{"id":"https://openalex.org/W4416617153","doi":"https://doi.org/10.1080/01616412.2025.2592116","title":"Analysis of factors associated with treatment-resistant depression in patients with depression in Parkinson\u2019s disease (DPD)","display_name":"Analysis of factors associated with treatment-resistant depression in patients with depression in Parkinson\u2019s disease (DPD)","publication_year":2025,"publication_date":"2025-11-25","ids":{"openalex":"https://openalex.org/W4416617153","doi":"https://doi.org/10.1080/01616412.2025.2592116","pmid":"https://pubmed.ncbi.nlm.nih.gov/41287900"},"language":"en","primary_location":{"id":"doi:10.1080/01616412.2025.2592116","doi":"https://doi.org/10.1080/01616412.2025.2592116","is_oa":false,"landing_page_url":"https://doi.org/10.1080/01616412.2025.2592116","pdf_url":null,"source":{"id":"https://openalex.org/S187584928","display_name":"Neurological Research","issn_l":"0161-6412","issn":["0161-6412","1743-1328"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurological Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Junfen Tang","orcid":"https://orcid.org/0009-0002-8142-3744","observed_orcids":["https://orcid.org/0009-0002-8142-3744"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]},{"id":"https://openalex.org/I4210116575","display_name":"Guangzhou First People's Hospital","ror":"https://ror.org/02bwytq13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junfen Tang","raw_affiliation_strings":["Guangzhou First People\u2019s Hospital","Jinan University","Department of Neurology, Guangzhou First People's Hospital, Guangzhou, Guangdong, PR China","Jinan University, Guangzhou, Guangdong, RP China"],"raw_orcid":"https://orcid.org/0009-0002-8142-3744","affiliations":[{"raw_affiliation_string":"Guangzhou First People\u2019s Hospital","institution_ids":["https://openalex.org/I4210116575"]},{"raw_affiliation_string":"Jinan University","institution_ids":["https://openalex.org/I159948400"]},{"raw_affiliation_string":"Department of Neurology, Guangzhou First People's Hospital, Guangzhou, Guangdong, PR China","institution_ids":["https://openalex.org/I4210116575"]},{"raw_affiliation_string":"Jinan University, Guangzhou, Guangdong, RP China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101131638","display_name":"Weikun Zheng","orcid":"https://orcid.org/0009-0001-6824-2554","observed_orcids":["https://orcid.org/0009-0001-6824-2554"]},"institutions":[{"id":"https://openalex.org/I4210116575","display_name":"Guangzhou First People's Hospital","ror":"https://ror.org/02bwytq13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weikun Zheng","raw_affiliation_strings":["Guangzhou First People\u2019s Hospital","Department of Orthopedics, Guangzhou First People's Hospital, Guangzhou, Guangdong, PR China"],"raw_orcid":"https://orcid.org/0009-0001-6824-2554","affiliations":[{"raw_affiliation_string":"Guangzhou First People\u2019s Hospital","institution_ids":["https://openalex.org/I4210116575"]},{"raw_affiliation_string":"Department of Orthopedics, Guangzhou First People's Hospital, Guangzhou, Guangdong, PR China","institution_ids":["https://openalex.org/I4210116575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057850753","display_name":"Yingjun Ouyang","orcid":"https://orcid.org/0009-0003-7845-0888","observed_orcids":["https://orcid.org/0009-0003-7845-0888","https://orcid.org/0000-0003-3504-2422"]},"institutions":[{"id":"https://openalex.org/I4210116575","display_name":"Guangzhou First People's Hospital","ror":"https://ror.org/02bwytq13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116575"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingjun OuYang","raw_affiliation_strings":["Guangzhou First People\u2019s Hospital","Department of Neurology, Guangzhou First People's Hospital, Guangzhou, Guangdong, PR China"],"raw_orcid":"https://orcid.org/0009-0003-7845-0888","affiliations":[{"raw_affiliation_string":"Guangzhou First People\u2019s Hospital","institution_ids":["https://openalex.org/I4210116575"]},{"raw_affiliation_string":"Department of Neurology, Guangzhou First People's Hospital, Guangzhou, Guangdong, PR China","institution_ids":["https://openalex.org/I4210116575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078181925","display_name":"Jun Dong","orcid":"https://orcid.org/0000-0002-6064-0814","observed_orcids":["https://orcid.org/0000-0002-6064-0814"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]},{"id":"https://openalex.org/I34949971","display_name":"University of Jinan","ror":"https://ror.org/02mjz6f26","country_code":"CN","type":"education","lineage":["https://openalex.org/I34949971"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Dong","raw_affiliation_strings":["School of Basic Medicine and Public health, Jinan