{"id":"https://openalex.org/W4416354580","doi":"https://doi.org/10.2174/0113892002395979251015105103","title":"A Systematic Review of Pharmacokinetic Models of Vancomycin in Adult Patients (2020-2024): Trends, Variability, and Key Covariates","display_name":"A Systematic Review of Pharmacokinetic Models of Vancomycin in Adult Patients (2020-2024): Trends, Variability, and Key Covariates","publication_year":2025,"publication_date":"2025-11-19","ids":{"openalex":"https://openalex.org/W4416354580","doi":"https://doi.org/10.2174/0113892002395979251015105103","pmid":"https://pubmed.ncbi.nlm.nih.gov/41255361","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13223505"},"language":"en","primary_location":{"id":"doi:10.2174/0113892002395979251015105103","doi":"https://doi.org/10.2174/0113892002395979251015105103","is_oa":true,"landing_page_url":"https://doi.org/10.2174/0113892002395979251015105103","pdf_url":null,"source":{"id":"https://openalex.org/S195680726","display_name":"Current Drug Metabolism","issn_l":"1389-2002","issn":["1389-2002","1875-5453"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Metabolism","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.2174/0113892002395979251015105103","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114030052","display_name":"Raquel Fresquet","orcid":"https://orcid.org/0000-0001-7945-1215","observed_orcids":["https://orcid.org/0000-0001-7945-1215"]},"institutions":[{"id":"https://openalex.org/I4210136512","display_name":"Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n","ror":"https://ror.org/03njn4610","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210136512"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Raquel Fresquet-Molina","raw_affiliation_strings":["Grupo de Investigaci\u00f3n de Farmacia Hospitalaria (GIFARH), Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n, Zaragoza, Spain","Primary Care Pharmacy Unit, Terres de l'Ebre Primary Care Department, Tortosa, Spain"],"raw_orcid":"https://orcid.org/0000-0001-7945-1215","affiliations":[{"raw_affiliation_string":"Grupo de Investigaci\u00f3n de Farmacia Hospitalaria (GIFARH), Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n, Zaragoza, Spain","institution_ids":["https://openalex.org/I4210136512"]},{"raw_affiliation_string":"Primary Care Pharmacy Unit, Terres de l'Ebre Primary Care Department, Tortosa, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082216089","display_name":"Mar\u00eda \u00c1ngeles Allende-Bandr\u00e9s","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135032","display_name":"Hospital Cl\u00ednico Universitario Lozano Blesa","ror":"https://ror.org/03fyv3102","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135032"]},{"id":"https://openalex.org/I4210136512","display_name":"Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n","ror":"https://ror.org/03njn4610","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210136512"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Maria de los Angeles Allende-Bandres","raw_affiliation_strings":["Grupo de Investigaci\u00f3n Cl\u00ednica en Enfermedades Infecciosas, Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n, Zaragoza, Spain","Pharmacy Department, Hospital Cl\u00ednico Universitario Lozano Blesa, Zaragoza, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grupo de Investigaci\u00f3n Cl\u00ednica en Enfermedades Infecciosas, Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n, Zaragoza, Spain","institution_ids":["https://openalex.org/I4210136512"]},{"raw_affiliation_string":"Pharmacy Department, Hospital Cl\u00ednico Universitario Lozano Blesa, Zaragoza, Spain","institution_ids":["https://openalex.org/I4210135032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108391643","display_name":"MERCEDES ARENERE MENDOZA","orcid":"https://orcid.org/0000-0002-2508-8585","observed_orcids":["https://orcid.org/0000-0002-2508-8585"]},"institutions":[{"id":"https://openalex.org/I4210135032","display_name":"Hospital Cl\u00ednico Universitario Lozano Blesa","ror":"https://ror.org/03fyv3102","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135032"]},{"id":"https://openalex.org/I4210136512","display_name":"Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n","ror":"https://ror.org/03njn4610","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210136512"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Mercedes Arenere-Mendoza","raw_affiliation_strings":["Grupo de Investigaci\u00f3n de Farmacia Hospitalaria (GIFARH), Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n, Zaragoza, Spain","Pharmacy Department, Hospital Cl\u00ednico Universitario Lozano Blesa, Zaragoza, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grupo de Investigaci\u00f3n de Farmacia Hospitalaria (GIFARH), Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n, Zaragoza, Spain","institution_ids":["https://openalex.org/I4210136512"]},{"raw_affiliation_string":"Pharmacy Department, Hospital Cl\u00ednico Universitario Lozano Blesa, Zaragoza, Spain","institution_ids":["https://openalex.org/I4210135032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108326144","display_name":"Luc\u00eda Sopena Carrera","orcid":"https://orcid.org/0000-0002-4382-6588","observed_orcids":["https://orcid.org/0000-0002-4382-6588"]},"institutions":[{"id":"https://openalex.org/I4210135032","display_name":"Hospital Cl\u00ednico Universitario Lozano Blesa","ror":"https://ror.org/03fyv3102","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135032"]},{"id":"https://openalex.org/I4210136512","display_name":"Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n","ror":"https://ror.org/03njn4610","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210136512"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Lucia Sopena-Carrera","raw_affiliation_strings":["Grupo de Investigaci\u00f3n de Farmacia Hospitalaria (GIFARH), Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n, Zaragoza, Spain","Pharmacy Department, Hospital Cl\u00ednico Universitario Lozano Blesa, Zaragoza, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grupo de Investigaci\u00f3n de Farmacia Hospitalaria (GIFARH), Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n, Zaragoza, Spain","institution_ids":["https://openalex.org/I4210136512"]},{"raw_affiliation_string":"Pharmacy Department, Hospital Cl\u00ednico Universitario Lozano Blesa, Zaragoza, Spain","institution_ids":["https://openalex.org/I4210135032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001833330","display_name":"Irene Navarro Pardo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135032","display_name":"Hospital Cl\u00ednico Universitario Lozano Blesa","ror":"https://ror.org/03fyv3102","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135032"]},{"id":"https://openalex.org/I4210136512","display_name":"Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n","ror":"https://ror.org/03njn4610","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210136512"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Irene Navarro-Pardo","raw_affiliation_strings":["Grupo de Investigaci\u00f3n de Farmacia Hospitalaria (GIFARH), Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n, Zaragoza, Spain","Pharmacy Department, Hospital Cl\u00ednico Universitario Lozano Blesa, Zaragoza, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grupo de Investigaci\u00f3n de Farmacia Hospitalaria (GIFARH), Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n, Zaragoza, Spain","institution_ids":["https://openalex.org/I4210136512"]},{"raw_affiliation_string":"Pharmacy Department, Hospital Cl\u00ednico Universitario Lozano Blesa, Zaragoza, Spain","institution_ids":["https://openalex.org/I4210135032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011095450","display_name":"\u00c1ngela Jimeno-Mart\u00edn","orcid":"https://orcid.org/0000-0003-4623-5529","observed_orcids":["https://orcid.org/0000-0003-4623-5529"]},"institutions":[{"id":"https://openalex.org/I4210121238","display_name":"Universidad San Jorge","ror":"https://ror.org/01wbg2c90","country_code":"ES","type":"education","lineage":["https://openalex.org/I4210121238"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Angela Jimeno-Martin","raw_affiliation_strings":["Faculty of Health Science, San Jorge University, Zaragoza, Spain","Universidad San Jorge Faculty of Health Science Zaragoza Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health Science, San Jorge University, Zaragoza, Spain","institution_ids":["https://openalex.org/I4210121238"]},{"raw_affiliation_string":"Universidad San Jorge Faculty of Health Science Zaragoza Spain","institution_ids":["https://openalex.org/I4210121238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008914544","display_name":"T Salvador G\u00f3mez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135032","display_name":"Hospital Cl\u00ednico Universitario Lozano Blesa","ror":"https://ror.org/03fyv3102","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135032"]},{"id":"https://openalex.org/I4210136512","display_name":"Instituto