{"id":"https://openalex.org/W4416612901","doi":"https://doi.org/10.3892/br.2025.2091","title":"Association of PLA2G2A single nucleotide polymorphism and cardiometabolic diseases in an HIV\u2011infected population","display_name":"Association of PLA2G2A single nucleotide polymorphism and cardiometabolic diseases in an HIV\u2011infected population","publication_year":2025,"publication_date":"2025-11-25","ids":{"openalex":"https://openalex.org/W4416612901","doi":"https://doi.org/10.3892/br.2025.2091","pmid":"https://pubmed.ncbi.nlm.nih.gov/41357814"},"language":"en","primary_location":{"id":"doi:10.3892/br.2025.2091","doi":"https://doi.org/10.3892/br.2025.2091","is_oa":true,"landing_page_url":"https://doi.org/10.3892/br.2025.2091","pdf_url":"http://www.spandidos-publications.com/10.3892/br.2025.2091/download","source":{"id":"https://openalex.org/S2754599785","display_name":"Biomedical Reports","issn_l":"2049-9434","issn":["2049-9434","2049-9442"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.spandidos-publications.com/10.3892/br.2025.2091/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008142488","display_name":"Elvis Ngwa Ndonwi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10947320","display_name":"South African Medical Research Council","ror":"https://ror.org/05q60vz69","country_code":"ZA","type":"other","lineage":["https://openalex.org/I10947320"]},{"id":"https://openalex.org/I159253421","display_name":"Cape Peninsula University of Technology","ror":"https://ror.org/056e9h402","country_code":"ZA","type":"education","lineage":["https://openalex.org/I159253421"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Elvis Ndonwi","raw_affiliation_strings":["South African Medical Research Council/Cape Peninsula University of Technology, Cardiometabolic Health Research Unit, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Cape Town, Western Cape 7535, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"South African Medical Research Council/Cape Peninsula University of Technology, Cardiometabolic Health Research Unit, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Cape Town, Western Cape 7535, South Africa","institution_ids":["https://openalex.org/I10947320","https://openalex.org/I159253421"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027732985","display_name":"Nolubabalo Unati Nqebelele","orcid":"https://orcid.org/0000-0003-1145-3446","observed_orcids":["https://orcid.org/0000-0003-1145-3446"]},"institutions":[{"id":"https://openalex.org/I10947320","display_name":"South African Medical Research Council","ror":"https://ror.org/05q60vz69","country_code":"ZA","type":"other","lineage":["https://openalex.org/I10947320"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Unati Nqebelele","raw_affiliation_strings":["Non\u2011Communicable Diseases Research Unit, South African Medical Research Council, Cape Town and Durban, Western Cape 7505, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Non\u2011Communicable Diseases Research Unit, South African Medical Research Council, Cape Town and Durban, Western Cape 7505, South Africa","institution_ids":["https://openalex.org/I10947320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001334352","display_name":"Tandi Edith Matsha","orcid":"https://orcid.org/0000-0001-7291-714X","observed_orcids":["https://orcid.org/0000-0001-7291-714X"]},"institutions":[{"id":"https://openalex.org/I10947320","display_name":"South African Medical Research Council","ror":"https://ror.org/05q60vz69","country_code":"ZA","type":"other","lineage":["https://openalex.org/I10947320"]},{"id":"https://openalex.org/I159253421","display_name":"Cape Peninsula University of Technology","ror":"https://ror.org/056e9h402","country_code":"ZA","type":"education","lineage":["https://openalex.org/I159253421"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Tandi Matsha","raw_affiliation_strings":["South African Medical Research Council/Cape Peninsula University of Technology, Cardiometabolic Health Research Unit, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Cape Town, Western Cape 7535, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"South African Medical Research Council/Cape Peninsula University of Technology, Cardiometabolic Health Research Unit, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Cape Town, Western Cape 7535, South Africa","institution_ids":["https://openalex.org/I10947320","https://openalex.org/I159253421"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016936793","display_name":"Andr\u00e9 Pascal Kengne","orcid":"https://orcid.org/0000-0002-5183-131X","observed_orcids":["https://orcid.org/0000-0002-5183-131X"]},"institutions":[{"id":"https://openalex.org/I10947320","display_name":"South African Medical Research Council","ror":"https://ror.org/05q60vz69","country_code":"ZA","type":"other","lineage":["https://openalex.org/I10947320"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Andre Kengne","raw_affiliation_strings":["Non\u2011Communicable Diseases Research Unit, South African Medical Research Council, Cape Town and Durban, Western Cape 7505, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Non\u2011Communicable Diseases Research Unit, South African Medical Research Council, Cape Town and Durban, Western Cape 7505, South Africa","institution_ids":["https://openalex.org/I10947320"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.4187175,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"2","first_page":"1","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.017100000753998756,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12975","display_name":"Paraoxonase enzyme and polymorphisms","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pla2g2a","display_name":"PLA2G2A","score":0.996999979019165},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9160000085830688},{"id":"https://openalex.org/keywords/cardiometabolic-disease","display_name":"cardiometabolic disease","score":0.8809999823570251},{"id":"https://openalex.org/keywords/hiv-infection","display_name":"HIV