{"id":"https://openalex.org/W4416620156","doi":"https://doi.org/10.2478/rrlm-2025-0023","title":"Comparison of platelet suspension solutions for preserving platelet aggregatory function","display_name":"Comparison of platelet suspension solutions for preserving platelet aggregatory function","publication_year":2025,"publication_date":"2025-10-01","ids":{"openalex":"https://openalex.org/W4416620156","doi":"https://doi.org/10.2478/rrlm-2025-0023"},"language":"en","primary_location":{"id":"doi:10.2478/rrlm-2025-0023","doi":"https://doi.org/10.2478/rrlm-2025-0023","is_oa":true,"landing_page_url":"https://doi.org/10.2478/rrlm-2025-0023","pdf_url":"https://reference-global.com/2/v2/download/article/10.2478/rrlm-2025-0023.pdf","source":{"id":"https://openalex.org/S2738061079","display_name":"Revista rom\u00e2n\u0103 de medicin\u0103 de laborator","issn_l":"1841-6624","issn":["1841-6624","2284-5623"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310320322","host_organization_name":"De Gruyter Open","host_organization_lineage":["https://openalex.org/P4310320322","https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter Open","De Gruyter"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista Romana de Medicina de Laborator","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://reference-global.com/2/v2/download/article/10.2478/rrlm-2025-0023.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101683786","display_name":"Jin jia Wei","orcid":"https://orcid.org/0000-0002-8949-7820","observed_orcids":["https://orcid.org/0000-0002-8949-7820"]},"institutions":[{"id":"https://openalex.org/I205490536","display_name":"Dongguk University","ror":"https://ror.org/057q6n778","country_code":"KR","type":"education","lineage":["https://openalex.org/I205490536"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Wei Jin","raw_affiliation_strings":["BK21 FOUR Team and Integrated Research Institute for Drug Development, College of Pharmacy , Dongguk University , Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BK21 FOUR Team and Integrated Research Institute for Drug Development, College of Pharmacy , Dongguk University , Republic of Korea","institution_ids":["https://openalex.org/I205490536"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069485195","display_name":"Jae-Hyeong Kim","orcid":"https://orcid.org/0009-0008-5024-5694","observed_orcids":["https://orcid.org/0009-0008-5024-5694"]},"institutions":[{"id":"https://openalex.org/I205490536","display_name":"Dongguk University","ror":"https://ror.org/057q6n778","country_code":"KR","type":"education","lineage":["https://openalex.org/I205490536"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae-Hyeong Kim","raw_affiliation_strings":["BK21 FOUR Team and Integrated Research Institute for Drug Development, College of Pharmacy , Dongguk University , Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BK21 FOUR Team and Integrated Research Institute for Drug Development, College of Pharmacy , Dongguk University , Republic of Korea","institution_ids":["https://openalex.org/I205490536"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101894901","display_name":"Jung Min Park","orcid":"https://orcid.org/0000-0001-9751-1592","observed_orcids":["https://orcid.org/0000-0001-9751-1592"]},"institutions":[{"id":"https://openalex.org/I205490536","display_name":"Dongguk University","ror":"https://ror.org/057q6n778","country_code":"KR","type":"education","lineage":["https://openalex.org/I205490536"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jung-Min Park","raw_affiliation_strings":["BK21 FOUR Team and Integrated Research Institute for Drug Development, College of Pharmacy , Dongguk University , Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BK21 FOUR Team and Integrated Research Institute for Drug Development, College of Pharmacy , Dongguk University , Republic of Korea","institution_ids":["https://openalex.org/I205490536"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057854172","display_name":"Yoon\u2010Seok Seo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205490536","display_name":"Dongguk University","ror":"https://ror.org/057q6n778","country_code":"KR","type":"education","lineage":["https://openalex.org/I205490536"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yoon-Seok Seo","raw_affiliation_strings":["BK21 FOUR Team and Integrated Research Institute for Drug Development, College of Pharmacy , Dongguk University , Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BK21 FOUR Team and Integrated Research Institute for Drug Development, College of Pharmacy , Dongguk University , Republic of Korea","institution_ids":["https://openalex.org/I205490536"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059327591","display_name":"Hee Jin Huh","orcid":"https://orcid.org/0000-0001-6587-8568","observed_orcids":["https://orcid.org/0000-0001-6587-8568"]},"institutions":[{"id":"https://openalex.org/I4210106928","display_name":"Dongguk University Ilsan Hospital","ror":"https://ror.org/01nwsar36","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I205490536","https://openalex.org/I4210106928","https://openalex.org/I4405259860"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hee