{"id":"https://openalex.org/W4416407355","doi":"https://doi.org/10.1021/cbmi.6c00011","title":"Deep Learning-Augmented Stimulated Raman Imaging for Cell-Type-Specific Metabolic Profiling in Live Neuronal Cocultures","display_name":"Deep Learning-Augmented Stimulated Raman Imaging for Cell-Type-Specific Metabolic Profiling in Live Neuronal Cocultures","publication_year":2026,"publication_date":"2026-05-28","ids":{"openalex":"https://openalex.org/W4416407355","doi":"https://doi.org/10.1021/cbmi.6c00011","pmid":"https://pubmed.ncbi.nlm.nih.gov/42953710","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13715321"},"language":"en","primary_location":{"id":"doi:10.1021/cbmi.6c00011","doi":"https://doi.org/10.1021/cbmi.6c00011","is_oa":true,"landing_page_url":"https://doi.org/10.1021/cbmi.6c00011","pdf_url":null,"source":{"id":"https://openalex.org/S4387287784","display_name":"Chemical & Biomedical Imaging","issn_l":"2832-3637","issn":["2832-3637"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","oarl"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical &amp; Biomedical Imaging","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1021/cbmi.6c00011","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011671865","display_name":"Li\u2010En Lin","orcid":"https://orcid.org/0000-0003-3086-6991","observed_orcids":["https://orcid.org/0000-0003-3086-6991"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li-En Lin","raw_affiliation_strings":["California Institute of Technology , , , ,","Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA"],"raw_orcid":"https://orcid.org/0000-0003-3086-6991","affiliations":[{"raw_affiliation_string":"California Institute of Technology , , , ,","institution_ids":["https://openalex.org/I122411786"]},{"raw_affiliation_string":"Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019660675","display_name":"Xiaotian Bi","orcid":"https://orcid.org/0000-0003-4449-7488","observed_orcids":["https://orcid.org/0000-0003-4449-7488"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaotian Bi","raw_affiliation_strings":["California Institute of Technology , , , ,","Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA"],"raw_orcid":"https://orcid.org/0000-0003-4449-7488","affiliations":[{"raw_affiliation_string":"California Institute of Technology , , , ,","institution_ids":["https://openalex.org/I122411786"]},{"raw_affiliation_string":"Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117078627","display_name":"Adrian Colazo","orcid":"https://orcid.org/0000-0002-0702-0851","observed_orcids":["https://orcid.org/0000-0002-0702-0851"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adrian Colazo","raw_affiliation_strings":["California Institute of Technology , , , ,","Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"California Institute of Technology , , , ,","institution_ids":["https://openalex.org/I122411786"]},{"raw_affiliation_string":"Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101462432","display_name":"Haomin Wang","orcid":"https://orcid.org/0000-0001-7193-8651","observed_orcids":["https://orcid.org/0000-0001-7193-8651"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haomin Wang","raw_affiliation_strings":["California Institute of Technology , , , ,","Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA"],"raw_orcid":"https://orcid.org/0000-0001-7193-8651","affiliations":[{"raw_affiliation_string":"California Institute of Technology , , , ,","institution_ids":["https://openalex.org/I122411786"]},{"raw_affiliation_string":"Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA","institution_ids":["https://openalex.org/I122411786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100752450","display_name":"Lu Wei","orcid":"https://orcid.org/0000-0001-9170-2283","observed_orcids":["https://orcid.org/0000-0001-9170-2283","https://orcid.org/0009-0002-2754-1432"]},"institutions":[{"id":"https://openalex.org/I122411786","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055","country_code":"US","type":"education","lineage":["https://openalex.org/I122411786"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lu Wei","raw_affiliation_strings":["California Institute of Technology , , , ,","Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA"],"raw_orcid":"https://orcid.org/0000-0001-9170-2283","affiliations":[{"raw_affiliation_string":"California Institute of Technology , , , ,","institution_ids":["https://openalex.org/I122411786"]},{"raw_affiliation_string":"Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA","institution_ids":["https://openalex.org/I122411786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100752450"],"corresponding_institution_ids":["https://openalex.org/I122411786"],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00968217,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":"10","first_page":"2203","last_page":"2215"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stimulated-raman-scattering-microscopy","display_name":"stimulated Raman scattering microscopy","score":0.9629999995231628},{"id":"https://openalex.org/keywords/neuronal-metabolism","display_name":"neuronal metabolism","score":0.7879999876022339},{"id":"https://openalex.org/keywords/recurrent-convolutional-neural-network","display_name":"recurrent convolutional neural