infection","score":0.9660000205039978},{"id":"https://openalex.org/keywords/dyslipidemia","display_name":"dyslipidemia","score":0.8399999737739563},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.8050000071525574},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.9430000185966492},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.8159999847412109},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7289999723434448},{"id":"https://openalex.org/keywords/african-populations","display_name":"African populations","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.800599992275238},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.7085999846458435},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.7046999931335449},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5741999745368958},{"id":"https://openalex.org/C2778096610","wikidata":"https://www.wikidata.org/wiki/Q1476525","display_name":"Dyslipidemia","level":3,"score":0.5376999974250793},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.46369999647140503},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4562000036239624},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.4113999903202057},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38769999146461487},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.353300005197525},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.3440999984741211},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3422999978065491},{"id":"https://openalex.org/C166976648","wikidata":"https://www.wikidata.org/wiki/Q7229824","display_name":"Population stratification","level":5,"score":0.32710000872612},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.3003999888896942},{"id":"https://openalex.org/C35605836","wikidata":"https://www.wikidata.org/wiki/Q2064311","display_name":"Linkage disequilibrium","level":5,"score":0.2939000129699707},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.28450000286102295},{"id":"https://openalex.org/C48921125","wikidata":"https://www.wikidata.org/wiki/Q10861030","display_name":"Linear regression","level":2,"score":0.274399995803833},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2718000113964081},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2606000006198883},{"id":"https://openalex.org/C61470247","wikidata":"https://www.wikidata.org/wiki/Q7229825","display_name":"Population study","level":3,"score":0.2547999918460846},{"id":"https://openalex.org/C76252995","wikidata":"https://www.wikidata.org/wiki/Q3395645","display_name":"Gene polymorphism","level":4,"score":0.25459998846054077}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3892/br.2025.2091","doi":"https://doi.org/10.3892/br.2025.2091","is_oa":true,"landing_page_url":"https://doi.org/10.3892/br.2025.2091","pdf_url":"http://www.spandidos-publications.com/10.3892/br.2025.2091/download","source":{"id":"https://openalex.org/S2754599785","display_name":"Biomedical Reports","issn_l":"2049-9434","issn":["2049-9434","2049-9442"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Reports","raw_type":"journal-article"},{"id":"pmid:41357814","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41357814","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12679532","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12679532/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomed Rep","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3892/br.2025.2091","doi":"https://doi.org/10.3892/br.2025.2091","is_oa":true,"landing_page_url":"https://doi.org/10.3892/br.2025.2091","pdf_url":"http://www.spandidos-publications.com/10.3892/br.2025.2091/download","source":{"id":"https://openalex.org/S2754599785","display_name":"Biomedical Reports","issn_l":"2049-9434","issn":["2049-9434","2049-9442"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320672","display_name":"South African Medical Research Council","ror":"https://ror.org/05q60vz69"},{"id":"https://openalex.org/F4320322921","display_name":"Grand Challenges Canada","ror":"https://ror.org/02snbhr24"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416612901.pdf","grobid_xml":"https://content.openalex.org/works/W4416612901.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"While":[0],"single":[1],"nucleotide":[2],"polymorphisms":[3],"(SNPs)":[4],"of":[5,37,79,99,144],"the":[6,33,38,71,77,80,97,102,104,134,141,145,148,181],"phospholipase":[7,182],"A2":[8,183],"(PLA2)":[9],"gene":[10,40,187],"have":[11],"been":[12],"associated":[13,153,173],"with":[14,48,108,133,138,140,154,174,199],"cardiometabolic":[15],"diseases":[16],"(CMDs),":[17],"such":[18],"associations":[19],"are":[20],"yet":[21],"to":[22,95],"be":[23],"demonstrated":[24],"in":[25,43,61,82,116,131,160,176,196],"a":[26,44,123,189],"human":[27],"immunodeficiency":[28],"virus":[29],"(HIV)-infected":[30],"African":[31,46,197],"population.Therefore,":[32],"association":[34],"between":[35],"SNPs":[36,72,81,105],"PLA2":[39],"and":[41,84,91,111,122,167,171],"CMDs":[42,100],"South":[45,64],"population":[47],"HIV":[49,59],"was":[50,68,152],"investigated.This":[51],"cross-sectional":[52],"study":[53],"included":[54],"716":[55],"participants":[56,132],"recruited":[57],"from":[58],"clinics":[60],"Cape":[62],"Town,":[63],"Africa.Hardy-Weinberg":[65],"equilibrium":[66],"(HWE)":[67],"assessed":[69],"for":[70,89,192],"investigated.CMDs":[73],"were":[74,93,115],"compared":[75,137],"across":[76,101],"genotypes":[78,114],"HWE.Linear":[83],"logistic":[85,168,177],"regression":[86,162,169,178],"analyses,":[87],"adjusting":[88],"age":[90],"sex":[92],"used":[94],"assess":[96],"risk":[98,194],"genotypes.Among":[103],"investigated,":[106],"rs4744":[107,146,149],"GG":[109],"(dominant)":[110],"AA":[112],"(recessive)":[113],"HWE":[117],"(P=0.998).High-density":[118],"lipoprotein-cholesterol":[119],"(HDL-C;":[120],"P=0.044)":[121],"BMI":[124],"\u226530":[125],"kg/m":[126],"2":[127],"(P=0.037)were":[128],"significantly":[129],"higher":[130],"dominant":[135],"genotype":[136,143,151],"those":[139],"recessive":[142,150],"SNP.Moreover,":[147],"dyslipidemia":[155],"characterized":[156],"by":[157],"low":[158],"HDL-C":[159],"linear":[161],"(\u03b2=":[163],"0.366;":[164],"P=":[165],"0.024)":[166],"(OR=0.19;P=0.049),":[170],"also":[172],"MetS":[175],"(OR=0.14;P=0.036).In":[179],"conclusion,":[180],"group":[184],"IIA":[185],"(PLA2G2A)":[186],"has":[188],"potential":[190],"utility":[191],"CMD":[193],"assessment":[195],"individuals":[198],"HIV.":[200]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2025-11-25T00:00:00"}