{"id":"https://openalex.org/W4416618258","doi":"https://doi.org/10.1007/s12029-025-01361-2","title":"Local Recurrence Rates in Locally Advanced Rectal Cancer Are Higher with KRAS Codon 13 Mutations","display_name":"Local Recurrence Rates in Locally Advanced Rectal Cancer Are Higher with KRAS Codon 13 Mutations","publication_year":2025,"publication_date":"2025-11-25","ids":{"openalex":"https://openalex.org/W4416618258","doi":"https://doi.org/10.1007/s12029-025-01361-2","pmid":"https://pubmed.ncbi.nlm.nih.gov/41288875"},"language":"en","primary_location":{"id":"doi:10.1007/s12029-025-01361-2","doi":"https://doi.org/10.1007/s12029-025-01361-2","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12029-025-01361-2","pdf_url":null,"source":{"id":"https://openalex.org/S76249319","display_name":"Journal of Gastrointestinal Cancer","issn_l":"1941-6628","issn":["1941-6628","1941-6636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastrointestinal Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038878913","display_name":"Richard Sassun","orcid":"https://orcid.org/0000-0001-7649-4703","observed_orcids":["https://orcid.org/0000-0001-7649-4703"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Sassun","raw_affiliation_strings":["Division of Colon and Rectal Surgery, Mayo Clinic, 200 First St. Southwest, Rochester, MN, 55905, USA","General surgery residency program, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Colon and Rectal Surgery, Mayo Clinic, 200 First St. Southwest, Rochester, MN, 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"General surgery residency program, Milan, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083248024","display_name":"Annaclara Sileo","orcid":"https://orcid.org/0000-0002-0789-8891","observed_orcids":["https://orcid.org/0000-0002-0789-8891"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Annaclara Sileo","raw_affiliation_strings":["Division of Colon and Rectal Surgery, Mayo Clinic, 200 First St. Southwest, Rochester, MN, 55905, USA","General surgery residency program, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Colon and Rectal Surgery, Mayo Clinic, 200 First St. Southwest, Rochester, MN, 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"General surgery residency program, Milan, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015496005","display_name":"Jyi Cheng Ng","orcid":"https://orcid.org/0000-0003-3531-5558","observed_orcids":["https://orcid.org/0000-0003-3531-5558"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jyi Cheng Ng","raw_affiliation_strings":["Division of Colon and Rectal Surgery, Mayo Clinic, 200 First St. Southwest, Rochester, MN, 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Colon and Rectal Surgery, Mayo Clinic, 200 First St. Southwest, Rochester, MN, 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093985012","display_name":"Sara A. Aboelmaaty","orcid":"https://orcid.org/0009-0006-9411-7892","observed_orcids":["https://orcid.org/0009-0006-9411-7892"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara Aboelmaaty","raw_affiliation_strings":["Division of Colon and Rectal Surgery, Mayo Clinic, 200 First St. Southwest, Rochester, MN, 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Colon and Rectal Surgery, Mayo Clinic, 200 First St. Southwest, Rochester, MN, 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103107473","display_name":"Ibrahim A. Gomaa","orcid":"https://orcid.org/0009-0001-1841-0302","observed_orcids":["https://orcid.org/0009-0001-1841-0302"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ibrahim A. Gomaa","raw_affiliation_strings":["Division of Colon and Rectal Surgery, Mayo Clinic, 200 First St. Southwest, Rochester, MN, 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Colon and Rectal Surgery, Mayo Clinic, 200 First St. Southwest, Rochester, MN, 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091459013","display_name":"Giulio Maria Mari","orcid":"https://orcid.org/0000-0002-2508-1359","observed_orcids":["https://orcid.org/0000-0002-2508-1359"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giulio Mari","raw_affiliation_strings":["Department of Colorectal Surgery, ASST Brianza, Desio, MB, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Colorectal Surgery, ASST Brianza, Desio, MB, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080560489","display_name":"Kellie Leanne Mathis","orcid":"https://orcid.org/0000-0002-2547-5606","observed_orcids":["https://orcid.org/0000-0002-2547-5606"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kellie L. Mathis","raw_affiliation_strings":["Division of Colon and Rectal Surgery, Mayo Clinic, 200 First St. Southwest, Rochester, MN, 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Colon and Rectal Surgery, Mayo Clinic, 200 First St. Southwest, Rochester, MN, 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005306368","display_name":"Eric J. Dozois","orcid":"https://orcid.org/0000-0002-2290-4735","observed_orcids":["https://orcid.org/0000-0002-2290-4735"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric J. Dozois","raw_affiliation_strings":["Division of Colon and Rectal Surgery, Mayo Clinic, 200 First St. Southwest, Rochester, MN, 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Colon and Rectal Surgery, Mayo Clinic, 200 First St. Southwest, Rochester, MN, 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031323337","display_name":"David W. Larson","orcid":"https://orcid.org/0000-0001-9177-4586","observed_orcids":["https://orcid.org/0000-0001-9177-4586"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David W. Larson","raw_affiliation_strings":["Division of Colon and Rectal Surgery, Mayo Clinic, 200 First St. Southwest, Rochester, MN, 