{"id":"https://openalex.org/W4416232182","doi":"https://doi.org/10.1158/1078-0432.30617848","title":"Supplementary Figure S2 from Evolution and Co-occurrence of PI3K Pathway Gene Mutations in Endometrial Carcinoma Molecular Subtypes at the Single-Cell Level","display_name":"Supplementary Figure S2 from Evolution and Co-occurrence of PI3K Pathway Gene Mutations in Endometrial Carcinoma Molecular Subtypes at the Single-Cell Level","publication_year":2025,"publication_date":"2025-11-14","ids":{"openalex":"https://openalex.org/W4416232182","doi":"https://doi.org/10.1158/1078-0432.30617848"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.30617848","doi":"https://doi.org/10.1158/1078-0432.30617848","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.30617848","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.30617848","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072735395","display_name":"Arnaud Da Cruz Paula","orcid":"https://orcid.org/0000-0001-7694-8760","observed_orcids":["https://orcid.org/0000-0001-7694-8760"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arnaud Da Cruz Paula","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7694-8760","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101408268","display_name":"Yingjie Zhu","orcid":"https://orcid.org/0000-0003-1849-6019","observed_orcids":["https://orcid.org/0000-0003-1849-6019"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yingjie Zhu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1849-6019","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047642576","display_name":"David N. Brown","orcid":"https://orcid.org/0000-0002-8249-3632","observed_orcids":["https://orcid.org/0000-0002-8249-3632"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David N. Brown","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8249-3632","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049502688","display_name":"Shirin Issa Bhaloo","orcid":"https://orcid.org/0000-0001-9765-8711","observed_orcids":["https://orcid.org/0000-0001-9765-8711"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shirin Issa Bhaloo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9765-8711","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003635959","display_name":"Fresia G. Pareja","orcid":"https://orcid.org/0000-0003-3748-8049","observed_orcids":["https://orcid.org/0000-0003-3748-8049"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fresia Pareja","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3748-8049","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066766989","display_name":"Timothy J. Hoang","orcid":"https://orcid.org/0000-0002-3012-3461","observed_orcids":["https://orcid.org/0000-0002-3012-3461"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timothy J. Hoang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3012-3461","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102929520","display_name":"Hunter Green","orcid":"https://orcid.org/0009-0002-3944-6803","observed_orcids":["https://orcid.org/0009-0002-3944-6803"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hunter Green","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-3944-6803","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087203729","display_name":"Thais Basili","orcid":"https://orcid.org/0000-0003-3216-3544","observed_orcids":["https://orcid.org/0000-0003-3216-3544"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thais Basili","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3216-3544","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080827385","display_name":"Higinio Dopeso","orcid":"https://orcid.org/0000-0003-0060-1861","observed_orcids":["https://orcid.org/0000-0003-0060-1861"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Higinio Dopeso","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0060-1861","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014140313","display_name":"Pier Selenica","orcid":"https://orcid.org/0000-0003-0086-0513","observed_orcids":["https://orcid.org/0000-0003-0086-0513"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pier Selenica","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0086-0513","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044597347","display_name":"Edaise M. da Silva","orcid":"https://orcid.org/0000-0003-3281-7333","observed_orcids":["https://orcid.org/0000-0003-3281-7333"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Edaise M. da Silva","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3281-7333","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027048828","display_name":"Nadeem Riaz","orcid":"https://orcid.org/0000-0001-9873-5862","observed_orcids":["https://orcid.org/0000-0001-9873-5862"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nadeem Riaz","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9873-5862","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041961484","display_name":"Sarat Chandarlapaty","orcid":"https://orcid.org/0000-0003-4532-8053","observed_orcids":["https://orcid.org/0000-0003-4532-8053"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarat Chandarlapaty","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4532-8053","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002011120","display_name":"Nadeem R. Abu\u2010Rustum","orcid":"https://orcid.org/0000-0001-9689-1298","observed_orcids":["https://orcid.org/0000-0001-9689-1298"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nadeem R. Abu-Rustum","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9689-1298","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077235697","display_name":"Jorge Sergio Reis-Filho","orcid":"https://orcid.org/0000-0003-2969-3173","observed_orcids":["https://orcid.org/0000-0003-2969-3173"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jorge S. Reis-Filho","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2969-3173","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5040506127","display_name":"Britta Weigelt","orcid":"https://orcid.org/0000-0001-9927-1270","observed_orcids":["https://orcid.org/0000-0001-9927-1270"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Britta Weigelt","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9927-1270","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.6786999702453613,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.6786999702453613,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.15139999985694885,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.04540000110864639,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endometrial-cancer","display_name":"endometrial cancer","score":0.8790000081062317},{"id":"https://openalex.org/keywords/pi3k-signaling","display_name":"PI3K signaling","score":0.9259999990463257},{"id":"https://openalex.org/keywords/mutation","display_name":"genetic mutations","score":0.8799999952316284},{"id":"https://openalex.org/keywords/molecular-subtypes","display_name":"molecular subtypes","score":0.8679999709129333},{"id":"https://openalex.org/keywords/single-cell-analysis","display_name":"single-cell analysis","score":0.5809999704360962},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.6603999733924866},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.6546000242233276},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6175000071525574},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5954999923706055},{"id":"https://openalex.org/C2777088508","wikidata":"https://www.wikidata.org/wiki/Q944777","display_name":"Endometrial cancer","level":3,"score":0.527899980545044},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.45570001006126404},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.43799999356269836},{"id":"https://openalex.org/C2994225774","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Gene mutation","level":4,"score":0.43320000171661377},{"id":"https://openalex.org/C143589142","wikidata":"https://www.wikidata.org/wiki/Q2617554","display_name":"Loss of heterozygosity","level":4,"score":0.3411000072956085},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3375000059604645},{"id":"https://openalex.org/C37463918","wikidata":"https://www.wikidata.org/wiki/Q387981","display_name":"Allele frequency","level":4,"score":0.3269999921321869},{"id":"https://openalex.org/C198352243","wikidata":"https://www.wikidata.org/wiki/Q37105","display_name":"Line (geometry)","level":2,"score":0.31779998540878296},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3003000020980835},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.2953999936580658},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.2727000117301941},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2517000138759613}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.30617848","doi":"https://doi.org/10.1158/1078-0432.30617848","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.30617848","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/30617848","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figure_S2_from_Evolution_and_Co-occurrence_of_PI3K_Pathway_Gene_Mutations_in_Endometrial_Carcinoma_Molecular_Subtypes_at_the_Single-Cell_Level/30617848","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.30617848","doi":"https://doi.org/10.1158/1078-0432.30617848","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.30617848","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6921393204","https://openalex.org/W4408795652","https://openalex.org/W4416195302","https://openalex.org/W4282976070","https://openalex.org/W2326226534","https://openalex.org/W6939274312","https://openalex.org/W4408796617","https://openalex.org/W3176543296","https://openalex.org/W2503057041","https://openalex.org/W6939715493"],"abstract_inverted_index":{"Supplementary":[0],"Figure":[1],"S2.":[2],"Alternative":[3],"allele":[4,22],"read":[5,23],"depths":[6,24],"of":[7,25],"each":[8,26],"mutation":[9,27,36],"present":[10,28],"in":[11,29],"both":[12,30],"endometrial":[13,31],"cell":[14,32],"line":[15,33],"admixtures.":[16,34],"Violin":[17],"plots":[18],"depicting":[19],"the":[20,42],"alternative":[21],"The":[35],"type":[37],"is":[38],"color-coded":[39],"according":[40],"to":[41],"legend.":[43]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2025-11-14T00:00:00"}