network","score":0.8169999718666077},{"id":"https://openalex.org/keywords/u-net-segmentation","display_name":"U-Net segmentation","score":0.8679999709129333},{"id":"https://openalex.org/keywords/nmda-receptor-activation","display_name":"NMDA receptor activation","score":0.8429999947547913},{"id":"https://openalex.org/keywords/proteasome-inhibition","display_name":"proteasome inhibition","score":0.9919999837875366},{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":0.9959999918937683},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.8970000147819519},{"id":"https://openalex.org/keywords/oligodendrocytes","display_name":"oligodendrocytes","score":0.9980000257492065},{"id":"https://openalex.org/keywords/3d-live-cell-imaging","display_name":"3D live-cell imaging","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5878000259399414},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.4562999904155731},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4074000120162964},{"id":"https://openalex.org/C101810790","wikidata":"https://www.wikidata.org/wiki/Q2263094","display_name":"Metabolic network","level":2,"score":0.38920000195503235},{"id":"https://openalex.org/C74254510","wikidata":"https://www.wikidata.org/wiki/Q7240508","display_name":"Premovement neuronal activity","level":2,"score":0.3813000023365021},{"id":"https://openalex.org/C2993927895","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolic activity","level":2,"score":0.38119998574256897},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3781999945640564},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.36800000071525574},{"id":"https://openalex.org/C2991704936","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Cell metabolism","level":3,"score":0.3513999879360199},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.3472999930381775},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3434000015258789},{"id":"https://openalex.org/C15526883","wikidata":"https://www.wikidata.org/wiki/Q6657126","display_name":"Live cell imaging","level":3,"score":0.33730000257492065},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.3224000036716461},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.3091999888420105},{"id":"https://openalex.org/C118403218","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Biological neural network","level":2,"score":0.2992999851703644},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.295199990272522},{"id":"https://openalex.org/C2994212657","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Cellular metabolism","level":3,"score":0.28929999470710754},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.2856000065803528},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2824999988079071},{"id":"https://openalex.org/C930959","wikidata":"https://www.wikidata.org/wiki/Q4086920","display_name":"Bioorthogonal chemistry","level":3,"score":0.27880001068115234},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.2777999937534332},{"id":"https://openalex.org/C182752723","wikidata":"https://www.wikidata.org/wiki/Q1474590","display_name":"Functional imaging","level":2,"score":0.25949999690055847}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1021/cbmi.6c00011","doi":"https://doi.org/10.1021/cbmi.6c00011","is_oa":true,"landing_page_url":"https://doi.org/10.1021/cbmi.6c00011","pdf_url":null,"source":{"id":"https://openalex.org/S4387287784","display_name":"Chemical & Biomedical Imaging","issn_l":"2832-3637","issn":["2832-3637"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","oarl"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical &amp; Biomedical Imaging","raw_type":"journal-article"},{"id":"doi:10.1101/2025.11.18.689078","doi":"https://doi.org/10.1101/2025.11.18.689078","is_oa":false,"landing_page_url":"https://doi.org/10.1101/2025.11.18.689078","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42953710","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42953710","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical & biomedical imaging","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13715321","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13715321/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chem Biomed Imaging","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:ef5eff6bd09a46de9a9ffbdc212f28b4","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ef5eff6bd09a46de9a9ffbdc212f28b4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Chemical & Biomedical Imaging, Vol 4, Iss 10, Pp 2203-2215 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1021/cbmi.6c00011","doi":"https://doi.org/10.1021/cbmi.6c00011","is_oa":true,"landing_page_url":"https://doi.org/10.1021/cbmi.6c00011","pdf_url":null,"source":{"id":"https://openalex.org/S4387287784","display_name":"Chemical & Biomedical Imaging","issn_l":"2832-3637","issn":["2832-3637"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","oarl"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical &amp; Biomedical Imaging","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4043000042438507}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4296485757","display_name":null,"funder_award_id":"2139433","funder_id":"https://openalex.org/F4562087700","funder_display_name":"National Science Foundation Graduate