{"id":"https://openalex.org/W4416219403","doi":"https://doi.org/10.1136/heartjnl-2025-bcs.216","title":"7-021 Impact of bempedoic acid, icosapent ethyl, inclisiran and monoclonal PCSK9 inhibitors on lipids in a real-world setting","display_name":"7-021 Impact of bempedoic acid, icosapent ethyl, inclisiran and monoclonal PCSK9 inhibitors on lipids in a real-world setting","publication_year":2025,"publication_date":"2025-08-13","ids":{"openalex":"https://openalex.org/W4416219403","doi":"https://doi.org/10.1136/heartjnl-2025-bcs.216"},"language":"en","primary_location":{"id":"doi:10.1136/heartjnl-2025-bcs.216","doi":"https://doi.org/10.1136/heartjnl-2025-bcs.216","is_oa":true,"landing_page_url":"https://doi.org/10.1136/heartjnl-2025-bcs.216","pdf_url":"https://heart.bmj.com/content/heartjnl/111/Suppl_3/A222.full.pdf","source":{"id":"https://openalex.org/S191565391","display_name":"Heart","issn_l":"1355-6037","issn":["1355-6037","1468-201X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stable IHD/Prevention/Hypertension/Lipids","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://heart.bmj.com/content/heartjnl/111/Suppl_3/A222.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013943027","display_name":"Sophia Khattak","orcid":"https://orcid.org/0000-0002-8683-5433","observed_orcids":["https://orcid.org/0000-0002-8683-5433"]},"institutions":[{"id":"https://openalex.org/I2799307867","display_name":"Queen Elizabeth Hospital Birmingham","ror":"https://ror.org/048emj907","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049","https://openalex.org/I2799307867"]},{"id":"https://openalex.org/I34931013","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013"]},{"id":"https://openalex.org/I4210162943","display_name":"NIHR Birmingham Biomedical Research Centre","ror":"https://ror.org/05ccjmp23","country_code":"GB","type":"facility","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210162943"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sophia Khattak","raw_affiliation_strings":["Institute of Cardiovascular Sciences, University of Birmingham, UK","National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre, UK","Queen Elizabeth Hospital, Birmingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cardiovascular Sciences, University of Birmingham, UK","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre, UK","institution_ids":["https://openalex.org/I34931013","https://openalex.org/I4210162943"]},{"raw_affiliation_string":"Queen Elizabeth Hospital, Birmingham, UK","institution_ids":["https://openalex.org/I2799307867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088574799","display_name":"Antonio F. Ochoa-Ferraro","orcid":"https://orcid.org/0000-0003-0406-1436","observed_orcids":["https://orcid.org/0000-0003-0406-1436"]},"institutions":[{"id":"https://openalex.org/I2799307867","display_name":"Queen Elizabeth Hospital Birmingham","ror":"https://ror.org/048emj907","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049","https://openalex.org/I2799307867"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Antonio Ochoa-Ferraro","raw_affiliation_strings":["Queen Elizabeth Hospital, Birmingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queen Elizabeth Hospital, Birmingham, UK","institution_ids":["https://openalex.org/I2799307867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087626274","display_name":"Nazish Khan","orcid":"https://orcid.org/0000-0003-4483-7390","observed_orcids":["https://orcid.org/0000-0003-4483-7390"]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nazish Khan","raw_affiliation_strings":["Institute of Cardiovascular Sciences, University of Birmingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cardiovascular Sciences, University of Birmingham, UK","institution_ids":["https://openalex.org/I79619799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086194417","display_name":"Sudhakar George","orcid":"https://orcid.org/0000-0002-2871-2363","observed_orcids":["https://orcid.org/0000-0002-2871-2363"]},"institutions":[{"id":"https://openalex.org/I2799307867","display_name":"Queen Elizabeth Hospital