{"id":"https://openalex.org/W4416446810","doi":"https://doi.org/10.1093/jimmun/vkaf283.132","title":"Circulating tumor-resident T-cell clonotypes with quasi-identical TCR nucleotide sequences exhibit distinct transcriptional states and response dynamics during immune checkpoint inhibitor therapy 2180","display_name":"Circulating tumor-resident T-cell clonotypes with quasi-identical TCR nucleotide sequences exhibit distinct transcriptional states and response dynamics during immune checkpoint inhibitor therapy 2180","publication_year":2025,"publication_date":"2025-11-01","ids":{"openalex":"https://openalex.org/W4416446810","doi":"https://doi.org/10.1093/jimmun/vkaf283.132"},"language":"en","primary_location":{"id":"doi:10.1093/jimmun/vkaf283.132","doi":"https://doi.org/10.1093/jimmun/vkaf283.132","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jimmun/vkaf283.132","pdf_url":"https://academic.oup.com/jimmunol/article-pdf/214/Supplement_1/vkaf283.132/65410756/vkaf283.132.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/jimmunol/article-pdf/214/Supplement_1/vkaf283.132/65410756/vkaf283.132.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023083411","display_name":"Ryutaro Kajihara","orcid":"https://orcid.org/0000-0003-0908-2543","observed_orcids":["https://orcid.org/0000-0003-0908-2543"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryutaro Kajihara","raw_affiliation_strings":["Roswell Park Comprehensive Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roswell Park Comprehensive Cancer Center","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028515700","display_name":"Mark D. Long","orcid":"https://orcid.org/0000-0003-1120-8176","observed_orcids":["https://orcid.org/0000-0003-1120-8176","https://orcid.org/0000-0001-6323-235X"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark D Long","raw_affiliation_strings":["Roswell Park Comprehensive Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roswell Park Comprehensive Cancer Center","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088180451","display_name":"Toshifumi Hoki","orcid":"https://orcid.org/0000-0002-8853-4167","observed_orcids":["https://orcid.org/0000-0002-8853-4167"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Toshifumi Hoki","raw_affiliation_strings":["Roswell Park Comprehensive Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roswell Park Comprehensive Cancer Center","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100647907","display_name":"Hongbin Chen","orcid":"https://orcid.org/0000-0001-9920-8802","observed_orcids":["https://orcid.org/0000-0001-9920-8802"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongbin Chen","raw_affiliation_strings":["Roswell Park Comprehensive Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roswell Park Comprehensive Cancer Center","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069388226","display_name":"Takayoshi Yamauchi","orcid":"https://orcid.org/0000-0002-5685-7658","observed_orcids":["https://orcid.org/0000-0002-5685-7658"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takayoshi Yamauchi","raw_affiliation_strings":["Roswell Park Comprehensive Cancer Center, University of Southern California (USC) Norris Comprehensive Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roswell Park Comprehensive Cancer Center, University of Southern California (USC) Norris Comprehensive Cancer Center","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1292894508","https://openalex.org/I4210117038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077422124","display_name":"Hisashi Kanemaru","orcid":"https://orcid.org/0000-0003-3725-6213","observed_orcids":["https://orcid.org/0000-0003-3725-6213"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hisashi Kanemaru","raw_affiliation_strings":["University of Southern California (USC) Norris Comprehensive Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Southern California (USC) Norris Comprehensive Cancer Center","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059770078","display_name":"Brahm H. Segal","orcid":"https://orcid.org/0000-0001-5043-7380","observed_orcids":["https://orcid.org/0000-0001-5043-7380"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brahm H Segal","raw_affiliation_strings":["Roswell Park Comprehensive Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roswell Park Comprehensive Cancer Center","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025646273","display_name":"Grace Kho Dy","orcid":"https://orcid.org/0000-0002-5061-0072","observed_orcids":["https://orcid.org/0000-0002-5061-0072"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grace K Dy","raw_affiliation_strings":["Roswell Park Comprehensive Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roswell Park Comprehensive Cancer Center","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009056123","display_name":"Fumito Ito","orcid":"https://orcid.org/0000-0002-6866-671X","observed_orcids":["https://orcid.org/0000-0002-6866-671X"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fumito Ito","raw_affiliation_strings":["Roswell Park Comprehensive Cancer Center, University of Southern California (USC) Norris Comprehensive Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roswell Park Comprehensive Cancer Center, University of Southern California (USC) Norris Comprehensive Cancer Center","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1292894508","https://openalex.org/I4210117038"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.35124722,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"214","issue":"Supplement_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.7770000100135803},{"id":"https://openalex.org/keywords/t-cell-clonotypes","display_name":"T cell clonotypes","score":0.8629999756813049},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.7870000004768372},{"id":"https://openalex.org/keywords/peripheral-blood-t-cells","display_name":"peripheral blood T cells","score":0.7409999966621399},{"id":"https://openalex.org/keywords/granzyme-k","display_name":"granzyme