{"id":"https://openalex.org/W4416612976","doi":"https://doi.org/10.48550/arxiv.2505.23659","title":"Information-Theoretical Measures for Developmental Cell-Fate Proportioning Processes","display_name":"Information-Theoretical Measures for Developmental Cell-Fate Proportioning Processes","publication_year":2025,"publication_date":"2025-05-29","ids":{"openalex":"https://openalex.org/W4416612976","doi":"https://doi.org/10.48550/arxiv.2505.23659"},"language":"en","primary_location":{"id":"pmh:oai:arXiv.org:2505.23659","doi":null,"is_oa":true,"landing_page_url":"http://arxiv.org/abs/2505.23659","pdf_url":"https://arxiv.org/pdf/2505.23659","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"volume":null,"type":"preprint","indexed_in":["arxiv","datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://arxiv.org/pdf/2505.23659","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5094008698","display_name":"Michael A. Ramirez-Sierra","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ramirez-Sierra, Michael A.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5022733451","display_name":"Thomas R. Sokolowski","orcid":"https://orcid.org/0000-0002-1287-3779","observed_orcids":["https://orcid.org/0000-0002-1287-3779"]},"institutions":[{"id":"https://openalex.org/I2801628138","display_name":"Frankfurt Institute for Advanced Studies","ror":"https://ror.org/05vmv8m79","country_code":"DE","type":"facility","lineage":["https://openalex.org/I114090438","https://openalex.org/I2801628138"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sokolowski, Thomas R.","raw_affiliation_strings":["Frankfurt Institute for Advanced Studies (FIAS) , Ruth-Moufang-Stra\u00dfe 1 , 60438 Frankfurt am Main , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Frankfurt Institute for Advanced Studies (FIAS) , Ruth-Moufang-Stra\u00dfe 1 , 60438 Frankfurt am Main , Germany","institution_ids":["https://openalex.org/I2801628138"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14299","display_name":"Complex Systems and Dynamics","score":0.01590000092983246,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/self-organization","display_name":"self-organization","score":0.8889999985694885},{"id":"https://openalex.org/keywords/cell-fate-patterning","display_name":"cell fate patterning","score":0.8820000290870667},{"id":"https://openalex.org/keywords/blastocyst-development","display_name":"blastocyst development","score":0.8059999942779541},{"id":"https://openalex.org/keywords/trophectoderm","display_name":"trophectoderm","score":0.8809999823570251},{"id":"https://openalex.org/keywords/positional-information","display_name":"positional information","score":0.718999981880188},{"id":"https://openalex.org/keywords/stochastic-simulation-model","display_name":"stochastic simulation model","score":0.5339999794960022},{"id":"https://openalex.org/keywords/early-mammalian-embryo","display_name":"early mammalian embryo","score":0.6110000014305115},{"id":"https://openalex.org/keywords/cell-fate-specification","display_name":"cell fate specification","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6244000196456909},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.486299991607666},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.47769999504089355},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.3971000015735626},{"id":"https://openalex.org/C2777212361","wikidata":"https://www.wikidata.org/wiki/Q5127848","display_name":"Class (philosophy)","level":2,"score":0.39419999718666077},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.3497999906539917},{"id":"https://openalex.org/C52622258","wikidata":"https://www.wikidata.org/wiki/Q131222","display_name":"Information theory","level":2,"score":0.3215999901294708},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.30799999833106995},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.30160000920295715},{"id":"https://openalex.org/C2776542497","wikidata":"https://www.wikidata.org/wiki/Q5266672","display_name":"Development (topology)","level":2,"score":0.2870999872684479},{"id":"https://openalex.org/C2778334786","wikidata":"https://www.wikidata.org/wiki/Q1586270","display_name":"Variation (astronomy)","level":2,"score":0.2822999954223633},{"id":"https://openalex.org/C76969082","wikidata":"https://www.wikidata.org/wiki/Q486902","display_name":"Mathematical