{"id":"https://openalex.org/W4416094591","doi":"https://doi.org/10.1111/cas.70248","title":"Carbonic Anhydrase 12 as a Novel Prognostic Biomarker and Therapeutic Target for High\u2010Risk Follicular Thyroid Carcinoma","display_name":"Carbonic Anhydrase 12 as a Novel Prognostic Biomarker and Therapeutic Target for High\u2010Risk Follicular Thyroid Carcinoma","publication_year":2025,"publication_date":"2025-11-10","ids":{"openalex":"https://openalex.org/W4416094591","doi":"https://doi.org/10.1111/cas.70248","pmid":"https://pubmed.ncbi.nlm.nih.gov/41208415","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12775590"},"language":"en","primary_location":{"id":"doi:10.1111/cas.70248","doi":"https://doi.org/10.1111/cas.70248","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cas.70248","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cas.70248","source":{"id":"https://openalex.org/S175946340","display_name":"Cancer Science","issn_l":"1347-9032","issn":["1347-9032","1349-7006"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cas.70248","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018646816","display_name":"Masashi Tanida","orcid":"https://orcid.org/0009-0006-9016-0420","observed_orcids":["https://orcid.org/0009-0006-9016-0420"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masashi Tanida","raw_affiliation_strings":["Department of Otorhinolaryngology\u2010Head and Neck Surgery, Graduate School of Medicine The University of Osaka  Osaka Japan","Department of Pathology, Graduate School of Medicine, The University of Osaka, Osaka, Japan"],"raw_orcid":"https://orcid.org/0009-0006-9016-0420","affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology\u2010Head and Neck Surgery, Graduate School of Medicine The University of Osaka  Osaka Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Pathology, Graduate School of Medicine, The University of Osaka, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026420631","display_name":"Tsuyoshi Takashima","orcid":"https://orcid.org/0000-0003-1362-3883","observed_orcids":["https://orcid.org/0000-0003-1362-3883"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tsuyoshi Takashima","raw_affiliation_strings":["Department of Pathology, Graduate School of Medicine, The University of Osaka, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Graduate School of Medicine, The University of Osaka, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033992195","display_name":"Shinichiro Tahara","orcid":"https://orcid.org/0000-0001-6134-3275","observed_orcids":["https://orcid.org/0000-0001-6134-3275"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinichiro Tahara","raw_affiliation_strings":["Department of Pathology, Graduate School of Medicine, The University of Osaka, Osaka, Japan"],"raw_orcid":"https://orcid.org/0000-0001-6134-3275","affiliations":[{"raw_affiliation_string":"Department of Pathology, Graduate School of Medicine, The University of Osaka, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084956446","display_name":"Masaharu Kohara","orcid":"https://orcid.org/0009-0006-7636-5833","observed_orcids":["https://orcid.org/0009-0006-7636-5833"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaharu Kohara","raw_affiliation_strings":["Department of Pathology, Graduate School of Medicine, The University of Osaka, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Graduate School of Medicine, The University of Osaka, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059500796","display_name":"Haruka Kanai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Haruka Kanai","raw_affiliation_strings":["Department of Otorhinolaryngology-Head and Neck Surgery, Graduate School of Medicine, The University of Osaka, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology-Head and Neck Surgery, Graduate School of Medicine, The University of Osaka, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081199011","display_name":"Masami Suzuki","orcid":"https://orcid.org/0000-0002-2179-938X","observed_orcids":["https://orcid.org/0000-0002-2179-938X"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masami Suzuki","raw_affiliation_strings":["Department of Otorhinolaryngology-Head and Neck Surgery, Graduate School of Medicine, The University of Osaka, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology-Head and Neck Surgery, Graduate School of Medicine, The University of Osaka, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112178830","display_name":"Motoyuki Suzuki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Motoyuki Suzuki","raw_affiliation_strings":["Department of Otorhinolaryngology-Head and Neck Surgery, Graduate School of Medicine, The University of Osaka, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology-Head and Neck Surgery, Graduate School of Medicine, The University of Osaka, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043611756","display_name":"Mitsuyoshi Hirokawa","orcid":"https://orcid.org/0000-0001-5558-7142","observed_orcids":["https://orcid.org/0000-0001-5558-7142"]},"institutions":[{"id":"https://openalex.org/I4210142353","display_name":"Kuma