I4405259118"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Nassiba Beghdadi","raw_affiliation_strings":["Hopital Paul Brousse, Villejuif, France","INSERM UMR 1193, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hopital Paul Brousse, Villejuif, France","institution_ids":["https://openalex.org/I4210164847"]},{"raw_affiliation_string":"INSERM UMR 1193, Villejuif, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040009155","display_name":"Alexis Texier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alexis Texier","raw_affiliation_strings":["INSERM UMR-S1176, Le Kremlin-Bic\u00eatre, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM UMR-S1176, Le Kremlin-Bic\u00eatre, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079979267","display_name":"Marc\u2010Antoine Allard","orcid":"https://orcid.org/0000-0003-3901-5632","observed_orcids":["https://orcid.org/0000-0003-3901-5632"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210164847","display_name":"H\u00f4pital Paul-Brousse","ror":"https://ror.org/05n7yzd13","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210164847","https://openalex.org/I4405259118"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marc Antoine Allard","raw_affiliation_strings":["Hopital Paul Brousse, Villejuif, France","INSERM UMR 1193, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hopital Paul Brousse, Villejuif, France","institution_ids":["https://openalex.org/I4210164847"]},{"raw_affiliation_string":"INSERM UMR 1193, Villejuif, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038945776","display_name":"Myl\u00e8ne Sebagh","orcid":"https://orcid.org/0000-0002-6122-2542","observed_orcids":["https://orcid.org/0000-0002-6122-2542"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210164847","display_name":"H\u00f4pital Paul-Brousse","ror":"https://ror.org/05n7yzd13","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210164847","https://openalex.org/I4405259118"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mylene Sebagh","raw_affiliation_strings":["AP-HP H\u00f4pital Paul-Brousse, Laboratoire d'Anatomopathologie, Villejuif, France","INSERM UMR 1193, Villejuif, France","Universit\u00e9 Paris-Saclay, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AP-HP H\u00f4pital Paul-Brousse, Laboratoire d'Anatomopathologie, Villejuif, France","institution_ids":["https://openalex.org/I4210164847"]},{"raw_affiliation_string":"INSERM UMR 1193, Villejuif, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, Villejuif, France","institution_ids":["https://openalex.org/I277688954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083859290","display_name":"Nour Bousaleh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164847","display_name":"H\u00f4pital Paul-Brousse","ror":"https://ror.org/05n7yzd13","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210164847","https://openalex.org/I4405259118"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nour Bousaleh","raw_affiliation_strings":["Hopital Paul Brousse, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hopital Paul Brousse, Villejuif, France","institution_ids":["https://openalex.org/I4210164847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003752607","display_name":"Haitham Triki","orcid":"https://orcid.org/0000-0002-9915-9219","observed_orcids":["https://orcid.org/0000-0002-9915-9219"]},"institutions":[{"id":"https://openalex.org/I4210164847","display_name":"H\u00f4pital Paul-Brousse","ror":"https://ror.org/05n7yzd13","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210164847","https://openalex.org/I4405259118"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Haitham Triki","raw_affiliation_strings":["Hopital Paul Brousse, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hopital Paul Brousse, Villejuif, France","institution_ids":["https://openalex.org/I4210164847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055837353","display_name":"Daniel Pietrasz","orcid":"https://orcid.org/0000-0002-0643-9917","observed_orcids":["https://orcid.org/0000-0002-0643-9917"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210164847","display_name":"H\u00f4pital Paul-Brousse","ror":"https://ror.org/05n7yzd13","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210164847","https://openalex.org/I4405259118"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Daniel Pietrasz","raw_affiliation_strings":["Hopital Paul Brousse, Villejuif, France","INSERM UMR 1193, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hopital Paul Brousse, Villejuif, France","institution_ids":["https://openalex.org/I4210164847"]},{"raw_affiliation_string":"INSERM UMR 1193, Villejuif, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033870098","display_name":"Nicolas Cabrit","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164847","display_name":"H\u00f4pital