{"id":"https://openalex.org/W4416211751","doi":"https://doi.org/10.1186/s13045-025-01756-5","title":"B7-H3 nanobody-based CAR T cells control multiple myeloma growth, while dual BCMA/B7-H3 CAR T cells overcome antigen escape","display_name":"B7-H3 nanobody-based CAR T cells control multiple myeloma growth, while dual BCMA/B7-H3 CAR T cells overcome antigen escape","publication_year":2025,"publication_date":"2025-11-14","ids":{"openalex":"https://openalex.org/W4416211751","doi":"https://doi.org/10.1186/s13045-025-01756-5","pmid":"https://pubmed.ncbi.nlm.nih.gov/41239377","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12619266"},"language":"en","primary_location":{"id":"doi:10.1186/s13045-025-01756-5","doi":"https://doi.org/10.1186/s13045-025-01756-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13045-025-01756-5","pdf_url":"https://jhoonline.biomedcentral.com/counter/pdf/10.1186/s13045-025-01756-5","source":{"id":"https://openalex.org/S46507181","display_name":"Journal of Hematology & Oncology","issn_l":"1756-8722","issn":["1756-8722"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hematology & Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jhoonline.biomedcentral.com/counter/pdf/10.1186/s13045-025-01756-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025492386","display_name":"Arne Van der Vreken","orcid":"https://orcid.org/0000-0003-0345-721X","observed_orcids":["https://orcid.org/0000-0003-0345-721X"]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Arne Van der Vreken","raw_affiliation_strings":["Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088608394","display_name":"Fien Meeus","orcid":"https://orcid.org/0000-0002-5866-2002","observed_orcids":["https://orcid.org/0000-0002-5866-2002"]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Fien Meeus","raw_affiliation_strings":["Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091516023","display_name":"Chenggong Tu","orcid":"https://orcid.org/0000-0001-9281-5298","observed_orcids":["https://orcid.org/0000-0001-9281-5298"]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Chenggong Tu","raw_affiliation_strings":["Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119592811","display_name":"Lauren van den Broecke","orcid":"https://orcid.org/0009-0008-0158-4630","observed_orcids":["https://orcid.org/0009-0008-0158-4630"]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Lauren van den Broecke","raw_affiliation_strings":["Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023389387","display_name":"Vincenzo Raimondi","orcid":"https://orcid.org/0000-0002-9870-7893","observed_orcids":["https://orcid.org/0000-0002-9870-7893"]},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vincenzo Raimondi","raw_affiliation_strings":["Laboratory of Hematology, Department of Medicine and Surgery, University of Parma, Parma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Hematology, Department of Medicine and Surgery, University of Parma, Parma, Italy","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035496022","display_name":"Rosanna Vescovini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rosanna Vescovini","raw_affiliation_strings":["Laboratory of Hematology, Department of Medicine and Surgery, University of Parma, Parma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Hematology, Department of Medicine and Surgery, University of Parma, Parma, Italy","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046629838","display_name":"Heleen Hanssens","orcid":"https://orcid.org/0000-0001-8996-4671","observed_orcids":["https://orcid.org/0000-0001-8996-4671"]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Heleen Hanssens","raw_affiliation_strings":["Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120400619","display_name":"Fenja Watt\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Fenja Watt\u00e9","raw_affiliation_strings":["Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015276260","display_name":"Dorien Autaers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Dorien Autaers","raw_affiliation_strings":["Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115025939","display_name":"Marta Marco Aragon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Marta Marco Aragon","raw_affiliation_strings":["Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092343456","display_name":"Janne Billiau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Janne Billiau","raw_affiliation_strings":["Faculty of Medicine, KU Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, KU Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069262831","display_name":"Kim De Veirman","orcid":"https://orcid.org/0000-0002-1313-6121","observed_orcids":["https://orcid.org/0000-0002-1313-6121"]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Kim De Veirman","raw_affiliation_strings":["Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014026887","display_name":"Karin