{"id":"https://openalex.org/W4416623800","doi":"https://doi.org/10.70401/cbm.2025.0003","title":"MediHerb: A multi-modal enhanced framework for disease inference via herbal knowledge","display_name":"MediHerb: A multi-modal enhanced framework for disease inference via herbal knowledge","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4416623800","doi":"https://doi.org/10.70401/cbm.2025.0003"},"language":"en","primary_location":{"id":"doi:10.70401/cbm.2025.0003","doi":"https://doi.org/10.70401/cbm.2025.0003","is_oa":true,"landing_page_url":"https://doi.org/10.70401/cbm.2025.0003","pdf_url":"https://oss.sciexplor.com/manuscript/512/publish/CBM_202509.pdf","source":{"id":"https://openalex.org/S5407056488","display_name":"Computational Biomedicine","issn_l":"3107-3131","issn":["3107-3131"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Biomedicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://oss.sciexplor.com/manuscript/512/publish/CBM_202509.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100667632","display_name":"Xiaoyi Liu","orcid":"https://orcid.org/0009-0006-5862-2031","observed_orcids":["https://orcid.org/0009-0006-5862-2031"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaoyi Liu","raw_affiliation_strings":["3School of Life Sciences , Central South University , Changsha 410083 , Hunan , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3School of Life Sciences , Central South University , Changsha 410083 , Hunan , China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100674251","display_name":"Fu Chen","orcid":"https://orcid.org/0000-0002-9073-5267","observed_orcids":["https://orcid.org/0000-0002-9073-5267"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fu Chen","raw_affiliation_strings":["3School of Life Sciences , Central South University , Changsha 410083 , Hunan , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3School of Life Sciences , Central South University , Changsha 410083 , Hunan , China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021365545","display_name":"Junnan Pan","orcid":"https://orcid.org/0000-0002-1699-624X","observed_orcids":["https://orcid.org/0000-0002-1699-624X"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junnan Pan","raw_affiliation_strings":["3School of Life Sciences , Central South University , Changsha 410083 , Hunan , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3School of Life Sciences , Central South University , Changsha 410083 , Hunan , China","institution_ids":["https://openalex.org/I139660479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088075730","display_name":"Chengwei Ai","orcid":"https://orcid.org/0000-0003-1314-660X","observed_orcids":["https://orcid.org/0000-0003-1314-660X"]},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]},{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengwei Ai","raw_affiliation_strings":["1School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing 100029 , China","6College of Intelligence and Computing , Tianjin University , Tianjin 300072 , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing 100029 , China","institution_ids":["https://openalex.org/I17747738"]},{"raw_affiliation_string":"6College of Intelligence and Computing , Tianjin University , Tianjin 300072 , China","institution_ids":["https://openalex.org/I162868743"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Fei Guo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Fei Guo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5001619694","display_name":"Jijun Tang","orcid":"https://orcid.org/0000-0002-6377-536X","observed_orcids":["https://orcid.org/0000-0002-6377-536X"]},"institutions":[{"id":"https://openalex.org/I17747738","display_name":"Beijing University of Chinese Medicine","ror":"https://ror.org/05damtm70","country_code":"CN","type":"education","lineage":["https://openalex.org/I17747738"]},{"id":"https://openalex.org/I4210145761","display_name":"Shenzhen Institutes of Advanced Technology","ror":"https://ror.org/04gh4er46","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210145761"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jijun Tang","raw_affiliation_strings":["5School of Computer Science and Control Engineering , Shenzhen Institutes of Advanced Technology , Shenzhen 518055 , Guangdong , China","School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing 100029 , China"],"raw_orcid":"https://orcid.org/0000-0002-6377-536X","affiliations":[{"raw_affiliation_string":"5School of Computer Science and Control Engineering , Shenzhen Institutes of Advanced Technology , Shenzhen 518055 , Guangdong , China","institution_ids":["https://openalex.org/I4210145761"]},{"raw_affiliation_string":"School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing 100029 , China","institution_ids":["https://openalex.org/I17747738"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5001619694","https://openalex.org/A5100667632"],"corresponding_institution_ids":["https://openalex.org/I139660479","https://openalex.org/I17747738","https://openalex.org/I4210145761"],"apc_list":null,"apc_paid":null,"fwci":0.5168,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.69158659,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.5692999958992004,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.5692999958992004,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12647","display_name":"Traditional