{"id":"https://openalex.org/W4416295667","doi":"https://doi.org/10.3390/ijms262211118","title":"The Involvement of Ceramide, Sphingosine-1-Phosphate and Ganglioside GM1 in Regulating Some Nervous System Functions","display_name":"The Involvement of Ceramide, Sphingosine-1-Phosphate and Ganglioside GM1 in Regulating Some Nervous System Functions","publication_year":2025,"publication_date":"2025-11-17","ids":{"openalex":"https://openalex.org/W4416295667","doi":"https://doi.org/10.3390/ijms262211118","pmid":"https://pubmed.ncbi.nlm.nih.gov/41303601","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12652369"},"language":"en","primary_location":{"id":"doi:10.3390/ijms262211118","doi":"https://doi.org/10.3390/ijms262211118","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms262211118","pdf_url":"https://www.mdpi.com/1422-0067/26/22/11118/pdf?version=1763391991","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/26/22/11118/pdf?version=1763391991","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031903259","display_name":"Paola Giussani","orcid":"https://orcid.org/0000-0002-7793-1757","observed_orcids":["https://orcid.org/0000-0002-7793-1757"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Paola Giussani","raw_affiliation_strings":["Department of Medical Biotechnology and Translational Medicine, Universit\u00e0 degli Studi di Milano, LITA Segrate, Via Fratelli Cervi, 93, 20054 Segrate, Italy"],"raw_orcid":"https://orcid.org/0000-0002-7793-1757","affiliations":[{"raw_affiliation_string":"Department of Medical Biotechnology and Translational Medicine, Universit\u00e0 degli Studi di Milano, LITA Segrate, Via Fratelli Cervi, 93, 20054 Segrate, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081743465","display_name":"Laura Mauri","orcid":"https://orcid.org/0000-0002-4194-4804","observed_orcids":["https://orcid.org/0000-0002-4194-4804","https://orcid.org/0009-0005-9781-5357"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Laura Mauri","raw_affiliation_strings":["Department of Medical Biotechnology and Translational Medicine, Universit\u00e0 degli Studi di Milano, LITA Segrate, Via Fratelli Cervi, 93, 20054 Segrate, Italy"],"raw_orcid":"https://orcid.org/0000-0002-4194-4804","affiliations":[{"raw_affiliation_string":"Department of Medical Biotechnology and Translational Medicine, Universit\u00e0 degli Studi di Milano, LITA Segrate, Via Fratelli Cervi, 93, 20054 Segrate, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035014869","display_name":"Sandro Sonnino","orcid":"https://orcid.org/0000-0001-8180-5908","observed_orcids":["https://orcid.org/0000-0001-8180-5908"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sandro Sonnino","raw_affiliation_strings":["Department of Medical Biotechnology and Translational Medicine, Universit\u00e0 degli Studi di Milano, LITA Segrate, Via Fratelli Cervi, 93, 20054 Segrate, Italy"],"raw_orcid":"https://orcid.org/0000-0001-8180-5908","affiliations":[{"raw_affiliation_string":"Department of Medical Biotechnology and Translational Medicine, Universit\u00e0 degli Studi di Milano, LITA Segrate, Via Fratelli Cervi, 93, 20054 Segrate, Italy","institution_ids":["https://openalex.org/I189158943"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5031903259"],"corresponding_institution_ids":["https://openalex.org/I189158943"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.4089,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.4287036,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"26","issue":"22","first_page":"11118","last_page":"11118"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sphingolipids","display_name":"sphingolipids","score":0.8949999809265137},{"id":"https://openalex.org/keywords/ceramide","display_name":"ceramide","score":0.9890000224113464},{"id":"https://openalex.org/keywords/sphingosine-1-phosphate","display_name":"sphingosine-1-phosphate","score":1.0},{"id":"https://openalex.org/keywords/gm1-ganglioside","display_name":"GM1 ganglioside","score":0.9319999814033508},{"id":"https://openalex.org/keywords/sphingolipid-metabolism","display_name":"sphingolipid metabolism","score":0.9470000267028809},{"id":"https://openalex.org/keywords/nervous-system","display_name":"nervous system","score":0.6620000004768372},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.8640000224113464},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9259999990463257},{"id":"https://openalex.org/keywords/neurotrophic-factors","display_name":"neurotrophic factors","score":0.6859999895095825},{"id":"https://openalex.org/keywords/neuronal-signaling","display_name":"neuronal