{"id":"https://openalex.org/W4416077936","doi":"https://doi.org/10.3390/cimb47110934","title":"Ethyl Acetate Extract of Cynanchi Auriculati Radix Inhibits LPS-Induced M1 Polarization of RAW264.7 Macrophages and Prolongs the Lifespan of Caenorhabditis elegans by Regulating NF-\u03baB and PMK-1/SKN-1 Signaling Pathways","display_name":"Ethyl Acetate Extract of Cynanchi Auriculati Radix Inhibits LPS-Induced M1 Polarization of RAW264.7 Macrophages and Prolongs the Lifespan of Caenorhabditis elegans by Regulating NF-\u03baB and PMK-1/SKN-1 Signaling Pathways","publication_year":2025,"publication_date":"2025-11-10","ids":{"openalex":"https://openalex.org/W4416077936","doi":"https://doi.org/10.3390/cimb47110934","pmid":"https://pubmed.ncbi.nlm.nih.gov/41296439","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12650852"},"language":"en","primary_location":{"id":"doi:10.3390/cimb47110934","doi":"https://doi.org/10.3390/cimb47110934","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cimb47110934","pdf_url":"https://www.mdpi.com/1467-3045/47/11/934/pdf?version=1762770482","source":{"id":"https://openalex.org/S62841813","display_name":"Current Issues in Molecular Biology","issn_l":"1467-3037","issn":["1467-3037","1467-3045"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311742","host_organization_name":"Caister Academic Press","host_organization_lineage":["https://openalex.org/P4310311742"],"host_organization_lineage_names":["Caister Academic Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Issues in Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1467-3045/47/11/934/pdf?version=1762770482","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jiawei Fan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153482","display_name":"Changzhou University","ror":"https://ror.org/04ymgwq66","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210153482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiawei Fan","raw_affiliation_strings":["School of Pharmacy, Changzhou University, 21 Gehu Road, Changzhou 213164, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Changzhou University, 21 Gehu Road, Changzhou 213164, China","institution_ids":["https://openalex.org/I4210153482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071518367","display_name":"Ya Su","orcid":"https://orcid.org/0000-0002-2689-3148","observed_orcids":["https://orcid.org/0000-0002-2689-3148"]},"institutions":[{"id":"https://openalex.org/I4210153482","display_name":"Changzhou University","ror":"https://ror.org/04ymgwq66","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210153482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ya Su","raw_affiliation_strings":["School of Pharmacy, Changzhou University, 21 Gehu Road, Changzhou 213164, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Changzhou University, 21 Gehu Road, Changzhou 213164, China","institution_ids":["https://openalex.org/I4210153482"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yi Xing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153482","display_name":"Changzhou University","ror":"https://ror.org/04ymgwq66","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210153482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Xing","raw_affiliation_strings":["School of Pharmacy, Changzhou University, 21 Gehu Road, Changzhou 213164, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Changzhou University, 21 Gehu Road, Changzhou 213164, China","institution_ids":["https://openalex.org/I4210153482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100668928","display_name":"Kun Hu","orcid":"https://orcid.org/0000-0003-4420-2467","observed_orcids":["https://orcid.org/0000-0003-4420-2467"]},"institutions":[{"id":"https://openalex.org/I4210153482","display_name":"Changzhou University","ror":"https://ror.org/04ymgwq66","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210153482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kun Hu","raw_affiliation_strings":["School of Pharmacy, Changzhou University, 21 Gehu Road, Changzhou 213164, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Changzhou University, 21 Gehu Road, Changzhou 213164, China","institution_ids":["https://openalex.org/I4210153482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039305944","display_name":"Jie Ren","orcid":"https://orcid.org/0000-0002-7440-5188","observed_orcids":["https://orcid.org/0000-0002-7440-5188"]},"institutions":[{"id":"https://openalex.org/I4210153482","display_name":"Changzhou