{"id":"https://openalex.org/W4416396238","doi":"https://doi.org/10.1111/pcn.13924","title":"Clinical relevance of venlafaxine ER for generalized anxiety disorder","display_name":"Clinical relevance of venlafaxine ER for generalized anxiety disorder","publication_year":2025,"publication_date":"2025-11-19","ids":{"openalex":"https://openalex.org/W4416396238","doi":"https://doi.org/10.1111/pcn.13924","pmid":"https://pubmed.ncbi.nlm.nih.gov/41255146"},"language":"en","primary_location":{"id":"doi:10.1111/pcn.13924","doi":"https://doi.org/10.1111/pcn.13924","is_oa":true,"landing_page_url":"https://doi.org/10.1111/pcn.13924","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/pcn.13924","source":{"id":"https://openalex.org/S111042112","display_name":"Psychiatry and Clinical Neurosciences","issn_l":"1323-1316","issn":["1323-1316","1440-1819"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychiatry and Clinical Neurosciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/pcn.13924","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010791224","display_name":"Itsuki Terao","orcid":"https://orcid.org/0000-0003-0662-5637","observed_orcids":["https://orcid.org/0000-0003-0662-5637"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Itsuki Terao","raw_affiliation_strings":["Department of Psychiatry Ikokoro Clinic Nihonbashi  Tokyo Japan","Department of Psychiatry, Ikokoro Clinic Nihonbashi, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0003-0662-5637","affiliations":[{"raw_affiliation_string":"Department of Psychiatry Ikokoro Clinic Nihonbashi  Tokyo Japan","institution_ids":[]},{"raw_affiliation_string":"Department of Psychiatry, Ikokoro Clinic Nihonbashi, Tokyo, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5010791224"],"corresponding_institution_ids":[],"apc_list":{"value":3240,"currency":"USD","value_usd":3240},"apc_paid":null,"fwci":1.0612,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.83623143,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"80","issue":"4","first_page":"358","last_page":"358"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.016200000420212746,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10786","display_name":"Maternal Mental Health During Pregnancy and Postpartum","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/venlafaxine-extended-release","display_name":"venlafaxine extended release","score":0.890999972820282},{"id":"https://openalex.org/keywords/generalized-anxiety-disorder","display_name":"generalized anxiety disorder","score":0.9919999837875366},{"id":"https://openalex.org/keywords/clinical-significance","display_name":"clinical significance","score":0.5759999752044678},{"id":"https://openalex.org/keywords/placebo-responders","display_name":"placebo responders","score":0.6079999804496765},{"id":"https://openalex.org/keywords/comorbid-depression","display_name":"comorbid depression","score":0.8420000076293945},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.7129999995231628},{"id":"https://openalex.org/keywords/treatment-discontinuation","display_name":"treatment discontinuation","score":0.7929999828338623},{"id":"https://openalex.org/keywords/risks-and-benefits","display_name":"benefits and risks","score":0.8799999952316284},{"id":"https://openalex.org/keywords/antidepressant-efficacy","display_name":"antidepressant efficacy","score":0.6880000233650208}],"concepts":[{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.8083000183105469},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.803600013256073},{"id":"https://openalex.org/C2776466888","wikidata":"https://www.wikidata.org/wiki/Q898407","display_name":"Venlafaxine","level":4,"score":0.794700026512146},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.5827999711036682},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.5218999981880188},{"id":"https://openalex.org/C2779911313","wikidata":"https://www.wikidata.org/wiki/Q845224","display_name":"Generalized anxiety disorder","level":3,"score":0.5157999992370605},{"id":"https://openalex.org/C65409693","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Statistical significance","level":2,"score":0.5013999938964844},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.4968999922275543},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.4772999882698059},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.453900009393692},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.444599986076355},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4162999987602234},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.4156000018119812},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4072999954223633},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3684000074863434},{"id":"https://openalex.org/C2776317618","wikidata":"https://www.wikidata.org/wiki/Q544006","display_name":"Anxiety