signaling","score":0.6010000109672546},{"id":"https://openalex.org/keywords/glia","display_name":"glia","score":0.6639999747276306},{"id":"https://openalex.org/keywords/cell-surface-receptors","display_name":"cell surface receptors","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C61705674","wikidata":"https://www.wikidata.org/wiki/Q410395","display_name":"Sphingolipid","level":2,"score":0.9562000036239624},{"id":"https://openalex.org/C2777851122","wikidata":"https://www.wikidata.org/wiki/Q424213","display_name":"Ceramide","level":3,"score":0.6722000241279602},{"id":"https://openalex.org/C545706735","wikidata":"https://www.wikidata.org/wiki/Q9404","display_name":"Nervous system","level":2,"score":0.6315000057220459},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.5788999795913696},{"id":"https://openalex.org/C2777331542","wikidata":"https://www.wikidata.org/wiki/Q419287","display_name":"Ganglioside","level":2,"score":0.5618000030517578},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5543000102043152},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.5483999848365784},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5483999848365784},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4596000015735626},{"id":"https://openalex.org/C92020748","wikidata":"https://www.wikidata.org/wiki/Q420457","display_name":"Neurotrophin","level":3,"score":0.450300008058548},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.43650001287460327},{"id":"https://openalex.org/C545314008","wikidata":"https://www.wikidata.org/wiki/Q169953","display_name":"Peripheral nervous system","level":3,"score":0.39430001378059387},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.37290000915527344},{"id":"https://openalex.org/C180899940","wikidata":"https://www.wikidata.org/wiki/Q117982","display_name":"Lipid signaling","level":3,"score":0.3140999972820282},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.2838999927043915},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.27559998631477356},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.2750000059604645},{"id":"https://openalex.org/C2778703144","wikidata":"https://www.wikidata.org/wiki/Q46298","display_name":"Sphingosine","level":3,"score":0.26260000467300415}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002518","descriptor_name":"Ceramides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005677","descriptor_name":"G(M1) Ganglioside","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008246","descriptor_name":"Lysophospholipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009420","descriptor_name":"Nervous System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms262211118","doi":"https://doi.org/10.3390/ijms262211118","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms262211118","pdf_url":"https://www.mdpi.com/1422-0067/26/22/11118/pdf?version=1763391991","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmid:41303601","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41303601","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:air.unimi.it:2434/1205652","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2434/1205652","pdf_url":"https://air.unimi.it/bitstream/2434/1205652/2/ijms-26-11118.pdf","source":{"id":"https://openalex.org/S4306400516","display_name":"Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I189158943","host_organization_name":"University of Milan","host_organization_lineage":["https://openalex.org/I189158943"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3390/ijms262211118","doi":"https://doi.org/10.3390/ijms262211118","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms262211118","pdf_url":"https://www.mdpi.com/1422-0067/26/22/11118/pdf?version=1763391991","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9074000120162964}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320313475","display_name":"Universit\u00e0 degli Studi di