{"id":"https://openalex.org/W4416628900","doi":"https://doi.org/10.1158/1078-0432.30706982","title":"Figure S5 from MEK Inhibition Synergizes with TYK2 Inhibitors in NF1-Associated Malignant Peripheral Nerve Sheath Tumors","display_name":"Figure S5 from MEK Inhibition Synergizes with TYK2 Inhibitors in NF1-Associated Malignant Peripheral Nerve Sheath Tumors","publication_year":2025,"publication_date":"2025-11-25","ids":{"openalex":"https://openalex.org/W4416628900","doi":"https://doi.org/10.1158/1078-0432.30706982"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.30706982","doi":"https://doi.org/10.1158/1078-0432.30706982","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.30706982","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Figure_S5_from_MEK_Inhibition_Synergizes_with_TYK2_Inhibitors_in_NF1-Associated_Malignant_Peripheral_Nerve_Sheath_Tumors/30706982/1/files/59831429.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacr.figshare.com/articles/journal_contribution/Figure_S5_from_MEK_Inhibition_Synergizes_with_TYK2_Inhibitors_in_NF1-Associated_Malignant_Peripheral_Nerve_Sheath_Tumors/30706982/1/files/59831429.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028552606","display_name":"Dana C. Borcherding","orcid":"https://orcid.org/0000-0002-8849-2139","observed_orcids":["https://orcid.org/0000-0002-8849-2139"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dana C. Borcherding","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8849-2139","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039998213","display_name":"Neha V. Amin","orcid":"https://orcid.org/0000-0002-5128-9065","observed_orcids":["https://orcid.org/0000-0002-5128-9065"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neha V. Amin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5128-9065","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024073568","display_name":"Kevin He","orcid":"https://orcid.org/0000-0003-2642-7830","observed_orcids":["https://orcid.org/0000-0003-2642-7830"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevin He","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2642-7830","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011985957","display_name":"Xiaochun Zhang","orcid":"https://orcid.org/0000-0002-6107-1182","observed_orcids":["https://orcid.org/0000-0002-6107-1182"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaochun Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6107-1182","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075861153","display_name":"Yang Lyu","orcid":"https://orcid.org/0000-0002-4353-0082","observed_orcids":["https://orcid.org/0000-0002-4353-0082"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yang Lyu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4353-0082","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077642249","display_name":"Carina Anja Dehner","orcid":"https://orcid.org/0000-0001-5214-4813","observed_orcids":["https://orcid.org/0000-0001-5214-4813","https://orcid.org/0009-0009-1559-1900"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carina Dehner","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5214-4813","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005788142","display_name":"Himanshi Bhatia","orcid":"https://orcid.org/0000-0001-9949-3412","observed_orcids":["https://orcid.org/0000-0001-9949-3412"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Himanshi Bhatia","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9949-3412","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041560635","display_name":"Angad Gothra","orcid":"https://orcid.org/0000-0002-8502-3548","observed_orcids":["https://orcid.org/0000-0002-8502-3548"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Angad Gothra","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8502-3548","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086976226","display_name":"Layla Daud","orcid":"https://orcid.org/0000-0001-9766-2155","observed_orcids":["https://orcid.org/0000-0001-9766-2155"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Layla Daud","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9766-2155","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018280436","display_name":"Peter Ruminski","orcid":"https://orcid.org/0000-0002-6269-2239","observed_orcids":["https://orcid.org/0000-0002-6269-2239"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Ruminski","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6269-2239","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075174884","display_name":"Christine A. Pratilas","orcid":"https://orcid.org/0000-0002-7116-0605","observed_orcids":["https://orcid.org/0000-0002-7116-0605"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christine A. Pratilas","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7116-0605","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090607487","display_name":"Kai Pollard","orcid":"https://orcid.org/0000-0002-2778-8884","observed_orcids":["https://orcid.org/0000-0002-2778-8884"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kai Pollard","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2778-8884","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034958185","display_name":"R. Taylor Sundby","orcid":"https://orcid.org/0000-0001-8485-0026","observed_orcids":["https://orcid.org/0000-0001-8485-0026"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Taylor