Vanderkerken","orcid":"https://orcid.org/0000-0002-2137-7179","observed_orcids":["https://orcid.org/0000-0002-2137-7179"]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Karin Vanderkerken","raw_affiliation_strings":["Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073798404","display_name":"Yannick De Vlaeminck","orcid":"https://orcid.org/0000-0002-1882-4740","observed_orcids":["https://orcid.org/0000-0002-1882-4740"]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Yannick De Vlaeminck","raw_affiliation_strings":["Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058869675","display_name":"Lorenzo Franceschini","orcid":"https://orcid.org/0000-0001-9013-9513","observed_orcids":["https://orcid.org/0000-0001-9013-9513"]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Lorenzo Franceschini","raw_affiliation_strings":["Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038525669","display_name":"Holly Lee","orcid":"https://orcid.org/0000-0001-8353-0848","observed_orcids":["https://orcid.org/0000-0001-8353-0848"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Holly Lee","raw_affiliation_strings":["Department of Medical Oncology and Hematology, Tom Baker Cancer Center, Calgary, AB, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology and Hematology, Tom Baker Cancer Center, Calgary, AB, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064430852","display_name":"Paola E. Neri","orcid":"https://orcid.org/0000-0002-2595-3647","observed_orcids":["https://orcid.org/0000-0002-2595-3647"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paola Neri","raw_affiliation_strings":["Department of Medical Oncology and Hematology, Tom Baker Cancer Center, Calgary, AB, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology and Hematology, Tom Baker Cancer Center, Calgary, AB, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027619485","display_name":"Elke De Bruyne","orcid":"https://orcid.org/0000-0003-4012-4617","observed_orcids":["https://orcid.org/0000-0003-4012-4617"]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Elke De Bruyne","raw_affiliation_strings":["Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043503519","display_name":"Paola Storti","orcid":"https://orcid.org/0000-0001-8014-8205","observed_orcids":["https://orcid.org/0000-0001-8014-8205"]},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paola Storti","raw_affiliation_strings":["Laboratory of Hematology, Department of Medicine and Surgery, University of Parma, Parma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Hematology, Department of Medicine and Surgery, University of Parma, Parma, Italy","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083314734","display_name":"Nicola Giuliani","orcid":"https://orcid.org/0000-0003-3457-3774","observed_orcids":["https://orcid.org/0000-0003-3457-3774","https://orcid.org/0009-0007-5943-3635"]},"institutions":[{"id":"https://openalex.org/I124601658","display_name":"University of Parma","ror":"https://ror.org/02k7wn190","country_code":"IT","type":"education","lineage":["https://openalex.org/I124601658"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Nicola Giuliani","raw_affiliation_strings":["Laboratory of Hematology, Department of Medicine and Surgery, University of Parma, Parma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Hematology, Department of Medicine and Surgery, University of Parma, Parma, Italy","institution_ids":["https://openalex.org/I124601658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048780479","display_name":"Karine Breckpot","orcid":"https://orcid.org/0000-0003-4331-3480","observed_orcids":["https://orcid.org/0000-0003-4331-3480"]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Karine Breckpot","raw_affiliation_strings":["Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium. karine.breckpot@vub.be","Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium. karine.breckpot@vub.be","institution_ids":["https://openalex.org/I13469542"]},{"raw_affiliation_string":"Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003658156","display_name":"Eline Menu","orcid":"https://orcid.org/0000-0002-0805-6581","observed_orcids":["https://orcid.org/0000-0002-0805-6581"]},"institutions":[{"id":"https://openalex.org/I13469542","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04","country_code":"BE","type":"education","lineage":["https://openalex.org/I13469542"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Eline Menu","raw_affiliation_strings":["Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium. eline.menu@vub.be","Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium. eline.menu@vub.be","institution_ids":["https://openalex.org/I13469542"]},{"raw_affiliation_string":"Translational Oncology Research Center, Department of Biomedical