Chinese Medicine Studies","score":0.3073999881744385,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.04470000043511391,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.8009999990463257},{"id":"https://openalex.org/keywords/tcm-prescriptions","display_name":"TCM prescriptions","score":0.8489999771118164},{"id":"https://openalex.org/keywords/multimodal-fusion","display_name":"multimodal fusion","score":0.9549999833106995},{"id":"https://openalex.org/keywords/attention-based-fusion","display_name":"attention fusion","score":0.7990000247955322},{"id":"https://openalex.org/keywords/molecular-fingerprints","display_name":"molecular fingerprints","score":0.4959999918937683},{"id":"https://openalex.org/keywords/physicochemical-properties","display_name":"physicochemical properties","score":0.9520000219345093}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6988000273704529},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.607699990272522},{"id":"https://openalex.org/C184337299","wikidata":"https://www.wikidata.org/wiki/Q1437428","display_name":"Semantics (computer science)","level":2,"score":0.5817999839782715},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5507000088691711},{"id":"https://openalex.org/C2780801425","wikidata":"https://www.wikidata.org/wiki/Q5164392","display_name":"Construct (python library)","level":2,"score":0.49079999327659607},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.47600001096725464},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.46459999680519104},{"id":"https://openalex.org/C2780451532","wikidata":"https://www.wikidata.org/wiki/Q759676","display_name":"Task (project management)","level":2,"score":0.41530001163482666},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.3865000009536743},{"id":"https://openalex.org/C185798385","wikidata":"https://www.wikidata.org/wiki/Q1161707","display_name":"Benchmark (surveying)","level":2,"score":0.3440999984741211},{"id":"https://openalex.org/C155846161","wikidata":"https://www.wikidata.org/wiki/Q1143367","display_name":"Graphical model","level":2,"score":0.3357999920845032},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.32899999618530273},{"id":"https://openalex.org/C161301231","wikidata":"https://www.wikidata.org/wiki/Q3478658","display_name":"Knowledge representation and reasoning","level":2,"score":0.32330000400543213},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.3160000145435333},{"id":"https://openalex.org/C113843644","wikidata":"https://www.wikidata.org/wiki/Q901882","display_name":"Interface (matter)","level":4,"score":0.2987000048160553},{"id":"https://openalex.org/C2780791683","wikidata":"https://www.wikidata.org/wiki/Q846785","display_name":"Action (physics)","level":2,"score":0.27639999985694885},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2741999924182892},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.257999986410141},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.2540999948978424},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.25110000371932983},{"id":"https://openalex.org/C175154964","wikidata":"https://www.wikidata.org/wiki/Q380077","display_name":"Task analysis","level":3,"score":0.2502000033855438}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.70401/cbm.2025.0003","doi":"https://doi.org/10.70401/cbm.2025.0003","is_oa":true,"landing_page_url":"https://doi.org/10.70401/cbm.2025.0003","pdf_url":"https://oss.sciexplor.com/manuscript/512/publish/CBM_202509.pdf","source":{"id":"https://openalex.org/S5407056488","display_name":"Computational Biomedicine","issn_l":"3107-3131","issn":["3107-3131"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Biomedicine","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.70401/cbm.2025.0003","doi":"https://doi.org/10.70401/cbm.2025.0003","is_oa":true,"landing_page_url":"https://doi.org/10.70401/cbm.2025.0003","pdf_url":"https://oss.sciexplor.com/manuscript/512/publish/CBM_202509.pdf","source":{"id":"https://openalex.org/S5407056488","display_name":"Computational Biomedicine","issn_l":"3107-3131","issn":["3107-3131"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Biomedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3075931670","display_name":null,"funder_award_id":"U24A20257","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3758836111","display_name":null,"funder_award_id":"62322215","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4076804852","display_name":null,"funder_award_id":"2020YFA0908400","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G626465873","display_name":null,"funder_award_id":"62322215","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G6624819937","display_name":null,"funder_award_id":"62532017","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7005921426","display_name":null,"funder_award_id":"KQTD20200820113106007","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7723570462","display_name":null,"funder_award_id":"62502050","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8136496760","display_name":null,"funder_award_id":"KQTD20200820113106007","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G8502045713","display_name":null,"funder_award_id":"2020YFA0908400","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416623800.pdf","grobid_xml":"https://content.openalex.org/works/W4416623800.