disorder","level":3,"score":0.3562999963760376},{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.35190001130104065},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3422999978065491},{"id":"https://openalex.org/C2777596629","wikidata":"https://www.wikidata.org/wiki/Q10858520","display_name":"Inclusion and exclusion criteria","level":3,"score":0.32899999618530273},{"id":"https://openalex.org/C2909532165","wikidata":"https://www.wikidata.org/wiki/Q898407","display_name":"Venlafaxine Hydrochloride","level":5,"score":0.31380000710487366},{"id":"https://openalex.org/C3018143278","wikidata":"https://www.wikidata.org/wiki/Q845224","display_name":"Generalized anxiety","level":3,"score":0.2770000100135803},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.2621999979019165},{"id":"https://openalex.org/C158154518","wikidata":"https://www.wikidata.org/wiki/Q7310970","display_name":"Relevance (law)","level":2,"score":0.2583000063896179},{"id":"https://openalex.org/C2991968784","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychiatry","level":2,"score":0.2533000111579895}],"mesh":[{"descriptor_ui":"D000068760","descriptor_name":"Serotonin and Noradrenaline Reuptake Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000068760","descriptor_name":"Serotonin and Noradrenaline Reuptake Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000069470","descriptor_name":"Venlafaxine Hydrochloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000069470","descriptor_name":"Venlafaxine Hydrochloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000092522","descriptor_name":"Clinical Relevance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000092522","descriptor_name":"Clinical Relevance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098647","descriptor_name":"Generalized Anxiety Disorder","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098647","descriptor_name":"Generalized Anxiety Disorder","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001008","descriptor_name":"Anxiety Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001008","descriptor_name":"Anxiety Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/pcn.13924","doi":"https://doi.org/10.1111/pcn.13924","is_oa":true,"landing_page_url":"https://doi.org/10.1111/pcn.13924","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/pcn.13924","source":{"id":"https://openalex.org/S111042112","display_name":"Psychiatry and Clinical Neurosciences","issn_l":"1323-1316","issn":["1323-1316","1440-1819"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychiatry and Clinical Neurosciences","raw_type":"journal-article"},{"id":"pmid:41255146","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41255146","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychiatry and clinical neurosciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/pcn.13924","doi":"https://doi.org/10.1111/pcn.13924","is_oa":true,"landing_page_url":"https://doi.org/10.1111/pcn.13924","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/pcn.13924","source":{"id":"https://openalex.org/S111042112","display_name":"Psychiatry and Clinical Neurosciences","issn_l":"1323-1316","issn":["1323-1316","1440-1819"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychiatry and Clinical Neurosciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416396238.pdf","grobid_xml":"https://content.openalex.org/works/W4416396238.grobid-xml"},"referenced_works_count":2,"referenced_works":["https://openalex.org/W3000661394","https://openalex.org/W4415408407"],"related_works":[],"abstract_inverted_index":{"A":[0],"randomized,":[1],"double-blinded,":[2],"placebo-controlled":[3],"study":[4],"by":[5],"Otsubo":[6],"et":[7],"al.":[8],"demonstrated":[9],"a":[10,48,73],"statistically":[11],"significant":[12],"effect":[13],"of":[14,25,36,41,51,61],"venlafaxine":[15,66],"in":[16],"patients":[17],"with":[18,43],"generalized":[19],"anxiety":[20],"disorder.":[21],"However,":[22],"the":[23,34,39,58,62],"magnitude":[24],"improvement":[26],"may":[27,71],"have":[28],"little":[29],"clinical":[30,59],"value.":[31],"Methodological":[32],"factors-including":[33],"exclusion":[35],"placebo":[37],"responders,":[38],"inclusion":[40],"participants":[42],"comorbid":[44],"depressive":[45],"disorders,":[46],"and":[47],"higher":[49],"rate":[50],"discontinuation":[52],"due":[53],"to":[54],"adverse":[55],"events-further":[56],"diminish":[57],"significance":[60],"findings.":[63],"Overall,":[64],"although":[65],"achieved":[67],"statistical":[68],"efficacy,":[69],"it":[70],"lack":[72],"clinically":[74],"meaningful":[75],"risk-benefit":[76],"balance.":[77]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-11-19T00:00:00"}