{"id":"https://openalex.org/W4416281069","doi":"https://doi.org/10.5812/ijpr-166286","title":"Traditional Chinese Medicine Approach to Renal Cell Carcinoma: Jing-Si Herbal Tea Triggers Apoptosis and Ferroptosis in HK-2 Cells","display_name":"Traditional Chinese Medicine Approach to Renal Cell Carcinoma: Jing-Si Herbal Tea Triggers Apoptosis and Ferroptosis in HK-2 Cells","publication_year":2025,"publication_date":"2025-11-15","ids":{"openalex":"https://openalex.org/W4416281069","doi":"https://doi.org/10.5812/ijpr-166286","pmid":"https://pubmed.ncbi.nlm.nih.gov/41347217","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12673877"},"language":"en","primary_location":{"id":"doi:10.5812/ijpr-166286","doi":"https://doi.org/10.5812/ijpr-166286","is_oa":true,"landing_page_url":"https://doi.org/10.5812/ijpr-166286","pdf_url":"https://brieflands.com/journals/ijpr/articles/166286.pdf","source":{"id":"https://openalex.org/S54803862","display_name":"Iranian journal of pharmaceutical research","issn_l":"1726-6882","issn":["1726-6882","1726-6890","1735-0328"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319054","host_organization_name":"Shahid Beheshti University","host_organization_lineage":["https://openalex.org/P4310319054"],"host_organization_lineage_names":["Shahid Beheshti University"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iranian Journal of Pharmaceutical Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://brieflands.com/journals/ijpr/articles/166286.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074005288","display_name":"Yao\u2010Chou Tsai","orcid":"https://orcid.org/0000-0002-2833-5609","observed_orcids":["https://orcid.org/0000-0002-2833-5609","https://orcid.org/0000-0001-7319-7834"]},"institutions":[{"id":"https://openalex.org/I4210097004","display_name":"Taipei Tzu Chi Hospital","ror":"https://ror.org/00q017g63","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210097004"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yao-Chou Tsai","raw_affiliation_strings":["Division of Urology, Department of Surgery, Taipei Tzuchi Hospital, The Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Urology, Department of Surgery, Taipei Tzuchi Hospital, The Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan","institution_ids":["https://openalex.org/I4210097004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048430283","display_name":"Chung\u2010Che Tsai","orcid":"https://orcid.org/0009-0001-9645-0609","observed_orcids":["https://orcid.org/0009-0001-9645-0609"]},"institutions":[{"id":"https://openalex.org/I4210097004","display_name":"Taipei Tzu Chi Hospital","ror":"https://ror.org/00q017g63","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210097004"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chung-Che Tsai","raw_affiliation_strings":["Department of Research, Taipei Tzu Chi Hospital, The Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research, Taipei Tzu Chi Hospital, The Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan","institution_ids":["https://openalex.org/I4210097004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033750383","display_name":"Jin\u2010Yin Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129488","display_name":"Cathay General Hospital","ror":"https://ror.org/03c8c9n80","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210129488"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jin\u2011Yin Chang","raw_affiliation_strings":["Department of Medical Research, Cathay General Hospital, Taipei City, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Research, Cathay General Hospital, Taipei City, Taiwan","institution_ids":["https://openalex.org/I4210129488"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hsu-Hung Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129488","display_name":"Cathay General Hospital","ror":"https://ror.org/03c8c9n80","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210129488"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Hsu-Hung Chang","raw_affiliation_strings":["Division of Nephrology, Department of Internal Medicine, Sijhih Cathay General Hospital, New Taipei City, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Internal Medicine, Sijhih Cathay General Hospital, New Taipei City, Taiwan","institution_ids":["https://openalex.org/I4210129488"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016823854","display_name":"Chan\u2010Yen Kuo","orcid":"https://orcid.org/0000-0002-5702-5730","observed_orcids":["https://orcid.org/0000-0002-5702-5730"]},"institutions":[{"id":"https://openalex.org/I189772984","display_name":"Tzu Chi University","ror":"https://ror.org/04ss1bw11","country_code":"TW","type":"education","lineage":["https://openalex.org/I189772984"]},{"id":"https://openalex.org/I4210097004","display_name":"Taipei Tzu Chi Hospital","ror":"https://ror.org/00q017g63","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210097004"]},{"id":"https://openalex.org/I4210129488","display_name":"Cathay General Hospital","ror":"https://ror.org/03c8c9n80","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210129488"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Chan-Yen Kuo","raw_affiliation_strings":["Institute of Oral Medicine and Materials, College of Medicine, Tzu Chi University, Hualien, Taiwan","Department of Medical Research, Cathay General Hospital, Taipei City, Taiwan","Department of Research, Taipei Tzu Chi