University","Department of Pathophysiology, School of Basic Medicine and Public health, Jinan University, Guangzhou, Guangdong, PR China"],"raw_orcid":"https://orcid.org/0000-0002-6064-0814","affiliations":[{"raw_affiliation_string":"School of Basic Medicine and Public health, Jinan University","institution_ids":["https://openalex.org/I159948400","https://openalex.org/I34949971"]},{"raw_affiliation_string":"Department of Pathophysiology, School of Basic Medicine and Public health, Jinan University, Guangzhou, Guangdong, PR China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"last","author":{"id":null,"display_name":"Bing Qin","orcid":"https://orcid.org/0009-0001-1429-3348","observed_orcids":["https://orcid.org/0009-0001-1429-3348"]},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bing Qin","raw_affiliation_strings":["Jinan University","Jinan University, Guangzhou, Guangdong, RP China"],"raw_orcid":"https://orcid.org/0009-0001-1429-3348","affiliations":[{"raw_affiliation_string":"Jinan University","institution_ids":["https://openalex.org/I159948400"]},{"raw_affiliation_string":"Jinan University, Guangzhou, Guangdong, RP China","institution_ids":["https://openalex.org/I159948400"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I159948400"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.31403228,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.5009999871253967,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.5009999871253967,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.4787999987602234,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/treatment-resistant-depression","display_name":"treatment-resistant depression","score":0.9409999847412109},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.8420000076293945},{"id":"https://openalex.org/keywords/depression-in-parkinson-s-disease","display_name":"depression in Parkinson's disease","score":0.8870000243186951},{"id":"https://openalex.org/keywords/sleep-disturbance","display_name":"sleep disorders","score":0.8270000219345093},{"id":"https://openalex.org/keywords/disease-duration","display_name":"disease duration","score":0.7900000214576721},{"id":"https://openalex.org/keywords/updrs-part-iii","display_name":"UPDRS part III","score":0.8450000286102295},{"id":"https://openalex.org/keywords/economic-income","display_name":"economic income","score":0.7200000286102295},{"id":"https://openalex.org/keywords/educational-attainment","display_name":"educational attainment","score":0.8529999852180481},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.9300000071525574},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.9110000133514404},{"id":"https://openalex.org/keywords/predictive-model","display_name":"prediction model","score":0.6290000081062317},{"id":"https://openalex.org/keywords/antidepressant-response","display_name":"antidepressant response","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.8113999962806702},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7843000292778015},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.724399983882904},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.6470000147819519},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5698000192642212},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.45179998874664307},{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.4490000009536743},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.39329999685287476},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.36809998750686646},{"id":"https://openalex.org/C3019719930","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value","level":2,"score":0.3244999945163727},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.3221000134944916},{"id":"https://openalex.org/C1513209611","wikidata":"https://www.wikidata.org/wiki/Q177190","display_name":"Sleep disorder","level":3,"score":0.3075000047683716},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.30149999260902405},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.2703000009059906},{"id":"https://openalex.org/C3019858935","wikidata":"https://www.wikidata.org/wiki/Q4340209","display_name":"Depressive symptoms","level":3,"score":0.26989999413490295},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.26759999990463257},{"id":"https://openalex.org/C83849319","wikidata":"https://www.wikidata.org/wiki/Q7295720","display_name":"Rating scale","level":2,"score":0.2540000081062317},{"id":"https://openalex.org/C2776291640","wikidata":"https://www.wikidata.org/wiki/Q2912517","display_name":"Value (mathematics)","level":2,"score":0.2500999867916107}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1080/01616412.2025.2592116","doi":"https://doi.org/10.1080/01616412.2025.2592116","is_oa":false,"landing_page_url":"https://doi.org/10.1080/01616412.2025.2592116","pdf_url":null,"source":{"id":"https://openalex.org/S187584928","display_name":"Neurological