de Investigaci\u00f3n Sanitaria Arag\u00f3n","ror":"https://ror.org/03njn4610","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210136512"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Transito Salvador-Gomez","raw_affiliation_strings":["Grupo de Investigaci\u00f3n de Farmacia Hospitalaria (GIFARH), Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n, Zaragoza, Spain","Pharmacy Department, Hospital Cl\u00ednico Universitario Lozano Blesa, Zaragoza, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Grupo de Investigaci\u00f3n de Farmacia Hospitalaria (GIFARH), Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n, Zaragoza, Spain","institution_ids":["https://openalex.org/I4210136512"]},{"raw_affiliation_string":"Pharmacy Department, Hospital Cl\u00ednico Universitario Lozano Blesa, Zaragoza, Spain","institution_ids":["https://openalex.org/I4210135032"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073102709","display_name":"Manuel G\u00f3mez-Barrera","orcid":"https://orcid.org/0000-0001-8357-1279","observed_orcids":["https://orcid.org/0000-0001-8357-1279"]},"institutions":[{"id":"https://openalex.org/I4210121238","display_name":"Universidad San Jorge","ror":"https://ror.org/01wbg2c90","country_code":"ES","type":"education","lineage":["https://openalex.org/I4210121238"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Manuel Gomez-Barrera","raw_affiliation_strings":["Faculty of Health Science, San Jorge University, Zaragoza, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health Science, San Jorge University, Zaragoza, Spain","institution_ids":["https://openalex.org/I4210121238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120604177","display_name":"Loreto S\u00e1ez-Benito-Suescun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121238","display_name":"Universidad San Jorge","ror":"https://ror.org/01wbg2c90","country_code":"ES","type":"education","lineage":["https://openalex.org/I4210121238"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Loreto S\u00e1ez-Benito-Suescun","raw_affiliation_strings":["Faculty of Health Science, San Jorge University, Zaragoza, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health Science, San Jorge University, Zaragoza, Spain","institution_ids":["https://openalex.org/I4210121238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087280257","display_name":"Nuria Berenguer Torrijo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121238","display_name":"Universidad San Jorge","ror":"https://ror.org/01wbg2c90","country_code":"ES","type":"education","lineage":["https://openalex.org/I4210121238"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Nuria Berenguer-Torrijo","raw_affiliation_strings":["Faculty of Health Science, San Jorge University, Zaragoza, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health Science, San Jorge University, Zaragoza, Spain","institution_ids":["https://openalex.org/I4210121238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5108391643"],"corresponding_institution_ids":["https://openalex.org/I4210135032","https://openalex.org/I4210136512"],"apc_list":null,"apc_paid":null,"fwci":0.3865,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.38287638,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"26","issue":"10","first_page":"698","last_page":"713"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vancomycin","display_name":"vancomycin","score":0.9900000095367432},{"id":"https://openalex.org/keywords/pharmacokinetic-modeling","display_name":"pharmacokinetic modeling","score":0.9629999995231628},{"id":"https://openalex.org/keywords/vancomycin-clearance","display_name":"vancomycin clearance","score":0.7480000257492065},{"id":"https://openalex.org/keywords/volume-of-distribution","display_name":"volume of distribution","score":0.949999988079071},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.925000011920929},{"id":"https://openalex.org/keywords/covariates","display_name":"covariates","score":0.8889999985694885},{"id":"https://openalex.org/keywords/creatinine-clearance","display_name":"creatinine clearance","score":0.8460000157356262},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.7699999809265137},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.5260000228881836},{"id":"https://openalex.org/keywords/continuous-renal-replacement-therapy","display_name":"continuous renal replacement therapy","score":0.9739999771118164},{"id":"https://openalex.org/keywords/intensive-care-unit-patients","display_name":"intensive