Paul-Brousse","ror":"https://ror.org/05n7yzd13","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210164847","https://openalex.org/I4405259118"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nicolas Cabrit","raw_affiliation_strings":["Hopital Paul Brousse, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hopital Paul Brousse, Villejuif, France","institution_ids":["https://openalex.org/I4210164847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050149605","display_name":"Nicolas Golse","orcid":"https://orcid.org/0000-0002-5261-1538","observed_orcids":["https://orcid.org/0000-0002-5261-1538"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210164847","display_name":"H\u00f4pital Paul-Brousse","ror":"https://ror.org/05n7yzd13","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210164847","https://openalex.org/I4405259118"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nicolas Golse","raw_affiliation_strings":["Hopital Paul Brousse, Villejuif, France","INSERM UMR 1193, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hopital Paul Brousse, Villejuif, France","institution_ids":["https://openalex.org/I4210164847"]},{"raw_affiliation_string":"INSERM UMR 1193, Villejuif, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106033733","display_name":"Ren\u00e9 A. Adam","orcid":"https://orcid.org/0000-0003-2169-5449","observed_orcids":["https://orcid.org/0000-0003-2169-5449","https://orcid.org/0000-0003-2627-4766"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210164847","display_name":"H\u00f4pital Paul-Brousse","ror":"https://ror.org/05n7yzd13","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210164847","https://openalex.org/I4405259118"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ren\u00e9 Adam","raw_affiliation_strings":["Hopital Paul Brousse, Villejuif, France","INSERM UMR 1193, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hopital Paul Brousse, Villejuif, France","institution_ids":["https://openalex.org/I4210164847"]},{"raw_affiliation_string":"INSERM UMR 1193, Villejuif, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013589390","display_name":"Cyrille F\u00e9ray","orcid":"https://orcid.org/0000-0002-8627-9676","observed_orcids":["https://orcid.org/0000-0002-8627-9676","https://orcid.org/0000-0002-3885-2052"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210164847","display_name":"H\u00f4pital Paul-Brousse","ror":"https://ror.org/05n7yzd13","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210164847","https://openalex.org/I4405259118"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Cyrille Feray","raw_affiliation_strings":["Hopital Paul Brousse, Villejuif, France","INSERM UMR 1193, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hopital Paul Brousse, Villejuif, France","institution_ids":["https://openalex.org/I4210164847"]},{"raw_affiliation_string":"INSERM UMR 1193, Villejuif, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049893255","display_name":"Peter J. Lenting","orcid":"https://orcid.org/0000-0002-7937-3429","observed_orcids":["https://orcid.org/0000-0002-7937-3429"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Peter J. Lenting","raw_affiliation_strings":["INSERM UMR-S1176, Le Kremlin-Bic\u00eatre, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM UMR-S1176, Le Kremlin-Bic\u00eatre, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012572436","display_name":"St\u00e9phanie Roullet","orcid":"https://orcid.org/0000-0002-1064-0621","observed_orcids":["https://orcid.org/0000-0002-1064-0621"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210164847","display_name":"H\u00f4pital Paul-Brousse","ror":"https://ror.org/05n7yzd13","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210164847","https://openalex.org/I4405259118"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"St\u00e9phanie Roullet","raw_affiliation_strings":["Hopital Paul Brousse, Villejuif, France","INSERM UMR-S1176, Le Kremlin-Bic\u00eatre, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hopital Paul Brousse, Villejuif, France","institution_ids":["https://openalex.org/I4210164847"]},{"raw_affiliation_string":"INSERM UMR-S1176, Le Kremlin-Bic\u00eatre, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086116904","display_name":"Daniel Azoulay","orcid":"https://orcid.org/0000-0002-0932-0540","observed_orcids":["https://orcid.org/0000-0002-0932-0540"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210164847","display_name":"H\u00f4pital Paul-Brousse","ror":"https://ror.org/05n7yzd13","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210164847","https://openalex.org/I4405259118"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Daniel Azoulay","raw_affiliation_strings":["Hopital Paul Brousse, Villejuif, France","INSERM UMR 1193, Villejuif, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hopital Paul