{"id":"https://openalex.org/W4416426730","doi":"https://doi.org/10.1016/j.actbio.2025.11.031","title":"Collagen nanofiber alignment attenuates leader-follower energetic and metabolic differences during collective migration in pancreatic cancer","display_name":"Collagen nanofiber alignment attenuates leader-follower energetic and metabolic differences during collective migration in pancreatic cancer","publication_year":2025,"publication_date":"2025-11-20","ids":{"openalex":"https://openalex.org/W4416426730","doi":"https://doi.org/10.1016/j.actbio.2025.11.031","pmid":"https://pubmed.ncbi.nlm.nih.gov/41271079"},"language":"en","primary_location":{"id":"doi:10.1016/j.actbio.2025.11.031","doi":"https://doi.org/10.1016/j.actbio.2025.11.031","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.actbio.2025.11.031","pdf_url":null,"source":{"id":"https://openalex.org/S173145877","display_name":"Acta Biomaterialia","issn_l":"1742-7061","issn":["1742-7061","1878-7568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Biomaterialia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.2139/ssrn.5217352","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045636359","display_name":"Madison Pickett","orcid":"https://orcid.org/0009-0005-2315-6328","observed_orcids":["https://orcid.org/0009-0005-2315-6328"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Madison R. Pickett","raw_affiliation_strings":["Department of Biomedical Engineering, The University of Texas, Austin, TX, 78712, USA. Electronic address: mrpickett@utexas.edu","Department of Biomedical Engineering, The University of Texas, Austin, Texas, 78712, USA. Electronic address: mrpickett@utexas.edu"],"raw_orcid":"https://orcid.org/0009-0005-2315-6328","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, The University of Texas, Austin, TX, 78712, USA. Electronic address: mrpickett@utexas.edu","institution_ids":["https://openalex.org/I86519309"]},{"raw_affiliation_string":"Department of Biomedical Engineering, The University of Texas, Austin, Texas, 78712, USA. Electronic address: mrpickett@utexas.edu","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081019203","display_name":"Mohini Kamra","orcid":"https://orcid.org/0009-0004-2405-3120","observed_orcids":["https://orcid.org/0009-0004-2405-3120"]},"institutions":[{"id":"https://openalex.org/I83809506","display_name":"University of South Alabama","ror":"https://ror.org/01s7b5y08","country_code":"US","type":"education","lineage":["https://openalex.org/I83809506"]},{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohini Kamra","raw_affiliation_strings":["Department of Biomedical Engineering, The University of Texas, Austin, TX, 78712, USA; Department of Biomedical Sciences, University of South Alabama, Mobile, AL 36688, USA","Department of Biomedical Engineering, The University of Texas, Austin, Texas, 78712, USA; Department of Biomedical Sciences, University of South Alabama, Mobile, Alabama 36688, USA"],"raw_orcid":"https://orcid.org/0009-0004-2405-3120","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, The University of Texas, Austin, TX, 78712, USA; Department of Biomedical Sciences, University of South Alabama, Mobile, AL 36688, USA","institution_ids":["https://openalex.org/I83809506","https://openalex.org/I86519309"]},{"raw_affiliation_string":"Department of Biomedical Engineering, The University of Texas, Austin, Texas, 78712, USA; Department of Biomedical Sciences, University of South Alabama, Mobile, Alabama 36688, USA","institution_ids":["https://openalex.org/I83809506","https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022256638","display_name":"David A. Castilla\u2010Casadiego","orcid":"https://orcid.org/0000-0003-2350-5194","observed_orcids":["https://orcid.org/0000-0003-2350-5194"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Castilla-Casadiego","raw_affiliation_strings":["Mcketta Department of Chemical Engineering, The University of Texas, Austin, TX, 78712, USA; Present address: Department of Biomedical Engineering, The University of Miami, Coral Gables, FL 33146, USA","Mcketta Department of Chemical Engineering, The University of Texas, Austin, Texas, 78712, USA; Present address: Department of Biomedical Engineering, The University of Miami, Coral Gables, Florida 33146, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mcketta Department of Chemical Engineering, The University of Texas, Austin, TX, 78712, USA; Present address: Department of Biomedical Engineering, The University of Miami, Coral Gables, FL 33146, USA","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I86519309"]},{"raw_affiliation_string":"Mcketta Department of Chemical Engineering, The University of Texas, Austin, Texas, 78712, USA; Present address: Department of Biomedical Engineering, The