{"id":"https://openalex.org/W4416630365","doi":"https://doi.org/10.1158/1078-0432.30709878","title":"CD38CD39 Population DEGs DS1 from A Population of Tumor-Infiltrating CD4+ T Cells Co-Expressing CD38 and CD39 Is Associated with Checkpoint Inhibitor Resistance","display_name":"CD38CD39 Population DEGs DS1 from A Population of Tumor-Infiltrating CD4+ T Cells Co-Expressing CD38 and CD39 Is Associated with Checkpoint Inhibitor Resistance","publication_year":2025,"publication_date":"2025-11-25","ids":{"openalex":"https://openalex.org/W4416630365","doi":"https://doi.org/10.1158/1078-0432.30709878"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.30709878","doi":"https://doi.org/10.1158/1078-0432.30709878","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.30709878","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.30709878","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072079484","display_name":"Ankita Mitra","orcid":"https://orcid.org/0000-0002-7368-1965","observed_orcids":["https://orcid.org/0000-0002-7368-1965"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ankita Mitra","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7368-1965","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Brian Thompson","orcid":"https://orcid.org/0000-0003-0983-2762","observed_orcids":["https://orcid.org/0000-0003-0983-2762"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian Thompson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0983-2762","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003597650","display_name":"Ann Strange","orcid":"https://orcid.org/0000-0002-6655-0959","observed_orcids":["https://orcid.org/0000-0002-6655-0959"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ann Strange","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6655-0959","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022583816","display_name":"Carol M. Amato","orcid":"https://orcid.org/0000-0002-4945-8819","observed_orcids":["https://orcid.org/0000-0002-4945-8819"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carol M. Amato","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4945-8819","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034423452","display_name":"Melinda Vassallo","orcid":"https://orcid.org/0009-0000-4948-7524","observed_orcids":["https://orcid.org/0009-0000-4948-7524"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melinda Vassallo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-4948-7524","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018407483","display_name":"Igor Dolgalev","orcid":"https://orcid.org/0000-0003-4451-126X","observed_orcids":["https://orcid.org/0000-0003-4451-126X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Igor Dolgalev","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4451-126X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059522233","display_name":"Jonathan Hester-McCullough","orcid":"https://orcid.org/0000-0003-0667-0307","observed_orcids":["https://orcid.org/0000-0003-0667-0307"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan Hester-McCullough","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0667-0307","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081231143","display_name":"Tomoaki Muramatsu","orcid":"https://orcid.org/0000-0002-6567-3498","observed_orcids":["https://orcid.org/0000-0002-6567-3498"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tomoaki Muramatsu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6567-3498","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017232180","display_name":"Diana A. Kimono","orcid":"https://orcid.org/0009-0008-9294-7205","observed_orcids":["https://orcid.org/0009-0008-9294-7205"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Diana Kimono","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0008-9294-7205","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041888067","display_name":"Amrutesh S. Puranik","orcid":"https://orcid.org/0000-0001-7249-5602","observed_orcids":["https://orcid.org/0000-0001-7249-5602"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amrutesh S. Puranik","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7249-5602","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047177507","display_name":"Jeffrey S. Weber","orcid":"https://orcid.org/0000-0002-4962-2957","observed_orcids":["https://orcid.org/0000-0002-4962-2957"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeffrey S. Weber","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4962-2957","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5067364305","display_name":"David Michael Woods","orcid":"https://orcid.org/0000-0002-6328-8107","observed_orcids":["https://orcid.org/0000-0002-6328-8107"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Woods","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6328-8107","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.02759999968111515,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd38","display_name":"CD38","score":0.9610000252723694},{"id":"https://openalex.org/keywords/cd39","display_name":"CD39","score":1.0},{"id":"https://openalex.org/keywords/tumor-infiltrating-cd4-t-cells","display_name":"tumor-infiltrating CD4+ T cells","score":0.8600000143051147},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.8080000281333923},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitor-resistance","display_name":"immune checkpoint inhibitor resistance","score":0.7850000262260437},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.5400000214576721},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.46399998664855957}],"concepts":[{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.640999972820282},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.566100001335144},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.47040000557899475},{"id":"https://openalex.org/C159912055","wikidata":"https://www.wikidata.org/wiki/Q14885119","display_name":"CD38","level":4,"score":0.43880000710487366},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38350000977516174},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33820000290870667},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.28780001401901245},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.2831000089645386},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2750999927520752},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27390000224113464},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.26589998602867126},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.26010000705718994},{"id":"https://openalex.org/C57473165","wikidata":"https://www.wikidata.org/wiki/Q7315604","display_name":"Resistance (ecology)","level":2,"score":0.25940001010894775},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.2558000087738037},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.251800000667572},{"id":"https://openalex.org/C54086632","wikidata":"https://www.wikidata.org/wiki/Q5512671","display_name":"G2-M DNA damage checkpoint","level":5,"score":0.2508000135421753}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.30709878","doi":"https://doi.org/10.1158/1078-0432.30709878","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.30709878","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/30709878","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/software/CD38CD39_Population_DEGs_DS1_from_A_Population_of_Tumor-Infiltrating_CD4_sup_sup_T_Cells_Co-Expressing_CD38_and_CD39_Is_Associated_with_Checkpoint_Inhibitor_Resistance/30709878","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Software"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.30709878","doi":"https://doi.org/10.1158/1078-0432.30709878","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.30709878","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4387602139","https://openalex.org/W4387608171","https://openalex.org/W4385330446","https://openalex.org/W4402797678","https://openalex.org/W3146110766","https://openalex.org/W3146593765","https://openalex.org/W3031392466","https://openalex.org/W3083571024","https://openalex.org/W7219879994","https://openalex.org/W4313381680"],"abstract_inverted_index":{"CD38/CD39":[0],"populations":[1],"DEGs":[2]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2025-11-25T00:00:00"}