{"id":"https://openalex.org/W4416629676","doi":"https://doi.org/10.1158/1078-0432.30708763","title":"Table S4 from Combined CDK4/6 and ERK1/2 Inhibition Enhances Antitumor Activity in NF1-Associated Plexiform Neurofibroma","display_name":"Table S4 from Combined CDK4/6 and ERK1/2 Inhibition Enhances Antitumor Activity in NF1-Associated Plexiform Neurofibroma","publication_year":2025,"publication_date":"2025-11-25","ids":{"openalex":"https://openalex.org/W4416629676","doi":"https://doi.org/10.1158/1078-0432.30708763"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.30708763","doi":"https://doi.org/10.1158/1078-0432.30708763","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.30708763","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Table_S4_from_Combined_CDK4_6_and_ERK1_2_Inhibition_Enhances_Antitumor_Activity_in_NF1-Associated_Plexiform_Neurofibroma/30708763/1/files/59833573.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacr.figshare.com/articles/journal_contribution/Table_S4_from_Combined_CDK4_6_and_ERK1_2_Inhibition_Enhances_Antitumor_Activity_in_NF1-Associated_Plexiform_Neurofibroma/30708763/1/files/59833573.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002388430","display_name":"Alyssa C. Flint","orcid":"https://orcid.org/0000-0001-5698-9776","observed_orcids":["https://orcid.org/0000-0001-5698-9776"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alyssa C. Flint","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5698-9776","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001582911","display_name":"Dana K. Mitchell","orcid":"https://orcid.org/0000-0002-1022-1072","observed_orcids":["https://orcid.org/0000-0002-1022-1072"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dana K. Mitchell","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1022-1072","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067366916","display_name":"Steven P. Angus","orcid":"https://orcid.org/0000-0002-7655-657X","observed_orcids":["https://orcid.org/0000-0002-7655-657X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven P. Angus","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7655-657X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084429604","display_name":"Abbi E. Smith","orcid":"https://orcid.org/0000-0002-4402-8959","observed_orcids":["https://orcid.org/0000-0002-4402-8959"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abbi E. Smith","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4402-8959","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011940249","display_name":"Waylan Bessler","orcid":"https://orcid.org/0000-0003-0685-9206","observed_orcids":["https://orcid.org/0000-0003-0685-9206"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Waylan Bessler","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0685-9206","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049617151","display_name":"Li Jiang","orcid":"https://orcid.org/0009-0003-6488-1927","observed_orcids":["https://orcid.org/0009-0003-6488-1927"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li Jiang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-6488-1927","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058070935","display_name":"Henry Elmer Mang","orcid":"https://orcid.org/0000-0002-2496-1442","observed_orcids":["https://orcid.org/0000-0002-2496-1442"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Henry Mang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2496-1442","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100767812","display_name":"Xiaohong Li","orcid":"https://orcid.org/0009-0000-2728-0565","observed_orcids":["https://orcid.org/0009-0000-2728-0565"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaohong Li","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-2728-0565","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020630997","display_name":"Qingbo Lu","orcid":"https://orcid.org/0009-0005-6786-9100","observed_orcids":["https://orcid.org/0009-0005-6786-9100","https://orcid.org/0009-0009-4283-0735"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qingbo Lu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-6786-9100","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081742889","display_name":"Brooke Rodriguez","orcid":"https://orcid.org/0009-0005-6313-3681","observed_orcids":["https://orcid.org/0009-0005-6313-3681"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brooke Rodriguez","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-6313-3681","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061385868","display_name":"George Earl Sandusky","orcid":"https://orcid.org/0000-0003-0769-057X","observed_orcids":["https://orcid.org/0000-0003-0769-057X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George E. Sandusky","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0769-057X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112540473","display_name":"Andi R. Masters","orcid":"https://orcid.org/0000-0002-9570-8786","observed_orcids":["https://orcid.org/0000-0002-9570-8786"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andi R. Masters","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9570-8786","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012408594","display_name":"Chi Zhang","orcid":"https://orcid.org/0000-0001-9553-0925","observed_orcids":["https://orcid.org/0000-0001-9553-0925"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chi Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9553-0925","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040167145","display_name":"Pengtao Dang","orcid":"https://orcid.org/0009-0005-0144-0432","observed_orcids":["https://orcid.org/0009-0005-0144-0432","https://orcid.org/0009-0000-3178-2090"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pengtao Dang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-0144-0432","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078591052","display_name":"Jenna K. Koenig","orcid":"https://orcid.org/0000-0001-6952-955X","observed_orcids":["https://orcid.org/0000-0001-6952-955X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jenna Koenig","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6952-955X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047612906","display_name":"Gary