{"id":"https://openalex.org/W4416396126","doi":"https://doi.org/10.36922/ijb025410415","title":"Electrohydrodynamically printed microfibrous scaffolds with different pore sizes regulate macrophage polarization and foreign body reaction to enhance bone regeneration","display_name":"Electrohydrodynamically printed microfibrous scaffolds with different pore sizes regulate macrophage polarization and foreign body reaction to enhance bone regeneration","publication_year":2025,"publication_date":"2025-11-19","ids":{"openalex":"https://openalex.org/W4416396126","doi":"https://doi.org/10.36922/ijb025410415"},"language":"en","primary_location":{"id":"doi:10.36922/ijb025410415","doi":"https://doi.org/10.36922/ijb025410415","is_oa":true,"landing_page_url":"https://doi.org/10.36922/ijb025410415","pdf_url":null,"source":{"id":"https://openalex.org/S4210170791","display_name":"International Journal of Bioprinting","issn_l":"2424-8002","issn":["2424-8002","2424-7723"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","poland-40","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Bioprinting","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.36922/ijb025410415","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082591321","display_name":"Junzheng Liu","orcid":"https://orcid.org/0009-0002-5784-0222","observed_orcids":["https://orcid.org/0009-0002-5784-0222"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Junzheng Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012834870","display_name":"Zijie Meng","orcid":"https://orcid.org/0000-0002-5375-5162","observed_orcids":["https://orcid.org/0000-0002-5375-5162","https://orcid.org/0009-0008-0973-332X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zijie Meng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101759009","display_name":"Jiaming Yu","orcid":"https://orcid.org/0009-0009-9613-3716","observed_orcids":["https://orcid.org/0009-0009-9613-3716"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiaming Yu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101810109","display_name":"Qin Guo","orcid":"https://orcid.org/0000-0001-5319-3510","observed_orcids":["https://orcid.org/0000-0001-5319-3510"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qin Guo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016712210","display_name":"Jiahao Zhang","orcid":"https://orcid.org/0000-0002-4008-5905","observed_orcids":["https://orcid.org/0000-0002-4008-5905","https://orcid.org/0000-0002-6552-5786"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiahao Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Yulin Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yulin Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103139081","display_name":"Le Jia","orcid":"https://orcid.org/0000-0002-1655-9816","observed_orcids":["https://orcid.org/0000-0002-1655-9816"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Le Jia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031332659","display_name":"Jiankang He","orcid":"https://orcid.org/0000-0002-9386-5833","observed_orcids":["https://orcid.org/0000-0002-9386-5833"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jiankang He","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5118969723","display_name":"Wei Wang","orcid":"https://orcid.org/0000-0002-2281-8706","observed_orcids":["https://orcid.org/0000-0002-2281-8706"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Wei Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5031332659","https://openalex.org/A5118969723"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2029,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.33064219,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"0","issue":"0","first_page":"025410415","last_page":"025410415"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/electrohydrodynamic-printing","display_name":"electrohydrodynamic printing","score":0.9200000166893005},{"id":"https://openalex.org/keywords/polycaprolactone-scaffolds","display_name":"polycaprolactone scaffolds","score":0.9520000219345093},{"id":"https://openalex.org/keywords/pore-size","display_name":"pore size","score":0.8389999866485596},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.8939999938011169},{"id":"https://openalex.org/keywords/m2-macrophages","display_name":"M2 macrophages","score":0.8009999990463257},{"id":"https://openalex.org/keywords/foreign-body-reaction","display_name":"foreign body reaction","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.9599999785423279},{"id":"https://openalex.org/keywords/osseointegration","display_name":"osseointegration","score":0.8970000147819519},{"id":"https://openalex.org/keywords/piezo1","display_name":"Piezo1","score":0.7319999933242798},{"id":"https://openalex.org/keywords/scaffold-stiffness","display_name":"scaffold stiffness","score":0.9010000228881836},{"id":"https://openalex.org/keywords/fibrous-capsule","display_name":"fibrous capsule","score":0.7260000109672546},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8289999961853027},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.9929999709129333},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.8289999961853027},{"id":"https://openalex.org/keywords/bone-defect-reconstruction","display_name":"bone defect repair","score":0.8859999775886536}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7369999885559082},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.6847000122070312},{"id":"https://openalex.org/C2776682551","wikidata":"https://www.wikidata.org/wiki/Q21072584","display_name":"Macrophage