Milano","ror":"https://ror.org/00wjc7c48"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416295667.pdf","grobid_xml":"https://content.openalex.org/works/W4416295667.grobid-xml"},"referenced_works_count":209,"referenced_works":["https://openalex.org/W157208926","https://openalex.org/W161101349","https://openalex.org/W379467690","https://openalex.org/W953673925","https://openalex.org/W1237068170","https://openalex.org/W1256777839","https://openalex.org/W1484441747","https://openalex.org/W1513792874","https://openalex.org/W1515018148","https://openalex.org/W1520286086","https://openalex.org/W1537101375","https://openalex.org/W1557233561","https://openalex.org/W1572888768","https://openalex.org/W1574169977","https://openalex.org/W1580745621","https://openalex.org/W1584661703","https://openalex.org/W1595397037","https://openalex.org/W1596652845","https://openalex.org/W1815714247","https://openalex.org/W1881674564","https://openalex.org/W1915942564","https://openalex.org/W1963935193","https://openalex.org/W1966452335","https://openalex.org/W1967966438","https://openalex.org/W1967982487","https://openalex.org/W1968640414","https://openalex.org/W1969405171","https://openalex.org/W1969869131","https://openalex.org/W1970241042","https://openalex.org/W1973310908","https://openalex.org/W1977563244","https://openalex.org/W1978968953","https://openalex.org/W1979555700","https://openalex.org/W1981426567","https://openalex.org/W1981950875","https://openalex.org/W1983079076","https://openalex.org/W1984808884","https://openalex.org/W1989832969","https://openalex.org/W1990473626","https://openalex.org/W1996192399","https://openalex.org/W1996977823","https://openalex.org/W1997126285","https://openalex.org/W1997985605","https://openalex.org/W1998751401","https://openalex.org/W1998796501","https://openalex.org/W2000987281","https://openalex.org/W2001956269","https://openalex.org/W2005467120","https://openalex.org/W2008291568","https://openalex.org/W2008787569","https://openalex.org/W2013840662","https://openalex.org/W2014504523","https://openalex.org/W2016087648","https://openalex.org/W2019256890","https://openalex.org/W2021032365","https://openalex.org/W2021505229","https://openalex.org/W2022083485","https://openalex.org/W2022589671","https://openalex.org/W2022770236","https://openalex.org/W2023962954","https://openalex.org/W2024215619","https://openalex.org/W2024517044","https://openalex.org/W2026717532","https://openalex.org/W2027422916","https://openalex.org/W2027429767","https://openalex.org/W2027949597","https://openalex.org/W2034607874","https://openalex.org/W2034707421","https://openalex.org/W2035512416","https://openalex.org/W2036428426","https://openalex.org/W2037049457","https://openalex.org/W2040114132","https://openalex.org/W2040620918","https://openalex.org/W2040861051","https://openalex.org/W2042384439","https://openalex.org/W2043112660","https://openalex.org/W2045068620","https://openalex.org/W2045248956","https://openalex.org/W2046353286","https://openalex.org/W2047453411","https://openalex.org/W2050175281","https://openalex.org/W2051584163","https://openalex.org/W2052710396","https://openalex.org/W2052890510","https://openalex.org/W2053310582","https://openalex.org/W2056142105","https://openalex.org/W2058006650","https://openalex.org/W2059572565","https://openalex.org/W2062851728","https://openalex.org/W2062989663","https://openalex.org/W2064107742","https://openalex.org/W2066170812","https://openalex.org/W2068826621","https://openalex.org/W2071944650","https://openalex.org/W2074300020","https://openalex.org/W2075146050","https://openalex.org/W2077080612","https://openalex.org/W2079701823","https://openalex.org/W2080220600","https://openalex.org/W2082101394","https://openalex.org/W2084537433","https://openalex.org/W2085246663","https://openalex.org/W2093371502","https://openalex.org/W2093816724","https://openalex.org/W2095743880","https://openalex.org/W2095764561","https://openalex.org/W2101672301","https://openalex.org/W2101791909","https://openalex.org/W2102312857","https://openalex.org/W2103623402","https://openalex.org/W2108825594","https://openalex.org/W2108906644","https://openalex.org/W2112071381","https://openalex.org/W2124007806","https://openalex.org/W2126505667","https://openalex.org/W2128206096","https://openalex.org/W2129004110","https://openalex.org/W2129146981","https://openalex.org/W2130398254","https://openalex.org/W2131746860","https://openalex.org/W2132801119","https://openalex.org/W2133756798","https://openalex.org/W2136920332","https://openalex.org/W2138459238","https://openalex.org/W2138976254","https://openalex.org/W2139872110","https://openalex.org/W2143068056","https://openalex.org/W2150339227","https://openalex.org/W2153346565","https://openalex.org/W2153518194","https://openalex.org/W2156520024","https://openalex.org/W2158353135","https://openalex.org/W2161353130","https://openalex.org/W2162059971","https://openalex.org/W2163788135","https://openalex.org/W2166375403","https://openalex.org/W2301025045","https://openalex.org/W2418275829","https://openalex.org/W2552037661","https://openalex.org/W2562196350","https://openalex.org/W2768617092","https://openalex.org/W2769383666","https://openalex.org/W2770691349","https