K","score":0.6129999756813049},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8550000190734863},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.925000011920929},{"id":"https://openalex.org/keywords/single-cell-rna-sequencing","display_name":"single-cell RNA sequencing","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.8296999931335449},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8073999881744385},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6455000042915344},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6100000143051147},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.5685999989509583},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5562000274658203},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.43959999084472656},{"id":"https://openalex.org/C64894306","wikidata":"https://www.wikidata.org/wiki/Q849622","display_name":"Homologous chromosome","level":3,"score":0.435699999332428},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43459999561309814},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.40389999747276306},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.3971000015735626},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.35019999742507935},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.34700000286102295},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3262999951839447},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.3253999948501587},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.3068999946117401},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.29589998722076416},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28679999709129333},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2791000008583069},{"id":"https://openalex.org/C45484198","wikidata":"https://www.wikidata.org/wiki/Q827246","display_name":"Sequence alignment","level":4,"score":0.2669999897480011},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.26080000400543213},{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.25999999046325684},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.257099986076355},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2563999891281128},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.2556000053882599},{"id":"https://openalex.org/C61053724","wikidata":"https://www.wikidata.org/wiki/Q1154615","display_name":"Sequence analysis","level":3,"score":0.2542000114917755},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.25060001015663147},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.2502000033855438}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/jimmun/vkaf283.132","doi":"https://doi.org/10.1093/jimmun/vkaf283.132","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jimmun/vkaf283.132","pdf_url":"https://academic.oup.com/jimmunol/article-pdf/214/Supplement_1/vkaf283.132/65410756/vkaf283.132.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/jimmun/vkaf283.132","doi":"https://doi.org/10.1093/jimmun/vkaf283.132","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jimmun/vkaf283.132","pdf_url":"https://academic.oup.com/jimmunol/article-pdf/214/Supplement_1/vkaf283.132/65410756/vkaf283.132.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416446810.pdf","grobid_xml":"https://content.openalex.org/works/W4416446810.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Description":[1],"The":[2],"development":[3],"of":[4,65],"immune":[5],"checkpoint":[6],"inhibitors":[7],"(ICIs)":[8],"has":[9,19],"transformed":[10],"cancer":[11],"treatment,":[12],"but":[13,35,105,154],"patient":[14,90],"responses":[15,124],"remain":[16,55],"inconsistent.":[17],"Evidence":[18],"shown":[20],"that":[21,173],"T-cell":[22,141],"receptors":[23],"(TCRs)":[24],"recognizing":[25],"the":[26,42,62,149,164],"same":[27],"epitopes":[28],"may":[29],"not":[30],"always":[31],"be":[32],"identical":[33,100,107],"clonotypes":[34,68],"instead":[36],"exhibit":[37,183],"subtle":[38],"sequence":[39,117],"variations.":[40],"However,":[41],"genomic":[43],"and":[44,109,127,168,187,199],"transcriptomic":[45],"changes":[46],"in":[47,70,88,189],"these":[48,119,144],"closely":[49],"related":[50],"T":[51,170,175],"cells":[52,176],"during":[53,148],"immunotherapy":[54,126],"unclear.":[56],"In":[57],"this":[58],"study,":[59],"we":[60],"explored":[61],"evolutionary":[63],"dynamics":[64,188],"circulating":[66,96,169],"TCR":[67,83,110,180],"identified":[69,95],"tumors":[71],"(TIL-TCRs)":[72],"by":[73,133],"integrating":[74],"single-cell":[75],"RNA/TCR":[76],"sequencing":[77,84],"from":[78,85],"longitudinal":[79],"blood":[80],"samples":[81],"with":[82,99,177],"tumor":[86],"tissue":[87],"a":[89],"undergoing":[91],"anti-CTLA-4/PD-1":[92],"therapy.":[93],"We":[94],"CD8+":[97,174],"TIL-TCRs":[98,121],"CDR3\u03b1":[101],"amino":[102],"acid":[103],"sequences":[104,181],"nearly":[106],"CDR3\u03b2":[108],"\u03b1/\u03b2":[111],"(TRA/TRB)":[112],"sequences.":[113],"Despite":[114],"their":[115],"high":[116],"similarity,":[118],"quasi-identical":[120,145],"displayed":[122],"differential":[123],"to":[125,152,191],"distinct":[128],"transcriptional":[129,185],"profiles,":[130],"particularly":[131],"marked":[132],"GZMK":[134],"expression.":[135],"Furthermore,":[136],"IFNG":[137],"expression":[138],"within":[139],"CD8A+":[140],"subsets,":[142],"including":[143],"TIL-TCRs,":[146],"increased":[147],"patient\u2019s":[150],"response":[151,190],"treatment":[153],"gradually":[155],"declined":[156],"as":[157],"acquired":[158],"resistance":[159],"developed.":[160],"These":[161],"findings":[162],"highlight":[163],"interplay":[165],"between":[166],"tumor-infiltrating":[167],"cells,":[171],"underscoring":[172],"highly":[178],"homologous":[179],"can":[182],"diverse":[184],"behaviors":[186],"immunotherapy.":[192],"Topic":[193],"Categories":[194],"Tumor":[195],"Immunology:":[196],"Checkpoints,":[197],"Prevention,":[198],"Treatment":[200],"(TIPT)":[201]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2025-11-23T00:00:00"}