care unit patients","score":0.8420000076293945},{"id":"https://openalex.org/keywords/individualized-dosing","display_name":"individualized dosing","score":0.8040000200271606},{"id":"https://openalex.org/keywords/model-validation","display_name":"model validation","score":0.5950000286102295},{"id":"https://openalex.org/keywords/hospitalized-adults","display_name":"hospitalized adults","score":0.5239999890327454}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7962999939918518},{"id":"https://openalex.org/C2778980435","wikidata":"https://www.wikidata.org/wiki/Q424027","display_name":"Vancomycin","level":4,"score":0.7315000295639038},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6833999752998352},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.6251000165939331},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.515999972820282},{"id":"https://openalex.org/C119043178","wikidata":"https://www.wikidata.org/wiki/Q320723","display_name":"Covariate","level":2,"score":0.5138000249862671},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3522999882698059},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.3183000087738037},{"id":"https://openalex.org/C185867374","wikidata":"https://www.wikidata.org/wiki/Q2562769","display_name":"Physiologically based pharmacokinetic modelling","level":3,"score":0.3050999939441681},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29750001430511475}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.2174/0113892002395979251015105103","doi":"https://doi.org/10.2174/0113892002395979251015105103","is_oa":true,"landing_page_url":"https://doi.org/10.2174/0113892002395979251015105103","pdf_url":null,"source":{"id":"https://openalex.org/S195680726","display_name":"Current Drug Metabolism","issn_l":"1389-2002","issn":["1389-2002","1875-5453"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Metabolism","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13223505","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13223505/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13223505/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Curr Drug Metab","raw_type":"Text"},{"id":"pmid:41255361","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41255361","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current drug metabolism","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.2174/0113892002395979251015105103","doi":"https://doi.org/10.2174/0113892002395979251015105103","is_oa":true,"landing_page_url":"https://doi.org/10.2174/0113892002395979251015105103","pdf_url":null,"source":{"id":"https://openalex.org/S195680726","display_name":"Current Drug Metabolism","issn_l":"1389-2002","issn":["1389-2002","1875-5453"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320308970","display_name":"Teva Pharmaceutical Industries","ror":"https://ror.org/01wfv3m53"},{"id":"https://openalex.org/F4320326208","display_name":"Gobierno de Arag\u00f3n","ror":"https://ror.org/0425pg203"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416354580.pdf","grobid_xml":"https://content.openalex.org/works/W4416354580.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1572855016","https://openalex.org/W1908342561","https://openalex.org/W1973677540","https://openalex.org/W2013678400","https://openalex.org/W2057605178","https://openalex.org/W2075534444","https://openalex.org/W2108039951","https://openalex.org/W2109178387","https://openalex.org/W2112712899","https://openalex.org/W2113030904","https://openalex.org/W2123859227","https://openalex.org/W2135206411","https://openalex.org/W2137476069","https://openalex.org/W2329641396","https://openalex.org/W2483833577","https://openalex.org/W2523033125","https://openalex.org/W2774974184","https://openalex.org/W2776411442","https://openalex.org/W2908393285","https://openalex.org/W2922330424","https://openalex.org/W2954939294","https://openalex.org/W2971302917","https://openalex.org/W2972004072","https://openalex.org/W2988389972","https://openalex.org/W3000300367","https://openalex.org/W3000435574","https://openalex.org/W3004945196","https://openalex.org/W3012260518","https://openalex.org/W3032867519","https://openalex.org/W3035029052","https://openalex.org/W3087468117","https://openalex.org/W3093561727","https://openalex.org/W3103735613","https://openalex.org/W3110197461","https://openalex.org/W3122257426","https://openalex.org/W3137613403","https://openalex.org/W3202015716","https://openalex.org/W3205132184