{"id":"https://openalex.org/W4416630613","doi":"https://doi.org/10.1016/j.jlb.2025.100393","title":"Prevalence and Characterization of ESR1 Alterations Detected with an Ultra-Sensitive, Liquid-Only CGP Assay in a Large Breast Cancer Cohort","display_name":"Prevalence and Characterization of ESR1 Alterations Detected with an Ultra-Sensitive, Liquid-Only CGP Assay in a Large Breast Cancer Cohort","publication_year":2025,"publication_date":"2025-11-01","ids":{"openalex":"https://openalex.org/W4416630613","doi":"https://doi.org/10.1016/j.jlb.2025.100393"},"language":"en","primary_location":{"id":"doi:10.1016/j.jlb.2025.100393","doi":"https://doi.org/10.1016/j.jlb.2025.100393","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jlb.2025.100393","pdf_url":"https://www.journalofliquidbiopsy.com/article/S2950-1954(25)00109-2/pdf","source":{"id":"https://openalex.org/S4387291454","display_name":"The Journal of Liquid Biopsy","issn_l":"2950-1954","issn":["2950-1954"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Liquid Biopsy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.journalofliquidbiopsy.com/article/S2950-1954(25)00109-2/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050279083","display_name":"Lenny K. Hong","orcid":"https://orcid.org/0000-0002-9237-4311","observed_orcids":["https://orcid.org/0000-0002-9237-4311"]},"institutions":[{"id":"https://openalex.org/I4405257773","display_name":"BillionToOne (United States)","ror":"https://ror.org/05nfch282","country_code":"US","type":"company","lineage":["https://openalex.org/I4405257773"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lenny K. Hong","raw_affiliation_strings":["BillionToOne, Menlo Park, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BillionToOne, Menlo Park, United States","institution_ids":["https://openalex.org/I4405257773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050279083","display_name":"Lenny K. Hong","orcid":"https://orcid.org/0000-0002-9237-4311","observed_orcids":["https://orcid.org/0000-0002-9237-4311"]},"institutions":[{"id":"https://openalex.org/I4405257773","display_name":"BillionToOne (United States)","ror":"https://ror.org/05nfch282","country_code":"US","type":"company","lineage":["https://openalex.org/I4405257773"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lenny Hong","raw_affiliation_strings":["BillionToOne, Menlo Park, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BillionToOne, Menlo Park, United States","institution_ids":["https://openalex.org/I4405257773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092085162","display_name":"Ali Aboosaiedi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405257773","display_name":"BillionToOne (United States)","ror":"https://ror.org/05nfch282","country_code":"US","type":"company","lineage":["https://openalex.org/I4405257773"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ali Aboosaiedi","raw_affiliation_strings":["BillionToOne, Menlo Park, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BillionToOne, Menlo Park, United States","institution_ids":["https://openalex.org/I4405257773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006764896","display_name":"Tiffany E. Farmer","orcid":"https://orcid.org/0009-0000-1149-3312","observed_orcids":["https://orcid.org/0009-0000-1149-3312"]},"institutions":[{"id":"https://openalex.org/I4405257773","display_name":"BillionToOne (United States)","ror":"https://ror.org/05nfch282","country_code":"US","type":"company","lineage":["https://openalex.org/I4405257773"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tiffany Farmer","raw_affiliation_strings":["BillionToOne, Menlo Park, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BillionToOne, Menlo Park, United States","institution_ids":["https://openalex.org/I4405257773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010224836","display_name":"Jeffrey M. Gaudet","orcid":"https://orcid.org/0000-0003-3519-5015","observed_orcids":["https://orcid.org/0000-0003-3519-5015"]},"institutions":[{"id":"https://openalex.org/I4405257773","display_name":"BillionToOne (United States)","ror":"https://ror.org/05nfch282","country_code":"US","type":"company","lineage":["https://openalex.org/I4405257773"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeff Gaudet","raw_affiliation_strings":["BillionToOne, Menlo Park, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BillionToOne, Menlo Park, United States","institution_ids":["https://openalex.org/I4405257773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010285873","display_name":"Atri Choksi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405257773","display_name":"BillionToOne (United States)","ror":"https://ror.org/05nfch282","country_code":"US","type":"company","lineage":["https://openalex.org/I4405257773"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Atri Choksi","raw_affiliation_strings":["BillionToOne, Menlo Park, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BillionToOne, Menlo Park, United States","institution_ids":["https://openalex.org/I4405257773"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael Castro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100502","display_name":"Beverly Hills Cancer Center","ror":"https://ror.org/00j1j3213","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210100502"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Castro","raw_affiliation_strings":["Beverly Hills Cancer Center and Personalized Cancer Medicine PLLC, Beverly Hills, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beverly Hills Cancer Center and Personalized Cancer Medicine PLLC, Beverly