{"id":"https://openalex.org/W4416447293","doi":"https://doi.org/10.1093/jimmun/vkaf283.094","title":"Prenatal maternal stress induces gut microbiota dysbiosis and long-term programming of autoreactive CD4 T cells in the context of neuroinflammation 2132","display_name":"Prenatal maternal stress induces gut microbiota dysbiosis and long-term programming of autoreactive CD4 T cells in the context of neuroinflammation 2132","publication_year":2025,"publication_date":"2025-11-01","ids":{"openalex":"https://openalex.org/W4416447293","doi":"https://doi.org/10.1093/jimmun/vkaf283.094"},"language":"en","primary_location":{"id":"doi:10.1093/jimmun/vkaf283.094","doi":"https://doi.org/10.1093/jimmun/vkaf283.094","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jimmun/vkaf283.094","pdf_url":"https://academic.oup.com/jimmunol/article-pdf/214/Supplement_1/vkaf283.094/65409847/vkaf283.094.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/jimmunol/article-pdf/214/Supplement_1/vkaf283.094/65409847/vkaf283.094.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5094331758","display_name":"R\u00e9becca Barascud","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"R\u00e9becca Barascud","raw_affiliation_strings":["INFINITY, INSERM (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale) (National Institute of Health and Medical Research)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INFINITY, INSERM (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale) (National Institute of Health and Medical Research)","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080006432","display_name":"R\u00e9mi Marrocco","orcid":"https://orcid.org/0000-0002-1549-9663","observed_orcids":["https://orcid.org/0000-0002-1549-9663"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Remi Marrocco","raw_affiliation_strings":["Yale School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale School of Medicine","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079299460","display_name":"Romain Peroceschi","orcid":"https://orcid.org/0009-0005-5399-5034","observed_orcids":["https://orcid.org/0009-0005-5399-5034"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Romain Peroceschi","raw_affiliation_strings":["INFINITY, INSERM (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale) (National Institute of Health and Medical Research)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INFINITY, INSERM (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale) (National Institute of Health and Medical Research)","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041856681","display_name":"Sarah Maurel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sarah Maurel","raw_affiliation_strings":["IRSD, INSERM (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale) (National Institute of Health and Medical Research)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRSD, INSERM (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale) (National Institute of Health and Medical Research)","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081021140","display_name":"I Bernard","orcid":"https://orcid.org/0000-0002-5847-1281","observed_orcids":["https://orcid.org/0000-0002-5847-1281"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Isabelle Cadenat","raw_affiliation_strings":["INFINITY, INSERM (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale) (National Institute of Health and Medical Research)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INFINITY, INSERM (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale) (National Institute of Health and Medical Research)","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018200092","display_name":"Matteo S\u00e9rino","orcid":"https://orcid.org/0000-0003-4644-8532","observed_orcids":["https://orcid.org/0000-0003-4644-8532"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Matteo Serino","raw_affiliation_strings":["IRSD, INSERM (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale) (National Institute of Health and Medical Research)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRSD, INSERM (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale) (National Institute of Health and Medical Research)","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008410004","display_name":"Nicolas C\u00e9nac","orcid":"https://orcid.org/0000-0002-1552-7812","observed_orcids":["https://orcid.org/0000-0002-1552-7812"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nicolas Cenac","raw_affiliation_strings":["IRSD, INSERM (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale) (National Institute of Health and Medical Research)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRSD, INSERM (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale) (National Institute of Health and Medical Research)","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075934106","display_name":"Abdelhadi