{"id":"https://openalex.org/W4416141012","doi":"https://doi.org/10.1093/neuonc/noaf201.0802","title":"IMMU-03. Sustained anti-PD1 response in refractory EBV-positive DLBCL with CNS involvement in an immunocompetent patient","display_name":"IMMU-03. Sustained anti-PD1 response in refractory EBV-positive DLBCL with CNS involvement in an immunocompetent patient","publication_year":2025,"publication_date":"2025-11-01","ids":{"openalex":"https://openalex.org/W4416141012","doi":"https://doi.org/10.1093/neuonc/noaf201.0802"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/noaf201.0802","doi":"https://doi.org/10.1093/neuonc/noaf201.0802","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noaf201.0802","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/27/Supplement_5/v202/65254946/noaf201.0802.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/neuro-oncology/article-pdf/27/Supplement_5/v202/65254946/noaf201.0802.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084711242","display_name":"Hannah Kim","orcid":"https://orcid.org/0000-0001-7360-011X","observed_orcids":["https://orcid.org/0000-0001-7360-011X"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hannah Kim","raw_affiliation_strings":["Northwestern University, Department of Neurology , Chicago,","Northwestern University, Department of Neurology, Chicago, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University, Department of Neurology , Chicago,","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Northwestern University, Department of Neurology, Chicago, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035710475","display_name":"Karan Dixit","orcid":"https://orcid.org/0000-0003-0403-6054","observed_orcids":["https://orcid.org/0000-0003-0403-6054"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karan Dixit","raw_affiliation_strings":["Lou & Jean Malnati Brain Tumor Institute , Chicago,","Northwestern University, Department of Neurology , Chicago,","Lou & Jean Malnati Brain Tumor Institute, Chicago, USA","Northwestern University, Department of Neurology, Chicago, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lou & Jean Malnati Brain Tumor Institute , Chicago,","institution_ids":[]},{"raw_affiliation_string":"Northwestern University, Department of Neurology , Chicago,","institution_ids":["https://openalex.org/I111979921"]},{"raw_affiliation_string":"Lou & Jean Malnati Brain Tumor Institute, Chicago, USA","institution_ids":[]},{"raw_affiliation_string":"Northwestern University, Department of Neurology, Chicago, USA","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I111979921"],"apc_list":{"value":5132,"currency":"USD","value_usd":5132},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"Supplement_5","first_page":"v202","last_page":"v202"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.8583999872207642,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.8583999872207642,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.11129999905824661,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12212","display_name":"CNS Lymphoma Diagnosis and Treatment","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/central-nervous-system-involvement","display_name":"central nervous system involvement","score":0.7639999985694885},{"id":"https://openalex.org/keywords/anti-pd-1-therapy","display_name":"anti-PD-1 therapy","score":0.9110000133514404},{"id":"https://openalex.org/keywords/nivolumab","display_name":"nivolumab","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pd-l1-expression","display_name":"PD-L1 expression","score":0.9010000228881836},{"id":"https://openalex.org/keywords/refractory-lymphoma","display_name":"refractory lymphoma","score":0.8769999742507935},{"id":"https://openalex.org/keywords/status-epilepticus","display_name":"status epilepticus","score":0.9190000295639038},{"id":"https://openalex.org/keywords/hypothalamic-dysfunction","display_name":"hypothalamic dysfunction","score":0.9409999847412109},{"id":"https://openalex.org/keywords/immunocompetent-patient","display_name":"immunocompetent patient","score":0.8220000267028809},{"id":"https://openalex.org/keywords/car-t-cell-therapy","display_name":"CAR T-cell therapy","score":0.7329999804496765},{"id":"https://openalex.org/keywords/r-ice","display_name":"R-ICE","score":0.8700000047683716},{"id":"https://openalex.org/keywords/intrathecal-methotrexate","display_name":"intrathecal methotrexate","score":0.9660000205039978}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8741000294685364},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.4968000054359436},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.48910000920295715},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.4814000129699707},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4796999990940094},{"id":"https://openalex.org/C2780372218","wikidata":"https://www.wikidata.org/wiki/Q417222","display_name":"Methylprednisolone","level":2,"score":0.4242999851703644},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.3869999945163727},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3804999887943268},{"id":"https://openalex.org/C2778559949","wikidata":"https://www.wikidata.org/wiki/Q2626074","display_name":"Diffuse large B-cell lymphoma","level":3,"score":0.37720000743865967},{"id":"https://openalex.org/C2779429289","wikidata":"https://www.wikidata.org/wiki/Q408977","display_name":"Vincristine","level":4,"score":0.3357999920845032},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3257000148296356},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.3203999996185303},{"id":"https://openalex.org/C2781173314","wikidata":"https://www.wikidata.org/wiki/Q3246818","display_name":"Primary