Jin Huh","raw_affiliation_strings":["Department of Laboratory Medicine , Dongguk University Ilsan Hospital , Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine , Dongguk University Ilsan Hospital , Republic of Korea","institution_ids":["https://openalex.org/I4210106928"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053353606","display_name":"Moo\u2010Yeol Lee","orcid":"https://orcid.org/0000-0003-4440-8967","observed_orcids":["https://orcid.org/0000-0003-4440-8967"]},"institutions":[{"id":"https://openalex.org/I205490536","display_name":"Dongguk University","ror":"https://ror.org/057q6n778","country_code":"KR","type":"education","lineage":["https://openalex.org/I205490536"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Moo-Yeol Lee","raw_affiliation_strings":["BK21 FOUR Team and Integrated Research Institute for Drug Development, College of Pharmacy , Dongguk University , Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BK21 FOUR Team and Integrated Research Institute for Drug Development, College of Pharmacy , Dongguk University , Republic of Korea","institution_ids":["https://openalex.org/I205490536"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.42185323,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":"4","first_page":"219","last_page":"226"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9053000211715698,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9053000211715698,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.0820000022649765,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-storage","display_name":"platelet storage","score":0.6990000009536743},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.8190000057220459},{"id":"https://openalex.org/keywords/washed-platelets","display_name":"washed platelets","score":0.8970000147819519},{"id":"https://openalex.org/keywords/hanks-solution","display_name":"Hank's solution","score":0.9869999885559082},{"id":"https://openalex.org/keywords/phosphatidylserine-exposure","display_name":"phosphatidylserine exposure","score":0.902999997138977},{"id":"https://openalex.org/keywords/ph-stability","display_name":"pH stability","score":0.8299999833106995},{"id":"https://openalex.org/keywords/thrombin-induced-aggregation","display_name":"thrombin-induced aggregation","score":0.9070000052452087},{"id":"https://openalex.org/keywords/collagen-induced-platelet-aggregation","display_name":"collagen-induced aggregation","score":0.9980000257492065}],"concepts":[{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.8988999724388123},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7397000193595886},{"id":"https://openalex.org/C105341887","wikidata":"https://www.wikidata.org/wiki/Q1307987","display_name":"Suspension (topology)","level":3,"score":0.6208000183105469},{"id":"https://openalex.org/C2779637612","wikidata":"https://www.wikidata.org/wiki/Q2354337","display_name":"Phosphatidylserine","level":4,"score":0.5273000001907349},{"id":"https://openalex.org/C2993921965","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Salt solution","level":3,"score":0.4514000117778778},{"id":"https://openalex.org/C2993802102","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet aggregation","level":3,"score":0.43950000405311584},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.41769999265670776},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.3919000029563904},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.37619999051094055},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3465999960899353},{"id":"https://openalex.org/C2776371256","wikidata":"https://www.wikidata.org/wiki/Q12370","display_name":"Salt (chemistry)","level":2,"score":0.28940001130104065},{"id":"https://openalex.org/C2780009322","wikidata":"https://www.wikidata.org/wiki/Q7202246","display_name":"Platelet adhesiveness","level":4,"score":0.2508000135421753}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.2478/rrlm-2025-0023","doi":"https://doi.org/10.2478/rrlm-2025-0023","is_oa":true,"landing_page_url":"https://doi.org/10.2478/rrlm-2025-0023","pdf_url":"https://reference-global.com/2/v2/download/article/10.2478/rrlm-2025-0023.pdf","source":{"id":"https://openalex.org/S2738061079","display_name":"Revista rom\u00e2n\u0103 de medicin\u0103 de laborator","issn_l":"1841-6624","issn":["1841-6624","2284-5623"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310320322","host_organization_name":"De Gruyter Open","host_organization_lineage":["https://openalex.org/P4310320322","https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter Open","De Gruyter"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista Romana de Medicina de Laborator","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:99de478ff2c04341a7d378c8f7409b27","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/99de478ff2c04341a7d378c8f7409b27","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Romanian Journal of Laboratory Medicine, Vol 33, Iss 4, Pp 219-226 