55905, USA. Larson.David2@mayo.edu","Division of Colon and Rectal Surgery, Mayo Clinic, 200 First St. Southwest, Rochester, MN, 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Colon and Rectal Surgery, Mayo Clinic, 200 First St. Southwest, Rochester, MN, 55905, USA. Larson.David2@mayo.edu","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Division of Colon and Rectal Surgery, Mayo Clinic, 200 First St. Southwest, Rochester, MN, 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5031323337"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":null,"fwci":1.2289,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.82025046,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"56","issue":"1","first_page":"228","last_page":"228"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13110","display_name":"Colorectal and Anal Carcinomas","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/locally-advanced-rectal-cancer","display_name":"locally advanced rectal cancer","score":0.8989999890327454},{"id":"https://openalex.org/keywords/local-recurrence","display_name":"local recurrence","score":0.9710000157356262},{"id":"https://openalex.org/keywords/kras-g13d","display_name":"KRAS G13D","score":0.8500000238418579},{"id":"https://openalex.org/keywords/total-mesorectal-excision","display_name":"total mesorectal excision","score":0.9259999990463257},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.6399999856948853},{"id":"https://openalex.org/keywords/preoperative-genetic-testing","display_name":"preoperative genetic testing","score":0.871999979019165},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.8349999785423279},{"id":"https://openalex.org/keywords/tumor-budding","display_name":"tumor budding","score":0.5529999732971191},{"id":"https://openalex.org/keywords/lymphovascular-invasion","display_name":"lymphovascular invasion","score":0.7080000042915344},{"id":"https://openalex.org/keywords/perineural-invasion","display_name":"perineural invasion","score":0.9490000009536743}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8913999795913696},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.8799999952316284},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6869000196456909},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.611299991607666},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6018000245094299},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5386000275611877},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4984999895095825},{"id":"https://openalex.org/C3018440083","wikidata":"https://www.wikidata.org/wiki/Q11083","display_name":"Colonic disease","level":4,"score":0.3693999946117401},{"id":"https://openalex.org/C2780673598","wikidata":"https://www.wikidata.org/wiki/Q285223","display_name":"Genetic testing","level":2,"score":0.32519999146461487},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3228999972343445},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30090001225471497},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.2768000066280365}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003062","descriptor_name":"Codon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012004","descriptor_name":"Rectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012004","descriptor_name":"Rectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012004","descriptor_name":"Rectal Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016283","descriptor_name":"Proto-Oncogene Proteins p21(ras)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s12029-025-01361-2","doi":"https://doi.org/10.1007/s12029-025-01361-2","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12029-025-01361-2","pdf_url":null,"source":{"id":"https://openalex.org/S76249319","display_name":"Journal of Gastrointestinal Cancer","issn_l":"1941-6628","issn":["1941-6628","1941-6636"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastrointestinal Cancer","raw_type":"journal-article"},{"id":"pmid:41288875","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41288875","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of gastrointestinal cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W191442366","https://openalex.org/W1683859538","https://openalex.org/W1981346090","https://openalex.org/W2017634829","https://openalex.org/W2045509446","https://openalex.org/W2082522255","https://openalex.org/W2145145022","https://openalex.org/W2155492044","https://openalex.org/W2167349838","https://openalex.org/W2168280541","https://openalex.org/W2318253468","https://openalex.org/W2464830908","https://openalex.org/W2731845303","https://openalex.org/W2915365125","https://openalex.org/W2915625677","https://openalex.org/W2937690234","https://openalex.org/W3049608122","https://openalex.org/W3092264525","https://openalex.org/W3157967101","https://openalex.org/W4283578259","https://openalex.org/W4306250770","https://openalex.org/W4306733622","https://openalex.org/W4320858027","https://openalex.org/W4385874718","https://openalex.org/W4387807475","https://openalex.org/W4391527043","https://openalex.org/W4403915934","https://openalex.org/W4406213625","https://openalex.org/W4407251464","https://openalex.org/W4408334075","https://openalex.org/W4410540507","https://openalex.org/W4412490699","https://openalex.org/W4413860192"],"related_works":["https://openalex.org/W4403915934","https://openalex.org/W2969967380","https://openalex.org/W2994999917","https://openalex.org/W2589572779","https://openalex.org/W3089905444","https://openalex.org/W849105639","https://openalex.org/W2082522255","https://openalex.org/W4361222545","https://openalex.org/W2950628134","https://openalex.org/W4401062175"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2025-11-25T00:00:00"}