model","level":2,"score":0.26339998841285706},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.25920000672340393},{"id":"https://openalex.org/C111335779","wikidata":"https://www.wikidata.org/wiki/Q3454686","display_name":"Reduction (mathematics)","level":2,"score":0.25760000944137573},{"id":"https://openalex.org/C149441793","wikidata":"https://www.wikidata.org/wiki/Q200726","display_name":"Probability distribution","level":2,"score":0.25690001249313354},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.2538999915122986},{"id":"https://openalex.org/C8272713","wikidata":"https://www.wikidata.org/wiki/Q176737","display_name":"Stochastic process","level":2,"score":0.2506999969482422},{"id":"https://openalex.org/C180198813","wikidata":"https://www.wikidata.org/wiki/Q121182","display_name":"Information system","level":2,"score":0.25049999356269836}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:arXiv.org:2505.23659","doi":null,"is_oa":true,"landing_page_url":"http://arxiv.org/abs/2505.23659","pdf_url":"https://arxiv.org/pdf/2505.23659","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"doi:10.48550/arxiv.2505.23659","doi":"https://doi.org/10.48550/arxiv.2505.23659","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2505.23659","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"pmh:oai:arXiv.org:2505.23659","doi":null,"is_oa":true,"landing_page_url":"http://arxiv.org/abs/2505.23659","pdf_url":"https://arxiv.org/pdf/2505.23659","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416612976.pdf","grobid_xml":"https://content.openalex.org/works/W4416612976.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Self-organization":[0],"is":[1],"a":[2,23,78,93,113,152,188,208],"fundamental":[3],"process":[4],"of":[5,14,31,47,50,56,70,88,120,135,146,174,201,218,224],"complex":[6],"biological":[7],"systems,":[8,91],"particularly":[9],"during":[10],"the":[11,17,27,45,53,64,67,85,140,144,158,165,172,203,215,222],"early":[12,227],"stages":[13],"development.":[15],"In":[16,73],"mammalian":[18],"embryo,":[19],"blastocyst":[20],"formation":[21],"exemplifies":[22],"self-organized":[24],"system,":[25],"involving":[26],"correct":[28],"spatio-temporal":[29],"segregation":[30],"three":[32],"distinct":[33],"cell":[34],"fates:":[35],"trophectoderm":[36],"(TE),":[37],"epiblast":[38],"(EPI),":[39],"and":[40,66,101,115,221],"primitive":[41],"endoderm":[42],"(PRE).":[43],"Despite":[44],"significance":[46],"this":[48,74,147,183],"class":[49],"processes,":[51],"quantifying":[52,193],"information":[54,100,104,126],"content":[55,127],"self-organizing":[57],"patterning":[58,90,168],"systems":[59],"remains":[60],"challenging":[61],"due":[62],"to":[63,164],"complexity":[65,225],"qualitative":[68],"diversity":[69],"developmental":[71,107,196,228],"mechanisms.":[72],"study,":[75],"we":[76,111,150],"applied":[77],"recently":[79],"proposed":[80],"information-theoretical":[81,185],"framework":[82,186,206],"which":[83],"quantifies":[84],"self-organization":[86,175,194],"potential":[87,176],"cell-fate":[89,160,167,179,219],"employing":[92],"utility":[94],"function":[95],"that":[96,155],"integrates":[97],"(local)":[98],"positional":[99],"(global)":[102],"correlational":[103],"extracted":[105],"from":[106],"pattern":[108],"ensembles.":[109],"Specifically,":[110],"examined":[112],"stochastic":[114],"spatially":[116],"resolved":[117],"simulation":[118,130],"model":[119],"EPI-PRE":[121],"lineage":[122],"proportioning,":[123],"evaluating":[124],"its":[125],"across":[128],"various":[129],"scenarios":[131],"with":[132],"different":[133],"numbers":[134],"system":[136],"cells.":[137],"To":[138],"overcome":[139],"computational":[141],"challenges":[142],"hindering":[143],"application":[145],"novel":[148,184],"framework,":[149],"developed":[151],"mathematical":[153],"strategy":[154],"indirectly":[156],"maps":[157],"low-dimensional":[159],"counting":[161],"probability":[162,169],"space":[163],"high-dimensional":[166],"space,":[170],"enabling":[171],"estimation":[173],"for":[177,192,211],"general":[178],"proportioning":[180],"processes.":[181],"Overall,":[182],"provides":[187],"promising,":[189],"universal":[190],"approach":[191],"in":[195,226],"biology.":[197],"By":[198],"formalizing":[199],"measures":[200],"self-organization,":[202],"employed":[204],"quantification":[205],"offers":[207],"valuable":[209],"tool":[210],"uncovering":[212],"insights":[213],"into":[214],"underlying":[216],"principles":[217],"specification":[220],"emergence":[223],"systems.":[229]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}
