{"id":"https://openalex.org/W4416232107","doi":"https://doi.org/10.1158/1078-0432.30617724","title":"Supplemental Figure 2 from MTA-Cooperative PRMT5 Inhibitors Are Efficacious in MTAP-Deleted Malignant Peripheral Nerve Sheath Tumor Models","display_name":"Supplemental Figure 2 from MTA-Cooperative PRMT5 Inhibitors Are Efficacious in MTAP-Deleted Malignant Peripheral Nerve Sheath Tumor Models","publication_year":2025,"publication_date":"2025-11-14","ids":{"openalex":"https://openalex.org/W4416232107","doi":"https://doi.org/10.1158/1078-0432.30617724"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.30617724","doi":"https://doi.org/10.1158/1078-0432.30617724","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.30617724","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.30617724","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011985957","display_name":"Xiaochun Zhang","orcid":"https://orcid.org/0000-0002-6107-1182","observed_orcids":["https://orcid.org/0000-0002-6107-1182"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaochun Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6107-1182","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028552606","display_name":"Dana C. Borcherding","orcid":"https://orcid.org/0000-0002-8849-2139","observed_orcids":["https://orcid.org/0000-0002-8849-2139"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dana C. Borcherding","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8849-2139","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019522100","display_name":"Minjie Zhang","orcid":"https://orcid.org/0000-0003-1778-3761","observed_orcids":["https://orcid.org/0000-0003-1778-3761"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Minjie Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1778-3761","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075861153","display_name":"Yang Lyu","orcid":"https://orcid.org/0000-0002-4353-0082","observed_orcids":["https://orcid.org/0000-0002-4353-0082"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yang Lyu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4353-0082","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109865640","display_name":"Guangfeng Wang","orcid":"https://orcid.org/0009-0007-0735-330X","observed_orcids":["https://orcid.org/0009-0007-0735-330X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guangfeng Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-0735-330X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024073568","display_name":"Kevin He","orcid":"https://orcid.org/0000-0003-2642-7830","observed_orcids":["https://orcid.org/0000-0003-2642-7830"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevin He","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2642-7830","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114594983","display_name":"Gorkem Oztosun","orcid":"https://orcid.org/0000-0002-8374-4405","observed_orcids":["https://orcid.org/0000-0002-8374-4405"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gorkem Oztosun","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8374-4405","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114592240","display_name":"Ishita Sachdeva","orcid":"https://orcid.org/0009-0006-9686-6432","observed_orcids":["https://orcid.org/0009-0006-9686-6432"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ishita Sachdeva","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0006-9686-6432","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109042633","display_name":"Liuzhan Yang","orcid":"https://orcid.org/0009-0002-9718-4768","observed_orcids":["https://orcid.org/0009-0002-9718-4768"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liuzhan Yang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-9718-4768","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083142662","display_name":"Kuangying Yang","orcid":"https://orcid.org/0000-0002-6992-9585","observed_orcids":["https://orcid.org/0000-0002-6992-9585"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kuangying Yang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6992-9585","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Alex Yuen","orcid":"https://orcid.org/0009-0004-9680-8625","observed_orcids":["https://orcid.org/0009-0004-9680-8625"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alex Yuen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0004-9680-8625","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037855397","display_name":"Heather J. DiBenedetto","orcid":"https://orcid.org/0009-0005-0211-8154","observed_orcids":["https://orcid.org/0009-0005-0211-8154"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heather DiBenedetto","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-0211-8154","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054495209","display_name":"Alice Tsai","orcid":"https://orcid.org/0009-0004-0728-3637","observed_orcids":["https://orcid.org/0009-0004-0728-3637","https://orcid.org/0000-0002-1939-6282"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alice Tsai","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0004-0728-3637","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044141815","display_name":"Alan Huang","orcid":"https://orcid.org/0000-0001-5501-0212","observed_orcids":["https://orcid.org/0000-0001-5501-0212"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alan Huang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5501-0212","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027692068","display_name":"John P. Maxwell","orcid":"https://orcid.org/0000-0002-5969-6490","observed_orcids":["https://orcid.org/0000-0002-5969-6490"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John P. Maxwell","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5969-6490","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020558233","display_name":"Kevin M. Cottrell","orcid":"https://orcid.org/0009-0008-6511-0696","observed_orcids":["https://orcid.org/0009-0008-6511-0696"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevin M. Cottrell","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0008-6511-0696","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103544664","display_name":"Kimberly J. Briggs","orcid":"https://orcid.org/0009-0007-4564-6576","observed_orcids":["https://orcid.org/0009-0007-4564-6576"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kimberly J. Briggs","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-4564-6576","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5036526586","display_name":"Angela C. Hirbe","orcid":"https://orcid.org/0000-0003-1719-0771","observed_orcids":["https://orcid.org/0000-0003-1719-0771"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Angela C. Hirbe","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1719-0771","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prmt5-inhibitors","display_name":"PRMT5 inhibitors","score":0.9779999852180481},{"id":"https://openalex.org/keywords/mtap-deletion","display_name":"MTAP deletion","score":0.671999990940094},{"id":"https://openalex.org/keywords/malignant-peripheral-nerve-sheath-tumor","display_name":"malignant peripheral nerve sheath tumor","score":0.9890000224113464},{"id":"https://openalex.org/keywords/drug-selectivity","display_name":"drug selectivity","score":0.7139999866485596},{"id":"https://openalex.org/keywords/epigenetic-reprogramming","display_name":"epigenetic reprogramming","score":0.4180000126361847}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7688000202178955},{"id":"https://openalex.org/C2778173781","wikidata":"https://www.wikidata.org/wiki/Q654485","display_name":"Malignant peripheral nerve sheath tumor","level":3,"score":0.6029000282287598},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.515999972820282},{"id":"https://openalex.org/C2910357046","wikidata":"https://www.wikidata.org/wiki/Q11590740","display_name":"Nerve sheath neoplasm","level":4,"score":0.47699999809265137},{"id":"https://openalex.org/C111819275","wikidata":"https://www.wikidata.org/wiki/Q18035368","display_name":"Protein arginine methyltransferase 5","level":5,"score":0.3668000102043152},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.359499990940094},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.305400013923645},{"id":"https://openalex.org/C3018498973","wikidata":"https://www.wikidata.org/wiki/Q9620","display_name":"Peripheral nerve","level":2,"score":0.2992999851703644},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.29490000009536743},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.2775999903678894},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.25679999589920044}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.30617724","doi":"https://doi.org/10.1158/1078-0432.30617724","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.30617724","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.30617724","doi":"https://doi.org/10.1158/1078-0432.30617724","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.30617724","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4411604628","https://openalex.org/W4388588380","https://openalex.org/W4416198721","https://openalex.org/W4416140126","https://openalex.org/W7135024742","https://openalex.org/W4408903712","https://openalex.org/W4406336250","https://openalex.org/W4402581269","https://openalex.org/W4414167116","https://openalex.org/W4414185531"],"abstract_inverted_index":{"Supplemental":[0],"Figure":[1],"2.":[2],"The":[3],"SAM-cooperative":[4],"PRMT5":[5],"inhibitor":[6],"GSK3326595":[7],"is":[8],"not":[9],"selective":[10],"for":[11],"MTAP":[12],"status":[13],"in":[14],"MPNST":[15],"cell":[16],"lines.":[17]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-11-14T00:00:00"}