Sciences, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090, Brussels, Belgium","institution_ids":["https://openalex.org/I13469542"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5003658156","https://openalex.org/A5048780479"],"corresponding_institution_ids":["https://openalex.org/I13469542"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":{"value":4990,"currency":"USD","value_usd":4990},"fwci":3.2858,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.93719707,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"18","issue":"1","first_page":"103","last_page":"103"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9449999928474426},{"id":"https://openalex.org/keywords/b7-h3","display_name":"B7-H3","score":0.9879999756813049},{"id":"https://openalex.org/keywords/b-cell-maturation-antigen","display_name":"BCMA","score":0.8690000176429749},{"id":"https://openalex.org/keywords/antigen-escape","display_name":"antigen escape","score":0.8769999742507935},{"id":"https://openalex.org/keywords/t-cell-exhaustion","display_name":"T cell exhaustion","score":0.7020000219345093},{"id":"https://openalex.org/keywords/carpooling","display_name":"carpooling","score":0.8309999704360962},{"id":"https://openalex.org/keywords/plasma-cells","display_name":"plasma cells","score":0.7120000123977661},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.6679999828338623},{"id":"https://openalex.org/keywords/xenograft-models","display_name":"xenograft models","score":0.7440000176429749}],"concepts":[{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.6847000122070312},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6069999933242798},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.588699996471405},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5841000080108643},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.5112000107765198},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.460099995136261},{"id":"https://openalex.org/C2780980858","wikidata":"https://www.wikidata.org/wiki/Q110022","display_name":"Dual (grammatical number)","level":2,"score":0.39469999074935913},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37790000438690186},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3467000126838684},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3312999904155731},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32519999146461487},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.32350000739097595},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.28940001130104065},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.2879999876022339},{"id":"https://openalex.org/C2776662205","wikidata":"https://www.wikidata.org/wiki/Q2459684","display_name":"Tumor antigen","level":4,"score":0.28780001401901245},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28700000047683716},{"id":"https://openalex.org/C2992881475","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T lymphocyte","level":3,"score":0.27489998936653137},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.27079999446868896},{"id":"https://openalex.org/C3019217517","wikidata":"https://www.wikidata.org/wiki/Q2459684","display_name":"Tumor associated antigen","level":4,"score":0.2705000042915344},{"id":"https://openalex.org/C3018558359","wikidata":"https://www.wikidata.org/wiki/Q1660157","display_name":"Immune escape","level":3,"score":0.2587999999523163},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.2574999928474426},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.2513999938964844}],"mesh":[{"descriptor_ui":"D000076962","descriptor_name":"Receptors, Chimeric Antigen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019139","descriptor_name":"Tumor Escape","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053301","descriptor_name":"B-Cell Maturation Antigen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D060887","descriptor_name":"B7 Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D061905","descriptor_name":"Single-Domain Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1186/s13045-025-01756-5","doi":"https://doi.org/10.1186/s13045-025-01756-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13045-025-01756-5","pdf_url":"https://jhoonline.biomedcentral.com/counter/pdf/10.1186/s13045-025-01756-5","source":{"id":"https://openalex.org/S46507181","display_name":"Journal of Hematology & Oncology","issn_l":"1756-8722","issn":["1756-8722"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hematology & Oncology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:11427274","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12619266","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:41239377","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41239377","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of hematology & oncology","raw_type":"Journal Article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:20.500.12942/790814","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/20.500.12942/790814","pdf_url":"https://lirias.kuleuven.be/retrieve/0098b542-9e93-44d4-90bb-ca0e3b82d4f0","source":{"id":"https://openalex.org/S4306401954","display_name":"Lirias (KU Leuven)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I99464096","host_organization_name":"KU Leuven","host_organization_lineage":["https://openalex.org/I99464096"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal Of Hematology & Oncology, vol. 18 (1), Art.No. ARTN 103","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:7e09da2d7f214adea0ea31c1c611c86e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7e09da2d7f214adea0ea31c1c611c86e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Hematology & Oncology, Vol 18, Iss 1, Pp 1-17 (2025)","raw_type":"article"},{"id":"pmh:oai:vubissmart:VUBISSMART:2000:261891","doi":null,"is_oa":false,"landing_page_url":"https://biblio.vub.ac.be/vubir/b7h3-nanobodybased-car-t-cells-control-multiple-myeloma-growth-while-dual-bcmab7h3-car-t-cells-overcome-antigen-escape(877911b4-8069-4737-a15b-d4ff6911dc48).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306402573","display_name":"VUBIR (Vrije Universiteit Brussel)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I13469542","host_organization_name":"Vrije Universiteit Brussel","host_organization_lineage":["https://openalex.org/I13469542"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:vubissmart:VUBISSMART:2000:262600","doi":null,"is_oa":false,"landing_page_url":"https://biblio.vub.ac.be/vubir/b7h3-nanobodybased-car-t-cells-control-multiple-myeloma-growth-while-dual-bcmab7h3-car-t-cells-overcome-antigen-escape(e62c5482-5f10-4bee-841d-e144283e7573).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306402573","display_name":"VUBIR (Vrije Universiteit Brussel)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I13469542","host_organization_name":"Vrije Universiteit Brussel","host_organization_lineage":["https://openalex.org/I13469542"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13045-025-01756-5","doi":"https://doi.org/10.1186/s13045-025-01756-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13045-025-01756-5","pdf_url":"https://jhoonline.biomedcentral.com/counter/pdf/10.1186/s13045-025-01756-5","source":{"id":"https://openalex.org/S46507181","display_name":"Journal of Hematology & Oncology","issn_l":"1756-8722","issn":["1756-8722"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hematology & Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2031332188","display_name":"Development of a NanoCAR-T cell approach for the treatment of multiple myeloma","funder_award_id":"1S55619N","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G2610537018","display_name":null,"funder_award_id":"V435824N","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G3170510191","display_name":"CARGO: advancing chimeric antigen receptor T cell therapy using nanobody-displaying lentiviral vectors","funder_award_id":"1S68523N","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G461524922","display_name":null,"funder_award_id":"2024-165_F2530","funder_id":"https://openalex.org/F4320323069","funder_display_name":"Stichting Tegen Kanker"},{"id":"https://openalex.org/G5860396662","display_name":null,"funder_award_id":"KOTK_VUB/2024/13879","funder_id":"https://openalex.org/F4320327317","funder_display_name":"Kom op tegen Kanker"},{"id":"https://openalex.org/G7780772506","display_name":null,"funder_award_id":"SRP84","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G7819152217","display_name":null,"funder_award_id":"2022-J1811380-E003","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G795723426","display_name":null,"funder_award_id":"40007555","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G817903939","display_name":null,"funder_award_id":"1S68523N","funder_id":"https://openalex.org/F4320323739","funder_display_name":"Koning Boudewijnstichting"},{"id":"https://openalex.org/G8230788692","display_name":null,"funder_award_id":"2022-J1811380-E003","funder_id":"https://openalex.org/F4320323739","funder_display_name":"Koning Boudewijnstichting"},{"id":"https://openalex.org/G8757702234","display_name":null,"funder_award_id":"strategic research program (SRP84)","funder_id":"https://openalex.org/F4320322634","funder_display_name":"Vrije Universiteit Brussel"}],"funders":[{"id":"https://openalex.org/F4320321730","display_name":"Fonds Wetenschappelijk Onderzoek","ror":"https://ror.org/03qtxy027"},{"id":"https://openalex.org/F4320322634","display_name":"Vrije Universiteit Brussel","ror":"https://ror.org/006e5kg04"},{"id":"https://openalex.org/F4320322875","display_name":"Universit\u00e0 degli Studi di Parma","ror":"https://ror.org/02k7wn190"},{"id":"https://openalex.org/F4320323069","display_name":"Stichting Tegen Kanker","ror":"https://ror.org/01h3dr788"},{"id":"https://openalex.org/F4320323739","display_name":"Koning Boudewijnstichting","ror":"https://ror.org/02am44w88"},{"id":"https://openalex.org/F4320327317","display_name":"Kom op tegen Kanker","ror":null},{"id":"https://openalex.org/F4320327336","display_name":"Vlaamse regering","ror":null},{"id":"https://openalex.org/F4320328144","display_name":"Fondation contre le Cancer","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416211751.pdf","grobid_xml":"https://content.openalex.org/works/W4416211751.