{"id":"https://openalex.org/W4416630107","doi":"https://doi.org/10.1158/1078-0432.30709192","title":"Supplementary Fig. 5 from MEK Inhibition Sensitizes Pancreatic Cancer to STING Agonism by Tumor Cell\u2013intrinsic Amplification of Type I IFN Signaling","display_name":"Supplementary Fig. 5 from MEK Inhibition Sensitizes Pancreatic Cancer to STING Agonism by Tumor Cell\u2013intrinsic Amplification of Type I IFN Signaling","publication_year":2025,"publication_date":"2025-11-25","ids":{"openalex":"https://openalex.org/W4416630107","doi":"https://doi.org/10.1158/1078-0432.30709192"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.30709192","doi":"https://doi.org/10.1158/1078-0432.30709192","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.30709192","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Fig_5_from_MEK_Inhibition_Sensitizes_Pancreatic_Cancer_to_STING_Agonism_by_Tumor_Cell_intrinsic_Amplification_of_Type_I_IFN_Signaling/30709192/1/files/59834008.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Fig_5_from_MEK_Inhibition_Sensitizes_Pancreatic_Cancer_to_STING_Agonism_by_Tumor_Cell_intrinsic_Amplification_of_Type_I_IFN_Signaling/30709192/1/files/59834008.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036481001","display_name":"Razmik Ghukasyan","orcid":"https://orcid.org/0000-0003-1795-1892","observed_orcids":["https://orcid.org/0000-0003-1795-1892"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Razmik Ghukasyan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1795-1892","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038792983","display_name":"Keke Liang","orcid":"https://orcid.org/0000-0002-0007-6326","observed_orcids":["https://orcid.org/0000-0002-0007-6326","https://orcid.org/0009-0001-5799-0231"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keke Liang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0007-6326","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063951168","display_name":"Kevin Chau","orcid":"https://orcid.org/0000-0001-9945-9169","observed_orcids":["https://orcid.org/0000-0001-9945-9169"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevin Chau","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9945-9169","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043782637","display_name":"Luyi Li","orcid":"https://orcid.org/0000-0001-6096-6403","observed_orcids":["https://orcid.org/0000-0001-6096-6403"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luyi Li","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6096-6403","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009235216","display_name":"Charlotte Chan","orcid":"https://orcid.org/0000-0001-5036-7298","observed_orcids":["https://orcid.org/0000-0001-5036-7298"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charlotte Chan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5036-7298","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066633792","display_name":"Evan R. Abt","orcid":"https://orcid.org/0000-0002-3160-7134","observed_orcids":["https://orcid.org/0000-0002-3160-7134"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Evan R. Abt","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3160-7134","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001373227","display_name":"Thuc M. Le","orcid":"https://orcid.org/0000-0003-2364-9374","observed_orcids":["https://orcid.org/0000-0003-2364-9374"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thuc Le","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2364-9374","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086695712","display_name":"Joon Y. Park","orcid":"https://orcid.org/0000-0002-3847-9198","observed_orcids":["https://orcid.org/0000-0002-3847-9198"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joon Y. Park","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3847-9198","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029117087","display_name":"Nanping Wu","orcid":"https://orcid.org/0000-0001-6415-009X","observed_orcids":["https://orcid.org/0000-0001-6415-009X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nanping Wu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6415-009X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008210852","display_name":"Alykhan Premji","orcid":"https://orcid.org/0000-0002-0326-3717","observed_orcids":["https://orcid.org/0000-0002-0326-3717"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alykhan Premji","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0326-3717","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045676945","display_name":"Robert D. Damoiseaux","orcid":"https://orcid.org/0000-0002-7611-7534","observed_orcids":["https://orcid.org/0000-0002-7611-7534"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Damoiseaux","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7611-7534","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042715452","display_name":"Tony Luu","orcid":"https://orcid.org/0009-0003-1014-9300","observed_orcids":["https://orcid.org/0009-0003-1014-9300"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tony Luu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-1014-9300","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053487389","display_name":"Amanda N. Labora","orcid":"https://orcid.org/0000-0001-6273-0939","observed_orcids":["https://orcid.org/0000-0001-6273-0939"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amanda Labora","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6273-0939","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032597456","display_name":"Khalid