L. Johnson","orcid":"https://orcid.org/0000-0003-2867-0551","observed_orcids":["https://orcid.org/0000-0003-2867-0551"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gary L. Johnson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2867-0551","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014196571","display_name":"Weihua Shen","orcid":"https://orcid.org/0009-0002-5249-5175","observed_orcids":["https://orcid.org/0009-0002-5249-5175"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Weihua Shen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-5249-5175","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080535835","display_name":"Jiangang Liu","orcid":"https://orcid.org/0000-0002-2800-077X","observed_orcids":["https://orcid.org/0000-0002-2800-077X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiangang Liu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2800-077X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078360952","display_name":"Amit Aggarwal","orcid":"https://orcid.org/0000-0003-4800-4046","observed_orcids":["https://orcid.org/0000-0003-4800-4046"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amit Aggarwal","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4800-4046","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071061160","display_name":"Gregory P. Donoho","orcid":"https://orcid.org/0009-0007-8865-5093","observed_orcids":["https://orcid.org/0009-0007-8865-5093"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gregory P. Donoho","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-8865-5093","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079993897","display_name":"Melinda D. Willard","orcid":"https://orcid.org/0000-0002-2937-962X","observed_orcids":["https://orcid.org/0000-0002-2937-962X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melinda D. Willard","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2937-962X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003086261","display_name":"Shripad V. Bhagwat","orcid":"https://orcid.org/0009-0001-1231-9735","observed_orcids":["https://orcid.org/0009-0001-1231-9735"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shripad V. Bhagwat","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-1231-9735","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056688749","display_name":"D. Wade Clapp","orcid":"https://orcid.org/0000-0001-9465-0917","observed_orcids":["https://orcid.org/0000-0001-9465-0917"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Wade Clapp","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9465-0917","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5062014907","display_name":"Steven D. Rhodes","orcid":"https://orcid.org/0000-0002-6551-8631","observed_orcids":["https://orcid.org/0000-0002-6551-8631"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven D. Rhodes","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6551-8631","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cdk4-6-inhibition","display_name":"CDK4/6 inhibition","score":0.8460000157356262},{"id":"https://openalex.org/keywords/erk1-2-inhibition","display_name":"ERK1/2 inhibition","score":0.9980000257492065},{"id":"https://openalex.org/keywords/plexiform-neurofibroma","display_name":"plexiform neurofibroma","score":0.8420000076293945},{"id":"https://openalex.org/keywords/neurofibromatosis-type-1","display_name":"neurofibromatosis type 1","score":0.8379999995231628},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.75},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6119999885559082},{"id":"https://openalex.org/keywords/mouse-tumor-model","display_name":"mouse tumor model","score":0.5329999923706055}],"concepts":[{"id":"https://openalex.org/C2910078708","wikidata":"https://www.wikidata.org/wiki/Q1418735","display_name":"Plexiform neurofibroma","level":4,"score":0.6204000115394592},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6194000244140625},{"id":"https://openalex.org/C45235069","wikidata":"https://www.wikidata.org/wiki/Q278425","display_name":"Table (database)","level":2,"score":0.48840001225471497},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42750000953674316},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.40529999136924744},{"id":"https://openalex.org/C2777831590","wikidata":"https://www.wikidata.org/wiki/Q1418735","display_name":"Neurofibroma","level":3,"score":0.39570000767707825},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2883000075817108},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.27250000834465027},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23759999871253967},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.22699999809265137}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.30708763","doi":"https://doi.org/10.1158/1078-0432.30708763","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.30708763","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Table_S4_from_Combined_CDK4_6_and_ERK1_2_Inhibition_Enhances_Antitumor_Activity_in_NF1-Associated_Plexiform_Neurofibroma/30708763/1/files/59833573.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/30708763","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Table_S4_from_Combined_CDK4_6_and_ERK1_2_Inhibition_Enhances_Antitumor_Activity_in_NF1-Associated_Plexiform_Neurofibroma/30708763","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.30708763","doi":"https://doi.org/10.1158/1078-0432.30708763","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.30708763","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Table_S4_from_Combined_CDK4_6_and_ERK1_2_Inhibition_Enhances_Antitumor_Activity_in_NF1-Associated_Plexiform_Neurofibroma/30708763/1/files/59833573.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416629676.pdf","grobid_xml":"https://content.openalex.org/works/W4416629676.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4402818743","https://openalex.org/W4402817481","https://openalex.org/W4402817282","https://openalex.org/W4402790180","https://openalex.org/W4402817478","https://openalex.org/W4402799356","https://openalex.org/W4385286794"],"abstract_inverted_index":{"Table":[0],"of":[1],"mice":[2],"enrolled":[3],"in":[4],"drug":[5],"study":[6]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-11-25T00:00:00"}