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1931471783","https://openalex.org/W1997001746","https://openalex.org/W2030872418","https://openalex.org/W2075520012","https://openalex.org/W2102777859","https://openalex.org/W2122465970","https://openalex.org/W2725962181","https://openalex.org/W2804159084","https://openalex.org/W2807637103","https://openalex.org/W2864786814","https://openalex.org/W2904238911","https://openalex.org/W2919051790","https://openalex.org/W2987995965","https://openalex.org/W3033991393","https://openalex.org/W3092496866","https://openalex.org/W3106753232","https://openalex.org/W3108926297","https://openalex.org/W3124142499","https://openalex.org/W3128868608","https://openalex.org/W3133229959","https://openalex.org/W3165252338","https://openalex.org/W4200326433","https://openalex.org/W4281714381","https://openalex.org/W4283323027","https://openalex.org/W4291926372","https://openalex.org/W4292262041","https://openalex.org/W4306795470","https://openalex.org/W4319812103","https://openalex.org/W4321327258","https://openalex.org/W4322753317","https://openalex.org/W4323043091","https://openalex.org/W4379375986","https://openalex.org/W4382751451","https://openalex.org/W4382934836","https://openalex.org/W4384820051","https://openalex.org/W4385720584","https://openalex.org/W4386324983","https://openalex.org/W4387030961","https://openalex.org/W4388692467","https://openalex.org/W4388750235","https://openalex.org/W4388794045","https://openalex.org/W4391022895","https://openalex.org/W4393381913","https://openalex.org/W4394959542","https://openalex.org/W4396620144","https://openalex.org/W4400094382","https://openalex.org/W4400496502","https://openalex.org/W4402400825","https://openalex.org/W4402824750","https://openalex.org/W4404500980","https://openalex.org/W4404512508","https://openalex.org/W4409910770","https://openalex.org/W4413210058"],"related_works":["https://openalex.org/W7212350969","https://openalex.org/W4416639442","https://openalex.org/W4416713376","https://openalex.org/W3194558981","https://openalex.org/W4200384666","https://openalex.org/W7161151664","https://openalex.org/W4417002307","https://openalex.org/W3022509419","https://openalex.org/W3047602217","https://openalex.org/W7126044784"],"abstract_inverted_index":{"BACKGROUND:":[0],"CAR":[1,51,82,93,146],"T":[2,20,52,83,94,120,147,191],"cell":[3,21],"therapy":[4],"targeting":[5,55,168],"BCMA":[6,90,159],"has":[7],"shown":[8],"remarkable":[9],"efficacy":[10,100],"in":[11,64,75,101,113,185],"multiple":[12],"myeloma":[13,69],"(MM),":[14],"but":[15],"relapses":[16],"occur":[17],"due":[18],"to":[19,33,173,197],"exhaustion":[22],"and":[23,57,61,86,91,126,141,149,188,201],"the":[24],"emergence":[25],"of":[26,89,115],"BCMA-negative":[27],"subpopulations.":[28],"Novel":[29],"targets":[30],"are":[31],"needed":[32],"overcome":[34,174],"antigen":[35,102,175,199],"escape.":[36],"METHODS:":[37],"B7-H3":[38,56,92,106,118,161,179],"(CD276)":[39],"expression":[40,107],"was":[41,73,108],"assessed":[42],"on":[43,110],"primary":[44,132],"MM":[45,78,116,133],"patient":[46],"samples.":[47],"We":[48],"engineered":[49],"nanobody-based":[50],"cells":[53,84,112,121,148,192],"(nanoCARs)":[54],"evaluated":[58],"their":[59],"cytotoxicity":[60,125],"cytokine":[62,128],"production":[63],"vitro,":[65],"including":[66,130],"against":[67,131],"patient-derived":[68],"cells.":[70,134],"Anti-tumor":[71],"activity":[72],"tested":[74,98],"two":[76],"different":[77],"xenograft":[79],"models.":[80,104],"Dual":[81,144],"(BCMA/B7-H3)":[85,145],"CARpooling":[87,150],"(mix":[88],"cells)":[95],"were":[96],"also":[97],"for":[99],"escape":[103,176,200],"RESULTS:":[105],"detected":[109],"plasma":[111],"60%":[114],"patients.":[117],"nanoCAR":[119,190],"exhibited":[122],"strong":[123],"antigen-specific":[124],"effector":[127],"secretion,":[129],"In":[135],"vivo,":[136],"they":[137],"reduced":[138],"tumor":[139,154],"burden":[140],"improved":[142],"survival.":[143],"effectively":[151],"eliminated":[152],"heterogeneous":[153],"populations":[155],"with":[156],"mutually":[157],"exclusive":[158],"or":[160],"expression.":[162],"These":[163],"findings":[164],"show":[165],"that":[166],"BCMA/B7-H3":[167],"may":[169],"be":[170],"a":[171,181,195],"strategy":[172,196],"mechanisms.":[177],"CONCLUSION:":[178],"is":[180],"promising":[182],"immunotherapy":[183],"target":[184],"MM.":[186],"B7-H3-specific":[187],"dual-targeting":[189],"could":[193],"offer":[194],"prevent":[198],"improve":[202],"treatment":[203],"durability.":[204]},"counts_by_year":[{"year":2026,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-11-14T00:00:00"}