polarization","level":4,"score":0.6650000214576721},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6467000246047974},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5327000021934509},{"id":"https://openalex.org/C2778778583","wikidata":"https://www.wikidata.org/wiki/Q147768","display_name":"Capsule","level":2,"score":0.5037000179290771},{"id":"https://openalex.org/C2779868350","wikidata":"https://www.wikidata.org/wiki/Q109674","display_name":"Polycaprolactone","level":3,"score":0.48809999227523804},{"id":"https://openalex.org/C101414908","wikidata":"https://www.wikidata.org/wiki/Q1541818","display_name":"Osseointegration","level":3,"score":0.4603999853134155},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4546999931335449},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.4408999979496002},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4106999933719635},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4068000018596649},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.4034000039100647},{"id":"https://openalex.org/C108657112","wikidata":"https://www.wikidata.org/wiki/Q3332118","display_name":"Foreign-body giant cell","level":2,"score":0.3840999901294708},{"id":"https://openalex.org/C8337478","wikidata":"https://www.wikidata.org/wiki/Q1777289","display_name":"Bone healing","level":2,"score":0.35359999537467957},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.33719998598098755},{"id":"https://openalex.org/C2778606738","wikidata":"https://www.wikidata.org/wiki/Q265868","display_name":"Bone tissue","level":2,"score":0.32269999384880066},{"id":"https://openalex.org/C30352789","wikidata":"https://www.wikidata.org/wiki/Q14903153","display_name":"Bone morphogenetic protein 2","level":3,"score":0.2985999882221222},{"id":"https://openalex.org/C41868710","wikidata":"https://www.wikidata.org/wiki/Q540092","display_name":"Periodontal fiber","level":2,"score":0.2946000099182129},{"id":"https://openalex.org/C175369904","wikidata":"https://www.wikidata.org/wiki/Q208395","display_name":"Spheroid","level":3,"score":0.2711000144481659},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.2700999975204468},{"id":"https://openalex.org/C2910375186","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"M2 Macrophage","level":4,"score":0.2653999924659729},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.26269999146461487},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2556999921798706},{"id":"https://openalex.org/C2993291840","wikidata":"https://www.wikidata.org/wiki/Q1121544","display_name":"Bone formation","level":2,"score":0.2508000135421753}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.36922/ijb025410415","doi":"https://doi.org/10.36922/ijb025410415","is_oa":true,"landing_page_url":"https://doi.org/10.36922/ijb025410415","pdf_url":null,"source":{"id":"https://openalex.org/S4210170791","display_name":"International Journal of Bioprinting","issn_l":"2424-8002","issn":["2424-8002","2424-7723"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","poland-40","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Bioprinting","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.36922/ijb025410415","doi":"https://doi.org/10.36922/ijb025410415","is_oa":true,"landing_page_url":"https://doi.org/10.36922/ijb025410415","pdf_url":null,"source":{"id":"https://openalex.org/S4210170791","display_name":"International Journal of Bioprinting","issn_l":"2424-8002","issn":["2424-8002","2424-7723"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","poland-40","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Bioprinting","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4225272163","https://openalex.org/W4378376618","https://openalex.org/W4392281315","https://openalex.org/W7126195769","https://openalex.org/W2070438219","https://openalex.org/W4212937643","https://openalex.org/W3048093952","https://openalex.org/W2943906508","https://openalex.org/W2066288600","https://openalex.org/W3183554099"],"abstract_inverted_index":{"Foreign":[0],"body":[1],"reaction":[2],"(FBR)":[3],"is":[4,20],"a":[5,21,199],"major":[6],"obstacle":[7],"to":[8,58,90,155],"effective":[9],"osseointegration":[10],"in":[11,35,111,128,208],"bone":[12,67,169,173,177,189,209],"defect":[13,210],"repair.":[14,211],"The":[15],"pore":[16,46,125],"size":[17],"of":[18,24,48,81],"scaffolds":[19,44,187],"key":[22],"determinant":[23],"FBR;":[25],"however,":[26],"its":[27],"impact":[28],"on":[29,62],"FBR":[30],"remains":[31],"controversial,":[32],"with":[33,45,171],"limited":[34],"vivo":[36,138],"evidence.":[37],"In":[38,69,137],"this":[39],"study,":[40],"electrohydrodynamic-printed":[41],"polycaprolactone":[42],"(PCL)":[43],"sizes":[47],"100":[49,92,157],"\u03bcm,":[50,52],"200":[51,160],"and":[53,66,87,94,98,103,120,152,159,166,176,195,205],"300":[54,75,143,184],"\u03bcm":[55,76,93,144,158,161,185],"were":[56],"fabricated":[57],"investigate":[59],"their":[60],"effects":[61],"macrophage":[63,135,193],"polarization,":[64],"FBR,":[65,197],"regeneration.":[68],"vitro":[70],"experiments":[71,139],"showed":[72,140],"that":[73,124,141,183],"the":[74,91,142,147,156],"group":[77,145],"promoted":[78],"M2":[79],"polarization":[80,194],"macrophages,":[82],"reduced":[83],"TNF-\u03b1":[84],"expression":[85,101,110],"(0.71-":[86],"0.81-fold":[88],"compared":[89,154],"200\u03bcm":[95],"groups,":[96,162],"respectively),":[97,105,163],"increased":[99,172],"TGF-\u03b21":[100],"(1.39-":[102],"1.19-fold,":[104],"thereby":[106],"enhancing":[107],"osteogenic":[108],"gene":[109],"MC3T3-E1":[112],"cells":[113],"(Runx2,":[114],"COL-I,":[115],"OCN).":[116],"Finite":[117],"element":[118],"analysis":[119],"transcriptomics":[121],"sequencing":[122],"revealed":[123],"size-dependent":[126],"changes":[127],"scaffold":[129,203],"stiffness":[130],"modulate":[131],"Piezo1":[132],"activation,":[133],"influencing":[134],"polarization.":[136],"exhibited":[146],"thinnest":[148],"fibrous":[149],"capsule":[150],"(0.78-":[151],"0.79-fold":[153],"enhanced":[164],"angiogenesis,":[165],"achieved":[167],"better":[168],"regeneration,":[170],"volume/total":[174],"volume":[175],"mineral":[178],"density.":[179],"These":[180],"findings":[181],"indicate":[182],"pore-sized":[186],"promote":[188],"regeneration":[190],"by":[191],"modulating":[192],"attenuating":[196],"providing":[198],"basis":[200],"for":[201],"optimized":[202],"design":[204],"clinical":[206],"translation":[207]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2025-11-19T00:00:00"}