Hospital","ror":"https://ror.org/049913966","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210142353"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsuyoshi Hirokawa","raw_affiliation_strings":["Department of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe, Japan","institution_ids":["https://openalex.org/I4210142353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064191255","display_name":"Ayana Suzuki","orcid":"https://orcid.org/0000-0002-0827-1580","observed_orcids":["https://orcid.org/0000-0002-0827-1580"]},"institutions":[{"id":"https://openalex.org/I4210142353","display_name":"Kuma Hospital","ror":"https://ror.org/049913966","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210142353"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ayana Suzuki","raw_affiliation_strings":["Department of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe, Japan","institution_ids":["https://openalex.org/I4210142353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102834275","display_name":"Shinya Satoh","orcid":"https://orcid.org/0000-0002-0761-6209","observed_orcids":["https://orcid.org/0000-0002-0761-6209"]},"institutions":[{"id":"https://openalex.org/I4387152207","display_name":"Yamashita Thyroid Hospital","ror":"https://ror.org/052rpwb50","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4387152207"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinya Sato","raw_affiliation_strings":["Department of Surgery, Yamashita Thyroid Hospital, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Yamashita Thyroid Hospital, Fukuoka, Japan","institution_ids":["https://openalex.org/I4387152207"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002727514","display_name":"Daisuke Okuzaki","orcid":"https://orcid.org/0000-0002-4552-783X","observed_orcids":["https://orcid.org/0000-0002-4552-783X"]},"institutions":[{"id":"https://openalex.org/I4405287342","display_name":"Immunology Frontier Research Center, The University of Osaka","ror":"https://ror.org/04xm7dy51","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287342","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Daisuke Okuzaki","raw_affiliation_strings":["Single Cell Genomics, Human Immunology, WPI Immunology Frontier Research Center, The University of Osaka, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Single Cell Genomics, Human Immunology, WPI Immunology Frontier Research Center, The University of Osaka, Osaka, Japan","institution_ids":["https://openalex.org/I4405287342","https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046856618","display_name":"Satoshi Nojima","orcid":"https://orcid.org/0000-0002-5124-0026","observed_orcids":["https://orcid.org/0000-0002-5124-0026"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Nojima","raw_affiliation_strings":["Department of Pathology, Graduate School of Medicine, The University of Osaka, Osaka, Japan"],"raw_orcid":"https://orcid.org/0000-0002-5124-0026","affiliations":[{"raw_affiliation_string":"Department of Pathology, Graduate School of Medicine, The University of Osaka, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048494715","display_name":"Takahiro Matsui","orcid":"https://orcid.org/0000-0002-6753-1688","observed_orcids":["https://orcid.org/0000-0002-6753-1688"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahiro Matsui","raw_affiliation_strings":["Department of Pathology, Graduate School of Medicine, The University of Osaka, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Graduate School of Medicine, The University of Osaka, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048212731","display_name":"Hidenori Inohara","orcid":"https://orcid.org/0000-0003-4473-1203","observed_orcids":["https://orcid.org/0000-0003-4473-1203"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hidenori Inohara","raw_affiliation_strings":["Department of Otorhinolaryngology-Head and Neck Surgery, Graduate School of Medicine, The University of Osaka, Osaka, Japan"],"raw_orcid":"https://orcid.org/0000-0003-4473-1203","affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology-Head and Neck Surgery, Graduate School of Medicine, The University of Osaka, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049747685","display_name":"Eiichi Morii","orcid":"https://orcid.org/0000-0001-8490-3650","observed_orcids":["https://orcid.org/0000-0001-8490-3650"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Eiichi Morii","raw_affiliation_strings":["Department of Pathology, Graduate School of Medicine, The University of Osaka, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Graduate School of Medicine, The University of Osaka, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5049747685"],"corresponding_institution_ids":["https://openalex.org/I98285908"],"apc_list":{"value":2600,"currency":"USD","value_usd":2600},"apc_paid":{"value":2600,"currency":"USD","value_usd":2600},"fwci":0.5087,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.59667066,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"117","issue":"1","first_page":"257","last_page":"271"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12412","display_name":"Enzyme function and inhibition","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/follicular-thyroid-carcinoma","display_name":"follicular