Birmingham","ror":"https://ror.org/048emj907","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049","https://openalex.org/I2799307867"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sudhakar George","raw_affiliation_strings":["Queen Elizabeth Hospital, Birmingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queen Elizabeth Hospital, Birmingham, UK","institution_ids":["https://openalex.org/I2799307867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066098090","display_name":"Sohail Q. Khan","orcid":"https://orcid.org/0000-0001-9951-4885","observed_orcids":["https://orcid.org/0000-0001-9951-4885"]},"institutions":[{"id":"https://openalex.org/I2799307867","display_name":"Queen Elizabeth Hospital Birmingham","ror":"https://ror.org/048emj907","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049","https://openalex.org/I2799307867"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sohail Khan","raw_affiliation_strings":["Institute of Cardiovascular Sciences, University of Birmingham, UK","Queen Elizabeth Hospital, Birmingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cardiovascular Sciences, University of Birmingham, UK","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"Queen Elizabeth Hospital, Birmingham, UK","institution_ids":["https://openalex.org/I2799307867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038300932","display_name":"John Townend","orcid":"https://orcid.org/0000-0002-5881-5806","observed_orcids":["https://orcid.org/0000-0002-5881-5806"]},"institutions":[{"id":"https://openalex.org/I2799307867","display_name":"Queen Elizabeth Hospital Birmingham","ror":"https://ror.org/048emj907","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049","https://openalex.org/I2799307867"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jonathan N Townend","raw_affiliation_strings":["Institute of Cardiovascular Sciences, University of Birmingham, UK","Queen Elizabeth Hospital, Birmingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cardiovascular Sciences, University of Birmingham, UK","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"Queen Elizabeth Hospital, Birmingham, UK","institution_ids":["https://openalex.org/I2799307867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026325788","display_name":"Charlotte Dawson","orcid":"https://orcid.org/0000-0001-9974-1244","observed_orcids":["https://orcid.org/0000-0001-9974-1244"]},"institutions":[{"id":"https://openalex.org/I2799307867","display_name":"Queen Elizabeth Hospital Birmingham","ror":"https://ror.org/048emj907","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049","https://openalex.org/I2799307867"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Charlotte Dawson","raw_affiliation_strings":["Queen Elizabeth Hospital, Birmingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queen Elizabeth Hospital, Birmingham, UK","institution_ids":["https://openalex.org/I2799307867"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043982558","display_name":"Mark Roland Thomas","orcid":"https://orcid.org/0000-0001-7048-7764","observed_orcids":["https://orcid.org/0000-0001-7048-7764"]},"institutions":[{"id":"https://openalex.org/I2799307867","display_name":"Queen Elizabeth Hospital Birmingham","ror":"https://ror.org/048emj907","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1308923049","https://openalex.org/I2799307867"]},{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark R Thomas","raw_affiliation_strings":["Institute of Cardiovascular Sciences, University of Birmingham, UK","Queen Elizabeth Hospital, Birmingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cardiovascular Sciences, University of Birmingham, UK","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"Queen Elizabeth Hospital, Birmingham, UK","institution_ids":["https://openalex.org/I2799307867"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.39521239,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A222","last_page":"A223"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bempedoic-acid","display_name":"bempedoic acid","score":0.9710000157356262},{"id":"https://openalex.org/keywords/icosapent-ethyl","display_name":"icosapent