Research","issn_l":"0161-6412","issn":["0161-6412","1743-1328"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurological Research","raw_type":"journal-article"},{"id":"pmid:41287900","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41287900","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurological research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W197990584","https://openalex.org/W1596577698","https://openalex.org/W1876158137","https://openalex.org/W1977261781","https://openalex.org/W1986216002","https://openalex.org/W2036817025","https://openalex.org/W2064476618","https://openalex.org/W2082708712","https://openalex.org/W2089695399","https://openalex.org/W2095584179","https://openalex.org/W2098750661","https://openalex.org/W2099944633","https://openalex.org/W2104346407","https://openalex.org/W2109326232","https://openalex.org/W2165626243","https://openalex.org/W2166211493","https://openalex.org/W2171916218","https://openalex.org/W2185416577","https://openalex.org/W2197561709","https://openalex.org/W2296360649","https://openalex.org/W2315146523","https://openalex.org/W2549683405","https://openalex.org/W2741481844","https://openalex.org/W2745382188","https://openalex.org/W2767609902","https://openalex.org/W2789616452","https://openalex.org/W2904096257","https://openalex.org/W2916226351","https://openalex.org/W2945321450","https://openalex.org/W2952425412","https://openalex.org/W2965873735","https://openalex.org/W2981767691","https://openalex.org/W3013365113","https://openalex.org/W3092078756","https://openalex.org/W3094797321","https://openalex.org/W3128231749","https://openalex.org/W4200009374","https://openalex.org/W4205143025","https://openalex.org/W4211263234","https://openalex.org/W4290729171","https://openalex.org/W4390263602","https://openalex.org/W4391430005"],"related_works":[],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"investigate":[2],"the":[3,54,62,67,94,188,200,204],"factors":[4,231],"associated":[5,78,138],"with":[6,12,38,57,139],"treatment-resistant":[7,58],"depression":[8,13,59],"(TRD)":[9],"in":[10,14,234,257],"patients":[11,33,65],"Parkinson's":[15,55],"disease":[16,56,120,155,221],"(DPD)":[17],"and":[18,25,134,180,223,243],"provide":[19],"a":[20,39,88],"reference":[21],"for":[22,74,232,255],"early":[23],"warning":[24],"intervention.":[26],"METHODS:":[27],"Clinical":[28],"data":[29],"from":[30,203],"156":[31],"DPD":[32,64],"were":[34,51],"retrospectively":[35],"analyzed.":[36],"Patients":[37],"17-item":[40],"Hamilton":[41],"Depression":[42],"Rating":[43],"Scale":[44],"(HAMD-17)":[45],"reduction":[46],"rate\u226420%":[47],"after":[48],"antidepressant":[49],"treatment":[50],"classified":[52],"into":[53],"(PD-TRD)":[60],"group;":[61],"remaining":[63],"constituted":[66],"control":[68],"group.":[69],"Univariate":[70,113],"analysis":[71,114],"was":[72,83,97,111,195,207],"performed":[73],"preliminary":[75],"screening":[76],"of":[77,93,109,212],"factors.":[79,247],"Binary":[80],"logistic":[81,142],"regression":[82,143,205],"used":[84],"to":[85],"further":[86],"establish":[87],"predictive":[89,95,253],"model.":[90],"The":[91,107,141,185,197,210],"accuracy":[92],"model":[96,144,206],"evaluated":[98],"using":[99,192,199],"receiver":[100],"operating":[101],"characteristic":[102],"(ROC)":[103],"curve":[104,190],"analysis.":[105],"RESULTS:":[106],"incidence":[108,211],"PD-TRD":[110,256],"55.8%.":[112],"indicated":[115],"that":[116],"sleep":[117,149,193,248],"disorders,":[118,219],"age,":[119],"duration,":[121,222],"UPDRS":[122,126,161,225],"Part":[123,127,162,226],"II":[124],"score,":[125,129],"III":[128,163,227],"economic":[130,169,238],"income,":[131,239],"education":[132,175,241],"level,":[133,242],"exercise":[135,181,244],"might":[136],"be":[137],"PD-TRD.":[140],"ultimately":[145],"incorporated":[146],"six":[147],"factors:":[148],"disorders":[150,249],"(OR":[151,157,165,171,177,182],"=":[152,158,166,172,178,183],"16.450),":[153],"longer":[154,220],"duration":[156],"1.245),":[159],"higher":[160,168,224,237],"score":[164],"8.829),":[167],"income":[170],"0.206),":[173],"better":[174,240],"level":[176],"0.318),":[179],"0.265).":[184],"area":[186],"under":[187],"ROC":[189],"(AUC)":[191],"disorder":[194],"0.703.":[196],"AUC":[198],"predicted":[201],"probability":[202],"0.911.":[208],"CONCLUSION:":[209],"TRD":[213,233],"is":[214],"high":[215],"among":[216],"DPD.":[217,258],"Sleep":[218],"scores":[228],"are":[229,245],"risk":[230],"DPD,":[235],"while":[236],"protective":[246],"alone":[250],"have":[251],"moderate":[252],"value":[254]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2025-11-25T00:00:00"}