thyroid carcinoma","score":0.8980000019073486},{"id":"https://openalex.org/keywords/high-risk-thyroid-cancer","display_name":"high-risk thyroid cancer","score":0.8529999852180481},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9980000257492065},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.9860000014305115},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.9049999713897705},{"id":"https://openalex.org/keywords/tumor-cell-migration-and-invasion","display_name":"tumor cell migration and invasion","score":0.5929999947547913},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.8050000071525574},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.8299999833106995}],"concepts":[{"id":"https://openalex.org/C187785154","wikidata":"https://www.wikidata.org/wiki/Q5464664","display_name":"Follicular phase","level":2,"score":0.8034999966621399},{"id":"https://openalex.org/C2993294228","wikidata":"https://www.wikidata.org/wiki/Q13632630","display_name":"Thyroid carcinoma","level":3,"score":0.7721999883651733},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.7217000126838684},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5992000102996826},{"id":"https://openalex.org/C2779341817","wikidata":"https://www.wikidata.org/wiki/Q5464665","display_name":"Follicular thyroid cancer","level":5,"score":0.5748000144958496},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5666999816894531},{"id":"https://openalex.org/C2778057883","wikidata":"https://www.wikidata.org/wiki/Q92793969","display_name":"Follicular cell","level":3,"score":0.5095000267028809},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4948999881744385},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.47620001435279846},{"id":"https://openalex.org/C2780416268","wikidata":"https://www.wikidata.org/wiki/Q18021049","display_name":"Carbonic anhydrase II","level":4,"score":0.44339999556541443},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.4296000003814697},{"id":"https://openalex.org/C2775914622","wikidata":"https://www.wikidata.org/wiki/Q284089","display_name":"Carbonic anhydrase","level":3,"score":0.41659998893737793},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4034000039100647},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.3955000042915344},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37540000677108765},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.35679998993873596},{"id":"https://openalex.org/C2911210155","wikidata":"https://www.wikidata.org/wiki/Q284089","display_name":"Carbonic Anhydrase I","level":4,"score":0.28139999508857727}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002256","descriptor_name":"Carbonic Anhydrases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002256","descriptor_name":"Carbonic Anhydrases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010671","descriptor_name":"Phenylurea Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018263","descriptor_name":"Adenocarcinoma, Follicular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018263","descriptor_name":"Adenocarcinoma, Follicular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018263","descriptor_name":"Adenocarcinoma, Follicular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020778","descriptor_name":"Matrix Metalloproteinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1111/cas.70248","doi":"https://doi.org/10.1111/cas.70248","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cas.70248","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cas.70248","source":{"id":"https://openalex.org/S175946340","display_name":"Cancer Science","issn_l":"1347-9032","issn":["1347-9032","1349-7006"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Science","raw_type":"journal-article"},{"id":"pmid:41208415","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41208415","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer science","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12775590","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12775590/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Sci","raw_type":"Text"},{"id":"pmh:oai:irdb.nii.ac.jp:01056:0007222796","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11094/103469","pdf_url":"https://ir.library.osaka-u.ac.jp/repo/ouka/all/103469/CancerSci.pdf","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Science","raw_type":"journal article"},{"id":"pmh:oai:ir.library.osaka-u.ac.jp:11094/103469","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.1111/cas.70248","pdf_url":null,"source":{"id":"https://openalex.org/S4306402540","display_name":"OUKA (Osaka University Knowledge Archive) (Osaka University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98285908","host_organization_name":"The University of Osaka","host_organization_lineage":["https://openalex.org/I98285908"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1111/cas.70248","doi":"https://doi.org/10.1111/cas.70248","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cas.70248","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cas.70248","source":{"id":"https://openalex.org/S175946340","display_name":"Cancer Science","issn_l":"1347-9032","issn":["1347-9032","1349-7006"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Science","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3909598355","display_name":null,"funder_award_id":"JP21ae0121049","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G8931524679","display_name":null,"funder_award_id":"Grant Number JP21ae0121049","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"}],"funders":[{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416094591.pdf","grobid_xml":"https://content.openalex.org/works/W4416094591.