{"id":"https://openalex.org/W4416587698","doi":"https://doi.org/10.1158/0008-5472.30699221","title":"Supplementary Data 5 from ATM Regulates Differentiation of Myofibroblastic Cancer-Associated Fibroblasts and Can Be Targeted to Overcome Immunotherapy Resistance","display_name":"Supplementary Data 5 from ATM Regulates Differentiation of Myofibroblastic Cancer-Associated Fibroblasts and Can Be Targeted to Overcome Immunotherapy Resistance","publication_year":2025,"publication_date":"2025-11-24","ids":{"openalex":"https://openalex.org/W4416587698","doi":"https://doi.org/10.1158/0008-5472.30699221"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.30699221","doi":"https://doi.org/10.1158/0008-5472.30699221","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.30699221","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.30699221","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055887137","display_name":"Massimiliano Mellone","orcid":"https://orcid.org/0000-0002-4964-9340","observed_orcids":["https://orcid.org/0000-0002-4964-9340"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Massimiliano Mellone","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4964-9340","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058557715","display_name":"Klaudia Piotrowska","orcid":"https://orcid.org/0000-0001-9553-9890","observed_orcids":["https://orcid.org/0000-0001-9553-9890"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Klaudia Piotrowska","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9553-9890","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003564401","display_name":"Giulia Venturi","orcid":"https://orcid.org/0000-0002-1624-8946","observed_orcids":["https://orcid.org/0000-0002-1624-8946"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giulia Venturi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1624-8946","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013756431","display_name":"Lija James","orcid":"https://orcid.org/0000-0003-3574-1565","observed_orcids":["https://orcid.org/0000-0003-3574-1565"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lija James","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3574-1565","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076033658","display_name":"Aleksandra Bzura","orcid":"https://orcid.org/0000-0001-5836-4905","observed_orcids":["https://orcid.org/0000-0001-5836-4905"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aleksandra Bzura","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5836-4905","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034563598","display_name":"Maria Antonette Lopez","orcid":"https://orcid.org/0000-0003-4398-775X","observed_orcids":["https://orcid.org/0000-0003-4398-775X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria A. Lopez","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4398-775X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003367418","display_name":"Sonya James","orcid":"https://orcid.org/0000-0002-0032-5935","observed_orcids":["https://orcid.org/0000-0002-0032-5935"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sonya James","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0032-5935","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014469246","display_name":"Chuan Wang","orcid":"https://orcid.org/0000-0003-3811-7725","observed_orcids":["https://orcid.org/0000-0003-3811-7725"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chuan Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3811-7725","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077930041","display_name":"Matthew J. Ellis","orcid":"https://orcid.org/0000-0002-5264-0531","observed_orcids":["https://orcid.org/0000-0002-5264-0531"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthew J. Ellis","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5264-0531","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090871943","display_name":"Christopher Jon Hanley","orcid":"https://orcid.org/0000-0003-3816-7220","observed_orcids":["https://orcid.org/0000-0003-3816-7220"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher J. Hanley","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3816-7220","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035182241","display_name":"Josephine F. Buckingham","orcid":"https://orcid.org/0000-0002-6314-973X","observed_orcids":["https://orcid.org/0000-0002-6314-973X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Josephine F. Buckingham","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6314-973X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040796674","display_name":"Kerry L. Cox","orcid":"https://orcid.org/0000-0003-0492-3024","observed_orcids":["https://orcid.org/0000-0003-0492-3024"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kerry L. Cox","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0492-3024","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065006932","display_name":"Gareth D. Hughes","orcid":"https://orcid.org/0000-0002-1938-8039","observed_orcids":["https://orcid.org/0000-0002-1938-8039"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gareth Hughes","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1938-8039","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084470600","display_name":"Viia Valge-Archer","orcid":"https://orcid.org/0000-0001-6661-6033","observed_orcids":["https://orcid.org/0000-0001-6661-6033"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Viia Valge-Archer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6661-6033","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020989903","display_name":"Emma Victoria King","orcid":"https://orcid.org/0000-0003-0658-1873","observed_orcids":["https://orcid.org/0000-0003-0658-1873"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emma V. King","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0658-1873","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073058385","display_name":"Stephen