Hospital, The Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Oral Medicine and Materials, College of Medicine, Tzu Chi University, Hualien, Taiwan","institution_ids":["https://openalex.org/I189772984"]},{"raw_affiliation_string":"Department of Medical Research, Cathay General Hospital, Taipei City, Taiwan","institution_ids":["https://openalex.org/I4210129488"]},{"raw_affiliation_string":"Department of Research, Taipei Tzu Chi Hospital, The Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan","institution_ids":["https://openalex.org/I4210097004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5016823854"],"corresponding_institution_ids":["https://openalex.org/I189772984","https://openalex.org/I4210097004","https://openalex.org/I4210129488"],"apc_list":null,"apc_paid":null,"fwci":0.2805,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.42925487,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"24","issue":"1","first_page":"e166286","last_page":"e166286"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13444","display_name":"Traditional Chinese Medicine Clinical Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":0.8429999947547913},{"id":"https://openalex.org/keywords/clear-cell-renal-cell-carcinoma","display_name":"clear cell renal cell carcinoma","score":0.9520000219345093},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6729999780654907},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":1.0},{"id":"https://openalex.org/keywords/hk-2-cells","display_name":"HK-2 cells","score":0.9679999947547913},{"id":"https://openalex.org/keywords/proximal-tubular-epithelial-cells","display_name":"proximal tubular epithelial cells","score":0.9200000166893005},{"id":"https://openalex.org/keywords/gpx4","display_name":"GPX4","score":0.9200000166893005},{"id":"https://openalex.org/keywords/slc7a11","display_name":"SLC7A11","score":1.0},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.847000002861023},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.5809999704360962},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.7609999775886536},{"id":"https://openalex.org/keywords/regulated-cell-death","display_name":"regulated cell death","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7886999845504761},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7559999823570251},{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.6601999998092651},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6468999981880188},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5683000087738037},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5297999978065491},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5256999731063843},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.4424000084400177},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.4377000033855438},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.42340001463890076},{"id":"https://openalex.org/C158154518","wikidata":"https://www.wikidata.org/wiki/Q7310970","display_name":"Relevance (law)","level":2,"score":0.3831999897956848},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.37869998812675476},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.3659999966621399},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.32429999113082886},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3192000091075897},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.3133000135421753},{"id":"https://openalex.org/C33618052","wikidata":"https://www.wikidata.org/wiki/Q6013136","display_name":"In vitro toxicology","level":3,"score":0.289900004863739},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2766000032424927},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.250900000333786}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.5812/ijpr-166286","doi":"https://doi.org/10.5812/ijpr-166286","is_oa":true,"landing_page_url":"https://doi.org/10.5812/ijpr-166286","pdf_url":"https://brieflands.com/journals/ijpr/articles/166286.pdf","source":{"id":"https://openalex.org/S54803862","display_name":"Iranian journal of pharmaceutical research","issn_l":"1726-6882","issn":["1726-6882","1726-6890","1735-0328"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319054","host_organization_name":"Shahid Beheshti University","host_organization_lineage":["https://openalex.org/P4310319054"],"host_organization_lineage_names":["Shahid Beheshti University"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iranian Journal of Pharmaceutical Research","raw_type":"journal-article"},{"id":"pmid:41347217","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41347217","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iranian journal of pharmaceutical research : IJPR","raw_type":"Letter"},{"id":"pmh:oai:pubmedcentral.nih.gov:12673877","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12673877/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iran J Pharm Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.5812/ijpr-166286","doi":"https://doi.org/10.5812/ijpr-166286","is_oa":true,"landing_page_url":"https://doi.org/10.5812/ijpr-166286","pdf_url":"https://brieflands.com/journals/ijpr/articles/166286.pdf","source":{"id":"https://openalex.org/S54803862","display_name":"Iranian journal of pharmaceutical research","issn_l":"1726-6882","issn":["1726-6882","1726-6890","1735-0328"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319054","host_organization_name":"Shahid Beheshti University","host_organization_lineage":["https://openalex.org/P4310319054"],"host_organization_lineage_names":["Shahid Beheshti University"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iranian Journal of Pharmaceutical Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416281069.pdf","grobid_xml":"https://content.openalex.org/works/W4416281069.