Sundby","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8485-0026","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071679104","display_name":"Brigitte C. Widemann","orcid":"https://orcid.org/0000-0002-9198-7175","observed_orcids":["https://orcid.org/0000-0002-9198-7175"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brigitte C. Widemann","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9198-7175","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5036526586","display_name":"Angela C. Hirbe","orcid":"https://orcid.org/0000-0003-1719-0771","observed_orcids":["https://orcid.org/0000-0003-1719-0771"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Angela C. Hirbe","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1719-0771","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mek-inhibition","display_name":"MEK inhibition","score":0.9150000214576721},{"id":"https://openalex.org/keywords/tyk2-inhibitor","display_name":"TYK2 inhibitor","score":0.9810000061988831},{"id":"https://openalex.org/keywords/malignant-peripheral-nerve-sheath-tumor","display_name":"malignant peripheral nerve sheath tumor","score":0.9399999976158142},{"id":"https://openalex.org/keywords/neurofibromatosis-type-1","display_name":"neurofibromatosis type 1","score":0.8700000047683716},{"id":"https://openalex.org/keywords/gene-expression-changes","display_name":"gene expression changes","score":0.8889999985694885},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5734999775886536},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.517300009727478},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4700999855995178},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4187000095844269},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3675000071525574},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36250001192092896},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3490000069141388},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34450000524520874},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.3271999955177307},{"id":"https://openalex.org/C130523297","wikidata":"https://www.wikidata.org/wiki/Q14914487","display_name":"Tyrosine kinase 2","level":5,"score":0.32670000195503235},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3075000047683716},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.2928999960422516},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.2874000072479248},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.28630000352859497},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2827000021934509},{"id":"https://openalex.org/C2781249067","wikidata":"https://www.wikidata.org/wiki/Q17142288","display_name":"MEK inhibitor","level":4,"score":0.2768999934196472},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2761000096797943},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.2732999920845032},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.2651999890804291},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2581000030040741},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.2556000053882599},{"id":"https://openalex.org/C2778173781","wikidata":"https://www.wikidata.org/wiki/Q654485","display_name":"Malignant peripheral nerve sheath tumor","level":3,"score":0.2524000108242035}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.30706982","doi":"https://doi.org/10.1158/1078-0432.30706982","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.30706982","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Figure_S5_from_MEK_Inhibition_Synergizes_with_TYK2_Inhibitors_in_NF1-Associated_Malignant_Peripheral_Nerve_Sheath_Tumors/30706982/1/files/59831429.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/30706982","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Figure_S5_from_MEK_Inhibition_Synergizes_with_TYK2_Inhibitors_in_NF1-Associated_Malignant_Peripheral_Nerve_Sheath_Tumors/30706982","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.30706982","doi":"https://doi.org/10.1158/1078-0432.30706982","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.30706982","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Figure_S5_from_MEK_Inhibition_Synergizes_with_TYK2_Inhibitors_in_NF1-Associated_Malignant_Peripheral_Nerve_Sheath_Tumors/30706982/1/files/59831429.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416628900.pdf","grobid_xml":"https://content.openalex.org/works/W4416628900.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4365510472","https://openalex.org/W4361956741","https://openalex.org/W4416628690","https://openalex.org/W4376171449","https://openalex.org/W4361956510","https://openalex.org/W4361956569","https://openalex.org/W4416628745","https://openalex.org/W4361956512","https://openalex.org/W4416628926","https://openalex.org/W4376171208"],"abstract_inverted_index":{"Supplemental":[0],"Fig.S5.":[1],"Validation":[2],"of":[3],"select":[4],"gene":[5,31],"expression":[6,32],"changes":[7],"with":[8,22],"TYK2":[9],"inhibitor":[10],"treatment":[11],"that":[12],"were":[13,20],"identified":[14],"by":[15,35],"qPCR":[16,36],"array.":[17],"JH-2-002":[18],"cells":[19],"incubated":[21],"40":[23],"\u00b5MWU-12":[24],"or":[25],"control":[26],"for":[27,37],"48":[28],"hours,":[29],"and":[30],"was":[33],"analyzed":[34],"select(A)up-regulated":[38],"or(B)down-regulated":[39],"genes.":[40]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-11-25T00:00:00"}