ethyl","score":0.9959999918937683},{"id":"https://openalex.org/keywords/inclisiran","display_name":"inclisiran","score":0.9950000047683716},{"id":"https://openalex.org/keywords/pcsk9-inhibitors","display_name":"PCSK9 inhibitors","score":0.9919999837875366},{"id":"https://openalex.org/keywords/evolocumab","display_name":"evolocumab","score":0.9369999766349792},{"id":"https://openalex.org/keywords/alirocumab","display_name":"alirocumab","score":1.0},{"id":"https://openalex.org/keywords/acute-coronary-syndrome","display_name":"acute coronary syndrome","score":0.8920000195503235},{"id":"https://openalex.org/keywords/ldl-cholesterol-lowering","display_name":"LDL cholesterol lowering","score":0.8500000238418579},{"id":"https://openalex.org/keywords/lipid-lowering-therapy","display_name":"lipid-lowering therapy","score":0.7549999952316284},{"id":"https://openalex.org/keywords/triglyceride-lowering","display_name":"triglyceride lowering","score":0.7480000257492065},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.847000002861023},{"id":"https://openalex.org/keywords/high-intensity-statin-therapy","display_name":"high-intensity statin therapy","score":0.8149999976158142},{"id":"https://openalex.org/keywords/ezetimibe","display_name":"ezetimibe","score":0.9649999737739563},{"id":"https://openalex.org/keywords/secondary-prevention","display_name":"secondary prevention","score":0.5270000100135803},{"id":"https://openalex.org/keywords/real-world-effectiveness","display_name":"real-world effectiveness","score":0.6880000233650208}],"concepts":[{"id":"https://openalex.org/C2780902209","wikidata":"https://www.wikidata.org/wiki/Q4726914","display_name":"Alirocumab","level":5,"score":0.9544000029563904},{"id":"https://openalex.org/C2778114629","wikidata":"https://www.wikidata.org/wiki/Q15623825","display_name":"Evolocumab","level":5,"score":0.911300003528595},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7979000210762024},{"id":"https://openalex.org/C2780948078","wikidata":"https://www.wikidata.org/wiki/Q21130010","display_name":"PCSK9","level":5,"score":0.5178999900817871},{"id":"https://openalex.org/C2777698277","wikidata":"https://www.wikidata.org/wiki/Q266018","display_name":"Acute coronary syndrome","level":3,"score":0.48570001125335693},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4740999937057495},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.44519999623298645},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.36579999327659607},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.3361000120639801},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.3312999904155731},{"id":"https://openalex.org/C2909478654","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Atherosclerotic cardiovascular disease","level":3,"score":0.31529998779296875},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.31299999356269836},{"id":"https://openalex.org/C111335779","wikidata":"https://www.wikidata.org/wiki/Q3454686","display_name":"Reduction (mathematics)","level":2,"score":0.2978000044822693},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.29249998927116394},{"id":"https://openalex.org/C2779120738","wikidata":"https://www.wikidata.org/wiki/Q2711291","display_name":"Familial hypercholesterolemia","level":3,"score":0.2888999879360199},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.27059999108314514},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.26019999384880066},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.25609999895095825}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1136/heartjnl-2025-bcs.216","doi":"https://doi.org/10.1136/heartjnl-2025-bcs.216","is_oa":true,"landing_page_url":"https://doi.org/10.1136/heartjnl-2025-bcs.216","pdf_url":"https://heart.bmj.com/content/heartjnl/111/Suppl_3/A222.full.pdf","source":{"id":"https://openalex.org/S191565391","display_name":"Heart","issn_l":"1355-6037","issn":["1355-6037","1468-201X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stable IHD/Prevention/Hypertension/Lipids","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1136/heartjnl-2025-bcs.216","doi":"https://doi.org/10.1136/heartjnl-2025-bcs.216","is_oa":true,"landing_page_url":"https://doi.org/10.1136/heartjnl-2025-bcs.216","pdf_url":"https://heart.bmj.com/content/heartjnl/111/Suppl_3/A222.full.pdf","source":{"id":"https://openalex.org/S191565391","display_name":"Heart","issn_l":"1355-6037","issn":["1355-6037","1468-201X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stable IHD/Prevention/Hypertension/Lipids","raw_type":"proceedings-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416219403.pdf","grobid_xml":"https://content.openalex.org/works/W4416219403.