{"id":"https://openalex.org/W4415940888","doi":"https://doi.org/10.1016/j.annonc.2025.08.1717","title":"1079P Biparatopic anti-HER2 antibody drug conjugate (ADC) JSKN003 in the treatment of primary platinum-refractory ovarian cancer (OC)","display_name":"1079P Biparatopic anti-HER2 antibody drug conjugate (ADC) JSKN003 in the treatment of primary platinum-refractory ovarian cancer (OC)","publication_year":2025,"publication_date":"2025-09-01","ids":{"openalex":"https://openalex.org/W4415940888","doi":"https://doi.org/10.1016/j.annonc.2025.08.1717"},"language":"en","primary_location":{"id":"doi:10.1016/j.annonc.2025.08.1717","doi":"https://doi.org/10.1016/j.annonc.2025.08.1717","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.annonc.2025.08.1717","pdf_url":null,"source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.annonc.2025.08.1717","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100694775","display_name":"Xiaohua Wu","orcid":"https://orcid.org/0000-0002-6889-3541","observed_orcids":["https://orcid.org/0000-0002-6889-3541","https://orcid.org/0000-0002-7664-8327","https://orcid.org/0000-0002-2271-2514","https://orcid.org/0000-0001-5908-004X","https://orcid.org/0000-0001-7692-7863","https://orcid.org/0000-0003-0725-775X","https://orcid.org/0009-0003-9674-8389","https://orcid.org/0000-0002-8213-3119"]},"institutions":[{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"X. Wu","raw_affiliation_strings":["Gynecologic Oncology II, Fudan University Shanghai Cancer Center, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gynecologic Oncology II, Fudan University Shanghai Cancer Center, Shanghai, China","institution_ids":["https://openalex.org/I4210093194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108050401","display_name":"Jiajia Li","orcid":"https://orcid.org/0000-0003-0330-4264","observed_orcids":["https://orcid.org/0000-0003-0330-4264"]},"institutions":[{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J. Li","raw_affiliation_strings":["Gynecologic Oncology II, Fudan University Shanghai Cancer Center, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gynecologic Oncology II, Fudan University Shanghai Cancer Center, Shanghai, China","institution_ids":["https://openalex.org/I4210093194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107957854","display_name":"Y. Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098734","display_name":"Zhejiang Cancer Hospital","ror":"https://ror.org/0144s0951","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098734"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Y. Chen","raw_affiliation_strings":["Gynecologic Oncology Surgery, Zhejiang Cancer Hospital, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gynecologic Oncology Surgery, Zhejiang Cancer Hospital, Hangzhou, China","institution_ids":["https://openalex.org/I4210098734"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Q. Rao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097354","display_name":"Sun Yat-sen Memorial Hospital","ror":"https://ror.org/01px77p81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097354"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Q. Rao","raw_affiliation_strings":["Gynecologic Oncology, Sun Yat-sen Memorial Hospital, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gynecologic Oncology, Sun Yat-sen Memorial Hospital, Guangzhou, China","institution_ids":["https://openalex.org/I4210097354"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A. Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148548","display_name":"Fujian Provincial Cancer Hospital","ror":"https://ror.org/058ms9w43","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210148548"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"A. Lin","raw_affiliation_strings":["Gynecologic Oncology Surgery, Fujian Provincial Cancer Hospital, Fuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gynecologic Oncology Surgery, Fujian Provincial Cancer Hospital, Fuzhou, China","institution_ids":["https://openalex.org/I4210148548"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109486655","display_name":"GuangDong Weng","orcid":"https://orcid.org/0009-0000-8869-4796","observed_orcids":["https://orcid.org/0009-0000-8869-4796"]},"institutions":[{"id":"https://openalex.org/I4210097945","display_name":"Linyi People's Hospital","ror":"https://ror.org/011r8ce56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097945"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"G. Weng","raw_affiliation_strings":["Clinical Pharmacology Research Unit, Linyi People's Hospital, Linyi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology Research Unit, Linyi People's Hospital, Linyi, China","institution_ids":["https://openalex.org/I4210097945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100786751","display_name":"Zhe Zhang","orcid":"https://orcid.org/0009-0006-8199-7456","observed_orcids":["https://orcid.org/0009-0006-8199-7456"]},"institutions":[{"id":"https://openalex.org/I4210097945","display_name":"Linyi People's Hospital","ror":"https://ror.org/011r8ce56","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097945"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Z. Zhang","raw_affiliation_strings":["Tumor Center, Linyi People's Hospital, Linyi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tumor Center, Linyi People's Hospital, Linyi, China","institution_ids":["https://openalex.org/I4210097945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052184198","display_name":"Bai-Lin Liu","orcid":"https://orcid.org/0000-0003-1240-8516","observed_orcids":["https://orcid.org/0000-0003-1240-8516"]},"institutions":[{"id":"https://openalex.org/I4210100830","display_name":"Shandong Tumor Hospital","ror":"https://ror.org/01413r497","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210100830"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"B. Liu","raw_affiliation_strings":["Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China","institution_ids":["https://openalex.org/I4210100830","https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060545585","display_name":"Chunyan Lan","orcid":"https://orcid.org/0000-0002-0127-2951","observed_orcids":["https://orcid.org/0000-0002-0127-2951"]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"C. Lan","raw_affiliation_strings":["Gynecologic Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gynecologic Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China","institution_ids":["https://openalex.org/I4210146711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045397288","display_name":"Q. Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128175","display_name":"Shanghai East Hospital","ror":"https://ror.org/038xmzj21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128175"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Q. Li","raw_affiliation_strings":["Oncology, Shanghai East Hospital, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology, Shanghai East Hospital, Shanghai, China","institution_ids":["https://openalex.org/I4210128175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100595046","display_name":"Dihong Tang","orcid":"https://orcid.org/0000-0003-1211-3726","observed_orcids":["https://orcid.org/0000-0003-1211-3726"]},"institutions":[{"id":"https://openalex.org/I4210115624","display_name":"Hunan Cancer Hospital","ror":"https://ror.org/025020z88","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115624"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"D. Tang","raw_affiliation_strings":["Gynecologic Oncology, Hunan Cancer Hospital, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gynecologic Oncology, Hunan Cancer Hospital, Changsha, China","institution_ids":["https://openalex.org/I4210115624"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101836811","display_name":"Jingyao Dai","orcid":"https://orcid.org/0000-0001-8510-3647","observed_orcids":["https://orcid.org/0000-0001-8510-3647"]},"institutions":[{"id":"https://openalex.org/I4210120234","display_name":"Zhongnan Hospital of Wuhan University","ror":"https://ror.org/01v5mqw79","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120234"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J. Dai","raw_affiliation_strings":["Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I4210120234"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080326933","display_name":"Ting Xu","orcid":"https://orcid.org/0000-0002-7851-3389","observed_orcids":["https://orcid.org/0000-0002-7851-3389"]},"institutions":[{"id":"https://openalex.org/I4405266976","display_name":"Jiangsu Alphamab Biopharmaceuticals Co., Ltd. (China)","ror":"https://ror.org/00jp0wa87","country_code":"CN","type":"company","lineage":["https://openalex.org/I4405266976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"T. Xu","raw_affiliation_strings":["Jiangsu Alphamab Biopharmaceuticals Co., Ltd., Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Alphamab Biopharmaceuticals Co., Ltd., Suzhou, China","institution_ids":["https://openalex.org/I4405266976"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":12,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":null,"fwci":0.3919,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.52902487,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"36","issue":null,"first_page":"S680","last_page":"S680"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antibody-drug-conjugates","display_name":"antibody-drug conjugates","score":0.8180000185966492},{"id":"https://openalex.org/keywords/biparatopic-antibody","display_name":"biparatopic antibody","score":0.8759999871253967},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.8510000109672546},{"id":"https://openalex.org/keywords/platinum-refractory-ovarian-cancer","display_name":"platinum-refractory ovarian cancer","score":0.8529999852180481},{"id":"https://openalex.org/keywords/topoisomerase-i-inhibitor","display_name":"topoisomerase I inhibitor","score":0.9829999804496765},{"id":"https://openalex.org/keywords/ovarian-cancer-treatment","display_name":"ovarian cancer treatment","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9740999937057495},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.7328000068664551},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.567799985408783},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5388000011444092},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47589999437332153},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.47440001368522644},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.42719998955726624},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41429999470710754},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3743000030517578},{"id":"https://openalex.org/C2777325958","wikidata":"https://www.wikidata.org/wiki/Q1069596","display_name":"Antibody-drug conjugate","level":4,"score":0.35899999737739563},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3264999985694885},{"id":"https://openalex.org/C147897179","wikidata":"https://www.wikidata.org/wiki/Q407828","display_name":"Topoisomerase","level":3,"score":0.3149000108242035},{"id":"https://openalex.org/C2777977315","wikidata":"https://www.wikidata.org/wiki/Q7243056","display_name":"Primary (astronomy)","level":2,"score":0.3111000061035156},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.2842999994754791},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.25999999046325684},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.25940001010894775},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25060001015663147}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.annonc.2025.08.1717","doi":"https://doi.org/10.1016/j.annonc.2025.08.1717","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.annonc.2025.08.1717","pdf_url":null,"source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.annonc.2025.08.1717","doi":"https://doi.org/10.1016/j.annonc.2025.08.1717","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.annonc.2025.08.1717","pdf_url":null,"source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4410812727","https://openalex.org/W4415940048","https://openalex.org/W4407197302","https://openalex.org/W4409552673","https://openalex.org/W4415940139","https://openalex.org/W3144619967","https://openalex.org/W4403134137","https://openalex.org/W4393987908","https://openalex.org/W4416273550","https://openalex.org/W4400265446"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2025-11-06T00:00:00"}