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1759375471","https://openalex.org/W1967980459","https://openalex.org/W2325707043","https://openalex.org/W2726542547","https://openalex.org/W2917503096","https://openalex.org/W3047298500","https://openalex.org/W3087040393","https://openalex.org/W3090693089","https://openalex.org/W3109716884","https://openalex.org/W3111027214","https://openalex.org/W3150198565","https://openalex.org/W3161297194","https://openalex.org/W4210243816","https://openalex.org/W4214539320","https://openalex.org/W4312126174","https://openalex.org/W4328114488","https://openalex.org/W4381469200","https://openalex.org/W4388496485","https://openalex.org/W4390789813","https://openalex.org/W4393171051","https://openalex.org/W4393855312","https://openalex.org/W4396613690","https://openalex.org/W4402273932","https://openalex.org/W4402934021","https://openalex.org/W4404863451","https://openalex.org/W4404928787","https://openalex.org/W4411042244"],"related_works":["https://openalex.org/W4403004910","https://openalex.org/W4410187746","https://openalex.org/W4402494681","https://openalex.org/W7118419330","https://openalex.org/W4393322685","https://openalex.org/W7164384012","https://openalex.org/W4393171443","https://openalex.org/W4395663674","https://openalex.org/W4313269533","https://openalex.org/W6944485765"],"abstract_inverted_index":{"Background:":[0],"Renal":[1],"cell":[2,16,18,145,189,268,285],"carcinoma":[3,19],"(RCC)":[4],"is":[5,253,261],"the":[6,12,43,108,230,262,271,298],"most":[7],"common":[8],"malignant":[9],"tumor":[10,279,288],"of":[11,70,92,114,159,164,176,187,219,232,258,264,301],"kidney,":[13],"with":[14,89,154],"clear":[15],"renal":[17,197,267],"(ccRCC)":[20],"representing":[21],"its":[22,68,236],"predominant":[23],"subtype.":[24],"Despite":[25],"significant":[26],"advances":[27],"in":[28,72,147,157,196,206,242,246,250,272,291],"targeted":[29],"and":[30,35,64,75,96,100,121,134,150,170,193,212,221,234,249,290],"immune":[31],"therapies,":[32],"treatment":[33],"resistance":[34],"recurrence":[36],"continue":[37],"to":[38,137,215,296],"pose":[39],"major":[40],"challenges,":[41],"underscoring":[42],"urgent":[44],"need":[45],"for":[46,98,239,307],"novel":[47],"therapeutic":[48,299],"strategies.":[49],"Jing-Si":[50],"Herbal":[51],"Tea":[52],"(JSHT),":[53],"a":[54,148,265,304],"traditional":[55],"Chinese":[56],"medicine":[57],"(TCM)":[58],"formulation,":[59],"has":[60],"demonstrated":[61],"anti-tumor,":[62],"anti-inflammatory,":[63],"antioxidant":[65],"properties;":[66],"however,":[67],"mechanisms":[69],"action":[71],"kidney":[73],"disease":[74],"cancer":[76],"remain":[77],"poorly":[78],"understood.":[79],"Methods:":[80],"Human":[81],"proximal":[82],"tubule":[83],"epithelial":[84,198],"(HK-2)":[85],"cells":[86,208,214],"were":[87,129],"treated":[88],"various":[90],"concentrations":[91],"JSHT":[93,141,155,183,202,233,302],"(0%,":[94],"4%,":[95],"8%)":[97],"24":[99],"48":[101],"hours.":[102],"Cell":[103],"viability":[104,146],"was":[105],"assessed":[106],"using":[107],"WST-1":[109],"assay.":[110],"The":[111,140,201],"expression":[112],"levels":[113],"cleaved-caspase":[115,160],"3,":[116,161],"glutathione":[117],"peroxidase":[118],"4":[119],"(GPX4),":[120],"solute":[122],"carrier":[123],"family":[124],"7":[125],"member":[126],"11":[127],"(SLC7A11)":[128],"analyzed":[130],"by":[131,209],"western":[132],"blotting":[133],"quantified":[135],"relative":[136],"\u03b2-actin.":[138],"Results:":[139],"significantly":[142],"reduced":[143],"HK-2":[144,207],"time-":[149],"concentration-dependent":[151],"manner.":[152],"Treatment":[153],"resulted":[156],"upregulation":[158],"indicating":[162],"activation":[163],"apoptosis,":[165],"while":[166],"concurrently":[167],"downregulating":[168],"GPX4":[169,220],"SLC7A11,":[171],"which":[172],"are":[173,294],"key":[174],"regulators":[175],"ferroptosis":[177,192,216],"resistance.":[178],"These":[179,223],"findings":[180,274],"demonstrate":[181],"that":[182],"induces":[184],"two":[185],"forms":[186],"regulated":[188],"death":[190],"-":[191,195],"apoptosis":[194,211],"cells.":[199],"Conclusions:":[200],"exhibits":[203],"antiproliferative":[204],"effects":[205,231],"promoting":[210],"sensitizing":[213],"through":[217],"suppression":[218],"SLC7A11.":[222],"results":[224],"provide":[225],"preliminary":[226],"mechanistic":[227],"insights":[228],"into":[229],"indicate":[235],"potential":[237,300],"relevance":[238],"future":[240],"research":[241],"RCC.":[243],"However,":[244],"validation":[245,293],"RCC-specific":[247],"models":[248],"vivo":[251,292],"systems":[252],"necessary.":[254],"A":[255],"notable":[256],"limitation":[257],"this":[259],"study":[260],"use":[263],"non-cancerous":[266],"line;":[269],"thus,":[270],"vitro":[273],"may":[275],"not":[276],"fully":[277],"recapitulate":[278],"biology.":[280],"Future":[281],"studies":[282],"employing":[283],"RCC":[284,308],"lines,":[286],"patient-derived":[287],"models,":[289],"warranted":[295],"elucidate":[297],"as":[303],"complementary":[305],"approach":[306],"management.":[309]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-11-17T00:00:00"}