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1531333757","https://openalex.org/W1975147762","https://openalex.org/W1987710883","https://openalex.org/W1988037271","https://openalex.org/W2200017991","https://openalex.org/W2221103459","https://openalex.org/W2575964080","https://openalex.org/W2606363764","https://openalex.org/W2782374321","https://openalex.org/W2958029267","https://openalex.org/W2970771982","https://openalex.org/W2985331920","https://openalex.org/W2997158276","https://openalex.org/W3046375318","https://openalex.org/W3108860514","https://openalex.org/W3128647010","https://openalex.org/W3214433768","https://openalex.org/W4214673031","https://openalex.org/W4214699666","https://openalex.org/W4226020019","https://openalex.org/W4390992364","https://openalex.org/W4392393090","https://openalex.org/W4392748121","https://openalex.org/W4401035236","https://openalex.org/W4401729983","https://openalex.org/W4405973188","https://openalex.org/W4408217933","https://openalex.org/W4408250731","https://openalex.org/W4408782369","https://openalex.org/W4413111577"],"related_works":["https://openalex.org/W7126068805","https://openalex.org/W7124245350","https://openalex.org/W4415592572","https://openalex.org/W4417427949","https://openalex.org/W4415681314","https://openalex.org/W7166527973","https://openalex.org/W7202144270","https://openalex.org/W4388460533","https://openalex.org/W3032163490","https://openalex.org/W7128485303"],"abstract_inverted_index":{"Aims:":[0],"Development":[1],"of":[2,18,55,67,90,122,206,214],"robust":[3],"and":[4,11,21,39,52,64,83,119,140,164,189,196,222,229],"effective":[5],"methods":[6],"for":[7,100],"uncovering":[8],"herb":[9,37],"interactions":[10,38],"constructing":[12],"herb\u2013disease":[13,42,181,207],"associations":[14],"requires":[15,46],"the":[16,48,75,79,88,120,135,162,186,203,212],"integration":[17,66],"diverse":[19],"biological":[20,195],"medical":[22],"information.":[23],"A":[24],"key":[25],"challenge":[26],"in":[27,180],"Traditional":[28],"Chinese":[29],"Medicine":[30],"(TCM)":[31],"research":[32],"is":[33],"to":[34,73,157,218,232],"robustly":[35],"uncover":[36],"construct":[40],"reliable":[41],"associations.":[43,208],"This":[44],"task":[45],"handling":[47],"inherently":[49],"high-dimensional,":[50],"multi-label,":[51],"cross-domain":[53],"nature":[54],"prescription":[56,117],"data.":[57],"Existing":[58],"approaches":[59],"provide":[60],"limited":[61],"representation":[62],"capacity":[63],"insufficient":[65],"biomedical":[68],"knowledge,":[69],"restricting":[70],"their":[71],"ability":[72],"capture":[74],"complex":[76],"semantics":[77,136],"underlying":[78],"relationships":[80],"between":[81],"herbs":[82],"diseases.":[84],"Methods:":[85],"To":[86,146],"address":[87],"limitations":[89],"existing":[91,178],"approaches,":[92],"we":[93],"propose":[94],"MediHerb,":[95],"a":[96,126,150,226],"multi-modal":[97,216],"enhanced":[98],"framework":[99],"disease":[101],"inference":[102],"via":[103],"herbal":[104],"knowledge.":[105],"MediHerb":[106,175,201,210],"unifies":[107],"five":[108],"complementary":[109],"modalities:":[110],"molecular":[111],"sequences,":[112],"fingerprints,":[113],"physicochemical":[114],"properties,":[115],"graphical":[116,152],"representations,":[118],"description":[121],"TCM":[123,234],"prescriptions":[124],"into":[125],"shared":[127],"latent":[128],"space.":[129],"An":[130],"attention-based":[131],"fusion":[132,217],"mechanism":[133],"aligns":[134],"across":[137],"molecular,":[138,220],"herbal,":[139,221],"diagnostic":[141],"levels,":[142],"enabling":[143],"multi-granularity":[144],"reasoning.":[145],"further":[147],"promote":[148],"accessibility,":[149],"lightweight":[151],"interface":[153],"has":[154],"been":[155],"developed":[156],"support":[158],"interaction":[159],"with":[160],"both":[161],"model":[163,190],"open":[165],"datasets.":[166],"Results:":[167],"Experimental":[168],"results":[169],"on":[170],"benchmark":[171],"datasets":[172],"demonstrate":[173],"that":[174,200],"substantially":[176],"outperforms":[177],"baselines":[179],"inference.":[182],"Beyond":[183],"predictive":[184],"accuracy,":[185],"learned":[187],"embeddings":[188],"attention":[191],"patterns":[192],"reveal":[193],"meaningful":[194],"pharmacological":[197],"insights,":[198],"confirming":[199],"captures":[202],"mechanistic":[204],"underpinnings":[205],"Conclusion:":[209],"highlights":[211],"potential":[213],"knowledge-enhanced":[215],"bridge":[219],"clinical":[223],"semantics,":[224],"offering":[225],"more":[227],"interpretable":[228],"holistic":[230],"approach":[231],"understanding":[233],"prescriptions.":[235]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2025-11-25T00:00:00"}