University","ror":"https://ror.org/04ymgwq66","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210153482"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jie Ren","raw_affiliation_strings":["School of Pharmacy, Changzhou University, 21 Gehu Road, Changzhou 213164, China"],"raw_orcid":"https://orcid.org/0000-0002-7440-5188","affiliations":[{"raw_affiliation_string":"School of Pharmacy, Changzhou University, 21 Gehu Road, Changzhou 213164, China","institution_ids":["https://openalex.org/I4210153482"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112550847","display_name":"Jia Yang","orcid":"https://orcid.org/0000-0003-4364-1804","observed_orcids":["https://orcid.org/0000-0003-4364-1804"]},"institutions":[{"id":"https://openalex.org/I4210151861","display_name":"Changzhou No.2 People's Hospital","ror":"https://ror.org/04bkhy554","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151861"]},{"id":"https://openalex.org/I4210153482","display_name":"Changzhou University","ror":"https://ror.org/04ymgwq66","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210153482"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jia Yang","raw_affiliation_strings":["Purchasing and Supply Department, The Affiliated Changzhou No. 2 People\u2019s Hospital of Nanjing Medical University, NO. 68. Gehu Middle Road, Changzhou 213164, China","School of Pharmacy, Changzhou University, 21 Gehu Road, Changzhou 213164, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Purchasing and Supply Department, The Affiliated Changzhou No. 2 People\u2019s Hospital of Nanjing Medical University, NO. 68. Gehu Middle Road, Changzhou 213164, China","institution_ids":["https://openalex.org/I4210151861","https://openalex.org/I83519826"]},{"raw_affiliation_string":"School of Pharmacy, Changzhou University, 21 Gehu Road, Changzhou 213164, China","institution_ids":["https://openalex.org/I4210153482"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5039305944","https://openalex.org/A5112550847"],"corresponding_institution_ids":["https://openalex.org/I4210151861","https://openalex.org/I4210153482","https://openalex.org/I83519826"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2654},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2654},"fwci":1.0511,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.80701062,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":95},"biblio":{"volume":"47","issue":"11","first_page":"934","last_page":"934"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.38089999556541443,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.38089999556541443,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.15139999985694885,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.15049999952316284,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cynanchum-auriculatum","display_name":"Cynanchum auriculatum","score":0.9940000176429749},{"id":"https://openalex.org/keywords/ethyl-acetate-extract","display_name":"ethyl acetate extract","score":0.8939999938011169},{"id":"https://openalex.org/keywords/anti-aging","display_name":"anti-aging","score":0.8140000104904175},{"id":"https://openalex.org/keywords/lifespan-extension","display_name":"lifespan extension","score":0.8259999752044678},{"id":"https://openalex.org/keywords/m1-macrophage-polarization","display_name":"M1 macrophage polarization","score":0.8650000095367432},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9190000295639038},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.8989999890327454},{"id":"https://openalex.org/keywords/lps-induced-inflammation","display_name":"lipopolysaccharide-induced inflammation","score":0.7940000295639038},{"id":"https://openalex.org/keywords/raw-264-7-macrophages","display_name":"RAW 264.7 macrophages","score":0.8669999837875366},{"id":"https://openalex.org/keywords/oxidative-stress-tolerance","display_name":"oxidative stress resistance","score":0.8429999947547913},{"id":"https://openalex.org/keywords/heat-stress-resistance","display_name":"heat stress resistance","score":0.9829999804496765},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.5540000200271606},{"id":"https://openalex.org/keywords/bioactive-compounds","display_name":"bioactive compounds","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.7954000234603882},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.6158999800682068},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5921000242233276},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5791000127792358},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5436000227928162},{"id":"https://openalex.org/C2779858419","wikidata":"https://www.wikidata.org/wiki/Q407153","display_name":"Ethyl