{"id":"https://openalex.org/W4416449727","doi":"https://doi.org/10.1093/jimmun/vkaf283.1695","title":"C1q and C1q receptors (gC1qR and cC1qR) as potential targets against cervical cancer among African Americans, East Asians, and Caucasians 3954","display_name":"C1q and C1q receptors (gC1qR and cC1qR) as potential targets against cervical cancer among African Americans, East Asians, and Caucasians 3954","publication_year":2025,"publication_date":"2025-11-01","ids":{"openalex":"https://openalex.org/W4416449727","doi":"https://doi.org/10.1093/jimmun/vkaf283.1695"},"language":"en","primary_location":{"id":"doi:10.1093/jimmun/vkaf283.1695","doi":"https://doi.org/10.1093/jimmun/vkaf283.1695","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jimmun/vkaf283.1695","pdf_url":"https://academic.oup.com/jimmunol/article-pdf/214/Supplement_1/vkaf283.1695/65412139/vkaf283.1695.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/jimmunol/article-pdf/214/Supplement_1/vkaf283.1695/65412139/vkaf283.1695.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012990589","display_name":"Berhane Ghebrehiwet","orcid":"https://orcid.org/0000-0001-5803-6872","observed_orcids":["https://orcid.org/0000-0001-5803-6872"]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Berhane Ghebrehiwet","raw_affiliation_strings":["Stony Brook University, SUNY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stony Brook University, SUNY","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"last","author":{"id":null,"display_name":"Katie Hsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katie Hsu","raw_affiliation_strings":["Stony Brook University, SUNY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stony Brook University, SUNY","institution_ids":["https://openalex.org/I59553526"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I59553526"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.28548038,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"214","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c1q","display_name":"C1q","score":0.8579999804496765},{"id":"https://openalex.org/keywords/c1q-receptor","display_name":"C1q receptor","score":0.8009999990463257},{"id":"https://openalex.org/keywords/gc1qr","display_name":"gC1qR","score":0.9449999928474426},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6669999957084656},{"id":"https://openalex.org/keywords/antibody-based-therapy","display_name":"antibody-based therapy","score":0.7549999952316284},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.7710000276565552},{"id":"https://openalex.org/keywords/siha-cells","display_name":"SiHa cells","score":0.9670000076293945},{"id":"https://openalex.org/keywords/c33a-cells","display_name":"C33A cells","score":0.9610000252723694},{"id":"https://openalex.org/keywords/african-americans","display_name":"African Americans","score":0.7149999737739563},{"id":"https://openalex.org/keywords/east-asians","display_name":"East Asians","score":0.9399999976158142},{"id":"https://openalex.org/keywords/caucasians","display_name":"Caucasians","score":0.9929999709129333}],"concepts":[{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.8184999823570251},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6277999877929688},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5935999751091003},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5030999779701233},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49779999256134033},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4952000081539154},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4916999936103821},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.44920000433921814},{"id":"https://openalex.org/C2780783641","wikidata":"https://www.wikidata.org/wiki/Q738686","display_name":"MTT assay","level":3,"score":0.40790000557899475},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3824999928474426},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.375900000333786},{"id":"https://openalex.org/C2994372470","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell lines","level":4,"score":0.3553999960422516},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35420000553131104},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.3190999925136566},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.3158000111579895},{"id":"https://openalex.org/C2993195994","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical carcinoma","level":4,"score":0.3102000057697296},{"id":"https://openalex.org/C197462201","wikidata":"https://www.wikidata.org/wiki/Q2476074","display_name":"Cell surface receptor","level":3,"score":0.30070000886917114},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.29589998722076416},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2906000018119812},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2838999927043915},{"id":"https://openalex.org/C2993684226","wikidata":"https://www.wikidata.org/wiki/Q2662727","display_name":"Human cell","level":3,"score":0.26649999618530273}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/jimmun/vkaf283.1695","doi":"https://doi.org/10.1093/jimmun/vkaf283.1695","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jimmun/vkaf283.1695","pdf_url":"https://academic.oup.com/jimmunol/article-pdf/214/Supplement_1/vkaf283.1695/65412139/vkaf283.1695.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/jimmun/vkaf283.1695","doi":"https://doi.org/10.1093/jimmun/vkaf283.1695","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jimmun/vkaf283.1695","pdf_url":"https://academic.oup.com/jimmunol/article-pdf/214/Supplement_1/vkaf283.1695/65412139/vkaf283.1695.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G339059223","display_name":null,"funder_award_id":"Z/17/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G8232082504","display_name":"Intestinal epithelial cells: at the interface of the microbiota and mucosal immunity","funder_award_id":"206245/Z/17/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4416449727.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Description":[1],"The":[2],"complement":[3],"protein":[4],"C1q":[5,45],"and":[6,10,16,46,67,83,89,106,123,148],"its":[7,47],"receptors,":[8],"gC1qR":[9],"cC1qR,":[11],"are":[12],"expressed":[13],"across":[14],"non-cancerous":[15],"malignant":[17],"cells,":[18],"playing":[19],"roles":[20],"in":[21,49,96],"either":[22],"promoting":[23],"or":[24,35,153],"inhibiting":[25],"cellular":[26],"proliferation":[27],"depending":[28],"on":[29],"their":[30,93],"localization":[31],"as":[32,71],"intracellular,":[33],"surface-bound,":[34],"secreted":[36,82],"forms.":[37],"This":[38],"study":[39,76],"investigates":[40],"the":[41,55,75,78,97,128],"multifaceted":[42],"nature":[43],"of":[44,80,86,161],"receptors":[48],"cervical":[50,72,143],"cancer":[51,73,155],"aiming":[52],"to":[53,141,151],"understand":[54],"specific":[56],"mechanisms":[57],"by":[58],"which":[59],"they":[60],"influence":[61],"cell":[62,69,98],"growth.":[63],"Using":[64],"HeLa,":[65],"SiHa,":[66],"C-33A":[68],"lines":[70,99],"models,":[74],"explores":[77],"functions":[79],"both":[81],"membrane":[84],"forms":[85],"C1q,":[87],"gC1qR,":[88],"cC1qR.":[90],"By":[91],"comparing":[92],"expression":[94],"levels":[95],"derived":[100],"from":[101],"African":[102],"American,":[103],"East":[104],"Asian,":[105],"Caucasian":[107],"models":[108],"through":[109],"enzyme-linked":[110],"immunosorbent":[111],"assays":[112],"(ELISAs),":[113],"Western":[114],"blots,":[115],"bicinchoninic":[116],"acid":[117],"assay":[118],"(BCA)":[119],"assays,":[120,122],"MTT":[121],"microscopy.":[124],"Results":[125],"suggest":[126],"that":[127],"gC1qR-C1q":[129],"axis":[130],"could":[131],"be":[132],"a":[133],"promising":[134],"target":[135],"for":[136],"developing":[137],"antibody-based":[138],"therapeutic":[139],"treatments":[140],"combat":[142],"cancer,":[144],"potentially":[145],"offering":[146],"new":[147],"effective":[149],"approaches":[150],"stop":[152],"reduce":[154],"progression.":[156],"Topic":[157],"Categories":[158],"Immune":[159],"Mechanisms":[160],"Human":[162],"Disease":[163],"(HUM)":[164]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2025-11-23T00:00:00"}