Research Fellowship Program"},{"id":"https://openalex.org/G7892935813","display_name":"Graduate Research Fellowship Program (GRFP)","funder_award_id":"2139433","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309398","display_name":"California Institute of Technology","ror":"https://ror.org/05dxps055"},{"id":"https://openalex.org/F4320309597","display_name":"Vallee Foundation","ror":"https://ror.org/05nmp3276"},{"id":"https://openalex.org/F4320314885","display_name":"Heritage Medical Research Institute","ror":"https://ror.org/03qf4j755"},{"id":"https://openalex.org/F4320315474","display_name":"Chan Zuckerberg Initiative","ror":"https://ror.org/02qenvm24"},{"id":"https://openalex.org/F4562087700","display_name":"National Science Foundation Graduate Research Fellowship Program","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1534306177","https://openalex.org/W1894322524","https://openalex.org/W1972638494","https://openalex.org/W1984034906","https://openalex.org/W1988432188","https://openalex.org/W2010105327","https://openalex.org/W2011641087","https://openalex.org/W2011700429","https://openalex.org/W2016927879","https://openalex.org/W2032488764","https://openalex.org/W2041192418","https://openalex.org/W2043565262","https://openalex.org/W2053129129","https://openalex.org/W2055030810","https://openalex.org/W2070980267","https://openalex.org/W2082891742","https://openalex.org/W2099172960","https://openalex.org/W2108576479","https://openalex.org/W2115318086","https://openalex.org/W2127394218","https://openalex.org/W2128776645","https://openalex.org/W2151288054","https://openalex.org/W2161568165","https://openalex.org/W2167916157","https://openalex.org/W2251857528","https://openalex.org/W2317590034","https://openalex.org/W2397912814","https://openalex.org/W2412875080","https://openalex.org/W2470966689","https://openalex.org/W2488162416","https://openalex.org/W2496353644","https://openalex.org/W2554444237","https://openalex.org/W2585407814","https://openalex.org/W2605756260","https://openalex.org/W2609511098","https://openalex.org/W2623012019","https://openalex.org/W2739924689","https://openalex.org/W2811106513","https://openalex.org/W2952902070","https://openalex.org/W3014974815","https://openalex.org/W3020709906","https://openalex.org/W3025128382","https://openalex.org/W3086545488","https://openalex.org/W3087886129","https://openalex.org/W3094118223","https://openalex.org/W3134761005","https://openalex.org/W3165513143","https://openalex.org/W3172002016","https://openalex.org/W4224142869","https://openalex.org/W4285010222","https://openalex.org/W4323811865","https://openalex.org/W4385515928","https://openalex.org/W4389489410","https://openalex.org/W4391882924","https://openalex.org/W4399999203","https://openalex.org/W4409682280"],"related_works":["https://openalex.org/W2566147354","https://openalex.org/W7162425097","https://openalex.org/W3080200011","https://openalex.org/W4414777465","https://openalex.org/W2973837962","https://openalex.org/W4415177269","https://openalex.org/W7163196899","https://openalex.org/W2738504463","https://openalex.org/W4416909718","https://openalex.org/W4401479087"],"abstract_inverted_index":{"Abstract":[0],"Neuronal":[1],"metabolism":[2,93],"is":[3],"fundamental":[4],"to":[5,86],"brain":[6],"functions":[7],"and":[8,13,16,43,70,91,98,102,111,124,136,153],"diseases,":[9],"yet":[10],"its":[11],"spatial":[12],"temporal":[14],"dynamics":[15],"interactions":[17,135],"remain":[18],"poorly":[19],"understood.":[20],"Here,":[21],"we":[22,82],"introduce":[23],"a":[24,56,71],"tandem":[25],"deep-learning":[26,52],"approach":[27],"integrated":[28],"with":[29,67,146],"bioorthogonal":[30],"chemical":[31],"imaging":[32,66,145],"using":[33],"stimulated":[34],"Raman":[35],"scattering":[36],"(SRS)":[37],"microscopy.":[38],"This":[39,139],"method":[40],"achieves":[41],"high-speed":[42],"quantitative":[44],"metabolic":[45,77,118,130],"profiling":[46,131],"in":[47,94,149],"live":[48,95],"neuronal":[49,121,134],"cocultures.":[50],"Our":[51,114],"framework":[53],"consists":[54],"of":[55,128],"recurrent":[57],"convolutional":[58],"neural":[59],"network":[60],"(RCNN)":[61],"that":[62],"enables":[63],"high-resolution":[64],"3D":[65],"minimal":[68],"photodamage":[69],"U-Net":[72],"segmentation":[73],"model":[74],"for":[75,132],"cell-type-specific":[76],"analysis.":[78],"Using":[79],"deuterium-labeled":[80],"metabolites,":[81],"demonstrate":[83],"the":[84,126],"ability":[85],"trace":[87],"lipid,":[88],"protein,":[89],"glucose,":[90],"D2O":[92],"neurons,":[96],"astrocytes,":[97],"oligodendrocytes":[99],"under":[100],"physiological":[101],"pathological":[103],"conditions,":[104],"including":[105],"NMDA":[106],"receptor":[107],"activation,":[108],"proteasome":[109],"inhibition,":[110],"Huntington\u2019s":[112],"disease.":[113],"findings":[115],"reveal":[116],"distinct":[117],"adaptations":[119],"among":[120],"cell":[122],"types":[123],"underscore":[125],"importance":[127],"noninvasive":[129],"understanding":[133],"disease":[137,151],"mechanisms.":[138],"platform":[140],"significantly":[141],"advances":[142],"live-cell":[143],"dynamic":[144],"broad":[147],"applications":[148],"neuroscience,":[150],"modeling,":[152],"therapeutic":[154],"screening.":[155]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2025-11-19T00:00:00"}