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.2478/rrlm-2025-0023","doi":"https://doi.org/10.2478/rrlm-2025-0023","is_oa":true,"landing_page_url":"https://doi.org/10.2478/rrlm-2025-0023","pdf_url":"https://reference-global.com/2/v2/download/article/10.2478/rrlm-2025-0023.pdf","source":{"id":"https://openalex.org/S2738061079","display_name":"Revista rom\u00e2n\u0103 de medicin\u0103 de laborator","issn_l":"1841-6624","issn":["1841-6624","2284-5623"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310320322","host_organization_name":"De Gruyter Open","host_organization_lineage":["https://openalex.org/P4310320322","https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter Open","De Gruyter"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista Romana de Medicina de Laborator","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1251031942","display_name":null,"funder_award_id":"BK 21 four","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G30685149","display_name":null,"funder_award_id":"BK21 FOUR","funder_id":"https://openalex.org/F4320320671","funder_display_name":"National Research Foundation"},{"id":"https://openalex.org/G3295063606","display_name":null,"funder_award_id":"2022R1A2C2007171","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G5268274703","display_name":null,"funder_award_id":"RS-2023-KH140699","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416620156.pdf","grobid_xml":"https://content.openalex.org/works/W4416620156.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W170372288","https://openalex.org/W1493000949","https://openalex.org/W1558866417","https://openalex.org/W1969415904","https://openalex.org/W2008937610","https://openalex.org/W2035423234","https://openalex.org/W2064413596","https://openalex.org/W2071871487","https://openalex.org/W2073282680","https://openalex.org/W2078885854","https://openalex.org/W2082043630","https://openalex.org/W2093754419","https://openalex.org/W2137574978","https://openalex.org/W2157942104","https://openalex.org/W2167850151","https://openalex.org/W2264816176","https://openalex.org/W2398670757","https://openalex.org/W2553714622","https://openalex.org/W2651277298","https://openalex.org/W2795843143","https://openalex.org/W2807317205","https://openalex.org/W2892023865","https://openalex.org/W2958799217","https://openalex.org/W2971414298","https://openalex.org/W2973212083","https://openalex.org/W2979726860","https://openalex.org/W2980342214","https://openalex.org/W3092412138","https://openalex.org/W3180423865","https://openalex.org/W4245219249","https://openalex.org/W4388326024"],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Despite":[2],"wide":[3],"agreement":[4],"on":[5],"various":[6],"aspects":[7],"of":[8,23,62],"platelet":[9,16,24,47,94,105,132,201,210],"protocols,":[10],"such":[11],"as":[12],"blood":[13],"collection,":[14],"anticoagulants,":[15],"isolation,":[17],"and":[18,67,80,116,165,169],"aggregometry,":[19],"the":[20,41,91,126,186,196],"optimal":[21],"composition":[22],"suspension":[25,37,57,211],"solutions":[26,38,86],"remains":[27],"unestablished.":[28],"Therefore,":[29],"this":[30,135],"study":[31],"aims":[32],"to":[33,39,99,103,130,154],"compare":[34],"five":[35,56],"different":[36],"determine":[40],"most":[42,197],"effective":[43,198],"one":[44],"for":[45,152,199,215],"maintaining":[46],"function.":[48,106,202],"Methods":[49],"Washed":[50],"platelets":[51],"(WP)":[52],"were":[53,87,123],"prepared":[54,159],"using":[55],"solutions:":[58],"two":[59],"modified":[60],"versions":[61],"Tyrode\u2019s":[63],"buffer":[64],"(Ty-rode":[65],"A":[66,143],"Tyrode":[68,137,142,161,163,193],"B),":[69],"Hank\u2019s":[70,75],"balanced":[71],"salt":[72],"solution":[73],"(HBSS),":[74],"minimum":[76],"essential":[77],"medium":[78,83],"(HMEM),":[79],"Leibovitz\u2019s":[81],"L-15":[82,170],"(L-15).":[84],"The":[85,128,148],"evaluated":[88],"by":[89],"monitoring":[90],"decline":[92,113],"in":[93,114,157,190],"aggregatory":[95],"responses":[96],"over":[97,119,177],"time":[98],"assess":[100],"their":[101],"ability":[102,129],"preserve":[104,131],"Results":[107],"Although":[108],"all":[109,183],"preparations":[110],"showed":[111],"a":[112,172],"thrombin-":[115],"collagen-induced":[117],"aggregations":[118],"time,":[120],"significant":[121,175],"differences":[122],"observed":[124,189],"among":[125],"solutions.":[127],"function":[133],"followed":[134],"order:":[136],"B":[138,194],">":[139,141,146],"HBSS":[140],"\u2248":[144],"HMEM":[145,168],"L-15.":[147],"pH":[149],"remained":[150],"stable":[151],"up":[153],"8":[155],"h":[156],"WP":[158],"with":[160,185,213],"A,":[162],"B,":[164],"HBSS,":[166],"while":[167],"exhibited":[171],"slight":[173],"but":[174],"decrease":[176],"time.":[178],"Phosphatidylserine":[179],"exposure":[180],"increased":[181],"across":[182],"WP,":[184],"lowest":[187],"increase":[188],"HMEM.":[191],"Conclusions":[192],"was":[195],"preserving":[200],"These":[203],"findings":[204],"offer":[205],"valuable":[206],"insights":[207],"into":[208],"optimizing":[209],"solutions,":[212],"potential":[214],"further":[216],"improvements.":[217]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-11-25T00:00:00"}