Brousse, Villejuif, France","institution_ids":["https://openalex.org/I4210164847"]},{"raw_affiliation_string":"INSERM UMR 1193, Villejuif, France","institution_ids":["https://openalex.org/I154526488"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5027673700"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210164847"],"apc_list":{"value":1950,"currency":"CHF","value_usd":2353},"apc_paid":{"value":1950,"currency":"CHF","value_usd":2353},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.44278493,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":null,"first_page":"1662187","last_page":"1662187"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glycocalyx-degradation","display_name":"glycocalyx degradation","score":0.9620000123977661},{"id":"https://openalex.org/keywords/early-allograft-dysfunction","display_name":"early allograft dysfunction","score":0.8619999885559082},{"id":"https://openalex.org/keywords/liver-transplantation","display_name":"liver transplantation","score":0.9660000205039978},{"id":"https://openalex.org/keywords/liver-procurement","display_name":"liver procurement","score":0.8349999785423279},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.9480000138282776},{"id":"https://openalex.org/keywords/syndecan-1","display_name":"syndecan-1","score":0.9160000085830688},{"id":"https://openalex.org/keywords/endothelial-injury","display_name":"endothelial injury","score":0.7319999933242798},{"id":"https://openalex.org/keywords/heparan-sulfate","display_name":"heparan sulfate","score":0.8009999990463257},{"id":"https://openalex.org/keywords/angiopoietin-1","display_name":"angiopoietin-1","score":0.9390000104904175},{"id":"https://openalex.org/keywords/angiopoietin-2","display_name":"angiopoietin-2","score":0.996999979019165},{"id":"https://openalex.org/keywords/cold-ischemia","display_name":"cold ischemia","score":0.7620000243186951},{"id":"https://openalex.org/keywords/post-transplant-complications","display_name":"post-transplant complications","score":0.6389999985694885},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7347999811172485},{"id":"https://openalex.org/C2780098789","wikidata":"https://www.wikidata.org/wiki/Q898356","display_name":"Glycocalyx","level":2,"score":0.629800021648407},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5819000005722046},{"id":"https://openalex.org/C201650216","wikidata":"https://www.wikidata.org/wiki/Q829492","display_name":"Procurement","level":2,"score":0.5684000253677368},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.515500009059906},{"id":"https://openalex.org/C3017901848","wikidata":"https://www.wikidata.org/wiki/Q3536444","display_name":"Organ procurement","level":3,"score":0.48840001225471497},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36480000615119934},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.31769999861717224},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.3138999938964844},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.31369999051094055},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.3061999976634979},{"id":"https://openalex.org/C179933525","wikidata":"https://www.wikidata.org/wiki/Q1144664","display_name":"Cryopreservation","level":3,"score":0.29280000925064087},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.2784000039100647},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.2590000033378601}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/frtra.2025.1662187","doi":"https://doi.org/10.3389/frtra.2025.1662187","is_oa":true,"landing_page_url":"https://doi.org/10.3389/frtra.2025.1662187","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/transplantation/articles/10.3389/frtra.2025.1662187/pdf","source":{"id":"https://openalex.org/S4387280090","display_name":"Frontiers in Transplantation","issn_l":"2813-2440","issn":["2813-2440"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Transplantation","raw_type":"journal-article"},{"id":"pmid:41377853","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41377853","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in transplantation","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:db8f6643449f48dca86e110acf45541a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/db8f6643449f48dca86e110acf45541a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Transplantation, Vol 4 (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12687380","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12687380/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Transplant","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3389/frtra.2025.1662187","doi":"https://doi.org/10.3389/frtra.2025.1662187","is_oa":true,"landing_page_url":"https://doi.org/10.3389/frtra.2025.1662187","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/transplantation/articles/10.3389/frtra.2025.1662187/pdf","source":{"id":"https://openalex.org/S4387280090","display_name":"Frontiers in Transplantation","issn_l":"2813-2440","issn":["2813-2440"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Transplantation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320309738","display_name":"Fondation de l'Avenir pour la Recherche M\u00e9dicale Appliqu\u00e9e","ror":"https://ror.org/02dddmh90"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416631659.pdf","grobid_xml":"https://content.openalex.org/works/W4416631659.