acetate","level":2,"score":0.517300009727478},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5049999952316284},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.4571000039577484},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.3928000032901764},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36910000443458557},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.35679998993873596},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.35030001401901245},{"id":"https://openalex.org/C2776682551","wikidata":"https://www.wikidata.org/wiki/Q21072584","display_name":"Macrophage polarization","level":4,"score":0.34850001335144043},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33309999108314514},{"id":"https://openalex.org/C2779091547","wikidata":"https://www.wikidata.org/wiki/Q287565","display_name":"Radix (gastropod)","level":2,"score":0.32179999351501465},{"id":"https://openalex.org/C2987418964","wikidata":"https://www.wikidata.org/wiki/Q242165","display_name":"Heat stress","level":2,"score":0.3012000024318695},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2903999984264374},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.2752000093460083},{"id":"https://openalex.org/C205049153","wikidata":"https://www.wikidata.org/wiki/Q2698605","display_name":"Polarization (electrochemistry)","level":2,"score":0.2736000120639801},{"id":"https://openalex.org/C3019987054","wikidata":"https://www.wikidata.org/wiki/Q1251001","display_name":"Dose dependence","level":2,"score":0.2547999918460846}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3390/cimb47110934","doi":"https://doi.org/10.3390/cimb47110934","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cimb47110934","pdf_url":"https://www.mdpi.com/1467-3045/47/11/934/pdf?version=1762770482","source":{"id":"https://openalex.org/S62841813","display_name":"Current Issues in Molecular Biology","issn_l":"1467-3037","issn":["1467-3037","1467-3045"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311742","host_organization_name":"Caister Academic Press","host_organization_lineage":["https://openalex.org/P4310311742"],"host_organization_lineage_names":["Caister Academic Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Issues in Molecular Biology","raw_type":"journal-article"},{"id":"pmid:41296439","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41296439","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current issues in molecular biology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:6170695619794e3ab7b0d52acd478f62","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6170695619794e3ab7b0d52acd478f62","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Current Issues in Molecular Biology, Vol 47, Iss 11, p 934 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/cimb47110934","doi":"https://doi.org/10.3390/cimb47110934","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cimb47110934","pdf_url":"https://www.mdpi.com/1467-3045/47/11/934/pdf?version=1762770482","source":{"id":"https://openalex.org/S62841813","display_name":"Current Issues in Molecular Biology","issn_l":"1467-3037","issn":["1467-3037","1467-3045"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310311742","host_organization_name":"Caister Academic Press","host_organization_lineage":["https://openalex.org/P4310311742"],"host_organization_lineage_names":["Caister Academic Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Issues in Molecular Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4416077936.pdf","grobid_xml":"https://content.openalex.org/works/W4416077936.grobid-xml"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W2037911961","https://openalex.org/W2087118969","https://openalex.org/W2092165052","https://openalex.org/W2594025193","https://openalex.org/W2782426171","https://openalex.org/W2911223027","https://openalex.org/W2950111581","https://openalex.org/W2991502704","https://openalex.org/W2996969437","https://openalex.org/W2997662890","https://openalex.org/W3031132417","https://openalex.org/W3047617638","https://openalex.org/W3126204273","https://openalex.org/W3134392646","https://openalex.org/W3137205095","https://openalex.org/W3194833230","https://openalex.org/W3196681928","https://openalex.org/W3206218751","https://openalex.org/W3208106134","https://openalex.org/W3217528845","https://openalex.org/W4210634031","https://openalex.org/W4210664012","https://openalex.org/W4210796776","https://openalex.org/W4223459443","https://openalex.org/W4223893115","https://openalex.org/W4225261487","https://openalex.org/W4284967369","https://openalex.org/W4287149234","https://openalex.org/W4291000418","https://openalex.org/W4292380346","https://openalex.org/W4296058581","https://openalex.org/W4303184312","https://openalex.org/W4308770875","https://openalex.org/W4309570905","https://openalex.org/W4309810214","https://openalex.org/W4319869782","https://openalex.org/W4322109788","https://openalex.org/W4322505937","https://openalex.org/W4323843541","https://openalex.org/W4366779908","https://openalex.org/W4376619382","https://openalex.org/W4378710490","https://openalex.org/W4380149424","https://openalex.org/W4380997709","https://openalex.org/W4382243880","https://openalex.org/W4382363993","https://openalex.org/W4386987627","https://openalex.org/W4388291090","https://openalex.org/W4389334765","https://openalex.org/W4389702487","https://openalex.org/W4391849988","https://openalex.org/W4392360350","https://openalex.org/W4392637501","https://openalex.org/W4392799093","https://openalex.org/W4392922246","https://openalex.org/W4393282390","https://openalex.org/W4394808227","https://openalex.org/W4394840110","https://openalex.org/W4399388029","https://openalex.org/W4401240600","https://openalex.org/W4401362468","https://openalex.org/W4401423177","https://openalex.org/W4402738721","https://openalex.org/W4403046712","https://openalex.org/W4405016973","https://openalex.org/W4406594117","https://openalex.org/W4407056161","https://openalex.org/W4407265437","https://openalex.org/W4407834251","https://openalex.org/W4407937094","https://openalex.org/W4408235432","https://openalex.org/W4408709309","https://openalex.org/W4409314042","https://openalex.org/W4409409784","https://openalex.org/W4409859696","https://openalex.org/W4410487671","https://openalex.org/W4412741225","https://openalex.org/W4412845463","https://openalex.org/W4413869617"],"related_works":["https://openalex.org/W4366779908","https://openalex.org/W4390756653","https://openalex.org/W7136569380","https://openalex.org/W852174574","https://openalex.org/W2965870470","https://openalex.org/W2585214201","https://openalex.org/W4408005168","https://openalex.org/W4214614577","https://openalex.org/W3095243290","https://openalex.org/W2316457997"],"abstract_inverted_index":{"Extracts":[0],"of":[1,10,30,48,94,106],"Cynanchi":[2],"Auriculati":[3],"Radix":[4],"(RCA),":[5],"derived":[6],"from":[7],"the":[8,27,42,104,116,140],"roots":[9],"Cynanchum":[11],"auriculatum":[12],"Royle":[13],"ex":[14],"Wight.":[15],"(CA),":[16],"have":[17],"been":[18],"documented":[19],"to":[20,40,56,68,79],"possess":[21],"anti-inflammatory":[22,70,154],"and":[23,46,51,59,82,113,125,128,153,159],"antioxidant":[24],"properties.":[25],"However,":[26],"molecular":[28],"mechanisms":[29,47],"their":[31],"anti-aging":[32,44,152],"action":[33],"remain":[34],"unclear.":[35],"The":[36,90],"present":[37],"study":[38],"aimed":[39],"explore":[41],"potential":[43],"components":[45,58,87],"RCA.":[49],"LC-MS/MS":[50],"network":[52],"pharmacology":[53],"were":[54,66,77,88,137],"used":[55,67],"identify":[57],"targets.":[60],"In":[61,72,119],"vitro,":[62],"LPS-induced":[63,98],"RAW264.7":[64],"macrophages":[65],"assess":[69],"effects.":[71],"vivo,":[73],"Caenorhabditis":[74],"elegans":[75],"models":[76],"employed":[78],"evaluate":[80],"lifespan":[81,124],"stress":[83,130],"resistance.":[84],"Five":[85],"bioactive":[86],"identified.":[89],"ethyl":[91],"acetate":[92],"extract":[93],"RCA":[95],"(RCAEA)":[96],"inhibited":[97],"M1":[99],"macrophage":[100],"polarization":[101],"by":[102,139],"suppressing":[103],"expression":[105],"NO,":[107],"PGE2,":[108],"IL-1\u03b2,":[109],"iNOS,":[110],"COX-2,":[111],"TNF-\u03b1,":[112],"IL-6":[114],"via":[115],"NF-\u03baB":[117,158],"pathway.":[118],"C.":[120],"elegans,":[121],"RCAEA":[122,148],"extended":[123],"enhanced":[126],"oxidative":[127],"heat":[129],"resistance,":[131],"without":[132],"affecting":[133],"reproduction.":[134],"These":[135],"benefits":[136],"mediated":[138],"PMK-1/SKN-1":[141,160],"pathway,":[142],"as":[143],"confirmed":[144],"using":[145],"mutant":[146],"strains.":[147],"is":[149],"a":[150],"promising":[151],"agent,":[155],"acting":[156],"through":[157],"signaling":[161],"pathways.":[162]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-11-10T00:00:00"}
