{"id":"https://openalex.org/W4416248306","doi":"https://doi.org/10.1101/2025.11.11.25339788","title":"Study Report from the Pragmatic Assessment of the NuvoAir Clinical Service in the Management of Patients with Chronic Obstructive Pulmonary Disease","display_name":"Study Report from the Pragmatic Assessment of the NuvoAir Clinical Service in the Management of Patients with Chronic Obstructive Pulmonary Disease","publication_year":2025,"publication_date":"2025-11-13","ids":{"openalex":"https://openalex.org/W4416248306","doi":"https://doi.org/10.1101/2025.11.11.25339788"},"language":"en","primary_location":{"id":"doi:10.1101/2025.11.11.25339788","doi":"https://doi.org/10.1101/2025.11.11.25339788","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.11.11.25339788","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2025/11/13/2025.11.11.25339788.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2025/11/13/2025.11.11.25339788.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093133135","display_name":"Eric Harker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric Harker","raw_affiliation_strings":["NuvoAir Medical PC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NuvoAir Medical PC","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002867484","display_name":"Jeffrey J. Van Wormer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269317","display_name":"Marshfield Clinic Research Foundation","ror":"https://ror.org/03sqpx865","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405269317"]},{"id":"https://openalex.org/I4405269587","display_name":"Marshfield Clinic Research Institute","ror":"https://ror.org/04ky5a503","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269587"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey J. Van Wormer","raw_affiliation_strings":["Marshfield Clinic Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Marshfield Clinic Research Institute","institution_ids":["https://openalex.org/I4405269317","https://openalex.org/I4405269587"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029228127","display_name":"Dandi Qiao","orcid":"https://orcid.org/0000-0001-9450-205X","observed_orcids":["https://orcid.org/0000-0001-9450-205X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Dandi Qiao","raw_affiliation_strings":["NuvoAir Medical Inc"],"raw_orcid":"https://orcid.org/0000-0001-9450-205X","affiliations":[{"raw_affiliation_string":"NuvoAir Medical Inc","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5029228127"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10912","display_name":"Telemedicine and Telehealth Implementation","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11590","display_name":"Primary Care and Health Outcomes","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2714","display_name":"Family Practice"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/telemedicine","display_name":"telemedicine","score":0.8889999985694885},{"id":"https://openalex.org/keywords/remote-patient-monitoring","display_name":"remote patient monitoring","score":0.9380000233650208},{"id":"https://openalex.org/keywords/home-health-care","display_name":"home health care","score":0.4580000042915344},{"id":"https://openalex.org/keywords/hospitalization-reduction","display_name":"hospitalization reduction","score":0.6589999794960022},{"id":"https://openalex.org/keywords/hospital-readmission","display_name":"hospital readmission","score":0.9599999785423279},{"id":"https://openalex.org/keywords/emergency-department-visits","display_name":"emergency department visits","score":0.656000018119812},{"id":"https://openalex.org/keywords/health-care-costs","display_name":"health care costs","score":0.800000011920929},{"id":"https://openalex.org/keywords/chronic-disease-management","display_name":"chronic disease management","score":0.5379999876022339},{"id":"https://openalex.org/keywords/proactive-care","display_name":"proactive care","score":0.42100000381469727}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.919700026512146},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.6211000084877014},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.6129000186920166},{"id":"https://openalex.org/C2992779976","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Pulmonary disease","level":2,"score":0.548799991607666},{"id":"https://openalex.org/C104863432","wikidata":"https://www.wikidata.org/wiki/Q614304","display_name":"Pharmacy","level":2,"score":0.4823000133037567},{"id":"https://openalex.org/C124306116","wikidata":"https://www.wikidata.org/wiki/Q2512965","display_name":"Ambulatory care","level":3,"score":0.43650001287460327},{"id":"https://openalex.org/C545542383","wikidata":"https://www.wikidata.org/wiki/Q2751242","display_name":"Medical emergency","level":1,"score":0.4357999861240387},{"id":"https://openalex.org/C2982889124","wikidata":"https://www.wikidata.org/wiki/Q107439039","display_name":"Disease management","level":4,"score":0.4117000102996826},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.40790000557899475},{"id":"https://openalex.org/C2780378061","wikidata":"https://www.wikidata.org/wiki/Q25351891","display_name":"Service (business)","level":2,"score":0.4000999927520752},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3808000087738037},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3416000008583069},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.33649998903274536},{"id":"https://openalex.org/C3019354653","wikidata":"https://www.wikidata.org/wiki/Q5690885","display_name":"Medical costs","level":3,"score":0.32260000705718994},{"id":"https://openalex.org/C3020110884","wikidata":"https://www.wikidata.org/wiki/Q695416","display_name":"Outpatient