Saoudi","orcid":"https://orcid.org/0000-0001-7015-8178","observed_orcids":["https://orcid.org/0000-0001-7015-8178"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Abdelhadi Saoudi","raw_affiliation_strings":["INFINITY, INSERM (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale) (National Institute of Health and Medical Research)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INFINITY, INSERM (Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale) (National Institute of Health and Medical Research)","institution_ids":["https://openalex.org/I154526488"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.39171913,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"214","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.5839999914169312,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.5839999914169312,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.1964000016450882,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.04010000079870224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prenatal-stress","display_name":"prenatal stress","score":0.9729999899864197},{"id":"https://openalex.org/keywords/gut-dysbiosis","display_name":"gut dysbiosis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8999999761581421},{"id":"https://openalex.org/keywords/autoreactive-t-cells","display_name":"autoreactive T cells","score":0.875},{"id":"https://openalex.org/keywords/experimental-autoimmune-encephalomyelitis","display_name":"experimental autoimmune encephalomyelitis","score":0.925000011920929},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9490000009536743},{"id":"https://openalex.org/keywords/immune-imprinting","display_name":"immune imprinting","score":0.6620000004768372},{"id":"https://openalex.org/keywords/epigenetic-modifications","display_name":"epigenetic modifications","score":0.8019999861717224},{"id":"https://openalex.org/keywords/microbiota-metabolites","display_name":"microbiota metabolites","score":0.871999979019165},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.718999981880188},{"id":"https://openalex.org/keywords/adoptive-transfer","display_name":"adoptive transfer","score":0.7829999923706055},{"id":"https://openalex.org/keywords/central-nervous-system-invasion","display_name":"central nervous system infiltration","score":0.7200000286102295},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8420000076293945}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.776199996471405},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6837000250816345},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.6305999755859375},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.5989999771118164},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.5848000049591064},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5418000221252441},{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.5177000164985657},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4691999852657318},{"id":"https://openalex.org/C2776443723","wikidata":"https://www.wikidata.org/wiki/Q7240529","display_name":"Prenatal stress","level":4,"score":0.45159998536109924},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.4242999851703644},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42179998755455017},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.3677999973297119},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.3644999861717224},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35910001397132874},{"id":"https://openalex.org/C177857423","wikidata":"https://www.wikidata.org/wiki/Q17077315","display_name":"Gut\u2013brain axis","level":3,"score":0.3521000146865845},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.3513999879360199},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.3508000075817108},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.3262999951839447},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.3068999946117401},{"id":"https://openalex.org/C2777702733","wikidata":"https://www.wikidata.org/wiki/Q1356761","display_name":"Immune tolerance","level":3,"score":0.29179999232292175},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.2865999937057495},{"id":"https://openalex.org/C47348012","wikidata":"https://www.wikidata.org/wiki/Q99486570","display_name":"Interleukin 17","level":3,"score":0.2759000062942505},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.2718000113964081},{"id":"https://openalex.org/C201934248","wikidata":"https://www.wikidata.org/wiki/Q2492999","display_name":"Neuroimmunology","level":3,"score":0.2703999876976013},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.26759999990463257},{"id":"https://openalex.org/C2780194698","wikidata":"https://www.wikidata.org/wiki/Q6005429","display_name":"Immune dysregulation","level":3,"score":0.26759999990463257},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.2667999863624573},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.2614000141620636},{"id":"https://openalex.org/C2992881475","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T lymphocyte","level":3,"score":0.25360000133514404},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.2529999911785126}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/jimmun/vkaf283.094","doi":"https://doi.org/10.1093/jimmun/vkaf283.094","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jimmun/vkaf283.094","pdf_url":"https://academic.oup.com/jimmunol/article-pdf/214/Supplement_1/vkaf283.094/65409847/vkaf283.094.