://openalex.org/W2783897659","https://openalex.org/W2784429314","https://openalex.org/W2791496286","https://openalex.org/W2793164739","https://openalex.org/W2804564451","https://openalex.org/W2808399879","https://openalex.org/W2809427654","https://openalex.org/W2809905001","https://openalex.org/W2888531539","https://openalex.org/W2896832033","https://openalex.org/W2903890042","https://openalex.org/W2906835093","https://openalex.org/W2909310706","https://openalex.org/W2909736472","https://openalex.org/W2912919723","https://openalex.org/W2913213143","https://openalex.org/W2915589964","https://openalex.org/W2950103628","https://openalex.org/W2950329150","https://openalex.org/W2950954590","https://openalex.org/W2951902916","https://openalex.org/W2972858860","https://openalex.org/W2995106027","https://openalex.org/W3003365674","https://openalex.org/W3005620600","https://openalex.org/W3009486254","https://openalex.org/W3011645475","https://openalex.org/W3015035760","https://openalex.org/W3017091732","https://openalex.org/W3046064102","https://openalex.org/W3088757653","https://openalex.org/W3101637373","https://openalex.org/W3113010918","https://openalex.org/W3130341140","https://openalex.org/W3140607877","https://openalex.org/W3168136370","https://openalex.org/W3169043618","https://openalex.org/W3177447515","https://openalex.org/W4200158030","https://openalex.org/W4211046863","https://openalex.org/W4214556160","https://openalex.org/W4281947007","https://openalex.org/W4285733837","https://openalex.org/W4293536922","https://openalex.org/W4294575999","https://openalex.org/W4306706936","https://openalex.org/W4316465510","https://openalex.org/W4376619475","https://openalex.org/W4380883184","https://openalex.org/W4387457008","https://openalex.org/W4387821707","https://openalex.org/W4389628024","https://openalex.org/W4402829707","https://openalex.org/W4403101674","https://openalex.org/W4403158410","https://openalex.org/W4404870407","https://openalex.org/W4406847487","https://openalex.org/W4408855100","https://openalex.org/W4409517060","https://openalex.org/W4409775449","https://openalex.org/W4409787402","https://openalex.org/W4410058970","https://openalex.org/W4410301491","https://openalex.org/W4410452609","https://openalex.org/W4411730215","https://openalex.org/W4412421038"],"related_works":["https://openalex.org/W2024071435","https://openalex.org/W2033677065","https://openalex.org/W2008787569","https://openalex.org/W1989089334","https://openalex.org/W2026948475","https://openalex.org/W1896405657","https://openalex.org/W7061913706","https://openalex.org/W2893349290","https://openalex.org/W4285733837","https://openalex.org/W4417427026"],"abstract_inverted_index":{"Sphingolipids":[0,31],"are":[1,14,32],"a":[2,51,95,115],"large":[3],"group":[4],"of":[5,9,57,76,109,136,142],"molecules,":[6],"crucial":[7,52],"components":[8],"all":[10],"mammalian":[11],"cells,":[12],"that":[13,114],"particularly":[15],"abundant":[16],"in":[17,54,62,65,72,83,117,120,126,147],"the":[18,55,66,106,121,140],"central":[19],"and":[20,24,37,42,48,85,97,100,145],"peripheral":[21],"nervous":[22],"system":[23],"associated":[25],"with":[26],"important":[27],"human":[28,149],"brain":[29,122],"functions.":[30,39],"necessary":[33,104],"for":[34,105],"membrane":[35,111],"organization":[36],"driving":[38],"Ceramide,":[40],"sphingosine-1-phosphate":[41,49],"GM1,":[43],"show":[44],"bioactive":[45],"properties.":[46],"Ceramide":[47],"play":[50],"role":[53,141],"regulation":[56],"physio-pathological":[58],"conditions.":[59],"Small":[60],"changes":[61],"their":[63],"levels,":[64],"ratio":[67],"sphingosine-1-phosphate/ceramide":[68],"as":[69,71],"well":[70],"chain":[73],"length":[74],"profiles":[75],"sphingolipids":[77],"contribute":[78],"to":[79,88,102],"alter":[80],"signaling":[81],"pathways":[82],"neurons":[84],"glia,":[86],"contributing":[87],"various":[89],"neurological":[90],"disorders.":[91],"GM1":[92,146],"is":[93],"considered":[94],"neurotrophic":[96],"neuroprotective":[98],"compound":[99],"seems":[101],"be":[103,124],"correct":[107],"functioning":[108],"neuronal":[110],"receptors,":[112],"suggesting":[113],"reduction":[116],"its":[118],"level":[119],"can":[123],"involved":[125],"neurodegenerative":[127],"diseases.":[128],"In":[129],"this":[130],"review,":[131],"we":[132],"give":[133],"an":[134],"overview":[135],"sphingolipid":[137],"metabolism,":[138],"summarizing":[139],"ceramide,":[143],"sphingosine-1-phosphate,":[144],"maintaining":[148],"health.":[150]},"counts_by_year":[{"year":2026,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-11-17T00:00:00"}