A. Beers","orcid":"https://orcid.org/0000-0002-3765-3342","observed_orcids":["https://orcid.org/0000-0002-3765-3342"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen A. Beers","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3765-3342","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044721302","display_name":"Vincent Jaquet","orcid":"https://orcid.org/0000-0003-2229-2406","observed_orcids":["https://orcid.org/0000-0003-2229-2406"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vincent Jaquet","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2229-2406","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007042251","display_name":"George D.D. Jones","orcid":"https://orcid.org/0000-0002-9543-2206","observed_orcids":["https://orcid.org/0000-0002-9543-2206"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George D.D. Jones","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9543-2206","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015610349","display_name":"Natalia Savelyeva","orcid":"https://orcid.org/0000-0002-7313-4769","observed_orcids":["https://orcid.org/0000-0002-7313-4769"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Natalia Savelyeva","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7313-4769","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087314007","display_name":"Emre Sayan","orcid":"https://orcid.org/0000-0002-5291-1485","observed_orcids":["https://orcid.org/0000-0002-5291-1485"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emre Sayan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5291-1485","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103161476","display_name":"Jason Luke Parsons","orcid":"https://orcid.org/0000-0002-5052-1125","observed_orcids":["https://orcid.org/0000-0002-5052-1125"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jason L. Parsons","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5052-1125","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050483295","display_name":"Stephen T. Durant","orcid":"https://orcid.org/0000-0003-4209-7499","observed_orcids":["https://orcid.org/0000-0003-4209-7499"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen Durant","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4209-7499","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5063219325","display_name":"Gareth J. Thomas","orcid":"https://orcid.org/0000-0003-3832-7335","observed_orcids":["https://orcid.org/0000-0003-3832-7335"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gareth J. Thomas","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3832-7335","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.5727999806404114,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.5727999806404114,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.2816999852657318,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.02410000003874302,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atm","display_name":"ATM","score":0.8999999761581421},{"id":"https://openalex.org/keywords/myofibroblastic-cancer-associated-fibroblasts","display_name":"myofibroblastic cancer-associated fibroblasts","score":0.9399999976158142},{"id":"https://openalex.org/keywords/fibroblast-differentiation","display_name":"fibroblast differentiation","score":0.8090000152587891},{"id":"https://openalex.org/keywords/immunotherapy-resistance","display_name":"immunotherapy resistance","score":0.968999981880188},{"id":"https://openalex.org/keywords/pathway-analysis","display_name":"pathway analysis","score":0.6190000176429749},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.6510000228881836},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.859000027179718}],"concepts":[{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6353999972343445},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5220999717712402},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5187000036239624},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4846999943256378},{"id":"https://openalex.org/C2994294914","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired resistance","level":3,"score":0.3662000000476837},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35120001435279846},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.33309999108314514},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.31290000677108765},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2957000136375427},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.27250000834465027},{"id":"https://openalex.org/C2781053074","wikidata":"https://www.wikidata.org/wiki/Q21100639","display_name":"PD-L1","level":4,"score":0.2583000063896179},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2581000030040741}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.30699221","doi":"https://doi.org/10.1158/0008-5472.30699221","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.30699221","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/30699221","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Supplementary_Data_5_from_ATM_Regulates_Differentiation_of_Myofibroblastic_Cancer-Associated_Fibroblasts_and_Can_Be_Targeted_to_Overcome_Immunotherapy_Resistance/30699221","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.30699221","doi":"https://doi.org/10.1158/0008-5472.30699221","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.30699221","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4416587861","https://openalex.org/W4416587838","https://openalex.org/W4361828476","https://openalex.org/W4308681430","https://openalex.org/W4416587799","https://openalex.org/W4416587684","https://openalex.org/W4416587729","https://openalex.org/W4361828547","https://openalex.org/W4388042384","https://openalex.org/W4308394985"],"abstract_inverted_index":{"Non-redundant":[0],"list":[1],"of":[2],"the":[3,11,20],"leading-edge":[4],"genes":[5],"and":[6],"ToppFun":[7],"pathway":[8],"analysis":[9],"from":[10],"genesets":[12],"in":[13],"Suppl.":[14],"File":[15],"4":[16],"used":[17],"to":[18],"make":[19],"DDR-TGFB_signature":[21],"geneset":[22]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2025-11-25T00:00:00"}