","https://openalex.org/W3205143970","https://openalex.org/W3206487859","https://openalex.org/W3213058724","https://openalex.org/W4211003757","https://openalex.org/W4213330092","https://openalex.org/W4281744628","https://openalex.org/W4285045417","https://openalex.org/W4297236361","https://openalex.org/W4317780651","https://openalex.org/W4318474015","https://openalex.org/W4389435472","https://openalex.org/W4390893275"],"related_works":["https://openalex.org/W4402075328","https://openalex.org/W3004945196","https://openalex.org/W2088521100","https://openalex.org/W7214207661","https://openalex.org/W3205056750","https://openalex.org/W3161390137","https://openalex.org/W4383337606","https://openalex.org/W7099655614","https://openalex.org/W7161003607","https://openalex.org/W2329641396"],"abstract_inverted_index":{"INTRODUCTION:":[0],"This":[1,277],"systematic":[2],"review":[3,278],"aimed":[4],"to":[5,250,284,293,312],"identify,":[6],"evaluate,":[7],"and":[8,21,25,48,57,97,111,118,147,163,200,209,225,270,290],"critically":[9],"an-alyze":[10],"pharmacokinetic":[11,90,310],"models":[12,36,52,85,257,286,311],"of":[13,43,78,99,155,181,207,221,236,242,267,306,316],"vancomycin":[14,94,134,296],"in":[15,19,41,55,64,89,121,143,160,179,188,260,272,287,298],"adult":[16],"populations":[17],"published":[18],"PubMed":[20],"EMBASE":[22],"between":[23],"2020":[24],"2024.":[26],"MATERIALS":[27],"AND":[28],"METHODS:":[29],"Twenty-two":[30],"studies":[31],"were":[32,53,73],"included,":[33],"describing":[34],"24":[35],"character-ized":[37],"by":[38,103],"substantial":[39,231],"heterogeneity":[40,127,214],"terms":[42],"study":[44,238],"populations,":[45,245],"methodological":[46],"design,":[47],"covariate":[49],"selection.":[50],"Most":[51],"developed":[54],"Asia":[56],"focused":[58],"on":[59,116],"hospitalized":[60],"patients,":[61,146],"particularly":[62],"those":[63,148,164],"intensive":[65],"care":[66],"units":[67],"(ICUs).":[68],"Data":[69],"from":[70],"2150":[71],"patients":[72,80,162],"analyzed,":[74],"with":[75,139,149,218],"an":[76],"average":[77,133],"93":[79],"per":[81],"model.":[82],"RESULTS:":[83],"The":[84,113,132,153,205,234,300],"demonstrated":[86],"high":[87,126,213],"variability":[88,120,159],"parameters,":[91],"such":[92,105,263],"as":[93,106,175,264],"clearance":[95,117,122,135,171],"(Cl)":[96],"volume":[98],"distribution":[100,156],"(Vd),":[101],"influenced":[102],"factors,":[104],"renal":[107,151,167],"function,":[108],"weight,":[109],"age,":[110,194],"comorbidities.":[112],"meta-analysis":[114,206],"conducted":[115],"interindividual":[119],"(IIV":[123],"Cl)":[124],"revealed":[125],"among":[128,215],"the":[129,182,201,216,240,243,252,256,265,282,304,313],"ana-lyzed":[130],"studies.":[131],"was":[136,173,186],"4.23":[137],"L/h,":[138],"higher":[140],"values":[141,220],"observed":[142],"neurosurgical,":[144],"oncohematologic":[145],"increased":[150],"function.":[152],"vol-ume":[154],"showed":[157,212,258],"greater":[158],"obese":[161],"undergoing":[165],"continu-ous":[166],"replacement":[168],"therapy.":[169],"Creatinine":[170],"(ClCr)":[172],"identified":[174],"a":[176],"significant":[177,187],"co-variate":[178],"66%":[180],"models,":[183],"while":[184],"weight":[185],"33%.":[189],"Other":[190],"important":[191],"covariates":[192],"included":[193,239],"sex,":[195],"serum":[196,198],"creatinine,":[197],"urea,":[199],"hospital":[202,318],"admission":[203],"unit.":[204],"Cl":[208,211,224],"IIV":[210,228],"studies,":[217],"I\u00b2":[219],"0.83":[222],"for":[223,227],"0.98":[226],"Cl,":[229],"indicating":[230],"variability.":[232],"DISCUSSION:":[233],"limitations":[235],"this":[237],"diversity":[241],"analyzed":[244],"which":[246],"made":[247],"it":[248],"challenging":[249],"assess":[251],"model's":[253],"suitability.":[254],"While":[255],"advances":[259],"precision,":[261],"challenges,":[262],"lack":[266],"external":[268],"validation":[269],"discrepancies":[271],"dosing":[273],"recommendations,":[274],"remain.":[275],"CONCLUSION:":[276],"paper":[279],"has":[280],"highlighted":[281,303],"need":[283],"validate":[285],"diverse":[288],"popula-tions":[289],"clinical":[291],"settings":[292],"optimize":[294],"personalized":[295],"therapy":[297],"adults.":[299],"findings":[301],"have":[302],"importance":[305],"validating":[307],"or":[308],"adapting":[309],"spe-cific":[314],"characteristics":[315],"each":[317],"population.":[319]},"counts_by_year":[{"year":2026,"cited_by_count":4}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2025-11-19T00:00:00"}