{"id":"https://openalex.org/W4416066925","doi":"https://doi.org/10.1681/asn.2025nf4wb4r7","title":"Convergence and Divergence of Mammalian Postbranching Nephrogenesis","display_name":"Convergence and Divergence of Mammalian Postbranching Nephrogenesis","publication_year":2025,"publication_date":"2025-10-01","ids":{"openalex":"https://openalex.org/W4416066925","doi":"https://doi.org/10.1681/asn.2025nf4wb4r7"},"language":"en","primary_location":{"id":"doi:10.1681/asn.2025nf4wb4r7","doi":"https://doi.org/10.1681/asn.2025nf4wb4r7","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.2025nf4wb4r7","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5138109110","display_name":"Cimran Nakum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cimran Nakum","raw_affiliation_strings":["Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States;","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118747116","display_name":"Shalini Indugula","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shalini Indugula","raw_affiliation_strings":["Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States;","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078684676","display_name":"Sunitha Yarlagadda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sunitha Yarlagadda","raw_affiliation_strings":["Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States;","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120324611","display_name":"Brandi C Bull","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brandi C Bull","raw_affiliation_strings":["Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States;","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Debarun Roy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Debarun Roy","raw_affiliation_strings":["The University of Texas at San Antonio, San Antonio, Texas, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas at San Antonio, San Antonio, Texas, United States;","institution_ids":["https://openalex.org/I45438204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081984405","display_name":"Brian P. Hermann","orcid":"https://orcid.org/0000-0002-0503-3616","observed_orcids":["https://orcid.org/0000-0002-0503-3616"]},"institutions":[{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian P Hermann","raw_affiliation_strings":["The University of Texas at San Antonio, San Antonio, Texas, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas at San Antonio, San Antonio, Texas, United States;","institution_ids":["https://openalex.org/I45438204"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014945172","display_name":"Meredith Posner Schuh","orcid":"https://orcid.org/0000-0001-7854-8138","observed_orcids":["https://orcid.org/0000-0001-7854-8138"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meredith Posner Schuh","raw_affiliation_strings":["Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States;","University of Cincinnati Department of Pediatrics, Cincinnati, Ohio, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States;","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"University of Cincinnati Department of Pediatrics, Cincinnati, Ohio, United States","institution_ids":["https://openalex.org/I63135867"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.33987325,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"10S","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nephron-development","display_name":"nephron development","score":0.7839999794960022},{"id":"https://openalex.org/keywords/ureteric-bud","display_name":"ureteric bud","score":0.9539999961853027},{"id":"https://openalex.org/keywords/six2","display_name":"Six2","score":0.7599999904632568},{"id":"https://openalex.org/keywords/wt1","display_name":"WT1","score":0.8920000195503235},{"id":"https://openalex.org/keywords/ret","display_name":"RET","score":0.9940000176429749},{"id":"https://openalex.org/keywords/marmoset","display_name":"marmoset","score":0.8610000014305115},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.9670000076293945},{"id":"https://openalex.org/keywords/rabbits","display_name":"rabbits","score":0.9959999918937683},{"id":"https://openalex.org/keywords/rhesus-macaques","display_name":"rhesus monkeys","score":0.871999979019165},{"id":"https://openalex.org/keywords/nephron-induction","display_name":"nephron induction","score":0.36899998784065247}],"concepts":[{"id":"https://openalex.org/C207390915","wikidata":"https://www.wikidata.org/wiki/Q1230525","display_name":"Divergence (linguistics)","level":2,"score":0.8659999966621399},{"id":"https://openalex.org/C2777303404","wikidata":"https://www.wikidata.org/wiki/Q759757","display_name":"Convergence (economics)","level":2,"score":0.7789000272750854},{"id":"https://openalex.org/C28826006","wikidata":"https://www.wikidata.org/wiki/Q33521","display_name":"Applied mathematics","level":1,"score":0.5019000172615051},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.4431999921798706},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3882000148296356},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.260699987411499},{"id":"https://openalex.org/C20129857","wikidata":"https://www.wikidata.org/wiki/Q751611","display_name":"Mathematical and theoretical biology","level":2,"score":0.25850000977516174},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.24940000474452972},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.24809999763965607},{"id":"https://openalex.org/C171752962","wikidata":"https://www.wikidata.org/wiki/Q255166","display_name":"Kullback\u2013Leibler divergence","level":2,"score":0.23639999330043793}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1681/asn.2025nf4wb4r7","doi":"https://doi.org/10.1681/asn.2025nf4wb4r7","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.2025nf4wb4r7","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4388406182","https://openalex.org/W4397046102","https://openalex.org/W4397025009","https://openalex.org/W3139956814","https://openalex.org/W4403811659","https://openalex.org/W7096198346","https://openalex.org/W2004410280","https://openalex.org/W2788218466","https://openalex.org/W3195091234","https://openalex.org/W7127179366"],"abstract_inverted_index":{"Background:":[0],"Human":[1],"nephrogenesis":[2,25,32,74,150,186],"ends":[3],"prior":[4],"to":[5,56,91,98,213],"birth":[6],"in":[7,22,76,206,230],"term":[8],"infants":[9],"(34-36":[10],"week":[11],"gestation),":[12],"with":[13,122,133,138,151,170],"most":[14],"(60%)":[15],"nephrons":[16,118],"being":[17],"formed":[18],"during":[19],"late":[20,207],"gestation":[21],"two":[23],"post-branching":[24,185],"(PBN)":[26],"periods:":[27],"arcading":[28,43,64,149,232],"and":[29,44,61,81,106,115,145,174,179,187,233,235],"lateral":[30,48,139],"branch":[31,49,140],"(LBN).":[33],"We":[34,83],"previously":[35],"demonstrated":[36,236],"the":[37,45,59,77,88,113,127,159,195,197,217,225,238],"rabbit":[38],"as":[39],"a":[40,166,220],"model":[41],"of":[42,47,87,101,112,154,184,203,219,224],"rhesus":[46],"nephrogenesis.":[50,141],"In":[51,157],"this":[52],"study,":[53],"we":[54],"sought":[55],"determine":[57],"if":[58],"marmoset":[60,114,146,198],"rat":[62,116],"underwent":[63],"and/or":[65],"LBN.":[66],"Methods:":[67],"Comparative":[68],"developmental":[69],"analyses":[70],"were":[71],"performed":[72,84,97],"before":[73],"cessation":[75],"rat,":[78,143],"rabbit,":[79,144],"marmoset,":[80],"rhesus.":[82],"3D":[85,109],"rendering":[86],"nephrogenic":[89,155],"niche":[90],"assess":[92],"for":[93,190],"PBN.":[94],"Immunofluorescence":[95],"was":[96],"evaluate":[99],"markers":[100],"nephrogenesis,":[102],"including":[103],"SIX2,":[104],"WT1,":[105],"RET.":[107],"Results:":[108],"morphologic":[110],"assessments":[111],"cortical":[117],"identified":[119],"elongated":[120],"tubules":[121],"attached":[123],"glomeruli":[124],"extending":[125],"below":[126],"ureteric":[128],"bud":[129],"(UB)":[130],"tip,":[131],"consistent":[132],"PBN":[134],"arcades,":[135],"but":[136],"not":[137,200],"The":[142],"all":[147],"demonstrate":[148],"similar":[152],"expression":[153],"markers.":[156],"all,":[158],"UB":[160,226],"tip":[161,227],"above":[162],"these":[163],"arcades":[164],"contained":[165],"horn-like":[167],"protrusion":[168],"interacting":[169],"an":[171],"immature":[172],"SIX2":[173],"NPC":[175],"population.":[176],"Conclusion:":[177],"Arcading":[178],"LBN":[180,210,234],"are":[181],"both":[182,231],"forms":[183],"critical":[188],"steps":[189],"human":[191],"nephron":[192,221],"formation.":[193],"Unlike":[194],"rhesus,":[196],"does":[199],"show":[201],"evidence":[202],"LBN,":[204],"even":[205],"gestation.":[208],"While":[209],"is":[211,228],"unique":[212],"old":[214],"world":[215],"primates,":[216],"induction":[218],"without":[222],"branching":[223],"conserved":[229],"among":[237],"species":[239],"described":[240],"here.":[241],"Funding:":[242],"NIDDK":[243],"Support":[244]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2025-11-10T00:00:00"}