University of Miami, Coral Gables, Florida 33146, USA","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sepehr Noori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sepehr Noori","raw_affiliation_strings":["Department of Biomedical Engineering, The University of Texas, Austin, TX, 78712, USA","Department of Biomedical Engineering, The University of Texas, Austin, Texas, 78712, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, The University of Texas, Austin, TX, 78712, USA","institution_ids":["https://openalex.org/I86519309"]},{"raw_affiliation_string":"Department of Biomedical Engineering, The University of Texas, Austin, Texas, 78712, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027419360","display_name":"William H. Matsui","orcid":"https://orcid.org/0000-0002-3088-0964","observed_orcids":["https://orcid.org/0000-0002-3088-0964"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Matsui","raw_affiliation_strings":["Livestrong Cancer Institutes, Dell Medical School, University of Texas at Austin, Austin, TX 78705, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Livestrong Cancer Institutes, Dell Medical School, University of Texas at Austin, Austin, TX 78705, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071746980","display_name":"Adrianne M. Rosales","orcid":"https://orcid.org/0000-0003-0207-7661","observed_orcids":["https://orcid.org/0000-0003-0207-7661"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adrianne M. Rosales","raw_affiliation_strings":["Mcketta Department of Chemical Engineering, The University of Texas, Austin, TX, 78712, USA","Mcketta Department of Chemical Engineering, The University of Texas, Austin, Texas, 78712, USA"],"raw_orcid":"https://orcid.org/0000-0003-0207-7661","affiliations":[{"raw_affiliation_string":"Mcketta Department of Chemical Engineering, The University of Texas, Austin, TX, 78712, USA","institution_ids":["https://openalex.org/I86519309"]},{"raw_affiliation_string":"Mcketta Department of Chemical Engineering, The University of Texas, Austin, Texas, 78712, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000028294","display_name":"Janet Zoldan","orcid":"https://orcid.org/0000-0001-7089-7683","observed_orcids":["https://orcid.org/0000-0001-7089-7683"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janet Zoldan","raw_affiliation_strings":["Department of Biomedical Engineering, The University of Texas, Austin, TX, 78712, USA","Department of Biomedical Engineering, The University of Texas, Austin, Texas, 78712, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, The University of Texas, Austin, TX, 78712, USA","institution_ids":["https://openalex.org/I86519309"]},{"raw_affiliation_string":"Department of Biomedical Engineering, The University of Texas, Austin, Texas, 78712, USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078362785","display_name":"Sapun H. Parekh","orcid":"https://orcid.org/0000-0001-8522-1854","observed_orcids":["https://orcid.org/0000-0001-8522-1854"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sapun H. Parekh","raw_affiliation_strings":["Department of Biomedical Engineering, The University of Texas, Austin, TX, 78712, USA. Electronic address: sparekh@utexas.edu","Department of Biomedical Engineering, The University of Texas, Austin, Texas, 78712, USA. Electronic address: sparekh@utexas.edu"],"raw_orcid":"https://orcid.org/0000-0001-8522-1854","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, The University of Texas, Austin, TX, 78712, USA. Electronic address: sparekh@utexas.edu","institution_ids":["https://openalex.org/I86519309"]},{"raw_affiliation_string":"Department of Biomedical Engineering, The University of Texas, Austin, Texas, 78712, USA. Electronic address: sparekh@utexas.edu","institution_ids":["https://openalex.org/I86519309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5045636359","https://openalex.org/A5078362785"],"corresponding_institution_ids":["https://openalex.org/I86519309"],"apc_list":{"value":3810,"currency":"USD","value_usd":3810},"apc_paid":null,"fwci":0.8936,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.64484452,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"209","issue":null,"first_page":"183","last_page":"193"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9950000047683716},{"id":"https://openalex.org/keywords/collective-cell-migration","display_name":"collective cell migration","score":0.9580000042915344},{"id":"https://openalex.org/keywords/collagen-fiber-alignment","display_name":"collagen fiber alignment","score":0.6990000009536743},{"id":"https://openalex.org/keywords/extracellular-matrix-architecture","display_name":"extracellular matrix architecture","score":0.9380000233650208},{"id":"https://openalex.org/keywords/cellular-metabolism","display_name":"cellular