Hills, USA","institution_ids":["https://openalex.org/I4210100502"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104110113","display_name":"Jason Jerome Lukas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason J. Lukas","raw_affiliation_strings":["Fred Hutch Cancer Center, Issaquah, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutch Cancer Center, Issaquah, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061636658","display_name":"Gary A. Palmer","orcid":"https://orcid.org/0000-0002-0173-1329","observed_orcids":["https://orcid.org/0000-0002-0173-1329"]},"institutions":[{"id":"https://openalex.org/I4405257773","display_name":"BillionToOne (United States)","ror":"https://ror.org/05nfch282","country_code":"US","type":"company","lineage":["https://openalex.org/I4405257773"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary Palmer","raw_affiliation_strings":["BillionToOne, Menlo Park, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BillionToOne, Menlo Park, United States","institution_ids":["https://openalex.org/I4405257773"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2080,"currency":"USD","value_usd":2080},"apc_paid":{"value":2080,"currency":"USD","value_usd":2080},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":null,"first_page":"100393","last_page":"100393"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.4993000030517578,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.4993000030517578,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.16740000247955322,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.13210000097751617,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8700000047683716},{"id":"https://openalex.org/keywords/endocrine-resistance","display_name":"endocrine therapy resistance","score":0.8880000114440918},{"id":"https://openalex.org/keywords/aromatase-inhibitor-resistance","display_name":"aromatase inhibitor resistance","score":0.8709999918937683},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.8970000147819519},{"id":"https://openalex.org/keywords/cell-free-dna","display_name":"cell-free DNA","score":0.6840000152587891},{"id":"https://openalex.org/keywords/circulating-tumor-dna","display_name":"circulating tumor DNA","score":0.6430000066757202},{"id":"https://openalex.org/keywords/acquired-resistance","display_name":"acquired resistance","score":0.4440000057220459},{"id":"https://openalex.org/keywords/serial-monitoring","display_name":"serial monitoring","score":0.4790000021457672}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6565999984741211},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5676000118255615},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4401000142097473},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3752000033855438},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.36010000109672546},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3555999994277954},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34279999136924744},{"id":"https://openalex.org/C2779880527","wikidata":"https://www.wikidata.org/wiki/Q4959796","display_name":"Breast disease","level":4,"score":0.30219998955726624},{"id":"https://openalex.org/C172313692","wikidata":"https://www.wikidata.org/wiki/Q14902310","display_name":"Estrogen receptor alpha","level":5,"score":0.2815000116825104},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.26190000772476196},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.25270000100135803}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jlb.2025.100393","doi":"https://doi.org/10.1016/j.jlb.2025.100393","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jlb.2025.100393","pdf_url":"https://www.journalofliquidbiopsy.com/article/S2950-1954(25)00109-2/pdf","source":{"id":"https://openalex.org/S4387291454","display_name":"The Journal of Liquid Biopsy","issn_l":"2950-1954","issn":["2950-1954"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Liquid Biopsy","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.jlb.2025.100393","doi":"https://doi.org/10.1016/j.jlb.2025.100393","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jlb.2025.100393","pdf_url":"https://www.journalofliquidbiopsy.com/article/S2950-1954(25)00109-2/pdf","source":{"id":"https://openalex.org/S4387291454","display_name":"The Journal of Liquid Biopsy","issn_l":"2950-1954","issn":["2950-1954"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Liquid Biopsy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416630613.pdf","grobid_xml":"https://content.openalex.org/works/W4416630613.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4387976085","https://openalex.org/W4414981568","https://openalex.org/W4413853208","https://openalex.org/W3111500129","https://openalex.org/W2763325962","https://openalex.org/W4386068163","https://openalex.org/W4409279292","https://openalex.org/W2951786961","https://openalex.org/W2949962195","https://openalex.org/W2805970419"],"abstract_inverted_index":{"Introduction:":[0],"ESR1":[1,38],"variants":[2],"are":[3],"a":[4],"key":[5],"mechanism":[6],"of":[7],"acquired":[8],"resistance":[9],"to":[10,43],"endocrine":[11],"therapy":[12,41],"in":[13],"advanced":[14],"breast":[15],"cancer,":[16],"particularly":[17],"after":[18],"aromatase":[19],"inhibitor":[20],"exposure.":[21],"Recent":[22],"guidelines":[23],"and":[24,46],"results":[25],"from":[26],"SERENA-6":[27],"now":[28],"support":[29],"liquid":[30],"biopsy":[31],"as":[32],"the":[33],"preferred":[34],"method":[35],"for":[36,48],"detecting":[37],"alterations":[39],"during":[40],"due":[42],"its":[44],"accessibility":[45],"suitability":[47],"serial":[49],"monitoring.":[50]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2025-11-25T00:00:00"}