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1236307033","https://openalex.org/W1967792499","https://openalex.org/W1973469475","https://openalex.org/W1978915600","https://openalex.org/W1995122735","https://openalex.org/W2033341544","https://openalex.org/W2038583226","https://openalex.org/W2090334145","https://openalex.org/W2113056676","https://openalex.org/W2136895644","https://openalex.org/W2168489020","https://openalex.org/W2478132860","https://openalex.org/W2605693728","https://openalex.org/W2703842945","https://openalex.org/W2765984386","https://openalex.org/W2773215951","https://openalex.org/W2888490364","https://openalex.org/W2903808414","https://openalex.org/W2914933414","https://openalex.org/W2945804800","https://openalex.org/W3009240947","https://openalex.org/W3014500359","https://openalex.org/W3045375094","https://openalex.org/W3092990449","https://openalex.org/W3212445799","https://openalex.org/W4214666393","https://openalex.org/W4220843355","https://openalex.org/W4220913211","https://openalex.org/W4229015125","https://openalex.org/W4297982558","https://openalex.org/W4366598488","https://openalex.org/W4388993587","https://openalex.org/W4389832759","https://openalex.org/W4390033404","https://openalex.org/W4390589534","https://openalex.org/W4390884211","https://openalex.org/W4391278468","https://openalex.org/W4391562669","https://openalex.org/W4401794109","https://openalex.org/W4405698348"],"related_works":["https://openalex.org/W2137413215","https://openalex.org/W1566950390","https://openalex.org/W2064271648","https://openalex.org/W2442623390","https://openalex.org/W2371682231","https://openalex.org/W2032808477","https://openalex.org/W2115839935","https://openalex.org/W3022601396","https://openalex.org/W4385467019","https://openalex.org/W2781886380"],"abstract_inverted_index":{"Follicular":[0],"thyroid":[1,15,33,42,70,88,104,118,148,189,210,241],"carcinoma":[2,16,43,71,149,190,211,242],"is":[3,27,72],"generally":[4],"associated":[5],"with":[6,55,221],"a":[7,11,134,215,235,244],"favorable":[8],"prognosis;":[9],"however,":[10],"subset":[12,26],"of":[13,53,61,65,115,172,239],"follicular":[14,32,41,69,87,103,117,147,153,188,209,240],"shows":[17],"poor":[18,173],"prognosis":[19],"and":[20,24,98,124,127,159,193,218,243],"frequent":[21],"distant":[22],"metastases,":[23],"this":[25,107],"referred":[28],"to":[29,50,93],"as":[30,82,133,234],"high-risk":[31,38,68,102,116],"carcinoma.":[34,89,105],"Difficulty":[35],"in":[36,146,151,156,214],"distinguishing":[37,67],"from":[39],"low-risk":[40],"based":[44],"on":[45],"current":[46],"diagnostic":[47],"approaches":[48],"leads":[49],"the":[51,59],"overtreatment":[52],"patients":[54],"indolent":[56],"disease.":[57],"Therefore,":[58],"identification":[60],"novel":[62,95,236],"biomarkers":[63,79],"capable":[64],"reliably":[66],"essential":[73],"for":[74,85,101],"accurate":[75],"risk":[76],"stratification.":[77],"Such":[78],"may":[80],"serve":[81],"therapeutic":[83,99,246],"targets":[84,100],"metastatic":[86,125],"This":[90],"study":[91],"aimed":[92],"identify":[94],"prognostic":[96,237],"markers":[97],"In":[106],"study,":[108],"we":[109,128],"conducted":[110],"bulk":[111],"ribonucleic":[112],"acid":[113],"sequencing":[114],"carcinoma,":[119],"including":[120],"widely":[121,157],"invasive":[122,158],"subtypes":[123],"tumors,":[126],"identified":[129,230],"carbonic":[130,142,164,184,203,231],"anhydrase":[131,143,165,185,204,232],"12":[132,144,166,186,205,233],"candidate":[135],"biomarker.":[136],"Immunohistochemical":[137],"analysis":[138],"revealed":[139],"significantly":[140],"higher":[141],"expression":[145,167],"than":[150],"benign":[152],"adenomas,":[154],"particularly":[155],"encapsulated":[160],"angioinvasive":[161],"subtypes.":[162],"High":[163],"was":[168],"an":[169],"independent":[170],"predictor":[171],"disease-free":[174],"survival,":[175],"surpassing":[176],"conventional":[177],"clinicopathological":[178],"parameters.":[179],"Functional":[180],"assays":[181],"showed":[182],"that":[183],"promoted":[187],"proliferation,":[191],"invasion,":[192],"migration":[194],"partly":[195],"by":[196],"regulating":[197],"matrix":[198],"metalloproteinase":[199],"2":[200],"expression.":[201],"Furthermore,":[202],"inhibitor":[206],"U104":[207],"suppressed":[208],"cell":[212],"growth":[213],"dose-dependent":[216],"manner,":[217],"its":[219],"combination":[220],"lenvatinib":[222],"exerted":[223],"synergistic":[224],"antiproliferative":[225],"effects.":[226],"Collectively,":[227],"these":[228],"findings":[229],"biomarker":[238],"promising":[245],"target.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2025-11-10T00:00:00"}