clinic","level":2,"score":0.3167000114917755},{"id":"https://openalex.org/C2987552334","wikidata":"https://www.wikidata.org/wiki/Q383126","display_name":"Chronic disease","level":2,"score":0.31369999051094055},{"id":"https://openalex.org/C2909321700","wikidata":"https://www.wikidata.org/wiki/Q181600","display_name":"Outpatient visits","level":3,"score":0.3091999888420105},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.29679998755455017},{"id":"https://openalex.org/C35785553","wikidata":"https://www.wikidata.org/wiki/Q756720","display_name":"Ambulatory","level":2,"score":0.28450000286102295},{"id":"https://openalex.org/C2780958618","wikidata":"https://www.wikidata.org/wiki/Q945621","display_name":"Average cost","level":2,"score":0.2696000039577484},{"id":"https://openalex.org/C3018838755","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Medical care","level":2,"score":0.267300009727478},{"id":"https://openalex.org/C2778373050","wikidata":"https://www.wikidata.org/wiki/Q1774706","display_name":"Clinical pathway","level":2,"score":0.26589998602867126},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.26420000195503235},{"id":"https://openalex.org/C3017977530","wikidata":"https://www.wikidata.org/wiki/Q557429","display_name":"Acute hospital","level":3,"score":0.2597000002861023},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.25429999828338623}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2025.11.11.25339788","doi":"https://doi.org/10.1101/2025.11.11.25339788","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.11.11.25339788","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2025/11/13/2025.11.11.25339788.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2025.11.11.25339788","doi":"https://doi.org/10.1101/2025.11.11.25339788","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.11.11.25339788","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2025/11/13/2025.11.11.25339788.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416248306.pdf","grobid_xml":"https://content.openalex.org/works/W4416248306.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W2036326371","https://openalex.org/W2159805452","https://openalex.org/W2462215050","https://openalex.org/W2783319287","https://openalex.org/W2904131086","https://openalex.org/W2904872980","https://openalex.org/W2941605630","https://openalex.org/W2980172796","https://openalex.org/W3092562614","https://openalex.org/W3107103696","https://openalex.org/W4226115219","https://openalex.org/W4288063868","https://openalex.org/W4316924375","https://openalex.org/W4382464072","https://openalex.org/W4385387591","https://openalex.org/W4400111555","https://openalex.org/W4401664331","https://openalex.org/W4402297950"],"related_works":["https://openalex.org/W4408876515","https://openalex.org/W2072439195","https://openalex.org/W2011161376","https://openalex.org/W2025344477","https://openalex.org/W2777704906","https://openalex.org/W2792367826","https://openalex.org/W1985303908","https://openalex.org/W2140217629","https://openalex.org/W2168724896","https://openalex.org/W4403690640"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"COPD":[2,24,67],"is":[3],"one":[4],"of":[5,9,23,95,112,148],"the":[6,16],"leading":[7],"causes":[8],"death,":[10],"disability":[11],"and":[12,18,44,134,158,175,195,219],"avoidable":[13],"hospitalization":[14,104,159],"in":[15,69,97,109,119,130,135,143,182,191],"US":[17],"abroad,":[19],"yet":[20],"proactive":[21,49],"management":[22,46],"has":[25],"historically":[26],"been":[27],"limited.":[28],"This":[29],"study":[30],"evaluates":[31],"NuvoAir":[32,207],"Home":[33,208],"Service":[34,209],"(NAHS),":[35],"a":[36,60,77,93,169,176,211],"novel":[37],"intervention":[38],"that":[39,206],"integrates":[40],"telemedicine,":[41],"remote":[42],"monitoring,":[43],"chronic-care":[45],"to":[47,51,87],"deliver":[48],"care":[50],"patients":[52],"with":[53,66,73,168],"COPD.":[54],"Methods":[55],"We":[56],"present":[57],"findings":[58],"from":[59,161],"six-month":[61],"pragmatic":[62],"program":[63],"evaluation.":[64],"Patients":[65],"enrolled":[68],"NAHS":[70,84],"were":[71,151,164,189],"compared":[72,86],"propensity-matched":[74],"controls":[75,91],"using":[76],"two-period":[78],"difference-in-difference":[79],"(DID)":[80],"design.":[81],"Results":[82],"280":[83],"participants":[85],"840":[88],"propensity":[89],"matched":[90],"showed":[92],"reduction":[94,171,178],"47%":[96],"post-to-pre":[98,183],"risk":[99],"ratio":[100],"(RR)":[101],"for":[102],"COPD-related":[103,154,196,216],"(p":[105,115,122],"=":[106,116,123,173,180],"0.06),":[107],"55%":[108],"average":[110],"days":[111],"hospital":[113,120,217],"stay":[114],"0.02),":[117],"53%":[118,177],"readmissions":[121],"0.32).":[124],"There":[125],"was":[126],"no":[127],"significant":[128,187],"change":[129],"ED":[131,224],"visits":[132,138],"(p=0.83),":[133],"outpatient":[136,226],"office":[137],"(p=0.89).":[139],"All-cause":[140],"utilization":[141,218],"moved":[142],"similar":[144],"directions,":[145],"but":[146],"none":[147],"those":[149],"changes":[150,188],"statistically":[152],"significant.":[153],"total":[155],"medical":[156,162],"cost":[157,160,184],"claims":[163],"also":[165],"significantly":[166,222],"reduced":[167],"28%":[170],"(p-value":[172,179],"0.05)":[174],"0.02)":[181],"ratio.":[185],"No":[186],"observed":[190],"all-cause":[192,194],"hospitalization,":[193],"ED,":[197],"outpatient,":[198],"or":[199,225],"pharmacy":[200],"costs.":[201],"Conclusion":[202],"These":[203],"data":[204],"indicate":[205],"had":[210],"clinically":[212],"positive":[213],"impact":[214],"on":[215],"costs":[220],"without":[221],"increasing":[223],"use,":[227],"though":[228],"not":[229],"all":[230],"results":[231],"met":[232],"statistical":[233],"significance.":[234]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2025-11-14T00:00:00"}