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W4416219388"],"related_works":["https://openalex.org/W4416074146","https://openalex.org/W7160955338","https://openalex.org/W7221829712","https://openalex.org/W4402721172","https://openalex.org/W4224236365","https://openalex.org/W4400581351","https://openalex.org/W4408867624","https://openalex.org/W4282966850","https://openalex.org/W4410405692","https://openalex.org/W7170092563"],"abstract_inverted_index":{"Background":[0],"Lowering":[1],"lipid":[2,36,49],"levels":[3,262,284],"after":[4],"an":[5],"acute":[6,72],"coronary":[7,73],"syndrome":[8,74],"is":[9,24],"critical":[10],"for":[11,134,280],"preventing":[12],"recurrent":[13],"adverse":[14],"cardiovascular":[15],"events.":[16],"Multiple":[17],"medications":[18,273],"are":[19],"now":[20],"available,":[21],"but":[22],"there":[23],"limited":[25],"evidence":[26],"comparing":[27],"how":[28],"frequently":[29],"they":[30],"lead":[31],"to":[32,130,197,205,222,236],"achievement":[33,92],"of":[34,47,66,71,79,93,112,149,158,165,190,217,231,240,285],"guideline-recommended":[35,162,278],"targets.":[37],"Methods":[38],"and":[39,57,98,105,119,141,156,168,171,185,200,225,289,302],"Results":[40],"This":[41,209],"observational":[42],"study":[43,110],"evaluated":[44],"the":[45,91,103,131,135,294],"impact":[46],"novel":[48],"lowering":[50],"therapies":[51],"(evolocumab,":[52],"alirocumab,":[53],"inclisiran,":[54,128,139],"bempedoic":[55,226,303],"acid":[56,227],"icosapent":[58],"ethyl)":[59],"in":[60,179,248,260,268,276,297],"patients":[61,150,159],"at":[62],"a":[63,69,123,161,188,215,229,245],"high":[64,283],"risk":[65],"and/or":[67],"with":[68,76,83,117,146,183,214,228,244,257,264,293],"history":[70],"treated":[75,116],"maximum-tolerated":[77],"doses":[78],"high-intensity":[80],"statin":[81],"therapy":[82],"or":[84,250],"without":[85],"ezetimibe.":[86],"Our":[87],"primary":[88],"assessment":[89],"was":[90,181,210,255],"LDL-C":[94,126,163,174,180],"below":[95],"1.4":[96],"mmol/L":[97,100,167,176],"2.0":[99],"as":[101],"per":[102],"ESC":[104],"NICE":[106],"guidelines":[107],"respectively.":[108,177,208],"The":[109],"comprised":[111],"299":[113],"patients.":[114],"Patients":[115],"alirocumab":[118,142,184],"evolocumab":[120,140,290],"started":[121],"from":[122],"higher":[124],"baseline":[125,286],"than":[127],"due":[129],"eligibility":[132],"criteria":[133],"medications.":[136],"Despite":[137],"this,":[138],"were":[143,242,274,291],"all":[144],"associated":[145,243,256,292],"similar":[147],"proportions":[148],"achieving":[151,187,277],"LDL":[152],"targets:":[153],"42%,":[154],"41%":[155],"38%":[157],"achieved":[160,173],"target":[164],"<1.4":[166],"53%,":[169],"56%":[170,172],"<2.0":[175],"Reduction":[178],"greatest":[182,295],"evolocumab,":[186],"reduction":[189,216,230,247,259,267],"61%":[191],"(95%":[192,202,219,233],"confidence":[193],"interval":[194],"[CI],":[195],"49":[196],"91,":[198],"P<0.001)":[199,207,224],"60%":[201],"CI,":[203,220,234],"48":[204],"93,":[206],"followed":[211,299],"by":[212,300],"inclisiran":[213,301],"51%":[218],"39":[221],"81,":[223],"36%":[232],"22":[235],"69,":[237],"P<0.001).":[238],"None":[239],"these":[241],"significant":[246,266],"triglycerides":[249],"C-reactive":[251],"protein.":[252],"Icosapent":[253],"ethyl":[254],"17%":[258],"triglyceride":[261],"(P=0.023)":[263],"no":[265],"LDL-C.":[269,287],"Conclusion":[270],"Novel":[271],"lipid-lowering":[272],"effective":[275],"targets":[279],"LDL-C,":[281,298],"despite":[282],"Alirocumab":[288],"reductions":[296],"acid.":[304]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-19T00:00:00"}