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/jimmun/vkaf283.094","doi":"https://doi.org/10.1093/jimmun/vkaf283.094","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jimmun/vkaf283.094","pdf_url":"https://academic.oup.com/jimmunol/article-pdf/214/Supplement_1/vkaf283.094/65409847/vkaf283.094.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4216714955","display_name":"Development of Novel Cancer Therapeutics by Targeting Sphingolipid Signaling","funder_award_id":"P01CA203628","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000183288","display_name":null,"funder_award_id":"CA203628","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000878829","display_name":"Ceramide Signaling in the Regulation of Head & Neck Cancer Cell Death and Therapy","funder_award_id":"R01DE016572","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G9000918851","display_name":"Ceramide metabolism and the regulation of PD-L1 signaling to control metastasis and resistance to immunotherapy in TNBC","funder_award_id":"R01CA214461","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320309737","display_name":"Fondation pour l'Aide \u00e0 la Recherche sur la Scl\u00e9rose en Plaques","ror":"https://ror.org/04gyrp304"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416447293.pdf","grobid_xml":"https://content.openalex.org/works/W4416447293.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4200172127","https://openalex.org/W3101371475","https://openalex.org/W2092533774","https://openalex.org/W2015419107","https://openalex.org/W1992138419","https://openalex.org/W3159758242","https://openalex.org/W3007783987","https://openalex.org/W2014174191","https://openalex.org/W2010302007","https://openalex.org/W3034747829"],"abstract_inverted_index":{"Abstract":[0],"Description":[1],"The":[2,197],"prenatal":[3,50],"period":[4],"is":[5,162],"a":[6,69,79,99,143,169,175,184,200,206],"sensitive":[7],"time":[8],"during":[9,29,78],"which":[10,49],"intrauterine":[11],"exposure":[12],"to":[13,130,154,164],"environmental":[14],"factors":[15],"can":[16],"shape":[17],"the":[18,46,85,113,132],"developing":[19],"immune":[20,33,54],"system":[21],"in":[22,35,56,92],"offspring.":[23],"Evidence":[24],"suggests":[25],"that":[26,110,140,159,172,181],"maternal":[27],"stress":[28,51,77],"pregnancy":[30],"weakens":[31],"adaptive":[32],"responses":[34,55,91],"offspring,":[36],"increasing":[37],"their":[38,122,128],"risk":[39],"of":[40,87,116,124,199],"infectious":[41],"diseases":[42],"and":[43,127,145,167,220],"cancer.":[44],"However,":[45],"mechanisms":[47],"through":[48],"(PS)":[52],"impairs":[53],"adulthood":[57],"are":[58],"not":[59],"fully":[60],"understood.":[61],"To":[62],"address":[63],"this":[64,160],"knowledge":[65],"gap,":[66],"we":[67],"developed":[68],"PS":[70,88,111,141,182],"animal":[71],"model":[72,101],"where":[73],"pregnant":[74],"females":[75],"experience":[76],"specific":[80],"gestational":[81],"period.":[82],"We":[83,157],"examined":[84],"effect":[86,147,161],"on":[89,148,188],"autoimmune":[90,97],"adult":[93],"offspring":[94],"using":[95],"experimental":[96],"encephalomyelitis,":[98],"well-suited":[100],"for":[102,210],"studying":[103],"T":[104,118,150,190],"lymphocyte":[105],"functions.":[106],"Our":[107],"findings":[108],"indicate":[109],"reduces":[112],"pathogenic":[114],"potential":[115,207],"CD4":[117,189],"cells":[119],"by":[120,217],"limiting":[121],"production":[123],"inflammatory":[125],"cytokines":[126],"ability":[129],"infiltrate":[131],"central":[133],"nervous":[134],"system.":[135],"Adoptive":[136],"transfer":[137],"experiments":[138],"confirmed":[139],"has":[142],"stable":[144],"intrinsic":[146],"CD4+":[149],"cells,":[151],"potentially":[152],"due":[153],"epigenetic":[155],"changes.":[156],"found":[158],"linked":[163],"intestinal":[165],"dysbiosis":[166],"identified":[168],"microbiota":[170,195],"metabolite":[171,202],"may":[173],"play":[174],"role.":[176],"Overall,":[177],"our":[178],"study":[179],"demonstrates":[180],"leaves":[183],"lasting":[185],"\u201cimmune":[186],"imprint\u201d":[187],"cell":[191],"function,":[192],"associated":[193],"with":[194],"dysbiosis.":[196],"discovery":[198],"relevant":[201],"could":[203],"serve":[204],"as":[205],"therapeutic":[208],"target":[209],"multiple":[211],"sclerosis":[212],"patients.":[213],"Funding":[214],"Sources":[215],"Supported":[216],"INSERM,":[218],"ARSEP":[219],"FRC":[221],"Topic":[222],"Categories":[223],"Neuroimmunology":[224],"(NEUR)":[225]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-11-23T00:00:00"}