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1269121966","https://openalex.org/W1548421436","https://openalex.org/W1567433779","https://openalex.org/W1970696225","https://openalex.org/W1970714964","https://openalex.org/W1992046032","https://openalex.org/W2013127121","https://openalex.org/W2017332381","https://openalex.org/W2018680532","https://openalex.org/W2022772983","https://openalex.org/W2030105817","https://openalex.org/W2040242558","https://openalex.org/W2054512362","https://openalex.org/W2058172582","https://openalex.org/W2077970463","https://openalex.org/W2083765383","https://openalex.org/W2091044581","https://openalex.org/W2093765752","https://openalex.org/W2096998881","https://openalex.org/W2105534832","https://openalex.org/W2111766323","https://openalex.org/W2111879266","https://openalex.org/W2115000187","https://openalex.org/W2118780215","https://openalex.org/W2121366225","https://openalex.org/W2128817315","https://openalex.org/W2133930237","https://openalex.org/W2319978280","https://openalex.org/W2606397736","https://openalex.org/W2621307756","https://openalex.org/W2763249451","https://openalex.org/W2763444432","https://openalex.org/W2785496833","https://openalex.org/W2799789325","https://openalex.org/W2939092765","https://openalex.org/W2959255818","https://openalex.org/W2968507067","https://openalex.org/W3133288057","https://openalex.org/W4211224425"],"related_works":[],"abstract_inverted_index":{"Introduction":[0],"Ischemia\u2013reperfusion":[1],"injury":[2],"causes":[3],"endothelial":[4,229],"damage,":[5],"partly":[6],"through":[7],"degradation":[8,18,66],"of":[9,31,74,163,220],"the":[10,72,228],"glycocalyx.":[11],"This":[12,40],"study":[13,44],"aimed":[14,225],"to":[15,22,54],"evaluate":[16],"glycocalyx":[17,108],"from":[19,51],"graft":[20,33,82,211,234],"procurement":[21,136,214,231],"reperfusion":[23],"and":[24,77,85,115,119],"assess":[25],"its":[26],"potential":[27],"as":[28,97,217],"a":[29,98,218],"biomarker":[30],"early":[32,221],"function":[34],"(early":[35],"allograft":[36,222],"dysfunction,":[37],"EAD).":[38],"Methods":[39],"single-center":[41],"observational":[42],"prospective":[43],"was":[45,67,94,197],"conducted":[46],"at":[47,69,71,135,226],"Paul":[48],"Brousse":[49],"Hospital":[50],"April":[52,55],"2022":[53],"2023.":[56],"All":[57],"primary":[58,92],"liver":[59,81,88],"transplantation":[60],"(LT)":[61],"recipients":[62],"were":[63,126,142],"included.":[64],"Glycocalyx":[65],"assessed":[68],"procurement,":[70],"end":[73],"cold":[75],"ischemia,":[76],"during":[78,213,230],"LT":[79],"in":[80,145,210],"caval":[83],"effluent":[84,212],"correlated":[86],"with":[87,147,199],"histological":[89],"injury.":[90],"The":[91],"endpoint":[93],"EAD,":[95],"defined":[96],"Model":[99],"for":[100],"Early":[101],"Allograft":[102],"Function":[103],"score":[104],"\u22659.":[105],"We":[106],"quantified":[107],"components":[109],"[Syndecan-1":[110],"(Synd-1),":[111],"heparan":[112],"sulfate,":[113],"angiopoietin-1,":[114],"angiopoietin-2],":[116],"inflammation":[117],"(TNF-alpha),":[118],"cell":[120],"death":[121],"markers.":[122],"Results":[123],"Thirty-one":[124],"patients":[125,146],"included;":[127],"12":[128],"(39%)":[129],"developed":[130],"EAD.":[131],"Synd-1":[132,138],"plasma":[133,160],"levels":[134,209],"(donor":[137],"level":[139],"=":[140,157,169,184,189,205],"d-Synd-1)":[141],"significantly":[143],"higher":[144],"EAD":[148,167],"[12,173":[149],"pg/mL":[150,154,165,196],"(10,538\u201317,570)":[151],"vs.":[152],"6,282":[153],"(4,604\u201310,002),":[155],"p":[156,191,204],"0.004].":[158],"A":[159],"d-Synd-1":[161,194,208],"cutoff":[162],"9,419.7":[164],"predicted":[166],"[AUC":[168],"0.81,":[170],"95%":[171],"confidence":[172],"interval":[173],"(95%":[174],"CI)":[175],"(0.65\u20130.97);":[176],"sensitivity":[177],"83%;":[178],"specificity":[179],"74%,":[180],"positive":[181],"predictive":[182,187],"value":[183,188],"67%,":[185],"negative":[186],"88%,":[190],"<":[192],"0.05].":[193],"\u22659,419.7":[195],"associated":[198],"severe":[200],"post-LT":[201],"complications":[202],"(":[203],"0.007).":[206],"Conclusions":[207],"may":[215],"serve":[216],"predictor":[219],"dysfunction.":[223],"Strategies":[224],"protecting":[227],"could":[232],"improve":[233],"outcomes.":[235]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-11-25T00:00:00"}