Rashid","orcid":"https://orcid.org/0000-0002-5070-8010","observed_orcids":["https://orcid.org/0000-0002-5070-8010"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Khalid Rashid","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5070-8010","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030632046","display_name":"Jason M. Link","orcid":"https://orcid.org/0000-0002-6892-0431","observed_orcids":["https://orcid.org/0000-0002-6892-0431"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jason M. Link","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6892-0431","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018755772","display_name":"Caius G. Radu","orcid":"https://orcid.org/0000-0002-9338-5397","observed_orcids":["https://orcid.org/0000-0002-9338-5397"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Caius G. Radu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9338-5397","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5058851560","display_name":"Timothy R. Donahue","orcid":"https://orcid.org/0000-0002-1175-2545","observed_orcids":["https://orcid.org/0000-0002-1175-2545"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timothy R. Donahue","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1175-2545","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.6484000086784363,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.6484000086784363,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.30250000953674316,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.011300000362098217,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mek-inhibition","display_name":"MEK inhibition","score":0.9789999723434448},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/type-i-interferon-signaling","display_name":"type I interferon signaling","score":0.8790000081062317},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.7250000238418579},{"id":"https://openalex.org/keywords/tumor-cell-intrinsic-signaling","display_name":"tumor cell-intrinsic signaling","score":0.675000011920929},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6769999861717224}],"concepts":[{"id":"https://openalex.org/C2779300339","wikidata":"https://www.wikidata.org/wiki/Q7617409","display_name":"Sting","level":2,"score":0.7432000041007996},{"id":"https://openalex.org/C14527384","wikidata":"https://www.wikidata.org/wiki/Q4693403","display_name":"Agonism","level":3,"score":0.6409000158309937},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.620199978351593},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5511999726295471},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5320000052452087},{"id":"https://openalex.org/C2777349159","wikidata":"https://www.wikidata.org/wiki/Q18055374","display_name":"Stimulator of interferon genes","level":4,"score":0.5220999717712402},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4745999872684479},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.3837999999523163},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.3521000146865845},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.3222000002861023},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.31859999895095825},{"id":"https://openalex.org/C2781249067","wikidata":"https://www.wikidata.org/wiki/Q17142288","display_name":"MEK inhibitor","level":4,"score":0.3174000084400177},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.30660000443458557},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27160000801086426},{"id":"https://openalex.org/C2778278966","wikidata":"https://www.wikidata.org/wiki/Q6046488","display_name":"Interferon type I","level":3,"score":0.26010000705718994},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.258899986743927},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2531999945640564}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.30709192","doi":"https://doi.org/10.1158/1078-0432.30709192","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.30709192","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Fig_5_from_MEK_Inhibition_Sensitizes_Pancreatic_Cancer_to_STING_Agonism_by_Tumor_Cell_intrinsic_Amplification_of_Type_I_IFN_Signaling/30709192/1/files/59834008.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/30709192","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Fig_5_from_MEK_Inhibition_Sensitizes_Pancreatic_Cancer_to_STING_Agonism_by_Tumor_Cell_intrinsic_Amplification_of_Type_I_IFN_Signaling/30709192","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.30709192","doi":"https://doi.org/10.1158/1078-0432.30709192","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.30709192","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Fig_5_from_MEK_Inhibition_Sensitizes_Pancreatic_Cancer_to_STING_Agonism_by_Tumor_Cell_intrinsic_Amplification_of_Type_I_IFN_Signaling/30709192/1/files/59834008.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416630107.pdf","grobid_xml":"https://content.openalex.org/works/W4416630107.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4376872402","https://openalex.org/W4385836420","https://openalex.org/W4402798244","https://openalex.org/W6903869673","https://openalex.org/W3213222536","https://openalex.org/W2947021030","https://openalex.org/W7163147220"],"abstract_inverted_index":{"Supplementary":[0],"Fig.":[1],"5":[2],"IL6":[3],"is":[4],"not":[5],"responsible":[6],"for":[7],"the":[8],"synergistic":[9],"effects":[10],"of":[11],"STING":[12],"agonism":[13],"and":[14],"MEK":[15],"inhibition.":[16]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2025-11-25T00:00:00"}