metabolism","score":0.7919999957084656},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.9089999794960022},{"id":"https://openalex.org/keywords/atp-adp-ratio","display_name":"ATP/ADP ratio","score":0.9679999947547913},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.9909999966621399},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.5139999985694885},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.42100000381469727}],"concepts":[{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.7957000136375427},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.7458999752998352},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.6812999844551086},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6621000170707703},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.6128000020980835},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.557200014591217},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5483999848365784},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5163000226020813},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5055999755859375},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.48500001430511475},{"id":"https://openalex.org/C91129048","wikidata":"https://www.wikidata.org/wiki/Q594196","display_name":"Nanofiber","level":2,"score":0.42260000109672546},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.40290001034736633},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.3921999931335449},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3691999912261963},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.3626999855041504},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35690000653266907},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.3127000033855438},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.29919999837875366},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.296999990940094},{"id":"https://openalex.org/C2991704936","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Cell metabolism","level":3,"score":0.28220000863075256},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.2759999930858612},{"id":"https://openalex.org/C2992026798","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic ductal adenocarcinoma","level":4,"score":0.2676999866962433},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.26350000500679016},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.26080000400543213},{"id":"https://openalex.org/C52124034","wikidata":"https://www.wikidata.org/wiki/Q557179","display_name":"Stroma","level":3,"score":0.25459998846054077}],"mesh":[{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D024042","descriptor_name":"Collagen Type I","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057139","descriptor_name":"Nanofibers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.actbio.2025.11.031","doi":"https://doi.org/10.1016/j.actbio.2025.11.031","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.actbio.2025.11.031","pdf_url":null,"source":{"id":"https://openalex.org/S173145877","display_name":"Acta Biomaterialia","issn_l":"1742-7061","issn":["1742-7061","1878-7568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Biomaterialia","raw_type":"journal-article"},{"id":"doi:10.2139/ssrn.5217352","doi":"https://doi.org/10.2139/ssrn.5217352","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.5217352","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmid:41271079","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41271079","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta biomaterialia","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.2139/ssrn.5217352","doi":"https://doi.org/10.2139/ssrn.5217352","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.5217352","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1076624496","display_name":null,"funder_award_id":"2021\\u2013236087","funder_id":"https://openalex.org/F4320315474","funder_display_name":"Chan Zuckerberg Initiative"},{"id":"https://openalex.org/G1234541941","display_name":null,"funder_award_id":"75N91019D00024","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2536349935","display_name":null,"funder_award_id":"F-2008\\u201320220331","funder_id":"https://openalex.org/F4320306196","funder_display_name":"Welch Foundation"},{"id":"https://openalex.org/G4537023692","display_name":"Systems Approaches to Understanding Subpopulation Heterogeneity in Therapeutic Resistance","funder_award_id":"U01CA253540","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4758552775","display_name":"Graduate Research Fellowship Program (GRFP)","funder_award_id":"2137420","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6328128517","display_name":null,"funder_award_id":"R35GM138193","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G7787191774","display_name":"CAREER: Controlling molecular enrichment in biomolecular condensate materials","funder_award_id":"2146549","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7815908676","display_name":null,"funder_award_id":"75N91020F00003","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8340809614","display_name":"Expanding the Functionality of Engineered Extracellular Matrices","funder_award_id":"R35GM138193","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000874111","display_name":"Dynamic Nanofibrous Hydrogels for Enhancing Stem Cells' Therapeutic Potency","funder_award_id":"R00GM151459","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306080","display_name":"Foundation for the National Institutes of Health","ror":"https://ror.org/00k86s890"},{"id":"https://openalex.org/F4320306196","display_name":"Welch Foundation","ror":"https://ror.org/00np6vq88"},{"id":"https://openalex.org/F4320315474","display_name":"Chan Zuckerberg Initiative","ror":"https://ror.org/02qenvm24"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":92,"referenced_works":["https://openalex.org/W1590178434","https://openalex.org/W1876890400","https://openalex.org/W1916854011","https://openalex.org/W1972382851","https://openalex.org/W1972659765","https://openalex.org/W1982204629","https://openalex.org/W1992171419","https://openalex.org/W1996360865","https://openalex.org/W1997552417","https://openalex.org/W1999293327","https://openalex.org/W2027631918","https://openalex.org/W2030204150","https://openalex.org/W2040034548","https://openalex.org/W2047253804","https://openalex.org/W2050209444","https://openalex.org/W2051069176","https://openalex.org/W2060033475","https://openalex.org/W2063659536","https://openalex.org/W2064005757","https://openalex.org/W2064141899","https://openalex.org/W2069202441","https://openalex.org/W2082208320","https://openalex.org/W2088812649","https://openalex.org/W2100592123","https://openalex.org/W2101547995","https://openalex.org/W2103630920","https://openalex.org/W2104479723","https://openalex.org/W2121827987","https://openalex.org/W2141235922","https://openalex.org/W2143468862","https://openalex.org/W2157220550","https://openalex.org/W2168182874","https://openalex.org/W2168992025","https://openalex.org/W2184171841","https://openalex.org/W2300962485","https://openalex.org/W2428249020","https://openalex.org/W2464386848","https://openalex.org/W2513260022","https://openalex.org/W2524040826","https://openalex.org/W2536479277","https://openalex.org/W2591119924","https://openalex.org/W2619354720","https://openalex.org/W2735307412","https://openalex.org/W2735590725","https://openalex.org/W2738916396","https://openalex.org/W2768084492","https://openalex.org/W2768973883","https://openalex.org/W2781844447","https://openalex.org/W2786843484","https://openalex.org/W2790784008","https://openalex.org/W2884914303","https://openalex.org/W2894407493","https://openalex.org/W2914114857","https://openalex.org/W2922889920","https://openalex.org/W2946847644","https://openalex.org/W2974147039","https://openalex.org/W2995117780","https://openalex.org/W3003173606","https://openalex.org/W3012260325","https://openalex.org/W3012307045","https://openalex.org/W3038115089","https://openalex.org/W3039340968","https://openalex.org/W3091397028","https://openalex.org/W3105015899","https://openalex.org/W3122784634","https://openalex.org/W3133651708","https://openalex.org/W3133710545","https://openalex.org/W3133734054","https://openalex.org/W3139664288","https://openalex.org/W3152583876","https://openalex.org/W3153358696","https://openalex.org/W3176488157","https://openalex.org/W3186595811","https://openalex.org/W3196711553","https://openalex.org/W3201764306","https://openalex.org/W3217463427","https://openalex.org/W4205537120","https://openalex.org/W4211146103","https://openalex.org/W4221048469","https://openalex.org/W4232283156","https://openalex.org/W4296713553","https://openalex.org/W4303476249","https://openalex.org/W4361284658","https://openalex.org/W4362669695","https://openalex.org/W4390496161","https://openalex.org/W4393318108","https://openalex.org/W4399361375","https://openalex.org/W4400499368","https://openalex.org/W4401249339","https://openalex.org/W4401851892","https://openalex.org/W4406212795","https://openalex.org/W4410357836"],"related_works":["https://openalex.org/W4401851892","https://openalex.org/W2547910334","https://openalex.org/W2895614576","https://openalex.org/W3028096043","https://openalex.org/W2775638497","https://openalex.org/W4399361375","https://openalex.org/W7135070768","https://openalex.org/W7000397017","https://openalex.org/W4293778265","https://openalex.org/W4385400302"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2025-11-20T00:00:00"}