central nervous system lymphoma","level":3,"score":0.3190000057220459},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3116999864578247},{"id":"https://openalex.org/C2779968505","wikidata":"https://www.wikidata.org/wiki/Q416507","display_name":"ThioTEPA","level":4,"score":0.31060001254081726},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2863999903202057},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2849000096321106},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.2842999994754791},{"id":"https://openalex.org/C2780653079","wikidata":"https://www.wikidata.org/wiki/Q412323","display_name":"Rituximab","level":3,"score":0.27399998903274536},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.2734000086784363},{"id":"https://openalex.org/C2777422395","wikidata":"https://www.wikidata.org/wiki/Q3149136","display_name":"Immunocompetence","level":3,"score":0.27070000767707825},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2687999904155731},{"id":"https://openalex.org/C2780775027","wikidata":"https://www.wikidata.org/wiki/Q17141389","display_name":"Salvage therapy","level":3,"score":0.2687000036239624},{"id":"https://openalex.org/C2780790343","wikidata":"https://www.wikidata.org/wiki/Q5090610","display_name":"Chemoimmunotherapy","level":4,"score":0.26179999113082886}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/neuonc/noaf201.0802","doi":"https://doi.org/10.1093/neuonc/noaf201.0802","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noaf201.0802","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/27/Supplement_5/v202/65254946/noaf201.0802.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/neuonc/noaf201.0802","doi":"https://doi.org/10.1093/neuonc/noaf201.0802","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noaf201.0802","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/27/Supplement_5/v202/65254946/noaf201.0802.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416141012.pdf","grobid_xml":"https://content.openalex.org/works/W4416141012.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Diffuse":[1],"large":[2],"B-cell":[3,114],"lymphoma":[4],"(DLBCL)":[5],"is":[6,25,43,93,250],"the":[7,103,165,226],"most":[8],"common":[9,45],"and":[10,35,48,57,92,120,144,204,213,222,229,285],"aggressive":[11,29],"form":[12],"of":[13,19,33,105,157,257,290],"non-Hodgkin":[14],"lymphoma,":[15],"accounting":[16],"for":[17,162,184,252,281],"30\u201340%":[18],"cases.":[20],"Epstein-Barr":[21],"virus":[22],"(EBV)-positive":[23],"DLBCL":[24,53,61,75,116,259],"a":[26,96,106,188,220,254,268],"rare,":[27],"more":[28,44,69],"subtype,":[30],"comprising":[31],"7\u20138%":[32],"cases":[34],"marked":[36],"by":[37],"EBV":[38,286],"within":[39],"tumor":[40],"cells.":[41],"It":[42],"in":[46,263,275],"elderly":[47],"immunocompromised":[49],"patients.":[50],"While":[51],"typical":[52],"presents":[54,63,83],"with":[55,68,76,84,95,110,117,147,177,201,210,241,260],"lymphadenopathy":[56],"constitutional":[58],"symptoms,":[59],"EBV-positive":[60,74,258],"often":[62],"at":[64],"an":[65,264],"advanced":[66],"stage,":[67],"frequent":[70],"extranodal":[71],"disease.":[72],"Furthermore,":[73],"central":[77],"nervous":[78],"system":[79],"(CNS)":[80],"involvement":[81,262],"typically":[82],"multifocal":[85],"lesions,":[86],"responds":[87],"poorly":[88],"to":[89,127,139,190,225,272,292],"standard":[90],"treatment,":[91],"associated":[94],"poorer":[97],"overall":[98],"prognosis.":[99],"Here,":[100],"we":[101],"describe":[102],"case":[104,249],"58-year-old":[107],"immunocompetent":[108,265],"male":[109],"EBV-positive,":[111],"non-germinal":[112],"center":[113],"(non-GCB)":[115],"synchronous":[118],"pulmonary":[119],"CNS":[121,261],"involvement.":[122],"His":[123],"disease":[124,218,277],"was":[125,167,208],"refractory":[126,276],"MR-CHOP":[128],"(high-dose":[129],"methotrexate,":[130],"rituximab,":[131],"cyclophosphamide,":[132],"doxorubicin,":[133],"vincristine,":[134],"prednisone),":[135],"as":[136,138,187,288],"well":[137],"R-ICE":[140],"(rituximab,":[141],"ifosfamide,":[142],"carboplatin,":[143],"etoposide)":[145],"combined":[146],"intrathecal":[148],"methotrexate":[149],"(IT-MTX).":[150],"Given":[151],"that":[152],"his":[153,217,245],"tissue":[154],"demonstrated":[155],">70%":[156],"neoplastic":[158],"B":[159],"cells":[160],"positive":[161],"PD-L1":[163,283],"staining,":[164],"patient":[166,195,266],"started":[168],"on":[169],"anti-PD-1":[170,273,293],"(anti-programmed":[171],"cell":[172,192],"death":[173],"protein":[174],"1)":[175],"therapy":[176,274],"nivolumab":[178],"(240":[179],"mg":[180],"every":[181],"14":[182],"days":[183],"three":[185],"doses)":[186],"bridge":[189],"CAR-T":[191],"therapy.":[193,294],"The":[194],"developed":[196],"severe":[197],"immune-checkpoint":[198],"inhibitor":[199],"encephalitis":[200],"status":[202],"epilepticus":[203],"hypothalamic":[205,246],"dysfunction":[206],"which":[207],"treated":[209],"intravenous":[211,214],"methylprednisolone":[212],"immunoglobulins.":[215],"Notably,":[216],"experienced":[219],"rapid":[221],"sustained":[223],"response":[224,271,291],"PD-1":[227],"blockade":[228],"he":[230],"has":[231],"remained":[232],"disease-free":[233],"four":[234],"years":[235],"later.":[236],"He":[237],"remains":[238],"clinically":[239],"stable,":[240],"occasional":[242],"hypothermia":[243],"from":[244],"injury.":[247],"This":[248],"notable":[251],"(1)":[253],"rare":[255],"presentation":[256],"(2)":[267],"successful":[269],"clinical":[270],"(3)":[278],"further":[279],"support":[280],"high":[282],"expression":[284],"positivity":[287],"predictors":[289]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2025-11-11T00:00:00"}